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Showing 1 to 15 of 15 found. | Sort by date

1 Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells
article 2000    
Author: Geutskens, S.B. · Eb, M.M. van der · Plomp, A.C. · Jonges, L.E. · Cramer, S.J. · Ensink, N.G. · Kuppen, P.J.K. · Hoeben, R.C.
Keywords: Cancer gene therapy · IL-2 · Recombinant adenovirus · complementary DNA · cytokine · recombinant interleukin 2 · tumor antigen · virus vector · Adenovirus · Animal cell · Animal experiment · Animal model · Antigen recognition · Antineoplastic activity · Cancer inhibition · Colorectal cancer · Controlled study · Delayed hypersensitivity · DNA transfer · Gene expression · Gene therapy · immune response · Immunotherapy · Liver metastasis · Lymphocyte activation · Nonhuman · Rat strain · T lymphocyte · Transgene · Tumor cell · Tumor regression · Virus plaque · Virus recombinant · Virus replication · Adenoviridae · Animals · Colorectal Neoplasms · Flow Cytometry · Gene Therapy · Genetic Vectors · Histocompatibility Antigens Class I · Histocompatibility Antigens Class II · Humans · Intercellular Adhesion Molecule-1 · Interleukin-2 · Liver Neoplasms, Experimental · Lymphocyte Activation · Rats · Rats, Inbred Strains · T-Lymphocytes · Tumor Cells, Cultured · Adenoviridae · Animalia · DNA viruses
[Abstract]

2 Critical role of tissue kallikrein in vessel formation and maturation : Implications for therapeutic revascularization
article 2009    
Author: Stone, O.A. · Richer, C. · Emanueli, C. · Weel, V. van · Quax, P.H.A. · Katare, R. · Kraenkel, N. · Campagnolo, P. · Barcelos, L.S. · Siragusa, M. · Sala-Newby, G.B. · Baldessari, D. · Mione, M. · Vincent, M.P. · Benest, A.V. · Al Haj Zen, A. · Gonzalez, J. · Bates, D.O. · Alhenc-Gelas, F. · Madeddu, P.
Keywords: Biology · Biomedical Research · Angiogenesis · Gene mutations · Gene therapy · Metalloproteinases · Animals · Hindlimb · Humans · Ischemia · Kallikrein-Kinin System · Male · Matrix Metalloproteinase 9 · Mice · Mice, Knockout · Neovascularization, Physiologic · Rats · Splanchnic Circulation · Tissue Kallikreins · Wound Healing · Zebrafish
[Abstract]

3 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

4 Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3
article 2003    
Author: Laan, W.H. van der · Quax, P.H.A. · Seemayer, C.A. · Huisman, L.G.M. · Pieterman, E.J. · Grimbergen, J.M. · Verheijen, J.H. · Breedveld, F.C. · Gay, R.E. · Gay, S. · Huizinga, T.W.J. · Pap, T.
Keywords: Adenoviridae · Animals · Arthritis, Rheumatoid · Cartilage, Articular · Cell Division · Fibroblasts · Gene Expression · Gene Therapy · Genetic Vectors · Humans · Matrix Metalloproteinases · Mice · Mice, SCID · Synovial Membrane · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Adenoviridae · Animalia
[Abstract]

5 Effect of neutralizing sera on factor X-mediated adenovirus serotype 5 gene transfer
article 2009    
Author: Parker, A.L. · Waddington, S.N. · Buckley, S.M.K. · Custers, J. · Havenga, M.J.E. · Rooijen, N. van · Goudsmit, J. · McVey, J.H. · Nicklin, S.A. · Baker, A.H.
Keywords: Biology · Biomedical Research · Adenovirus · article · correlation analysis · fiber · gene therapy · gene transfer · genetic transduction · immunity · in vitro study · liver cell · nonhuman · priority journal · pseudotyping · screening · serotype · gene vector · human · immunology · metabolism · methodology · serodiagnosis · tumor cell line · virology · virus attachment · Adenoviridae · antiserum · blood clotting factor 10 · Adenoviridae · Cell Line, Tumor · Factor X · Gene Therapy · Genetic Vectors · Hepatocytes · Humans · Immune Sera · Neutralization Tests · Transduction, Genetic · Virus Attachment
[Abstract]

