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1 Effect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients
article 1996    
Author: Sijbrands, E.J.G. · Westendorp, R.G.J. · Hoffer, M.J.V. · Frants, R.R. · Meinders, A.E. · Souverijn, J.H.M. · Leuven, J.A.G. · Laarse, A. van der · Havekes, L.M. · Smelt, A.H.M.
Keywords: Biology · ApoE · Combined hyperlipidemia · Hyperinsulinemia · Particle size · VLDL · apolipoprotein e · insulin · very low density lipoprotein · adult · aged · article · clinical trial · controlled clinical trial · controlled study · diet · female · genetic analysis · heterozygosity · human · human tissue · hyperlipidemia · hypertriglyceridemia · insulin resistance · lipid analysis · major clinical study · male · priority journal · Adult · Aged · Apolipoproteins E · Cholesterol, VLDL · Fasting · Female · Humans · Hyperlipidemia, Familial Combined · Insulin · Insulin Resistance · Lipoproteins, VLDL · Male · Middle Aged · Particle Size · Triglycerides
[Abstract]

2 Computational models for analyzing lipoprotein profiles
article 2011    
Author: Graaf, A.A. de · Schalkwijk, D.B. van
Keywords: Nutrition · cardiovascular disease · cholesterol · computational modeling · diabetes · diagnostic biomarkers · HDL · hyperlipidemia · LDL · lipoprotein · triglyceride · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase
article 2017    
Author: Simic, B. · Mocharla, P. · Crucet, M. · Osto, E. · Kratzer, A. · Stivala, S. · Kühnast, S. · Speet, T. · Doycheva, P. · Princen, H.M.G. · Hoorn, J.W.A. van der · Jukema, J.W. · Giral, H. · Tailleux, A. · Landmesser, U. · Syaels, B. · Lüscher, T.F.
Keywords: Biology · CETP · Hyperlipidemia · Endothelial dysfunction · HDL-Cholesterol · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

4 C-reactive protein: A cardiovascular risk factor report on the CRP hot-topic workshop october 1, 1997
article 1998    
Author: Maat, M.P.M. de · Haverkate, F. · Kluft, C.
Keywords: Biology · Antilipemic agent · C reactive protein · Estradiol · Estrogen receptor · Pravastatin · Acute phase response · Agina pectoris · Animal model · Atherosclerosis · Cardiovascular disease · Chlamydophila pneumoniae · Controlled study · Coronary artery disease · Disease association · Estrogen therapy · Human · Hyperlipidemia · Inflammation · Nonhuman · Rrisk factor
[Abstract]

5 Gender-related association between the -93T →Gg/D9N haplotype of the lipoprotein lipase gene and elevated lipid levels in familial combined hyperlipidemia
article 1998    
Author: Hoffer, M.J.V. · Bredie, S.J.H. · Snieder, H. · Reymer, P.W.A. · Demacker, P.N.M. · Havekes, L.M. · Boomsma, D.I. · Stalenhoef, A.F.H. · Frants, R.R. · Kastelein, J.J.P.
Keywords: Health · Familial combined hyperlipidemia · Family study · Genetic predisposition · Lipoprotein lipase · Mutation analysis · Adult · Amino Acid Sequence · DNA Mutational Analysis · Female · Haplotypes · Heterozygote · Humans · Hyperlipidemias · Likelihood Functions · Linkage (Genetics) · Lipids · Lipoprotein Lipase · Male · Middle Aged · Pedigree · Promoter Regions (Genetics) · Sex Characteristics
[Abstract]

