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1 A strategy for modelling dynamic responses in metabolic samples characterized by GC/MS
article 2006    
Author: Jonsson, P. · Stenlund, H. · Moritz, T. · Trygg, J. · Sjöström, M. · Verheij, E.R. · Lindberg, J. · Schuppe-Koistinen, I. · Antti, H.
Keywords: Analytical research · Batch modelling · Chemometrics · Curve resolution · GC/MS · Hepatotoxicity · Metabolomics · Metabonomics · Toxicology · Animalia
[Abstract]

2 A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Jong, C.H.C. de · Gottschalk, R. · Herwijnen, M. van · Boorsma, A. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Biology · Biomedical Research · Coumarin · Gene expression profiling · Hepatotoxicity · Parallelogram approach · Primary human hepatocytes · Species difference · Toxicogenomics · Coumarin · Adult · Aged · Blood clotting · Concentration response · Controlled study · Disorders of mitochondrial functions · Down regulation · Energy consumption · Female · Gene expression profiling · Genomics · Human · Human cell · Liver cell · Liver toxicity · Male · Species difference · Toxicogenetics · Transcriptomics · Animalia · Rattus
[Abstract]

3 Toxicogenomics of bromobenzene hepatotoxicity: A combined transcriptomics and proteomics approach
article 2003    
Author: Heijne, W.H.M. · Stierum, R.H. · Slijper, M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Toxicology Health · Physiological Sciences · Bromobenzene · cDNA microarray · Hepatotoxicity · Proteomics · Toxicogenomics · Transcriptomics · alpha glutamylcysteine synthetase · bromobenzene · cathepsin L · enzyme · epoxide hydrolase · glutathione · glutathione transferase · heme oxygenase · messenger RNA · peroxiredoxin · proteasome · unclassified drug · animal experiment · animal model · animal tissue · article · controlled study · enzyme activity · enzyme induction · enzyme regulation · enzyme subunit · gene control · gene expression · gene identification · gene induction · genomics · glutathione metabolism · liver toxicity · lysosome · male · nonhuman · nucleotide sequence · oxidative stress · priority journal · protein content · protein degradation · protein depletion · protein expression · protein synthesis · proteomics · rat · RNA analysis · tissue level · unindexed sequence · weight reduction · Animals · Bromobenzenes · Liver · Male · Oligonucleotide Array Sequence Analysis · Pharmacogenetics · Proteomics · Rats · Rats, Wistar · Transcription, Genetic
[Abstract]

