Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date

1 Chemically-induced immunopathology and immune functional changes
article 2004    
Author: Vos, J.G. · Kuper, C.F.
Keywords: Biology · Toxicology and Applied Pharmacology · Cyclosporin A · HCB · Immune function · Immunopathology · Immunostimulation · Immunosuppression · Immunotoxicity · TBTO · TCDD
[PDF] [Abstract]

2 Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agents
article 2012    
Author: Menke, A. · Wolterbeek, A. · Snel, C. · Bruijntjes, J. · Groot, D.D. · Oostrum, L.V. · Waalkens, I. · Kuper, C.F.
Keywords: Biology · DOTC · immunotoxicity · lactation · pregnancy · sensitive periods · thymus · Healthy for Life · Healthy Living · Life Triskelion · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

3 Controlling persistent organic pollutants-what next?
article 1998    
Author: Vallack, H.W. · Bakker, D.J. · Brandt, I. · Broström-Lundén, E. · Brouwer, A. · Bull, K.R. · Gough, C. · Guardans, R. · Holoubek, I. · Jansson, B. · Koch, R. · Kuylenstierna, J. · Lecloux, A. · Mackay, D. · McCutcheon, P. · Mocarelli, P. · Taalman, R.D.F. · Weavers, N.G.
Keywords: Environment · Bioaccumulation · Biomagnification · Carcinogenicity · Chronic toxicity · Endocrine disruption · Global distillation · Immunotoxicity · Monitoring · Persistence · Persistent organic pollutants · Risk assessment · Chlorinated hydrocarbon · Dioxin · Organic compound · Organochlorine pesticide · Pesticide · Pesticide residue · Polychlorinated dibenzodioxin · Polychlorinated dibenzofuran · Polycyclic aromatic hydrocarbon · Bioaccumulation · Carcinogenicity · Environmental exposure · Cnvironmental monitoring · Environmental protection · Human · Immunotoxicity · Pollution control · Pollution transport · Priority journal · Review · Risk assessment
[Abstract]

4 Toxicity to nasal-associated lymphoid tissue
article 2003    
Author: Kuper, C.F. · Arts, J.H.E. · Feron, V.J.
Keywords: Toxicology Health · Toxicology and Applied Pharmacology · Immunotoxicity · Mucosal immunity · NALT · clinical examination · conference paper · histopathology · immune system · lymphoid tissue · nonhuman · nose · practice guideline · priority journal · toxicity · Hazardous Substances · Humans · Nasal Mucosa · Toxicity Tests · Animalia
[Abstract]

5 A Sub Acute Immunotoxicity Study in Göttingen Minipigs® With The Immunosuppresive Compounds Cyclosporin A and Dexamethasone
article 2013    
Author: Mierlo, G.J.D. van · Kuper, C.F. · de Zeeuw-Brouwer, M.L. · Schijf, M.A. · Bruijntjes, J.P. · Otto, M. · Ganderup, N.C. · Penninks, A.H.
Keywords: Nutrition · Cyclosporin A · Dexamethasone · Sub acute immunotoxicity study · KLH · Lymphoid organs · Minipig · TDAR · Toxicologic pathology · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

6 The transferability from rat subacute 4-week oral toxicity study to translational research exemplified by two pharmaceutical immunosuppressants and two environmental pollutants with immunomodulating properties
article 2015    
Author: Kemmerling, J. · Fehlert, E. · Kuper, C.F. · Rühl-Fehlert, C. · Stropp, G. · Vogels, J. · Krul, C. · Vohr, H.W.
Keywords: Pharmacology · Azathioprine · Benzo[a]pyrene · Cyclosporine A · Hexachlorobenzene · Immunotoxicology · Test Guideline · Immunotoxicity · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Developmental immunotoxicity of di-n-octyltin dichloride (DOTC) in an extended one-generation reproductive toxicity study
article 2011    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Penninks, A.H. · Waalkens-Berendsen, I.D.H. · Wolterbeek, A.P.M. · Piersma, A.H. · Loveren, H. van
Keywords: Nutrition · Delayed-type hypersensitivity response (DTH) · Developmental immunotoxicity · Extended one-generation reproductive toxicity study (EOGRTS) · Organotin · Triskelion BV Life · TAP - Toxicology and Applied Pharmacology QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Transmaternal bisphenol a exposure accelerates diabetes type 1 development in NOD mice
article 2014    
Author: Bodin, J. · Bølling, A.B. · Becher, R. · Kuper, F. · Løvik, M. · Nygaard, U.C.
Keywords: Biology · Bisphenol A · Developmental toxicity · Diabetes mellitus type 1 · Immunotoxicity · Insulitis · NOD mice · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

