Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date

1 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

2 Semi-continuous high speed gas analysis of generated vapors of chemical warfare agents
article 1999    
Author: Trap, H.C. · Langenberg, J.P.
Keywords: Automation · Data acquisition · Nerve agents · Sulfur mustard · Valve injection · Vapor analysis · Mustard gas · Nerve gas · Neurotoxin · Sarin · Soman · Analytic method · Animal experiment · Article · Autoanalysis · Chemical warfare · Chromatography · Gas analysis · Gas chromatography · Guinea pig · Neurotoxicity · Nonhuman · Toxicokinetics · Vapor · Mustard gas, 505-60-2 · Neurotoxin, 39386-17-9 · Sarin, 107-44-8 · Soman, 96-64-0
[Abstract]

3 Low level nose-only exposure to the nerve agent soman: Toxicokinetics of soman stereoisomers and cholinesterase inhibition in atropinized guinea pigs
article 1998    
Author: Benschop, H.P. · Trap, H.C. · Spruit, H.E.T. · Wiel, H.J. van der · Langenberg, J.P. · Jong, L.P.A. de
Keywords: Perception · Atropine · Carboxylesterase · Cholinesterase · Animal cell · Blood level · Enzyme inhibition · Exposure · Guinea pig · Inhalation · Male · Neurotoxicity · Nonhuman · Stereoisomerism · Toxicokinetics · Administration, Inhalation · Animals · Carboxylic ester hydrolases · Chemical warfare agents · Dose-response relationship · Drugs · Erythrocytes · Soman · Stereoisomerism · Time factors · Atropine, 51-55-8 · Carboxylesterase, EC 3.1.1.1 · Carboxylic ester hydrolases, EC 3.1.1.- · Soman, 96-64-0
[Abstract]

4 Safety evaluation of β-glucanase derived from Trichoderma reesei: Summary of toxicological data
article 1995    
Author: Coenen, T.M.M. · Schoenmakers, A.C.M. · Verhagen, H.
Keywords: Toxicology · barlican · beta glucan hydrolase · unclassified drug · animal experiment · article · chicken · chronic toxicity · controlled study · eye irritation · female · guinea pig · male · mutagenicity · nonhuman · rabbit · rat · skin irritation · skin sensitization · Administration, Oral · Animal · Animal Feed · beta-Glucosidase · Biological Products · Chickens · CHO Cells · Dermatitis, Contact · Environmental Exposure · Female · Food Additives · Guinea Pigs · Hamsters · Lethal Dose 50 · Male · Mutagenicity Tests · No-Observed-Adverse-Effect Level · Rabbits · Rats · Rats, Wistar · Salmonella typhimurium · Toxicity Tests · Trichoderma · Animalia · Cavia porcellus · Gallus gallus · Hypocrea jecorina · Oryctolagus cuniculus · Sus scrofa · Trichoderma
[Abstract]

5 Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs
article 2003    
Author: Lamers, R.-J.A.N. · Groot, J. de · Spies-Faber, E.J. · Jellema, R.H. · Kraus, V.B. · Verzijl, N. · Koppele, J.M. te · Spijksma, G.K. · Vogels, J.T.W.E. · Greef, J. van der · Nesselrooij, J.H.J. van
Keywords: Biology · Analytical research · Biomedical research · 1H NMR spectroscopy · Metabolic fingerprinting · Multivariate data analysis · Osteoarthritis · Vitamin C · ascorbic acid · biological marker · purine · animal experiment · animal model · article · controlled study · data analysis · dietary intake · disease marker · energy metabolism · guinea pig · inbred strain · male · metabolic fingerprint · metabolism · metabolite · multivariate analysis · nonhuman · nutrient · nutrition · osteoarthritis · pathophysiology · proton nuclear magnetic resonance · purine metabolism · strain difference · urinalysis · vitamin intake · Animal Nutrition Physiology · Animals · Ascorbic Acid · Diet · Dose-Response Relationship, Drug · Energy Metabolism · Guinea Pigs · Magnetic Resonance Spectroscopy · Male · Multivariate Analysis · Osteoarthritis · Peptide Mapping · Purines · Treatment Outcome · Animalia · Cavia · Cavia porcellus · Sus scrofa
[Abstract]

