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Showing 1 to 17 of 17 found. | Sort by date

1 Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans
article 1988    
Author: Kempen, H.J.M. · Glatz, J.F.C. · Gevers Leuven, J.A. · Voort, H.A. van der · Katan, M.B.
Keywords: Biology · Fatty acid · Hydroxymethylglutaryl coenzyme a reductase · Lanosterol · Lathosterol · Simvastatin · Cholesterol synthesis · Clinical article · Diet · Familial hypercholesterolemia · Human cell · Normal human · Serum · Anticholesteremic Agents · Biological Markers · Cholesterol · Female · Human · Hypercholesterolemia, Familial · Isomerism · Lovastatin · Male · Simvastatin
[PDF] [Abstract]

2 Different effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors on sterol synthesis in various human cell types
article 1995    
Author: Vliet, A.K. van · Thiel, G.C.F. van · Huisman, R.H. · Moshage, H. · Yap, S.H. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitor · Human cell · Lovastatin · Pravastatin · Simvastatin · Sterol synthesis · Transport · hydroxymethylglutaryl coenzyme a reductase inhibitor · mevinolin · pravastatin · simvastatin · controlled study · human · human cell · liver cell · priority journal · sterol synthesis · Blotting, Northern · Cells, Cultured · Endothelium, Vascular · Female · Granulosa Cells · Human · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Liver · Lovastatin · Pigment Epithelium of Eye · RNA, Messenger · Simvastatin · Sterols · Umbilical Veins
[Abstract]

3 Different effects of the hypolipidemic drugs pravastatin and lovastatin on the cholesterol biosynthesis of the human ocular lens in organ culture and on the cholesterol content of the rat lens in vivo
article 1993    
Author: Vries, A.C.J. de · Cohen, L.H.
Keywords: Health · HMG-CoA reductase inhibitor · Ocular lens · Pravastatin · Vastatin · hydroxymethylglutaryl coenzyme a reductase · mevinolin · animal experiment · cholesterol synthesis · human tissue · lens · Adult · Aged · Animal · Cholesterol · Comparative Study · Fatty Acids · Human · Lens, Crystalline · Lovastatin · Middle Age · Organ Culture · Pravastatin · Rats · Rats, Wistar · Animalia · Rattus norvegicus
[Abstract]

4 Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice
article 2003    
Author: Delsing, D.J.M. · Jukema, J.W. · Wiel, M.A. van de · Emeis, J.J. · Laarse, A. van der · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Atherosclerosis · Calcification · Calcium antagonists · Inflammation · Statins · Amlodipine · Atorvastatin · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Very low density lipoprotein cholesterol · Animal model · Animal tissue · Aorta root · Cholesterol blood level · Cholesterol diet · Controlled study · Drug effect · Inflammation · Mouse · Nonhuman · Amlodipine · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Blood Pressure · Calcium Channel Blockers · Cholesterol · Cholesterol, Dietary · Drug Therapy, Combination · Female · Heptanoic Acids · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Mice · Mice, Transgenic · Pyrroles
[Abstract]

5 Action of lovastatin, simvastatin, and pravastatin on sterol synthesis and their antiproliferative effect in cultured myoblasts from human striated muscle
article 1996    
Author: Vliet, A.K. van · Nègre-Arrariou, P. · Thiel, G.C.F. van · Bolhuis, P.A. · Cohen, L.H.
Keywords: Biology · HMG-CoA reductase inhibitors · Human myoblasts · Sterol synthesis · Adenosine triphosphate · Hydroxymethylglutaryl coenzyme a reductase inhibitor · Mevinolin · Mitochondrial enzyme · Cell culture · Cell proliferation · Cell viability · Concentration response · Controlled study · Dna synthesis · Human cell · Human tissue · Muscle biopsy · Myoblast · Myopathy · Skeletal muscle · Acetic Acid · Adenosine Triphosphate · Anticholesteremic Agents · Cell Division · Cell Survival · Cells, Cultured · DNA · Enzyme Inhibitors · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lovastatin · Mitochondria · Muscle, Skeletal · Oxidoreductases · Pravastatin · Simvastatin · Sterols
[Abstract]