6 Quantitative assessment of aortic atherosclerosis in APOE*3 leiden transgenic mice and its relationship to serum cholesterol exposure
article 1996    
Author: Groot, P.H.E. · Vlijmen, B.J.M. van · Benson, G.M. · Hofker, M.H. · Schiffelers, R. · Vidgeon-Hart, M. · Havekes, L.M.
Keywords: Biology · animal model · apolipoprotein E · diet · familial dyslipoproteinemia · hyperlipidemia · apolipoprotein e · cholesterol · animal experiment · animal model · animal tissue · aorta atherosclerosis · aorta sinus · article · atherosclerosis · cholesterol blood level · cholesterol diet · controlled study · dyslipoproteinemia · feeding · female · hyperlipidemia · hypolipemia · lipid diet · male · mouse · nonhuman · priority journal · transgenic mouse · Animals · Aortic Diseases · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Dietary Fats · Female · Hyperlipidemias · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Sinus of Valsalva
[Abstract]

7 The effect of PPE-induced emphysema and chronic LPS-induced pulmonary inflammation on atherosclerosis development in APOE*3-LEIDEN mice
article 2013    
Author: Khedoe, P.P.S.J. · Wong, M.C. · Wagenaar, G.T.M. · Plomp, J.J. · Eck, M. van · Havekes, L.M. · Rensen, P.C.N. · Hiemstra, P.S. · Berbée, J.F.P.
Keywords: Biology · Apolipoprotein E3 · Blood clotting factor 5 Leiden · Cholesterol · Interleukin 6 · Lipopolysaccharide · Pancreatic elastase · Phospholipid · Triacylglycerol · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Cardiovascular disease · Cholesterol blood level · Chronic inflammation · Controlled study Ccytokine release · Hyperlipidemia · Lung emphysema · Macrophage · Mouse · Neutrophil · Nonhuman · Phospholipid blood level · Pneumonia · Triacylglycerol blood level · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

8 Apolipoprotein CI aggravates atherosclerosis development in ApoE-knockout mice despite mediating cholesterol efflux from macrophages
article 2007    
Author: Westerterp, M. · Eck, M. van · Haan, W. de · Offerman, E.H. · Berkel, T.J.C. van · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · ApoCI · Cholesterol efflux · Hyperlipidemia · Macrophages · Transgenic mice · Triacylglycerol · Adipose tissue · Aorta root · Artery wall · Atherosclerosis · Protein expression · Statistical significance · Triacylglycerol blood level · Animals · Apolipoprotein C-I · Apolipoproteins E · Atherosclerosis · Bone Marrow Cells · Bone Marrow Transplantation · Cholesterol · Female · Gene Expression Regulation · Liver · Macrophages · Male · Mice · Mice, Knockout · Mice, Transgenic
[Abstract]

9 Effect of macrophage-derived mouse ApoE, human ApoE3-Leiden, and human ApoE2 (Arg158→Cys) on cholesterol levels and atherosclerosis in ApoE- deficient mice
article 2000    
Author: Eck, M. van · Herijgers, N. · Dijk, K.W. van · Havekes, L.M. · Hofker, M.H. · Groot, P.H.E. · Berkel, T.J.C. van
Keywords: Atherosclerosis · Hyperlipidemia · Low density lipoprotein · Animal model · Animal tissue · Cholesterol blood level · Cholesterol transport · Mouse · Nonhuman · Transgenic mouse · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Bone Marrow Transplantation · Cholesterol · Humans · Liver · Macrophages, Peritoneal · Mice · Mice, Knockout · Mice, Transgenic
[Abstract]

10 Triglyceride-rich lipoprotein metabolism in unique VLDL receptor, LDL receptor, and LRP triple-deficient mice
article 2005    
Author: Espirito Santo, S.M.S. · Rensen, P.C.N. · Goudriaan, J.R. · Bensadoun, A. · Bovenschen, N. · Voshol, P.J. · Havekes, L.M. · Vlijmen, B.J.M. van
Keywords: Biology · Biomedical Research · Apolipoprotein E · Hepatic lipase · Hyperlipidemia · Lipoprotein lipase · Low density lipoprotein receptor · Postprandial response · Transgenic mice · Very low density lipoprotein receptor · Very low density lipoproteins · Lipid · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Triacylglycerol lipase · Very low density lipoprotein receptor · Leucine responsive regulatory protein · Lipoprotein · Transcription factor · Animal experiment · Animal model · Animal tissue · Controlled study · Female · gene deletion · Hyperlipidemia · Lipid blood level · Lipid diet · Male · Mouse · Nonhuman · Protein defect · Species comparison · Triacylglycerol blood level · Triacylglycerol lipase blood level · Wild type · Chemistry · Genetics · Metabolism · Pathology · Physiology · Polymerase chain reaction · Time · Transgenic mouse · Alleles · Animals · Cholesterol · DNA-Binding Proteins · Genotype · Hyperlipidemias · Leucine-Responsive Regulatory Protein · Lipid Metabolism · Lipoproteins · Mice · Mice, Transgenic · Polymerase Chain Reaction · Receptors, LDL · Time Factors · Transcription Factors · Triglycerides
[PDF] [Abstract]