6 CD34+ cells home, proliferate, and participate in capillary formation, and in combination with CD34- cells enhance tube formation in a 3-dimensional matrix
article 2005    
Author: Rookmaaker, M.B. · Verhaar, M.C. · Loomans, C.J.M. · Verloop, R. · Peters, E. · Westerweel, P.E. · Murohara, T. · Staal, F.J.T. · Zonneveld, A.J. van · Koolwijk, P. · Rabelink, T.J. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Angiogenesis · Gene therapy · Nitric oxide, endothelium, vascular type · CD34 antigen · Nitric oxide · Bone marrow cell · Capillary endothelium · Capillary proliferation · Cell population · Cell proliferation · Facilitation · Gene therapy · Hhematopoietic stem cell · Human cell · Immunohistochemistry · Marker gene · Neovascularization (pathology) · Nerve sprouting · Neural tube · Peripheral vascular disease · Antigens, CD34 · Biological Markers · Capillaries · Cell Differentiation · Cell Division · Cell Movement · Cell Separation · Cells, Cultured · Coculture Techniques · Endothelium, Vascular · Fetal Blood · Hematopoietic Stem Cells · Humans · Neovascularization, Physiologic
[Abstract]

7 Vascular Growth in Ischemic Limbs: A Review of Mechanisms and Possible Therapeutic Stimulation
article 2008    
Author: Weel, V. van · Tongeren, R.B. van · Hinsbergh, V.W.M. van · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · adenovirus vector · angiogenic factor · fibrin · fibroblast growth factor · fibroblast growth factor 4 · granulocyte macrophage colony stimulating factor · placebo · plasmid vector · protein · scatter factor · vasculotropin · vasculotropin 121 · vasculotropin 165 · vasculotropin A · vasculotropin C · angiogenesis · autologous bone marrow transplantation · bone marrow · Buerger disease · cell therapy · clinical trial · comprehension · coronary artery disease · diabetes mellitus · gene therapy · human · immune system · inflammatory cell · intermittent claudication · introspection · limb ischemia · neovascularization (pathology) · nonhuman · pain · peripheral occlusive artery disease · priority journal · review · stem cell · stenosis · stimulation · Angiogenesis Inducing Agents · Animals · Collateral Circulation · Gene Therapy · Humans · Ischemia · Leg · Neovascularization, Physiologic · Stem Cell Transplantation · Vascular Endothelial Growth Factor A
[Abstract]

8 In vivo suppression of restenosis in balloon-injured rat carotid artery by adenovirus-mediated gene transfer of the cell surface-directed plasmin inhibitor ATF.BPTI
article 2001    
Author: Lamfers, M.L.M. · Lardenoye, J.H.P. · Vries, M.R. de · Aalders, M.C. · Engelse, M.A. · Grimbergen, J.M. · Hinsbergh, V.W.M. van · Quax, P.H.A.
Keywords: Adenoviridae · Angioplasty, Balloon · Animals · Aprotinin · Carotid Arteries · Carotid Stenosis · Cell Culture Techniques · Gene Expression · Gene Therapy · Gene Transfer Techniques · Genetic Vectors · Humans · Male · Peptide Fragments · Plasmin · Rats · Rats, Sprague-Dawley · Recurrence · RNA, Messenger · Tunica Intima · Tunica Media · Urinary Plasminogen Activator · Adenoviridae · Animalia · Bovinae
[Abstract]

9 The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice
article 2007    
Author: Eefting, D. · Schepers, A. · Vries, M.R. de · Pires, N.M.M. · Grimbergen, J.M. · Lagerweij, T. · Nagelkerken, L.M. · Monraats, P.S. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Animal models · Cytokines · Electroporation · Gene therapy · In vivo delivery · Inflammation · Restenosis · cytokine · interleukin 10 · animal experiment · animal model · article · cholesterol blood level · controlled study · electroporation · experimental model · gene overexpression · gene transfer · hypercholesterolemia · immunohistochemistry · inflammation · intima · male · morphometrics · mouse · nonhuman · priority journal · restenosis · reverse transcription polymerase chain reaction · RNA isolation · Animals · Disease Models, Animal · Hypercholesterolemia · Interleukin-10 · Mice · Mice, Knockout · Tunica Intima · Vascular Diseases
[Abstract]