6 Long-term, low-level exposure of guinea pigs and marmosets to sarin vapor in air: Lowest observable effect level
article 2003    
Author: Helden, H.P.M. van · Trap, H.C. · Oostdijk, J.P. · Kuijpers, W.C. · Langenberg, J.P. · Benschop, H.P.
Keywords: Fluoride-induced reactivation · Guinea pigs · Internal dose · Lowest observable effect level (LOEL) · Marmosets · Nerve agent · O-Isopropyl methylphosphonofluoridate · Occupational exposure limits · Respiratory exposure · Sarin · Worker population limit (WPL) · Cholinesterase · Sarin · Animal experiment · Animal trapping · Article · Binding site · Chemical warfare · Cholinesterase inhibition · Controlled study · Enzyme activity · Gas chromatography · Gas mask · Guinea pig · Long term exposure · Male · Marmoset · Measurement · Nonhuman · Occupational exposure · Species comparison · Vaporization · Worker · Animals · Atmosphere Exposure Chambers · Callithrix · Dose-Response Relationship, Drug · Female · Gases · Guinea Pigs · Male · No-Observed-Adverse-Effect Level · Sarin · Threshold Limit Values · Volatilization · Animalia · Cavia · Cholinesterase, 9001-08-5 · Sarin, 107-44-8 · Gases
[Abstract]

7 Biomonitoring of exposure to lewisite based on adducts to haemoglobin
article 2000    
Author: Fidder, A. · Noort, D. · Hulst, A.G. · Jong, L.P.A.de · Benschop, H.P.
Keywords: Toxicology · Adducts · Electrospray mass spectroscopy · Gas chromatography-mass spectroscopy · Haemoglobin · 2 chlorovinylarsonous acid · Arsenic acid derivative · Beta globin · Dimercaprol · Hemoglobin · Imidazole derivative · Lewisite · Unclassified drug · Animal experiment · Biological monitoring · Chemical warfare · Controlled study · Erythrocyte · Gas chromatography · Guinea pig · Health hazard · Human · Human cell · Male · Mass spectrometry · Nonhuman · Radioactivity · Urinalysis · Animals · Arsenicals · Binding Sites · Carbon Radioisotopes · Chelating Agents · Dimercaprol · Environmental Exposure · Erythrocytes · Gas Chromatography-Mass Spectrometry · Globins · Guinea Pigs · Hemoglobins · Humans · Imidazoles · Male · Protein Binding · Mass spectrometry · Electrospray ionization · 1-(heptafluorobutyryl)imidazole, 32477-35-3 · 2-chlorovinylarsonous acid · Arsenicals · Carbon radioisotopes · Chelating agents · Dimercaprol, 59-52-9 · Globins, 9004-22-2 · Hemoglobins · Imidazoles · Lewisite, 541-25-3
[Abstract]

8 A comparative analysis of bone and cartilage metabolism in two strains of guinea-pig with varying degrees of naturally occurring osteoarthritis
article 2002    
Author: Huebner, J.L. · Hanes, M.A. · Beekman, B. · TeKoppele, J.M. · Kraus, V.B.
Keywords: Health Biology · Biomedical Research · Bone and cartilage metabolism · Guinea-pig · Biological marker · Collagen · Deoxypyridinoline · Proteoglycan · Pyridinoline · Animal experiment · Animal model · Animal tissue · Bone metabolism · Cartilage · Cartilage degeneration · Clinical feature · Controlled study · Correlation analysis · Cross linking · Disease course · Disease predisposition · Disease severity · Histopathology · Knee osteoarthritis · Nonhuman · Ossification · Osteolysis · Pathogenesis · Pilot study · Protein metabolism · Strain difference · Synovial fluid · Thickness · Tissue metabolism · Urinary excretion · Amino Acids · Animals · Bone and Bones · Bone Density · Cartilage, Articular · Guinea Pigs · Hindlimb · Joints · Keratan Sulfate · Male · Microscopy, Electron · Osteoarthritis · Osteocalcin · Pilot Projects · Synovial Fluid
[Abstract]