11 The expression of type III hyperlipoproteinemia: Involvement of lipolysis genes
article 2009    
Author: Henneman, P. · Sman-de Beer, F. van der · Moghaddam, P.H. · Huijts, P. · Stalenhoef, A.F.H. · Kastelein, J.J.P. · Duijn, C.M. van · Havekes, L.M. · Frants, R.R. · Dijk, K.W. van · Smelt, A.H.M.
Keywords: Biology · Biomedical Research · adenine · apolipoprotein A5 · apolipoprotein C3 · apolipoprotein E2 · cytosine · guanine · lipoprotein lipase · liver triacylglycerol lipase · thymine · adult · aged · article · controlled study · disease severity · female · gene expression · gene frequency · gene function · gene linkage disequilibrium · genetic association · genetic polymorphism · genetic variability · human · human cell · hyperlipidemia · hyperlipoproteinemia type 3 · hypertriglyceridemia · lipolysis · lipoprotein blood level · major clinical study · male · mutational analysis · Netherlands · priority journal
[Abstract]

12 Modulating effect of the A-278C promoter polymorphism in the cholesterol 7alpha-hydroxylase gene on serum lipid levels in normolipidaemic and hypertriglyceridaemic individuals
article 2004    
Author: Hofman, M.K. · Groenendijk, M. · Verkuijlen, P.J.J.H. · Jonkers, I.J.A.M. · Mohrschladt, M.F. · Smelt, A.H.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · CYP7A1 · Hyperlipidaemia · Modifier gene · Polymorphism · Triglycerides · apolipoprotein E3 · cholesterol · cholesterol 7alpha monooxygenase · isoprotein · lipid · low density lipoprotein · triacylglycerol · very low density lipoprotein · controlled study · DNA polymorphism · familial hypercholesterolemia · gene control · homozygosity · hyperlipidemia · hyperlipoproteinemia type 3 · lipid blood level · major clinical study · promoter region · triacylglycerol blood level · Adult · Aged · Cholesterol 7-alpha-Hydroxylase · Female · Gene Frequency · Genotype · Humans · Hypertriglyceridemia · Male · Middle Aged · Polymorphism, Genetic · Promoter Regions (Genetics) · Triglycerides
[Abstract]

13 Severe hypertriglyceridemia in human APOC1 transgenic mice is caused by apoC-I-induced inhibition of LPL
article 2005    
Author: Berbée, J.F.P. · Hoogt, C.C. van der · Sundararaman, D. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein C-I · Fatty acids · Lipid metabolism · Lipoprotein lipase · Triglycerides · Very low density lipoprotein · Lipoprotein receptor · Tritium · Very low density lipoprotein · Animal experiment · Animal model · Cholesterol blood level · Controlled study · Enzyme activity · Half life time · Hyperlipidemia · Hyperlipoproteinemia type 3 · Lipolysis · Mouse · Nonhuman · Pathophysiology · Protein expression · Transgenic mouse · Animals · Apolipoproteins · Apolipoproteins C · Apolipoproteins E · Humans · Hypertriglyceridemia · Lactoferrin · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Mice, Transgenic · Phenotype · Time Factors
[PDF] [Abstract]