6 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

7 Cholesteryl ester transfer protein inhibition: Effect on reverse cholesterol transport?
article 2006    
Author: Rensen, P.C.N. · Havekes, L.M.
Keywords: Biology · Biomedical Research · 2 methylpropanethioic acid s [2 [1 (2 ethylbutyl)cyclohexylcarboxamido]phenyl] ester · Atorvastatin · Cholesterol ester transfer protein inhibitor · Fibric acid derivative · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Nicotinic acid · Torcetrapib · Atherosclerosis · Cholesterol transport · Clinical trial · Drug efficacy · Drug mechanism · Dyslipidemia · Editorial · Ischemic heart disease · Nonhuman · Plasma clearance · Protein expression · Reverse cholesterol transport · Animals · Biological Transport · Cardiovascular Diseases · Carrier Proteins · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Glycoproteins · Humans · Lipid Metabolism · Lipoproteins, HDL · Rabbits · Risk Factors
[Abstract]

8 Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-κB activity and lowering of cholesterol
article 2010    
Author: Vries-van der Weij, J. de · Toet, K. · Zadelaar, A.S.M. · Wielinga, P.Y. · Kleemann, R. · Rensen, P.C.N. · Kooistra, T.
Keywords: Health · Biomedical Research · Anti-inflammatory treatment · Established lesions · Inflammation · Mouse model of atherosclerosis · NF-κB · On-top of statin treatment · Reduce further progression of atherosclerosis · Serum amyloid A (SAA) · Statin · hydroxymethylglutaryl coenzyme A reductase inhibitor · immunoglobulin enhancer binding protein · salicylic acid · serum amyloid A · STAT3 protein · animal experiment · animal model · antiinflammatory activity · aorta · article · atherosclerosis · atherosclerotic plaque · cholesterol blood level · cholesterol diet · controlled study · disease course · drug effect · female · histology · hypercholesterolemia · inflammation · liver · low fat diet · macrophage · mouse · nonhuman · priority journal · risk factor · treatment outcome
[Abstract]

9 Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins
article 2008    
Author: Bergheanu, S.C. · Reijmers, T. · Zwinderman, A.H. · Bobeldijk, I. · Ramaker, R. · Liem, A.-H. · Greef, J. van der · Hankemeier, T. · Jukema, J.W.
Keywords: Biology · Atorvastatin · Cardiovascular risk · Phosphatidylcholines · Rosuvastatin · Sphingomyelins · Atorvastatin · Cholesterol · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Low density lipoprotein cholesterol · Phosphatidylcholine · Rosuvastatin · Sphingomyelin · Triacylglycerol · Adult · Aged · Article · Cardiovascular risk · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Coronary artery disease · Drug dose increase · Drug efficacy · Drug megadose · Female · Human · Lipid blood level · Lipid metabolism · Lipidomics · Liquid chromatography · Low drug dose · Major clinical study · Male · Mass spectrometry · Multicenter study · Phase 3 clinical trial · Randomized controlled trial · Therapy effect · Treatment outcome · Chromatography, Liquid · Dose-Response Relationship, Drug · Fluorobenzenes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Mass Spectrometry · Prospective Studies · Pyrimidines · Pyrroles · Sulfonamides
[Abstract]