9 Low-level exposure of guinea pigs and marmosets to sarin vapour in air: Lowest-observable-adverse-effect level (LOAEL) for miosis
article 2004    
Author: Helden, H.P.M. van · Trap, H.C. · Kuijpers, W.C. · Oostdijk, J.P. · Benschop, H.P. · Langenberg, J.P.
Keywords: Biology · Exposure limits · Field alarm · Lowest-observable-adverse-effect level (LOAEL) · Miosis · Nerve agent · o-isopropyl methylphosphonofluoridate · Pupil size · Pyridostigmine · Sarin · Whole-body exposure · Acetylcholinesterase · Erythrocyte enzyme · Pyridostigmine · Sarin · Air · Animal experiment · Article · Calculation · Concentration (parameters) · Controlled study · Data analysis · Environmental exposure · Eye photography · Guinea pig · Iris · Male · Marmoset · Miosis · Nonhuman · Pilot study · Priority journal · Pupil · Statistical analysis · Vapor · Acetylcholinesterase · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Dose-Response Relationship, Drug · Guinea Pigs · Inhalation Exposure · Pyridostigmine Bromide · Sarin · Volatilization · Animalia · Cavia · Marmosets · Acetylcholinesterase, 9000-81-1 · Pyridostigmine, 101-26-8, 155-97-5 · Sarin, 107-44-8 · Chemical warfare agents
[Abstract]

10 The efficacy of some bis-pyridinium oximes as antidotes to soman in isolated muscles of several species including man
article 1981    
Author: Wolthuis, O. · Vanwersch, R.A.P. · Wiel, H.J. van der
Keywords: Biology · 1 (3 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · [(3 isobutyryl 1 pyridiniomethyl) (2 hydroxyiminomethyl 1 pyridiniomethyl)] ether · Sarin · Soman · Tubocurarine chloride · Unclassified drug · Animal experiment · Bispyridinium oxime · Diaphragm · Dog · Dose response · Drug comparison · Drug response · Guinea pig · Human cell · In vitro study · Intercostal muscle · Intravenous drug administration · Neuromuscular transmission · Rat · Adult · Aged · Animal · Antidotes · Chorionic Gonadotropin · Comparative Study · Dogs · Electric Stimulation · Female · Guinea Pigs · Human · In Vitro · Male · Middle Age · Neuromuscular Junction · Organophosphorus Compounds · Pralidoxime Compounds · Pyridinium Compounds · Rats · Sarin · Soman · Species Specificity · Synaptic Transmission
[Abstract]

11 Identification of an urinary metabolite profile associated with osteoarthritis
article 2005    
Author: Lamers, R.J.A.N. · Nesselrooij, J.H.J. van · Kraus, V.B. · Jordan, J.M. · Renner, J.B. · Dragomir, A.D. · Luta, G. · Greef, J. van der · Groot, J. de
Keywords: Biomedical Research · 1H NMR spectroscopy · Biomarker · Multivariate data analysis · Osteoarthritis · biological marker · adult · aged · animal experiment · animal model · article · bone density · bone radiography · controlled study · correlation analysis · disease marker · disease severity · dual energy X ray absorptiometry · female · geriatric disorder · guinea pig · hip osteoarthritis · hip radiography · human · knee osteoarthritis · knee radiography · major clinical study · male · metabolite · multivariate analysis · nonhuman · nuclear magnetic resonance spectroscopy · priority journal · regression analysis · United States · urinalysis · Aged · Aged, 80 and over · Biological Markers · Case-Control Studies · Female · Humans · Joints · Least-Squares Analysis · Magnetic Resonance Spectroscopy · Male · Middle Aged · Osteoarthritis
[Abstract]

12 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

13 Dose-response relationships and threshold levels in skin and respiratory allergy
article 2006    
Author: Arts, J.H.E. · Mommers, C. · Heer, C.de
Keywords: Health · Toxicology and Applied Pharmacology · Dose-Response · Elicitation · Respiratory Allergy · Sensitization · Skin Allergy · 1 chloro 2,4 dinitrobenzene · 1 fluoro 2,4 dinitrobenzene · acid anhydride · aldehyde · benzocaine · bronopol · chlorocresol · cytokine · dichromate potassium · diethylamine · ethylene · eugenol · formaldehyde · geraniol · glutaraldehyde · immunoglobulin E antibody · isocyanic acid derivative · isoeugenol · kathon cg · linalool · methacrylic acid derivative · myristic acid isopropyl ester · nickel · oxazolone · phthalic anhydride · rubber · subtilisin · toluene diisocyanate · tuberculin · unindexed drug · airway obstruction · analytic method · antigen specificity · CD4+ T lymphocyte · clinical study · concentration (parameters) · Dermatophagoides farinae · Dermatophagoides pteronyssinus · dose response · expiratory flow · exposure · forced expiratory volume · guinea pig · human · hypersensitivity reaction · Langerhans cell · nonhuman · occupational asthma · occupational hazard · respiratory tract allergy · review · safety · sensitivity analysis · skin allergy · skin defect · skin irritation · skin sensitization · skin test · urticaria · Allergens · Animals · Dermatitis, Allergic Contact · Dose-Response Relationship, Drug · Guidelines · Humans · Molecular Weight · No-Observed-Adverse-Effect Level · Occupational Exposure · Respiratory Hypersensitivity · Risk Assessment · Skin Tests · Animalia · Cavia porcellus · Dermatophagoides farinae · Dermatophagoides pteronyssinus
[Abstract]