4 Toxicogenomics directory of chemically exposed human hepatocytes
article 2014    
Author: Grinberg, M. · Stöber, R.M. · Edlund, K. · Rempel, E. · Godoy, P. · Reif, R. · Widera, A. · Madjar, K. · Schmidt-Heck, W. · Marchan, R. · Sachinidis, A. · Spitkovsky, D. · Hescheler, J. · Carmo, H. · Arbo, M.D. · Water, B. van de · Wink, S. · Vinken, M. · Rogiers, V. · Escher, S. · Hardy, B. · Mitic, D. · Myatt, G. · Waldmann, T. · Mardinoglu, A. · Damm, G. · Seehofer, D. · Nüssler, A. · Weiss, T.S. · Oberemm, A. · Lampen, A. · Schaap, M.M. · Luijten, M. · van Steeg, H. · Thasler, W.E. · Kleinjans, J.C.S. · Stierum, R.H. · Leist, M. · Rahnenführer, J. · Hengstler, J.G.
Keywords: Biology · Bioinformatics · Biomarker identification · Cirrhosis · Hepatocellular cancer · Hepatotoxicity · In vivo validation · SEURAT-1 · Steatosis · Toxicotranscriptomics · Unsupervised clustering · allyl alcohol · biological marker · chemical compound · cytochrome P450 1A1 · cytochrome P450 3A4 · galactosamine · isoniazid · ketoconazole · liver protein · paracetamol · propranolol · thyroid hormone · transcription factor · triazolam · valproic acid · binding site · cell stress · data base · down regulation · fatty liver · gene expression · gene ontology · human · liver cell · liver cell carcinoma · liver cirrhosis · liver disease · microarray analysis · mutation · nonalcoholic fatty liver · quantitative analysis · real time polymerase chain reaction · RNA extraction · toxicogenomics · transcriptomics · upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
article 2015    
Author: Mesens, N. · Crawfordb, A.D. · Menke, A. · Hung, P.D. · Goethem, F. van · Nuyts, R. · Hansen, E. · Wolterbeek, A. · Gompel, J. van · Witte, P. de · Esguerra, C.V.
Keywords: Nutrition · Zebrafish larvae · Screening assay · Lfabp10a · Hepatotoxicity · DILI · Alpidem · Amiodarone · Bosentan · Buspirone · Diclofenac · Fatty acid binding protein · Fatty acid binding protein 10a · Glycogen · Ketorolac · Nefazodone · Paracetamol · Reactive oxygen metabolite · Rosiglitazone · Tacrine · Tamoxifen · Tetracycline · Troglitazone · Unclassified drug · Zolpidem · Adult · Animal tissue · Cell vacuole · Cholestasis · Circulation · Concentration response · Controlled study · Drug safety · Female · Glycogen analysis · Heart rate · Histology · Histopathology · In situ hybridization · Larval stage · Liver cell · Liver level · Liver size · Liver toxicity · Male · Mitochondrial membrane · Mitochondrial toxicity · Molecular cloning · Nonhuman · Protein expression · Steatosis · Toxicity testing · Zebra fish · Danio rerio · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Toxicogenomic analysis of gene expression changes in rat liver after a 28-day oral benzene exposure
article 2005    
Author: Heijne, W.H.M. · Jonker, D. · Stierum, R.H. · Ommen, B. van · Groten, J.P.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · Benzene · cDNA microarrays · Gene expression · Hepatotoxicity · Metabolomics · Toxicogenomics · Transcriptomics · benzene · bromobenzene · paracetamol · animal experiment · animal tissue · biotransformation · blood toxicity · cholesterol metabolism · conference paper · DNA microarray · gene expression · genetic analysis · genetic toxicology · glutathione metabolism · liver necrosis · liver weight · male · nonhuman · nuclear magnetic resonance spectroscopy · nucleotide sequence · priority journal · rat · rat strain · unindexed sequence · Animals · Benzene · Blood Cell Count · Cholesterol · Fatty Acids · Gene Expression Profiling · Gene Expression Regulation · Hemoglobins · Liver · Male · Mutagens · Oligonucleotide Array Sequence Analysis · Organ Size · Rats · Rats, Inbred F344 · Spleen · Thymus Gland · Time Factors · Urinalysis · Martes pennanti
[Abstract]

7 Bromobenzene-induced hepatotoxicity at the transcriptome level
article 2004    
Author: Heijne, W.H.M. · Slitt, A.L. · Bladeren, P.J. van · Groten, J.P. · Klaassen, C.D. · Stierum, R.H. · Ommen, B. van
Keywords: Biology Toxicology · Physiological Sciences · Bromobenzene · cDNA microarray · Hepatotoxicity · Rat · Toxicogenomics · Transcriptomics · Bromobenzene · Cholesterol · Complementary DNA · Cytochrome P450 4A · Fatty acid · Glutathione · Messenger RNA · Metallothionein · Protein · Sterol · Acute phase response · Animal experiment · Animal model · Animal tissue · Cell communication · Cholesterol metabolism · Concentration response · Controlled study · Cytoskeleton · DNA determination · DNA microarray · DNA responsive element · Drug metabolism · Electron · Fatty acid metabolism · Gene amplification · Gene expression profiling · Gene rearrangement · Liver toxicity · Nonhuman · Nucleotide sequence · Oxidative stress · Protein depletion · Protein metabolism · Protein synthesis · Rat · Signal transduction · Transcription regulation · Animals · Bromobenzenes · Gene Expression Profiling · Gene Expression Regulation · Glutathione · Hepatitis, Toxic · Liver · Male · Microarray Analysis · Oligonucleotide Array Sequence Analysis · Rats · Rats, Inbred Strains · Time Factors · Transcription, Genetic
[Abstract]

