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1 Comparison of the X-gal- and P-gal-based systems for screening of mutant λlacZ phages originating from the transgenic mouse strain 40.6
article 1996    
Author: Mientjes, E.J. · Steenwinkel, M.J.S.T. · Delft, J.H.M. van · Lohman, P.H.M. · Baan, R.A.
Keywords: Nutrition · λgt10lacZ phage · Muta Mouse · P-gal · Positive selection · Transgenic mouse, strain 40.6 · X-gal · benzo[a]pyrene · ethylnitrosourea · animal experiment · article · bacteriophage · brain · controlled study · female · genotoxicity · liver · mouse · mutagen testing · mutant · mutation rate · nonhuman · priority journal · screening test · transgenic mouse · Animals · Bacteriophage lambda · Benzo(a)pyrene · Brain · Ethylnitrosourea · Galactosides · Indoles · Liver · Mice · Mice, Transgenic · Mutagens · Mutation
[Abstract]

2 Molecular dosimetry of DNA damage caused by alkylation. I. Single-strand breaks induced by ethylating agents in cultured mammalian cells in relation to survival
article 1982    
Author: Abbondandolo, A. · Dogliotti, E. · Lohman, P.H.M. · Berends, F.
Keywords: Biology · Chemical mutagen · Diethyl sulfate · Ethylnitronitrosoguanidine · Ethylnitrosourea · Mesylic acid ethyl ester · Alkylation · Animal experiment · Cell survival · DNA damage · Dosimetry · Ethylation · Heredity · In vitro study · Mammal · Thymidine h 3 · Alkylating Agents · Animal · Cell Line · Cell Survival · Cricetulus · DNA · DNA Repair · Dose-Response Relationship, Drug · Ethyl Methanesulfonate · Ethylnitrosourea · Female · Hamsters · Hydrogen-Ion Concentration · Methylnitronitrosoguanidine · Ovary · Sulfuric Acid Esters · Support, Non-U.S. Gov't · Time Factors
[Abstract]

3 Germ cell mutagenesis in lambdalacZ transgenic mice treated with ethylnitrosourea : comparison with specific-locus test
article 1995    
Author: Delft, J.H.M. van · Baan, R.A.
Keywords: Biology · Animal · Comparative Study · DNA · Dose-Response Relationship, Drug · Ethylnitrosourea · Guanidine · Guanidines · Lac Operon · Male · Mice · Mice, Transgenic · Mutagenesis · Mutagenicity Tests · Spermatogenesis · Spermatozoa · Support, Non-U.S. Gov't · Time Factors
[Abstract]

4 Gene-mutation assays in lambda-lacZ transgenic mice : comparison of lacZ with endogenous genes in splenocytes and small intestinal epithelium
article 1998    
Author: Delft, J.H.M. van · Bergmans, A. · Dam, F.J. van · Tates, A.D. · Howard, L. · Winton, D.J. · Baan, R.A.
Keywords: Biology · λlacZ · Dlb-1 · hprt · Mutagenesis · Transgenic mouse · ethylnitrosourea · hypoxanthine phosphoribosyltransferase · mesylic acid ethyl ester · methylnitrosourea · mutagenic agent · animal cell · animal experiment · animal tissue · article · controlled study · gene · gene mutation · intestine epithelium · mouse · mutagenesis · mutagenicity · nonhuman · priority journal · small intestine mucosa · spleen cell · transgenic mouse · Alkylating Agents · Animals · Ethyl Methanesulfonate · Ethylnitrosourea · Genetic Markers · Hypoxanthine Phosphoribosyltransferase · Intestinal Mucosa · Intestine, Small · Lac Operon · Methylnitrosourea · Mice · Mice, Inbred C57BL · Mice, Transgenic · Mutagenicity Tests · Mutagens · Mutation · Spleen · Animalia · Mus musculus
[Abstract]

5 DNA adducts, mutant frequencies, and mutation spectra in various organs of λlacZ mice exposed to ethylating agents
article 1998    
Author: Mientjes, E.J. · Luiten-Schuite, A. · Wolf, E. van der · Borsboom, Y. · Bergmans, A. · Berends, F. · Lohman, P.H.M. · Baan, R.A. · Delft, J.H.M. van
Keywords: Nutrition · λlacZ transgenic mice · Ethyl DNA adducts · Muta(TM)Mouse · Mutagenesis · Mutation spectra · Alkylating agent · Diethylnitrosamine · Ethylnitrosourea · Guanine derivative · Mesylic acid ethyl ester · Animal experiment · Animal tissue · Bone marrow · Brain · Controlled study · Dna adduct · Female · Liver · Mouse · Mutagenesis · Mutation · Mutation rate · Nonhuman · Sequence analysis · Transgenic mouse · Animals · Bone Marrow · Brain · Diethylnitrosamine · DNA Adducts · Ethyl Methanesulfonate · Ethylnitrosourea · Female · Guanine · Lac Operon · Liver · Mice · Mice, Transgenic · Mutagens
[Abstract]

6 Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of λlacZ transgenic mice treated with N-ethyl-N-nitrosourea
article 1996    
Author: Mientjes, E.J. · Hochleitner, K. · Luiten-Schuite, A. · Delft, J.H.M. van · Thomale, J. · Berends, F. · Rajewsky, M.F. · Lohman, P.H.M. · Baan, R.A.
Keywords: Toxicology · 6 o alkylguanine dna alkyltransferase · dna · ethylnitrosourea · guanine derivative · 6 ethylguanine · 6-ethylguanine · 7 ethylguanine · 7-ethylguanine · DNA · drug derivative · guanine · mutagenic agent · animal experiment · animal tissue · article · brain · controlled study · dna adduct · dna repair · enzyme inhibition · female · immunoblotting · liver · mouse · mutagenicity · nonhuman · priority journal · transgene · transgenic mouse · animal · bacteriophage lambda · biosynthesis · DNA repair · drug effect · genetics · genome · lactose operon · metabolism · mutagen testing · physiology · polymerase chain reaction · sensitivity and specificity · Animals · Bacteriophage lambda · Brain · DNA · DNA Repair · Ethylnitrosourea · Female · Genome · Guanine · Immunoblotting · Lac Operon · Liver · Mice · Mice, Transgenic · Mutagenicity Tests · Mutagens · Polymerase Chain Reaction · Sensitivity and Specificity
[Abstract]

7 Validation of the 3D Skin Comet assay using full thickness skin models: Transferability and reproducibility
article 2018    
Author: Reisinger, K. · Blatz, V. · Brinkmann, J. · Downs, T.R. · Fischer, A. · Henkler, F. · Hoffmann, S. · Krul, C. · Liebsch, M. · Luch, A. · Pirow, R. · Reus, A.A. · Schulz, M. · Pfuhler, S.
Keywords: Biology · Comet assay · Dermal exposure · DNA damage · In vitro genotoxicity · Phenion®FT · Skin · 7,12 dimethylbenz[a]anthracene · Aphidicolin · Cadmium chloride · Cyclohexanone · Ethylnitrosourea · Fallic acid propyl ester · Mitomycin · Phthalic acid bis(2 ethylhexyl) ester · Cell isolation · Controlled study · Cytotoxicity test · Genotoxicity assay · Human · Human tissue · Predictive value · Priority journal · Reproducibility · Validation study · Biomedical Innovation · Healthy Living · Life Triskelion BV · RAPID - Risk Analysis for Products in Development TARA - Toxicology and Risk Assessment · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 7 of 7 found. | Sort by date