9 General aspects of immunotoxicology including validation issues
article 2006    
Author: Frieke Kuper, C.
Keywords: Biology · Toxicology and Applied Pharmacology · Immunopathology · Organ sampling · Validation · allergy · article · autoimmune disease · histology · histopathology · human · immunotoxicity · immunotoxicology · lymphoid cell · lymphoid organ · lymphoid tissue · sensitivity and specificity · thymus · toxicology · validation study · Animals · Immune System · Immunosuppressive Agents · Lymphoid Tissue · Reproducibility of Results · Toxicity Tests · Xenobiotics
[Abstract]

10 Histopathologic approaches to detect changes indicative of immunotoxicity
article 2000    
Author: Kuper, C.F. · Harleman, J.H. · Richter-Reichelm, H.B. · Vos, J.G.
Keywords: Immunomodulation · Immunosuppression · Lymph node · Lymphoid organs · Morphology · Mucosa-associated lymphoid tissue (MALT) · Spleen · Thymus · Animal tissue · Cell structure · Histopathology · Immunomodulation · Immunotoxicity · Lymph node · Lymphoid organ · Lymphoid tissue · Nonhuman · Priority journal · Review · Spleen · Thymus · Animals · Female · Immune System · Immunosuppressive Agents · Immunotoxins · Lymphoid Tissue · Male · Rats · Animalia · Rodentia
[Abstract]

11 Integration of efficacy, pharmacokinetic and safety assessment of interleukin-1 receptor antagonist in a preclinical model of arthritis
article 2011    
Author: Zuurmond, A.M. · Koudijs, A. · El, B. van · Doornbos, R.P. · Manen-Vernooij, B.C.T. van · Bastiaans, J.H.M.W. · Penninks, A.H. · Bilsen, J.H.M. van · Cnubben, N.H.P. · Groot, J. de
Keywords: Nutrition · Anakinra · Biologics · Cytokines · IL-1 receptor antagonist · Immunotoxicity · Inflammation · Joint degradation markers · Pharmacokinetics · Rat adjuvant arthritis · Rheumatoid arthritis · Life Triskelion BV · MHR - Metabolic Health Research TAP - Toxicology and Applied Pharmacology QS - Quality & Safety PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

12 The accuracy of extended histopathology to detect immunotoxic chemicals
article 2004    
Author: Germolec, D.R. · Kashon, M. · Nyska, A. · Kuper, C.F. · Portier, C. · Kommineni, C. · Johnson, K.A. · Luster, M.I.
Keywords: Biology · Toxicology and Applied Pharmacology · B6C3F1 mice · Extended histopathology · Immunotoxicity · Safety Assessment · Screening tests · 2',3' dideoxyadenosine · 2,3,7,8 tetrachlorodibenzo para dioxin · 2,4 diaminotoluene · 4 nitrotoluene · aldicarb · chemical agent · didanosine · drug vehicle · gallium arsenide · immunosuppressive agent · oxymetholone · ribavirin · thalidomide · accuracy · analytical error · animal experiment · animal model · animal tissue · article · body weight · chemical analysis · controlled study · correlation analysis · disease severity · female · health program · histopathology · immune system · immunological procedures · immunotoxicity · incidence · intermethod comparison · leukocyte count · lymph node · lymphoid tissue · mouse · nonhuman · organ weight · pathologist · plaque forming cell · prediction · scoring system · sensitivity analysis · spleen · thymus · toxicity testing · toxicology · Animals · Body Weight · Dose-Response Relationship, Drug · Endpoint Determination · False Positive Reactions · Hemolytic Plaque Technique · Immune System · Immunity, Cellular · Lymph Nodes · Lymphocyte Count · Mice · Mice, Inbred Strains · Organ Size · Organ Specificity · Predictive Value of Tests · Reproducibility of Results · Spleen · Thymus Gland · Toxicity Tests · Vehicles
[Abstract]

