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1 Half-lives of pesticides on greenhouse crops
article 1997    
Author: Brouwer, D.H. · Haan, M. de · Leenheers, L.H. · Vreede, S.A.F. de · Hemmen, J.J. van
Keywords: pesticide · analytic method · article · crop · drug half life · environmental factor · exposure · nonhuman · pesticide spraying · residue analysis · risk assessment · Analysis of Variance · Chromatography, High Pressure Liquid · Crops, Agricultural · Fungicides, Industrial · Half-Life · Hydrogen-Ion Concentration · Insecticides · Pesticide Residues · Plants · Risk Assessment

2 In vitro stabililty of a tissue-type plasminogen activator mutant, BM 06.022, in human plasma
article 1994    
Author: Rijken, D.C. · Groeneveld, E. · Barrett-Bergshoeff, M.M.
Keywords: Biology · alpha 1 antitrypsin · alpha 2 antiplasmin · alteplase · fibrinogen · plasmin · reteplase · tissue plasminogen activator · fibrinolytic agent · proteinase inhibitor · recombinant protein · dose response · drug activity · drug half life · drug inactivation · drug stability · immunoblotting · plasma · polyacrylamide gel electrophoresis · blood · genetics · half life time · mutation · Drug Stability · Fibrinolytic Agents · Half-Life · Human · Mutation · Protease Inhibitors · Recombinant Proteins · Tissue Plasminogen Activator
[Abstract]

3 Influence of amifostine on the pharmacokinetics of cisplatin in cancer patients
article 1998    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Gall, H.E. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Creatinine · Adult · Aged · Area under the curve · Clinical article · Creatinine blood level · Dna adduct · Dna drug complex · Drug blood level · Drug effect · Drug half life · Female · Human · Intravenous drug administration · Kidney function · Male · Malignant neoplastic disease · Priority journal · Amifostine · Antineoplastic Agents · Cisplatin · DNA Adducts · Drug Interactions · Female · Half-Life · Hemofiltration · Humans · Leukocytes · Male · Middle Aged · Neoplasms · Platinum · Radiation-Protective Agents
[Abstract]

4 Pharmacokinetics of carboplatin with and without amifostine in patients with solid tumors
article 1997    
Author: Korst, A.E.C. · Sterre, M.L.T. van der · Eeltink, C.M. · Fichtinger-Schepman, A.M.J. · Vermorken, J.B. · Vijgh, W.J.F. van der
Keywords: Pharmacology · Amifostine · Carboplatin · Adult · Blood sampling · Clinical article · Clinical trial · Controlled clinical trial · Creatinine blood level · Creatinine clearance · Drug blood level · Drug efficacy · Drug half life · Enzyme linked immunosorbent assay · Female · Human · Intravenous drug administration · Male · Phase 1 clinical trial · Solid tumor · Amifostine · Animals · Antineoplastic Agents · Carboplatin · Dose-Response Relationship, Drug · Half-Life · Kidney · Kidney Function Tests · Metabolic Clearance Rate · Mice · Mice, Nude · Neoplasms
[Abstract]

5 Insulin suppresses apolipoprotein(a) synthesis in cultured cynomolgus monkey hepatocytes
article 1999    
Author: Princen, H.M.G.
Keywords: Biology · Apolipoprotein a · Apolipoprotein b · Cholesterol · Insulin · Lipoprotein a · Very low density lipoprotein · Animal cell · Drug half life · Hepatoma cell · Human · Hyperinsulinemia · Insulin dependent diabetes mellitus · Letter · Lipoprotein synthesis · Liver cell · Monkey · Nonhuman