10 Rosuvastatin reduces atherosclerosis development beyond and independent of its plasma cholesterol-lowering effect in APOE*3-Leiden transgenic mice: Evidence for antiinflammatory effects of rosuvastatin
article 2003    
Author: Kleemann, R. · Princen, H.M.G. · Emeis, J.J. · Jukema, J.W. · Fontijn, R.D. · Horrevoets, A.J.G. · Kooistra, T. · Havekes, L.M.
Keywords: Biology · Biomedical Research · Cell adhesion molecules · Inhibitors · Amyloid A protein · Cell adhesion molecule · Fibrinogen · Monocyte chemotactic protein 1 · Rosuvastatin · Statine derivative · Tumor necrosis factor alpha · Antiinflammatory agent · Apolipoprotein E · Apolipoprotein E3 (Leidein) · Cytokine · Fluorobenzene · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Lipid · Lipoprotein · Pyrimidine derivative · Sulfonamide · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta root · Cell adhesion · Cholesterol blood level · Cholesterol diet · Controlled study · Inflammation · Monocyte · Mouse · Nonhuman · Nucleotide sequence · Transgenic mouse · Blood · Drug effect · Genetics · Immunology · Metabolism · Pathology · Animals · Anti-Inflammatory Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cell Adhesion · Cholesterol · Cytokines · Female · Fluorobenzenes · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Lipoproteins · Macrophages · Mice · Mice, Transgenic · Monocytes · Pyrimidines · Sulfonamides
[Abstract]

11 Effects of simvastatin on plasma lipids and apolipoproteins in familial hypercholesterolemic swine
article 1996    
Author: Hasler-Rapacz, J. · Kempen, H.J. · Princen, H.M.G. · Kudchodkar, B.J. · Lacko, A. · Rapacz, J.
Keywords: Biology · animal model · apolipoproteins · familial hypercholesterolemia · simvastatin · swine · apolipoprotein a · apolipoprotein b · apolipoprotein c3 · apolipoprotein e · high density lipoprotein cholesterol · hydroxymethylglutaryl coenzyme a reductase · lathosterol · lipid · low density lipoprotein cholesterol · phosphatidylcholine sterol acyltransferase · simvastatin · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · animal tissue · article · calculation · cholesterol blood level · dose response · enzyme activity · hypercholesterolemia · hyperlipidemia · lipid analysis · lipid blood level · lipoprotein blood level · nonhuman · priority journal · statistical analysis · swine · Animals · Apolipoprotein A-I · Apolipoprotein C-III · Apolipoproteins · Apolipoproteins B · Apolipoproteins C · Apolipoproteins E · Cholesterol · Cholesterol, HDL · Cholesterol, LDL · Enzyme Inhibitors · Female · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hyperlipoproteinemia Type II · Lipids · Male · Swine · Swine Diseases · Triglycerides
[Abstract]

12 Rosuvastatin reduces plasma lipids by inhibiting VLDL production and enhancing hepatobiliary lipid excretion in ApoE*3-Leiden mice
article 2005    
Author: Delsing, D.J.M. · Post, S.M. · Groenendijk, M. · Solaas, K. · Boom, H. van der · Duyvenvoorde, W. van · Wit, E.C.M. de · Bloks, V.W. · Kuipers, F. · Havekes, L.M. · Princen, H.M.G.
Keywords: Biomedical Research · Gene expression · Lipid metabolism · Lipoproteins · Statin · diacylglycerol acyltransferase · hydroxymethylglutaryl coenzyme A reductase inhibitor · mevinolin · phospholipid · rosuvastatin · very low density lipoprotein · animal tissue · biliary excretion · cholesterol blood level · cholesterol diet · cholesterol synthesis · controlled study · enzyme activity · gene expression · hepatobiliary system · lipid blood level · lipid composition · lipid diet · lipid liver level · lipolysis · mouse · nonhuman · priority journal · rat · statistical significance · triacylglycerol blood level · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Bile · Bile Acids and Salts · Cholesterol · Cholesterol, VLDL · Chromatography, High Pressure Liquid · Feces · Female · Fluorobenzenes · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Liver · Mice · Mice, Transgenic · Pyrimidines · Reverse Transcriptase Polymerase Chain Reaction · RNA, Messenger · Sterols · Sulfonamides · Triglycerides
[Abstract]