13 Developmental immunotoxicity of ethanol in an extended one-generation reproductive toxicity study
article 2013    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Wolterbeek, A.P.M. · Penninks, A.H. · Waalkens-Berendsen, I.D.H. · Piersma, A.H. · Loveren, H. van
Keywords: Biology · Benchmark dose approach · Developmental immunotoxicity · Ethanol · Extended one-generation reproductive toxicity study · Alcohol · Concanavalin A · Drinking water · Keyhole limpet hemocyanin · Lipopolysaccharide · Nitric oxide · Tumor necrosis factor alpha · Adaptive immunity · Adult animal · Animal experiment · Animal model · blood cell · Cell adhesion · Cell proliferation · Cell stimulation · Cell subpopulation · Chemical parameters · Controlled study · Cytokine production · Developmental parameters · Developmental toxicity · Female · Immune response · Immunization · Immunological parameters · Immunomodulation · Immunotoxicity · Innate immunity · Lactation · Male · Mating · Medical parameters · Perinatal period · Priority journal · Rat · Reproductive toxicity · Spleen cell · Toxicity testing · Wistar rat · Rattus norvegicus · Biomedical Innovation · Healthy Living · Life Triskelion BV · QS - Quality & Safety TARA - Toxicology and Risk Assessment RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

14 Developmental immunotoxicity of methylmercury: The relative sensitivity of developmental and immune parameters
article 2010    
Author: Tonk, E.C.M. · Groot, D.M.G. de · Penninks, A.H. · Waalkens - Berendsen, I.D.H. · Wolterbeek, A.P.M. · Slob, W. · Piersma, A.H. · Loveren, H. van
Keywords: Toxicology · Biomedical Research · Benchmark dose · Developmental immunotoxicity · Developmental toxicity · Dose-response modeling · Methylmercury · Perinatal exposure · Rat · gamma interferon · interleukin 10 · interleukin 13 · interleukin 2 · interleukin 4 · interleukin 6 · keyhole limpet hemocyanin · methylmercury · T lymphocyte antibody · adherent cell · animal tissue · antibody response · article · basophil · body weight · CD3+ T lymphocyte · CD4 CD8 ratio · CD8+ T lymphocyte · clinical evaluation · controlled study · cytokine production · delayed hypersensitivity · developmental screening · diagnostic value · environmental exposure · epididymis · erythrocyte · female · gestational age · immunological parameters · immunotoxicity · kidney mass · leukocyte count · litter size · liver weight · lymphocyte proliferation · natural killer cell · newborn mortality · nonhuman · rat · reticulocyte count · sensitivity and specificity · spleen cell · spleen weight · stillbirth · testis weight · thrombocyte count · thymus · weight reduction
[Abstract]

15 Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age
article 2007    
Author: Kuper, C.F. · Zijverden, M. van · Klaassen, C. · Tegelenbosch-Schouten, M. · Wolterbeek, A.P.M.
Keywords: Biology · Toxicology and Applied Pharmacology · Adult exposure · Cyclophosphamide · Cyclosporin · Fetal exposure · Peyer's patches · Rat · cyclophosphamide · cyclosporin A · animal experiment · animal tissue · article · controlled study · drug effect · female · fetotoxicity · germinal center · gestation period · immunotoxicity · lactation · lymphocyte · male · microscopy · newborn period · nonhuman · Peyer patch · pregnancy · priority journal · rat · small intestine · Wistar rat · Administration, Oral · Aging · Animals · Cell Count · Cyclophosphamide · Cyclosporine · Female · Germinal Center · Immunosuppressive Agents · Injections, Intravenous · Male · Peyer's Patches · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Animalia · Rattus · Rattus norvegicus
[Abstract]

16 The SCID-hu mouse as a tool in immunotoxicological risk assessment: Effects of 2-acetyl-4(5)-tetrahydroxybutyl-imidazole (THI) and di-n-butyltin dichloride (DBTC) on the human thymus in SCID-hu mice
article 1995    
Author: Heer, C. de · Schuurman, H.J. · Houben, G.F. · Pieters, R.H.H. · Penninks, A.H. · Loveren, H. van
Keywords: Nutrition · Caramel colour III · Immunotoxicology · Organotins · Risk assessment · SCID-hu · Thymus · 2 acetyl 4 (1,2,3,4 tetrahydroxybutyl)imidazole · Dibutyltin dichloride · Food additive · Imidazole derivative · Animal experiment · Animal model · Animal tissue · Controlled study · Female · Histopathology · Immunotoxicity · Mouse · Nonhuman · Priority journal · Risk assessment · Thymus · Ammonia · Animal · Female · Food Coloring Agents · Human · Imidazoles · Immunosuppressive Agents · Mice · Mice, SCID · Organotin Compounds · Risk Assessment · Specific Pathogen-Free Organisms · Support, Non-U.S. Gov't · Teratogens · Thymus Gland · Animalia · Rodentia
[Abstract]