10 A novel urokinase receptor-targeted inhibitor for plasmin and matrix metalloproteinases suppresses vein graft disease
article 2010    
Author: Eefting, D. · Seghers, L. · Grimbergen, J.M. · Vries, M.R. de · Boer, H.C. de · Lardenoye, J.W.H.P. · Jukema, J.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Health · Biomedical Research · Gene therapy · Matrix metalloproteinases · Plasmin(ogen) · Vascular surgery · Vein graft disease · apolipoprotein E3 · aprotinin · hybrid protein · matrix metalloproteinase · matrix metalloproteinase inhibitor · plasmin · plasmin inhibitor · plasminogen activator · tissue inhibitor of metalloproteinase 1 · tissue inhibitor of metalloproteinase 1 amino terminal fragment of urokinase type plasminogen activator bovine pancreas trypsin inhibitor · unclassified drug · urokinase receptor · animal cell · animal experiment · animal model · animal tissue · article · carotid artery · cell surface · controlled study · electroporation · expression vector · female · gene overexpression · gene targeting · genetic transfection · human · human tissue · hypercholesterolemia · in vivo culture · intima · male · mouse · nonhuman · nonviral gene delivery system · priority journal · vein graft disease
[Abstract]

11 Local lentiviral short hairpin RNA silencing of CCR2 inhibits vein graft thickening in hypercholesterolemic apolipoprotein E3-Leiden mice
article 2009    
Author: Eefting, D. · Bot, I. · Vries, M.R. de · Schepers, A. · Bockel, J.H. van · Berkel, T.J.C. van · Biessen, E.A.L. · Quax, P.H.A.
Keywords: Biology · Biomedical Research · apolipoprotein E3 · chemokine receptor CCR2 · lentiviral short hairpin RNA · lentivirus vector · messenger RNA · monocyte chemotactic protein 1 · unclassified drug · animal cell · animal model · article · atherosclerosis · carotid artery · cell migration · cell proliferation · clinical feature · controlled study · disease course · drug delivery system · drug efficacy · drug targeting · gene silencing · gene therapy · hypercholesterolemia · in vitro study · in vivo study · infection · Lentivirinae · male · morphometrics · mouse · nonhuman · priority journal · protein expression · receptor upregulation · smooth muscle fiber · treatment outcome · vein graft · vein graft disease · vein surgery · viral gene delivery system · Animals · Apolipoprotein E3 · Atherosclerosis · Chemokine CCL2 · Disease Models, Animal · Graft Occlusion, Vascular · Hypercholesterolemia · Lentivirus · Male · Mice · Receptors, CCR2 · RNA Interference · Veins
[Abstract]

12 Vascular endothelial growth factor overexpression in ischemic skeletal muscle enhances myoglobin expression in vivo
article 2004    
Author: Weel, V. van · Deckers, M.M.L. · Grimbergen, J.M. · Leuven, K.J.M. van · Lardenoye, J.W.H.P. · Schlingemann, R.O. · Nieuw Amerongen, G.P. van · Bockel, J.H. van · Hinsbergh, V.W.M. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Angiogenesis · Ischemia · Myoglobin · Peripheral vascular disease · Vascular endothelial growth factor · adenovirus vector · beta galactosidase · messenger RNA · myoglobin · protein tyrosine kinase inhibitor · semaxanib · vasculotropin · vasculotropin A · angina pectoris · angiography · animal cell · animal experiment · animal model · capillary density · controlled study · drug inhibition · gastrocnemius muscle · in vivo study · mouse · muscle function · muscle ischemia · myotube · nonhuman · pain · protein expression · RNA analysis · skeletal muscle · vascularization · Adenoviridae · Aged · Amputation · Animals · Capillaries · Female · Gene Expression · Gene Therapy · Genetic Vectors · Humans · Ischemia · Male · Mice · Middle Aged · Muscle Fibers · Muscle, Skeletal · Myoglobin · Neovascularization, Physiologic · RNA, Messenger · Vascular Endothelial Growth Factor A
[Abstract]