13 Doxycycline therapy for abdominal aneurysm: Improved proteolytic balance through reduced neutrophil content
article 2009    
Author: Abdul-Hussien, H. · Hanemaaijer, R. · Verheijen, J.H. · Bockel, J.H. van · Geelkerken, R.H. · Lindeman, J.H.N.
Keywords: Biology · Biomedical Research · antihypertensive agent · antithrombocytic agent · cystatin C · cysteine proteinase · doxycycline · gelatinase B · hydroxymethylglutaryl coenzyme A reductase inhibitor · messenger RNA · neutrophil collagenase · stromelysin · tissue inhibitor of metalloproteinase 1 · abdominal aorta aneurysm · adult · aged · aorta wall · article · clinical article · clinical trial · controlled clinical trial · controlled study · dose response · drug effect · drug megadose · drug tolerability · enzyme activity · enzyme assay · female · gene expression · human · human tissue · immunohistochemistry · low drug dose · male · neutrophil · polymerase chain reaction · priority journal · protein degradation · quantitative analysis · randomized controlled trial · treatment duration · Western blotting · Aged · Aged, 80 and over · Aorta, Abdominal · Aortic Aneurysm, Abdominal · Cardiovascular Agents · Cystatin C · Cysteine Endopeptidases · Dose-Response Relationship, Drug · Doxycycline · Female · Gene Expression Regulation, Enzymologic · Humans · Male · Matrix Metalloproteinases · Middle Aged · Neutrophil Infiltration · Neutrophils · Prospective Studies · Protease Inhibitors · RNA, Messenger · Time Factors · Tissue Inhibitor of Metalloproteinase-1 · Treatment Outcome · Vascular Surgical Procedures
[Abstract]

14 Mouse models for atherosclerosis and pharmaceutical modifiers
article 2007    
Author: Zadelaar, A.S.M. · Kleemann, R. · Verschuren, L. · Vries-van der Weij, J. de · Hoorn, J. van der · Princen, H.M. · Kooistra, T.
Keywords: Biology · Biomedical Research · ACE inhibitors · AT1 receptor antagonists · Atherosclerosis · LXR · Mouse models · Pharmaceutical drugs · PPAR · Statins · atorvastatin · avasimibe · candesartan · captopril · cholesterol acyltransferase inhibitor · dipeptidyl carboxypeptidase inhibitor · hydralazine · hydroxymethylglutaryl coenzyme A reductase inhibitor · irbesartan · losartan · ly 465608 · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · olmesartan · perindopril · peroxisome proliferator activated receptor alpha agonist · pirinixic acid · pitavastatin · pravastatin · quinapril · ramipril · rosuvastatin · simvastatin · telmisartan · temocapril · unindexed drug · valsartan · zofenopril · antihypertensive agent · antilipemic agent · apolipoprotein E · atherosclerosis · pathophysiology · sensitivity and specificity · Animals · Antihypertensive Agents · Antilipemic Agents · Apolipoproteins E · Atherosclerosis · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Dyslipidemias · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypertension · Male · Mice · Mice, Knockout · Mice, Transgenic · Sensitivity and Specificity
[Abstract]

15 Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro
article 2004    
Author: Kleemann, R. · Verschuren, L. · Rooij, B.J. de · Lindeman, J. · Maat, M.M.de · Szalai, A.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biomedical Research · Antilipemic agent · C reactive protein · CCAAT enhancer binding protein · Cholesterol · Fenofibrate · Hydroxymethylglutaryl coenzyme A reductase inhibitor · I kappa B alpha · Immunoglobulin enhancer binding protein · Interleukin 1beta · Peroxisome proliferator activated receptor agonist · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor alpha agonist · Pirinixic acid · Protein p50 · Unclassified drug · Animal experiment · Animal model · Animal tissue · Antiinflammatory activity · Atherogenesis · Atherosclerosis · Cardiovascular risk · Cell culture · Cholesterol blood level · Controlled study · Hepatoma cell · Human cell · Inflammation · Liver cell · Mouse · Nonhuman · Transgenic mouse · Animals · C-Reactive Protein · Carcinoma, Hepatocellular · CCAAT-Enhancer-Binding Proteins · Cell Line, Tumor · Cholesterol · Down-Regulation · Gene Expression · Hepatocytes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · I-kappa B Proteins · Interleukin-1 · Male · Mice · Mice, Transgenic · NF-kappa B · NF-kappa B p50 Subunit · Pyrroles · Receptors, Cytoplasmic and Nuclear · Simvastatin · Transcription Factors · Up-Regulation
[Abstract]