14 Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels
article 1994    
Author: Knijff, P. de · Maagdenberg, A.M.J.M. van den · Frants, R.R. · Havekes, L.M.
Keywords: Biology · Apolipoprotein (apo) E · Atherosclerosis · Familial Dysbetalipoproteinemia (FD) · Mutations · Polymorphisms · Type III Hyperlipoproteinemia · Cholesterol · Chylomicron · Low density lipoprotein receptor · Triacylglycerol · Very low density lipoprotein · Alzheimer disease · Atherosclerosis · Cholesterol blood level · Coronary artery disease · Creutzfeldt jakob disease · Gene mutation · Genetic heterogeneity · Genetic linkage · Genetic polymorphism · Ligand binding · Lipoprotein metabolism · Alleles · Amino Acid Sequence · Base Sequence · DNA · Female · Gene Frequency · Human · Hyperlipidemia · Hyperlipoproteinemia Type III · Lipids · Lipoproteins · Male · Molecular Sequence Data · Mutation · Variation (Genetics)
[Abstract]

15 Effects of fish oil on oxidation resistance of VLDL in hypertriglyceridemic patients
article 1996    
Author: Hau, M.-F. · Smelt, A.H.M. · Bindels, A.J.G.H. · Sijbrands, E.J.G. · Laarse, A. van der · Onkenhout, W. · Duyvenvoorde, W. van · Princen, H.M.G.
Keywords: Biology · fish oil · hypertriglyceridemia · LDL oxidation · omega-3 fatty acids · VLDL oxidation · alpha tocopherol · cholesterol · fish oil · high density lipoprotein cholesterol · low density lipoprotein cholesterol · omega 3 fatty acid · polyunsaturated fatty acid · triacylglycerol · very low density lipoprotein cholesterol · adult · article · clinical article · diet supplementation · fat intake · fatty acid blood level · human · hyperlipidemia · hypertriglyceridemia · lipid blood level · lipid oxidation · lipoprotein blood level · male · oral drug administration · priority journal · Adult · Diet · Fish Oils · Humans · Hypertriglyceridemia · Lipid Peroxidation · Lipoproteins, VLDL · Male · Middle Aged
[Abstract]

16 Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor : Contribution to the hypertriglyceridemic action of retinoids
article 1998    
Author: Vu-Dac, N. · Gervois, P. · Torra, I.P. · Fruchart, J.C. · Kosykh, V. · Kooistra, T. · Princen, H.M.G. · Dallongeville, J. · Staels, B.
Keywords: Health · Gene regulation · Hyperlipidemia · Nuclear receptors · Retinoids · Triglycerides · Adult · Apolipoprotein C-III · Apolipoproteins C · Benzoates · Carcinoma, Hepatocellular · Cells, Cultured · Dimerization · Double-Blind Method · Gene Expression Regulation · Hela Cells · Humans · Hypertriglyceridemia · Isotretinoin · Liver · Liver Neoplasms · Male · Mutagenesis, Site-Directed · Promoter Regions (Genetics) · Receptors, Cytoplasmic and Nuclear · Receptors, Retinoic Acid · Recombinant Fusion Proteins · Regulatory Sequences, Nucleic Acid · Retinoid X Receptors · Retinoids · Tetrahydronaphthalenes · Transcription Factors · Transcription, Genetic · Transfection · Tumor Cells, Cultured
[PDF] [Abstract]

17 Cholesteryl ester transfer protein decreases high-density lipoprotein and severely aggravates atherosclerosis in APOE*3-Leiden mice
article 2006    
Author: Westerterp, M. · Hoogt, C.C. van der · Haan, W. de · Offerman, E.H. · Dallinga-Thie, G.M. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · CETP · Cholesterol efflux · Hyperlipidemia · Reverse cholesterol transport · Transgenic mice cholesterol · High density lipoprotein · Low density lipoprotein · Very low density lipoprotein · Animal cell · Animal experiment · Animal model · Animal tissue · Aorta root · Atherosclerosis · Cholesterol blood level · Controlled study · Diet · Mouse · Nonhuman · Plasma · Protein expression · Transgenic mouse · Animals · Antigens, CD36 · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Carrier Proteins · Cell Line, Tumor · Cholesterol · Cholesterol Ester Transfer Proteins · Diet · Female · Glycoproteins · Humans · Lipids · Lipoproteins · Lipoproteins, HDL · Macrophages · Mice · Mice, Transgenic · Rats
[Abstract]