6 Antimalarial activity of the bisquinoline trans-N1,N2-bis (7- chloroquinolin-4-yl)cyclohexane-1,2-diamine: Comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737
article 1997    
Author: Ridley, R.G. · Matile, H. · Jaquet, C. · Dorn, A. · Hofheinz, W. · Leupin, W. · Masciadri, R. · Theil, F.P. · Richter, W.F. · Girometta, M.A. · Guenzi, A. · Urwyler, H. · Gocke, E. · Potthast, J.M. · Csato, M. · Thomas, A. · Peters, W.
Keywords: Health · Plasmodium berghei · Subcutaneous drug administration · Animals · Antimalarials · Chloroquine · Cyclohexylamines · Dogs · Drug Resistance · Half-Life · Heme · Malaria, Vivax · Male · Mice · Plasmodium falciparum · Plasmodium vivax · Quinolines · Rats · Rats, Wistar · Stereoisomerism
[Abstract]

7 The mutual relationship between the two molecular forms of the major fibrinolysis inhibitor alpha-2-antiplasmin in blood
article 1986    
Author: Kluft, C. · Los, P. · Jie, A.F.H.
Keywords: Biology · Alpha 2 antiplasmin · Asparaginase · Streptokinase · Acute phase response · Blood · Blood and hemopoietic system · Heart · Heart infarction · Plasminogen blood levelA · Protein polymorphism · Antiplasmin · Asparaginase · Cells, Cultured · Half-Life · Human · Myocardial Infarction · Streptokinase · Support, Non-U.S. Gov't
[Abstract]

8 Renal and hepatic handling of endogenous tissue-type plasminogen activator (t-PA) and its inhibitor in man
article 1988    
Author: Brommer, E.J.P. · Derkx, F.H.M. · Schalekamp, M.A.D.H. · Dooijewaard, G. · Klaauw, V.D.M.M.
Keywords: Fibrinolysis · Human experiment · Hypertension · Intravenous drug administration · Liver vein · Adult · Blood Coagulation Factors · Blood Specimen Collection · Catheterization · Desmopressin · Glycoproteins · Half-Life · Human · Kidney · Liver · Male · Middle Age · Plasminogen Activators · Plasminogen Inactivators · Support, Non-U.S. Gov't · Tissue Plasminogen Activator
[Abstract]

9 Pulmonary response of hamsters to fibrous glass. - Clearance and morphology after a single intratracheal instillation
article 1986    
Author: Graft, M. van · Spit, B.J. · Immel, H.R. · Feron, V.J.
Keywords: Glass fiber · Animal experiment · Hamster · Injury · Intoxication · Lung clearance · Nonhuman · Pneumoconiosis · Pneumonia · Respiratory system · Animal · Female · Glass · Granuloma · Half-Life · Hamsters · Lung · Macrophages · Male · Mesocricetus · Microscopy, Electron · Neutrophils · Phagocytosis · Pneumonia · Support, Non-U.S. Gov't
[Abstract]

10 Free and total urinary 2-butoxyacetic acid following dermal and inhalation exposure to 2-butoxyethanol in human volunteers
article 2004    
Author: Kezic, S. · Meuling, W.J.A. · Jakasa, I.
Keywords: Health · Physiological Sciences · 2-Butoxyacetic acid · 2-Butoxyethanol · Dermal exposure · Skin absorption · 2 butoxyacetic acid · 2 butoxyethanol · acetic acid derivative · biochemical marker · unclassified drug · adult · aqueous solution · article · blood level · calculation · conjugation · controlled study · dermis · environmental exposure · forearm · half life time · human · human experiment · inhalation · kinetics · male · mouth · normal human · sampling · urinalysis · urinary excretion · urine level · volunteer · Administration, Cutaneous · Administration, Inhalation · Adult · Ethylene Glycols · Glycolates · Half-Life · Humans · Male · Middle Aged · Skin Absorption
[Abstract]