17 13-Week oral toxicity study with isomaltulose (Palatinose®) in rats
article 2002    
Author: Jonker, D. · Lina, B.A.R. · Kozianowski, G.
Keywords: Toxicology and Applied Pharmacology · Isomaltulose · Oral administration · Rat · Safety · Subchronic toxicity study · Palatinose · Animal experiment · Animal tissue · Behavior · Blood analysis · Body weight · Carbohydrate analysis · Chronic toxicity · Clinical chemistry · Controlled study · Diet · Female · Fluid intake · Food analysis · Food intake · Histopathology · Immunotoxicity · Ingestion · Male · Motor activity · Neurologic examination · Nonhuman · Cphthalmoscopy · Organ weight · Rat · Safety · Urinalysis · Animals · Blood Coagulation · Body Weight · Diet · Eating · Erythrocyte Count · Erythrocyte Indices · Female · Isomaltose · Leukocyte Count · Male · Organ Size · Rats · Rats, Wistar · Rattus norvegicus
[Abstract]

18 Extended histopathology in immunotoxicity testing: Interlaboratory validation studies
article 2004    
Author: Germolec, D.R. · Nyska, A. · Kashon, M. · Kuper, C.F. · Portier, C. · Kommineni, C. · Johnson, K.A. · Luster, M.I.
Keywords: Biology · Physiological Sciences · Histopathology · Immunology · Immunopathology · Lymph node · Pathology · Risk assessment · Spleen · Thymus · chemical agent · analysis of variance · animal cell · animal tissue · article · cellular distribution · concentration response · controlled study · disease severity · error · experience · factorial analysis · female · germinal center · health program · histopathology · immunopathology · immunotoxicity · intermethod comparison · laboratory test · lymph node · lymphatic system disease · lymphoid tissue · medical education · medical expert · mouse · nonhuman · observer variation · organogenesis · pathologist · quantitative analysis · reproducibility · screening test · sensitivity analysis · spleen cell · thymus · tissue injury · tissue structure · toxicity testing · validation process · Allergy and Immunology · Animals · Computational Biology · Data Interpretation, Statistical · Dose-Response Relationship, Drug · Histology · Immune System · Laboratories · Models, Statistical · Reproducibility of Results · Terminology · Toxicology
[Abstract]

19 The evaluation of the immunomodulating properties of ERA-63 a pharmaceutical with estrogenic activity
article 2008    
Author: Janssen, G.B. · Penninks, A.H. · Knippels, L.M.J. · Zijverden, M. van · Spanhaak, S.
Keywords: Chemistry · Ethinyl estradiol · Host resistance · Immunotoxicity · Listeria monocytogenes · PFC · Plaque-forming cell assay · T cell-dependent antibody response · bilirubin · era 63 · ethinylestradiol · gamma glutamyltransferase · immunomodulating agent · unclassified drug · animal experiment · antibody response · article · bilirubin blood level · body weight · controlled study · drug dose comparison · drug megadose · drug screening · estrogen activity · female · gamma glutamyl transferase blood level · immunomodulation · Listeria monocytogenes · low drug dose · male · nonhuman · priority journal · qualitative analysis · rat · testis weight · thymus · Animals · Antibody Formation · Body Weight · Estrogens · Ethinyl Estradiol · Female · Hemolytic Plaque Technique · Immunologic Factors · Listeria Infections · Male · Organ Size · Rats · Rats, Sprague-Dawley · Risk Assessment · T-Lymphocytes · Listeria monocytogenes · Rattus
[Abstract]

20 Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
article 2015    
Author: Bodin, J. · Kocbach Bølling, A. · Wendt, A. · Eliasson, L. · Becher, R. · Kuper, F. · Løvik, M. · Nygaard, U.C.
Keywords: Toxicology · Bisphenol A · Diabetes mellitus type 1 · Immunotoxicity · Insulitis · NOD mice · Phthalates · Prenatal exposure · 4,4' isopropylidenediphenol · Caspase 3 · CD68 antigen · Gamma interferon · Glucose · Insulin · Interleukin 10 · Interleukin 4 · Interleukin 6 · Nitric oxide · Phthalic acid · Testosterone · Transcription factor FOXP3 · Tumor necrosis factor alpha · Animal cell · Animal experiment · Animal model · Animal tissue · Blood glucose monitoring · Controlled study · Cytokine release · Environmental exposure · Flow cytometry · Histopathology · Immunocytochemistry · Immunohistochemistry · Incidence · Insulin dependent diabetes mellitus · Insulin release · Lymphocytic infiltration · Male · Mouse · Pancreas islet · Phagocytosis · Regulatory T lymphocyte · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 22 found. Next | Sort by date