13 Replication-deficient human adenovirus type 35 vectors for gene transfer and vaccination: Efficient human cell infection and bypass of preexisting adenovirus immunity
article 2003    
Author: Vogels, R. · Zuijdgeest, D. · Rijnsoever, R. van · Hartkoorn, E. · Damen, I. · Béthune, M.-P. de · Kostense, S. · Penders, G. · Helmus, N. · Koudstaal, W. · Cecchini, M. · Wetterwald, A. · Sprangers, M. · Lemckert, A. · Ophorst, O. · Koel, B. · Meerendonk, M. van · Quax, P. · Panitti, L. · Grimbergen, J. · Bout, A. · Goudsmit, J. · Havenga, M.
Keywords: Biology · Biomedical Research · Adenovirus vector · Animal cell · Controlled study · Dendritic cell · Gene insertion · Gene sequence · Gene therapy · Gene transfer · Genetic complementation · Genetic transduction · Human · Human adenovirus · Human adenovirus 35 · Human adenovirus 5 · Human cell · Immune response · Mouse · Nonhuman · Plasmid · Prevalence · Smooth muscle fiber · Synoviocyte · Vaccination · Virus immunity · Virus replication · Adenovirus E1B Proteins · Adenoviruses, Human · Animals · Antibodies, Viral · Cell Line · Cells, Cultured · Dendritic Cells · Gene Transfer Techniques · Genetic Vectors · Humans · Mice · Mice, Inbred BALB C · Muscle, Smooth · Neutralization Tests · Plasmids · Synovial Membrane · Vaccination · Virus Assembly · Virus Replication
[Abstract]

14 Anti-MCP-1 gene therapy inhibits vascular smooth muscle cells proliferation and attenuates vein graft thickening both in vitro and in vivo
article 2006    
Author: Schepers, A. · Eefting, D. · Bonta, P.I. · Grimbergen, J.M. · Vries, M.R. de · Weel, V. van · Vries, C.J. de · Egashira, K. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · Inflammation · Intimal hyperplasia · MCP-1 · Smooth muscle cells · Vein graft disease · Apolipoprotein E · Chemokine receptor CCR2 · Monocyte chemotactic protein 1 · Animal experiment · Animal model · Animal tissue · Artery intima proliferation · Atherosclerosis · Carotid artery · Cell proliferation · Controlled study · Graft failure · Human · Human cell · Human tissue · Hypercholesterolemia · In vitro study · In vivo study · Monocyte · Mouse · Nonhuman · Protein expression · Saphenous vein · Vascular smooth muscle · Vein graft · Amino Acid Sequence · Animals · Carotid Arteries · Cell Proliferation · Cells, Cultured · Chemokine CCL2 · Gene Therapy · Humans · Hypercholesterolemia · Male · Mice · Mice, Inbred C57BL · Muscle, Smooth, Vascular · Myocytes, Smooth Muscle · Organ Culture Techniques · Receptors, Chemokine · Saphenous Vein · Sequence Deletion · Tunica Intima
[Abstract]

15 Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma
article 2009    
Author: Kuhlmann, K.F.D. · Geer, M.A. van · Bakker, C.T. · Dekker, J.E.M. · Havenga, M.J.E. · Oude Elferink, R.P.J. · Gouma, D.J. · Bosma, P.J. · Wesseling, J.G.
Keywords: Biology · Biomedical Research · Adenovirus · Fiber-chimeric · Pancreatic cancer · Serotype · adenovirus vector · bacterial enzyme · coxsackie virus and adenovirus receptor · cytosine deaminase · flucytosine · green fluorescent protein · red fluorescent protein · virus DNA · virus fiber protein · Adenovirus fiber gene · Adenovirus fiber knob 5 · Adenovirus type 16 · Adenovirus type 50 · antineoplastic activity · article · bacterial gene · cancer cell culture · cell viability · controlled study · cytosine deaminase gene · drug cytotoxicity · drug efficacy · drug mechanism · drug specificity · fiber chimeric human adenovirus 5 · gene directed enzyme prodrug therapy · gene expression · gene targeting · human · Human adenovirus · Human adenovirus 5 · human cell · human tissue · liver cell culture · molecular cloning · nonhuman · pancreas adenocarcinoma · priority journal · protein domain · protein expression · suicide gene · viral gene delivery system · virus fiber · virus gene · Adenoviridae · Cell Line · Cell Line, Tumor · Flow Cytometry · Gene Therapy · Genetic Vectors · Green Fluorescent Proteins · Humans · Pancreatic Neoplasms · Polymerase Chain Reaction · Recombinant Fusion Proteins · Recombination, Genetic · Transduction, Genetic · Viral Envelope Proteins · Adenoviridae
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date