11 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

12 Exposure to fungicides in fruit growing: Re-entry time as a predictor for dermal exposure
article 1999    
Author: Tielemans, E. · Louwerse, E. · Cock, J. de · Brouwer, D. · Zielhuis, G. · Heederik, D.
Keywords: Nutrition · Epidemiology · Exposure assessment · Fungicides · Captan · Fungicide · Agricultural worker · Clinical article · Glove · Half life time · High performance liquid chromatography · Human · Occupational exposure · Prediction · Skin · Time · Agricultural Workers' Diseases · Aniline Compounds · Chromatography, High Pressure Liquid · Dermatitis, Occupational · Fruit · Fungicides, Industrial · Humans · Male · Netherlands · Occupational Exposure · Pilot Projects · Predictive Value of Tests · Regression Analysis · Seasons · Sulfonamides · Time Factors
[Abstract]

13 Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: The use of pentosidine levels as a quantitative measure of protein turnover
article 2001    
Author: Verzijl, N. · Groot, J. de · Bank, R.A. · Bayliss, M.T. · Bijlsma, J.W.J. · Lafeber, F.P.J.G. · Maroudas, A. · TeKoppele, J.M.
Keywords: Health Biology · Biomedical Research · Articular cartilage · Osteoarthritis · Pentosidine · Turnover · Aspartic acid · Collagen · Hyaluronic acid · Protein · Binding site · Controlled study · Glycation · Half life time · Human tissue · Protein domain · Protein metabolism · School child · Adolescent · Adult · Aged · Aged, 80 and over · Aggrecans · Aging · Arginine · Cartilage, Articular · Chemical Fractionation · Child · Extracellular Matrix Proteins · Glycosylation End Products, Advanced · Humans · Lectins, C-Type · Lysine · Middle Aged · Osteoarthritis · Proteochondroitin Sulfates · Proteoglycans
[Abstract]

14 Interaction of mutants of tissue-type plasminogen activator with liver cells: Effect of domain deletions
article 1996    
Author: Kuiper, J. · Hof, A. van 't · Otter, M. · Biessen, E.A.L. · Rijken, D.C. · Berkel, T.J.C. van
Keywords: Biology · tissue plasminogen activator · animal cell · animal experiment · article · controlled study · deletion mutant · drug clearance · drug structure · gene cassette · kringle domain · liver cell · male · molecular interaction · nonhuman · plasma clearance · priority journal · protein domain · rat · Animals · Binding Sites · Biological Transport, Active · Endothelium · Epidermal Growth Factor · Half-Life · Kringles · Liver · Male · Molecular Structure · Mutation · Rats · Rats, Wistar · Tissue Plasminogen Activator · Animalia
[Abstract]

15 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

16 Percutaneous absorption of mexoryl SX® in human volunteers: Comparison with in vitro data
article 2003    
Author: Benech-Kieffer, F. · Meuling, W.J.A. · Leclerc, C. · Roza, L. · Leclaire, J. · Nohynek, G.
Keywords: Nutrition Health · Physiological Sciences · Human skin · Mass balance · Mexoryl SX® · Percutaneous absorption · Sunscreen · carbon 14 · mexoryl sr · sulfonic acid derivative · sunscreen · terephthalylidene dicamphor sulfonic acid · unclassified drug · adult · article · blood sampling · correlation analysis · dermis · drug absorption · drug exposure · feces analysis · human · human experiment · human tissue · in vitro study · male · normal human · priority journal · radioactivity · single drug dose · skin absorption · skin surface · urinalysis · Administration, Topical · Adult · Bornanes · Camphor · Diffusion · Diffusion Chambers, Culture · Half-Life · Humans · Male · Mesylates · Skin Absorption · Sulfonic Acids · Sunscreening Agents
[Abstract]

17 Plasma plasminogen activator inhibitor-1 level is not regulated by the hepatic low-density lipoprotein receptor-related protein [2]
article 2007    
Author: Hu, L. · Bovenschen, N. · Havekes, L.M. · Vlijmen, B.J.M. van · Tamsma, J.T.
Keywords: Biology · Biomedical Research · adenovirus vector · beta galactosidase · complementary DNA · liver protein · low density lipoprotein receptor related protein · plasminogen activator inhibitor 1 · protein inhibitor · receptor associated protein · serum amyloid A · animal experiment · animal model · controlled study · half life time · in vivo study · letter · mouse · nonhuman · plasma clearance · priority journal · protein blood level · protein expression · protein function · protein protein interaction · regulatory mechanism · Animals · LDL-Receptor Related Protein 1 · Mice · Mice, Knockout · Pharmacokinetics · Plasminogen Activator Inhibitor 1