18 Effects of gemfibrozil and ciprofibrate on plasma levels of tissue-type plasminogen activator, plasminogen activator inhibitor-1 and fibrinogen in hyperlipidaemic patients
article 1997    
Author: Kockx, M. · Maat, M.P.M. de · Knipscheer, H.C. · Kastelein, J.P. · Kluft, C. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Antigen · Antilipemic agent · Cholesterol · Ciprofibrate · Fibrinogen · Gemfibrozil · Plasminogen activator inhibitor · Tissue plasminogen activator · Triacylglycerol · Adult · Blood level · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Double blind procedure · Drug effect · Enzyme immunoassay · Female · Fibrinogen blood level · Hyperlipidemia · Major clinical study · Male · Priority journal · Triacylglycerol blood level · Aged · Antilipemic Agents · Cholesterol · Clofibric Acid · Double-Blind Method · Female · Fibrinogen · Gemfibrozil · Humans · Hyperlipoproteinemia Type II · Male · Middle Aged · Plasminogen Activator Inhibitor 1 · Smoking · Tissue Plasminogen Activator · Treatment Outcome
[Abstract]

19 ApoC-III deficiency prevents hyperlipidemia induced by apoE overexpression
article 2005    
Author: Gerritsen, G. · Rensen, P.C.N. · Kypreos, K.E. · Zannis, V.I. · Havekes, L.M. · Dijk, K.W. van
Keywords: Biology · Biomedical Research · Adenovirus-mediated gene transfer · Lipoprotein lipase-mediated triglyceride hydrolysis · Mice · Very low density lipoprotein · Cholesterol · Fatty acid · Intermediate density lipoprotein · Lipoprotein · Triacylglycerol · Lipid · Lipoprotein lipase · Animal experiment · Animal tissue · Cholesterol blood level · Controlled study · Dose response · Emulsion · Female · Gene dosage · Gene overexpression · Hydrolysis · Hyperlipidemia · In vitro study · In vivo study · Injection · Lipoprotein deficiency · Mouse · Nonhuman · Protein blood level · White adipose tissue · Animal · Biosynthesis · Blood · Genetic transfection · Genetics · Metabolism · Mouse mutant · Animals · Apolipoprotein C-III · Apolipoprotein E4 · Apolipoproteins C · Apolipoproteins E · Humans · Hyperlipidemias · Lipids · Lipoprotein Lipase · Lipoproteins · Lipoproteins, VLDL · Mice · Mice, Knockout · Transfection · Triglycerides
[PDF] [Abstract]

20 Endogenous apoC-I increases hyperlipidemia in apoE-knockout mice by stimulating VLDL production and inhibiting LPL
article 2006    
Author: Westerterp, M. · Haan, W. de · Berbée, J.F.P. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Lipases transgenic mouse models · Very low density lipoprotein · apolipoprotein B · cholesterol · fatty acid · heparin · lipid · olive oil · triacylglycerol · very low density lipoprotein · animal experiment · animal tissue · cholesterol blood level · concentration response · controlled study · enzyme inhibition · gene dosage · gonad · hyperlipidemia · intestine absorption · knockout mouse · lipid absorption · lipid blood level · lipid metabolism · lipolysis · mouse · nonhuman · postprandial state · protein expression · triacylglycerol blood level · white adipose tissue · Animals · Apolipoprotein C-I · Apolipoproteins C · Apolipoproteins E · Cholesterol · Hyperlipidemias · Intestines · Lipase · Lipoprotein Lipase · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Postprandial Period
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 32 found. Next | Sort by date