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1 Endotoxin-induced liver damage in rats is minimized by β2- adrenoceptor stimulation
article 2004    
Author: Izeboud, C.A. · Hoebe, K.H.N. · Grootendorst, A.F. · Nijmeijer, S.M. · Miert, A.S. van · Witkamp, R.F. · Rodenburg, R.J.T.
Keywords: Biology Pharmacology · Physiological Sciences · Adrenoceptor agonists · Cytokines · Endotoxemia · Immunopharmacology · Liver-failure · alanine aminotransferase · aspartate aminotransferase · beta adrenergic receptor · bilirubin · clenbuterol · cytokine · endotoxin · interleukin 10 · interleukin 1beta · interleukin 6 · lipopolysaccharide · propranolol · tumor necrosis factor alpha · animal model · animal tissue · article · controlled study · enzyme linked immunosorbent assay · liver failure · liver injury · male · nonhuman · rat · Adrenergic beta-Agonists · Adrenergic beta-Antagonists · Alanine Transaminase · Animals · Aspartate Aminotransferases · Clenbuterol · Endotoxins · Inflammation · Interleukin-1 · Interleukin-10 · Interleukin-6 · Lipopolysaccharides · Liver · Liver Failure · Male · Osmolar Concentration · Propranolol · Rats · Rats, Wistar · Tumor Necrosis Factor-alpha
[Abstract]

2 Unheated Cannabis sativa extracts and its major compound THC-acid have potential immuno-modulating properties not mediated by CB1 and CB2 receptor coupled pathways
article 2006    
Author: Verhoeckx, K.C.M. · Korthout, H.A.A.J. · Meeteren-Kreikamp, A.P. van · Ehlert, K.A. · Wang, M. · Greef, J. van der · Rodenburg, R.J.T. · Witkamp, R.F.
Keywords: Health · Analytical research · Biomedical research · Δ9-tetrahydrocanabinoid · Δ9-tetrahydrocanabinoid acid · cAMP · Cannabis sativa · Inflammation · PC-PLC · TNF-alpha · 1 (2,4 dichlorophenyl) 5 (4 iodophenyl) 4 methyl n morpholino 1h pyrazole 3 carboxamide · 6 iodo 3 (4 methoxybenzoyl) 2 methyl 1 (2 morpholinoethyl)indole · Beta 2 adrenergic receptor stimulating agent · Cannabidiol · Cannabidiolic acid · Cannabinoid 1 receptor · Cannabinoid 2 receptor · Cannabinoid derivative · Cannabis · Delta 9 tetrahydrocannabinoid acid · Dronabinol · Immunomodulating agent · Lipopolysaccharide · Phosphatidylcholine · Phospholipase C · Tumor necrosis factor alpha · Unclassified drug · Zilpaterol · Cell strain U937 · Concentration response · Controlled study · Cytokine production · Down regulation · Drug effect · Drug mechanism · Enzyme activity · Heating · Human cell · Immunomodulation · Immunopharmacology · Immunostimulation · Long term exposure · Macrophage · Metabolism · Protein induction · Protein synthesis regulation · Supernatant · Upregulation · Cannabis · Cell Line · Cells, Cultured · Cyclic AMP · Dose-Response Relationship, Drug · Heat · Humans · Immunologic Factors · Macrophage Activation · Macrophages · Phospholipase C · Plant Extracts · Receptor, Cannabinoid, CB1 · Receptor, Cannabinoid, CB2 · Signal Transduction · Tetrahydrocannabinol · Tumor Necrosis Factor-alpha
[Abstract]

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