8 Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II : Comparison of NMR profiles classification of hepatotoxicity
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.-P.H.T.M. · Smit, M.J. · Zandberg, P. · Horbach, G.J. · Mellema, J.-R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Cholestasis · Hepatotoxicity · Metabonomics · Necrosis · NMR · Steatosis · Urinalysis · 1 naphthyl isothiocyanate · biological marker · bromobenzene · carbon tetrachloride · chlorpromazine · ethinylestradiol · ibuprofen · iproniazid · isoniazid · methyltestosterone · mianserin · paracetamol · phenobarbital · placebo · tetracycline · thioacetamide · animal experiment · animal tissue · article · controlled study · diagnostic accuracy · diagnostic value · drug blood level · drug urine level · early diagnosis · fatty liver · histopathology · intermethod comparison · intrahepatic cholestasis · liver necrosis · liver toxicity · male · nonhuman · pattern recognition · prediction · principal component analysis · proton nuclear magnetic resonance · rat · urinalysis · Animals · Biological Markers · Cholestasis · Fatty Liver · Hepatitis, Toxic · Liver · Magnetic Resonance Spectroscopy · Male · Necrosis · Pattern Recognition, Automated · Principal Component Analysis · Rats · Rats, Wistar · Urine · Animalia · Rattus
[Abstract]

9 Sensitivity of 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: Dose-dependent toxic fffects of Bromobenzene and paracetamol
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.P.H.T.M. · Horbach, G.J. · Smit, M.J. · Zandberg, P. · Mellema, J.R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Biomarkers · Bromobenzene · Hepatotoxicity · Metabonomics · Necrosis · Paracetamol · Urinalysis · alanine aminotransferase · aspartate aminotransferase · biological marker · bromobenzene · paracetamol · alanine aminotransferase blood level · animal experiment · animal tissue · article · aspartate aminotransferase blood level · clinical chemistry · controlled study · diagnostic accuracy · diagnostic value · dose response · drug blood level · drug urine level · early diagnosis · histopathology · intermethod comparison · liver dysfunction · liver necrosis · liver toxicity · male · non invasive measurement · nonhuman · pattern recognition · principal component analysis · proton nuclear magnetic resonance · rat · sensitivity analysis · spectrometer · urinalysis · Acetaminophen · Alanine Transaminase · Analgesics, Non-Narcotic · Animals · Aspartate Aminotransferases · Bromobenzenes · Dose-Response Relationship, Drug · Hepatitis, Toxic · Kidney · Liver · Magnetic Resonance Spectroscopy · Necrosis · Principal Component Analysis · Rats · Rattus
[Abstract]

10 Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis
article 2005    
Author: Heijne, W.H.M. · Lamers, R.J.A.N. · Bladeren, P.J. van · Groten, J.P. · Nesselrooij, J.H.J. van · Ommen, B. van
Keywords: Biology · Physiological Sciences · Bromobenzene · Centrilobular necrosis · Hepatotoxicity · Metabolite profiling · Metabolomics · Toxicogenomics · Transcriptomics · alanine · asialoglycoprotein receptor · beta actin · bromobenzene · casein kinase II · creatine · creatinine · cyclin G1 · cycline · dimethylglycine · ferritin · fibrinogen · fructose bisphosphate aldolase · glyceraldehyde 3 phosphate dehydrogenase · lactic acid · methionine · nucleophosmin · orosomucoid · peroxiredoxin · phosphatidylcholine sterol acyltransferase · phosphoglycerate mutase · phospholipid · protein bcl 2 · protein p21 · protein p53 · taurine · tissue inhibitor of metalloproteinase 1 · tubulin · tyrosine · unindexed drug · amino acid metabolism · animal model · apoptosis · article · blood level · controlled study · DNA microarray · dose response · gene · gene expression · gene sequence · glycolysis · liver necrosis · liver toxicity · male · metabolomics · nonhuman · nuclear magnetic resonance spectroscopy · nucleotide sequence · priority journal · rat · transcriptomics · urine level · Amino Acids · Animals · Bromobenzenes · Dose-Response Relationship, Drug · Gene Expression Profiling · Hepatitis, Toxic · Liver · Male · Necrosis · Principal Component Analysis · Rats · Rats, Wistar · Transcription, Genetic
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 10 of 10 found. | Sort by date