14 Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
article 2003    
Author: Schans, M.J. van der · Lander, B.J. · Wiel, H. van der · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Chiral HPLC · Hairless guinea pigs · Intravenous · Marmosets · Percutaneous · Persistence · Stereospecificity · Toxicokinetics · Treatment · Carbamic acid · Oxime · Volatile agent · Anesthesia · Animal experiment · Animal model · Bioavailability · Blood level · Dose response · Enantiomer · Guinea pig · Intoxication · Marmoset · Nonhuman · Primate · Toxicokinetics · Administration, Topical · Anesthesia · Animals · Atropine · Callithrix · Chemical Warfare Agents · Chromatography, Gas · Chromatography, High Pressure Liquid · Electrochemistry · Injections, Intravenous · Kinetics · Lethal Dose 50 · Male · Muscarinic Antagonists · Organothiophosphorus Compounds · Stereoisomerism · Animalia · Cavia · Cavia porcellus · Primates · Sus scrofa · Acetylcholinesterase, 9000-81-1 · Carbamic acid, 463-77-4 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Sarin, 107-44-8 · Soman, 96-64-0 · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Muscarinic antagonists · Organothiophosphorus compounds · VX, 50782-69-9
[Abstract]

15 Antidotes to organophosphate poisoning. 2. Thiadiazole-5-carboxaldoximes
article 1979    
Author: Benschop, H.P. · Berg, G.R. van den · Hooidonk, C. van · Jong, L.P.A. de · Kientz, C.E. · Berends, F. · Kepner, L.A. · Meeter, E. · Visser, R.P.L.S.
Keywords: Biology · Acetylcholinesterase · Antidote · Atropine · Cholinesterase reactivator · Diacetyl oxime · Enzyme · Obidoxime P · Paraoxon · Sarin · Tri ortho cresyl phosphate · 1,2,3 thiadiazole 5 carboxaldoxime · 2 (hydroximinomethyl) 1 methylpyridinium salt · 2 methyl 1,2,3 thiadiazolium salt carboxaldoxime · 3 methyl 1,2,3 thiadiazolium salt 5 carboxaldoxime · Animal experiment · Blood · Blood and hemopoietic system · Dose response · Drug administration · Drug analysis · Drug blood level · Drug comparison · Drug elimination · Drug half life · Drug interaction · Drug intoxication · Drug metabolism · Drug response · Drug screening · Drug synthesis · Drug tolerance · Drug toxicity · Drug urine level · Goat · Guinea pig · High performance liquid chromatography · Hydroximinoacetone · In vitro study · Intoxication · Intraperitoneal drug administration · Intravenous drug administration · Mouse · Nuclear magnetic resonance · Oral drug administration · Organophosphate intoxication · Pharmacokinetics · Prevention · Prophylaxis · Rabbit · Rat · Subcutaneous drug administration · Theoretical study · Therapy · Thiadiazole 5 carboxaldoxime derivative · Ultraviolet spectrophotometry · Urine · Acetylcholinesterase · Animal · Antidotes · Body Temperature · Cattle · Chemistry · Dose-Response Relationship, Drug · Enzyme Reactivators · Female · Goats · Guinea Pigs · Half-Life · In Vitro · Lethal Dose 50 · Male · Mice · Organophosphorus Compounds · Oximes · Rabbits · Rats · Rats, Inbred Strains · Sarin · Solubility · Structure-Activity Relationship
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date