18 Observational infant exploratory [14C]-paracetamol pharmacokinetic microdose/therapeutic dose study with accelerator mass spectrometry bioanalysis
article 2015    
Author: Garner, C.R. · Park, K.B. · French, N.S. · Earnshaw, C. · Schipani, A. · Selby, A.M. · Byrne, L. · Siner, S. · Crawley, F.P. · Vaes, W.H.J. · Duijn, E. van · ligt, R. de · Varendi, H. · Lass, J. · Grynkiewicz, G. · Maruszak, W. · Turner, M.A.
Keywords: Biology · Exploratory clinical study · Microdosing · Paediatric pharmacokinetics · Paracetamol · Unclassified drug · Accelerator mass spectrometry · Area under the curve · Child · Drug blood level · Drug clearance · Drug half life · Female · Human · Infant · Major clinical study · Male · Mass spectrometry · Maximum plasma concentration · Pharmacokinetics · Plasma concentration-time curve · Time to maximum plasma concentration · Ultra performance liquid chromatography · Volume of distribution · Healthy for Life · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

19 Collagen turnover in normal and degenerate human intervertebral discs as determined by the racemization of aspartic acid
article 2008    
Author: Sivan, S.-S. · Wachtel, E. · Tsitron, E. · Sakkee, N. · Ham, F. van der · Groot, J.de · Roberts, S. · Maroudas, A.
Keywords: Biology · Acids · Histology · Implants (surgical) · Isomers · Organic acids · Population statistics · Probability density function · Aspartic acids · Collagen molecules · Collagenous tissues · Decreasing functions · Intervertebral discs · Pentosidine · Racemization rates · Statistical analysis · Turnover rates · Dextro aspartic acid · Arginine · Drug derivative · Lysine · Controlled study · Dentin · Half life time · Human tissue · Intervertebral disk · Intervertebral disk degeneration · Isomer · Protein metabolism · Racemization · Statistical analysis · Turnover time · Metabolism · Pathology · Spine disease · Adolescent · Adult · Age Factors · Aged · Arginine · Collagen · D-Aspartic Acid · Dentin · Female · Humans · Intervertebral Disk · Lysine · Male · Middle Aged · Spinal Diseases
[PDF] [Abstract]

20 Prophylactic and therapeutic effects of a humanized monoclonal antibody against the IL-2 receptor (DACLIZUMAB) on collagen-induced arthritis (CIA) in rhesus monkeys
article 2001    
Author: Brok, H.P.M. · Tekoppele, J.M. · Hakimi, J. · Kerwin, J.A. · Nijenhuist, E.M. · Groot, C.W.de · Bontrop, R.E. · Hart 't, B.A.
Keywords: Biology · Biomedical Research · Animal model · Inflammation · Joint destruction · Nonhuman primate · Rheumatoid arthritis · Collagen · Interleukin 2 receptor · Interleukin 2 receptor antibody · Monoclonal antibody · Animal experiment · Animal model · Autoimmune disease · Controlled study · Drug blood level · Drug half life · Immunization · Immunogenicity · Inflammation · Joint destruction · Male · Nonhuman · Priority journal · Prophylaxis · Rhesus monkey · Rheumatoid arthritis · Animals · Antibodies, Monoclonal · Antibody Specificity · Arthritis, Rheumatoid · Autoantibodies · Autoimmune Diseases · C-Reactive Protein · Collagen · Disease Models, Animal · Drug Evaluation, Preclinical · Humans · Hydroxyproline · Immunization · Immunoglobulin G · Macaca mulatta · Male · Receptors, Interleukin-2 · Weight Loss
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 35 found. Next | Sort by date