16 Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
article 2006    
Author: Korsheninnikova, E. · Zon, G.C.M. van der · Voshol, P.J. · Janssen, G.M. · Havekes, L.M. · Grefhorst, A. · Kuipers, F. · Reijngoud, D.-J. · Romijn, J.A. · Ouwens, D.M. · Maassen, J.A.
Keywords: Biology · Biomedical Research · Hepatic steatosis · High-fat feeding · Nutrient sensing · Enzyme inhibitor · Glucose · Hydroxymethylglutaryl coenzyme A reductase kinase · Mammalian target of rapamycin · Protein kinase B · Protein S6 · S6 kinase · Tetradecylglycidic acid · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Diabetic obesity · Diabetogenesis · Enzyme activation · Glucose clamp technique · Hyperinsulinemia · Insulin resistance · Lipid diet · Liver homogenate · Liver mitochondrion · Mitochondrial membrane · Nonhuman · Nutrient concentration · Nutrient content · Protein blood level · Protein induction · Protein phosphorylation · Protein synthesis · Protein targeting · Species comparison · 1-Phosphatidylinositol 3-Kinase · Animals · Blood Glucose · Dietary Fats · DNA, Mitochondrial · Electron Transport Complex IV · Fatty Acids · Fatty Liver · Insulin · Insulin Resistance · Leucine · Liver · Male · Mice · Mice, Inbred C57BL · Phosphorylation · Protein Kinases · Ribosomal Proteins
[Abstract]

17 Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: A combined transcriptomics and metabolomics analysis
article 2007    
Author: Kleemann, R. · Verschuren, L. · Erk, M.J. van · Nikolsky, Y. · Cnubben, N.H.P. · Verheij, E.R. · Smilde, A.K. · Hendriks, H.F.J. · Zadelaar, A.S.M. · Smith, G.J. · Kaznacheev, V. · Nikolskaya, T. · Melnikov, A. · Hurt-Camejo, E. · Greef, J. van der · Ommen, B. van · Kooistra, T.
Keywords: Analytical research · Biomedical research · alanine aminotransferase · aspartate aminotransferase · cholesterol · endothelial leukocyte adhesion molecule 1 · gamma interferon · high density lipoprotein · hydroxymethylglutaryl coenzyme A reductase · immunoglobulin enhancer binding protein · interleukin 1 · low density lipoprotein · peroxisome proliferator activated receptor alpha · platelet derived growth factor · protein p53 · retinoid X receptor · retinoid X receptor alpha · serum amyloid A · Smad3 protein · STAT1 protein · STAT3 protein · STAT5 protein · sterol regulatory element binding protein 1 · sterol regulatory element binding protein 2 · transcription factor FKHR · transcription factor Sp1 · transcription factor YY1 · triacylglycerol · tumor necrosis factor alpha · very low density lipoprotein · alanine aminotransferase blood level · animal experiment · animal model · animal tissue · article · aspartate aminotransferase blood level · atherosclerosis · cholesterol blood level · cholesterol diet · cholesterol intake · controlled study · diet supplementation · female · gene control · genetic transcription · hepatitis · hypercholesterolemia · lipid metabolism · metabolomics · mouse · nonhuman · pathophysiology · protein blood level · stress · transcription regulation · transcriptomics · triacylglycerol blood level · upregulation · animal · biological model · diet · disease model · gene expression regulation · inflammation · liver · metabolism · pathology · systems biology · Mus · Animals · Atherosclerosis · Cholesterol, Dietary · Diet · Disease Models, Animal · Female · Gene Expression Regulation · Inflammation · Lipid Metabolism · Liver · Metabolism · Mice · Models, Biological · Systems Biology · Transcription, Genetic
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date