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1 Development of a combined in Vitro Physiologically Based Kinetic (PBK) and Monte Carlo modelling approach to predict interindividual human variation in phenol-induced developmental toxicity
article 2017    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Nutrition · Alternatives for animal testing · In vitro-in vivo extrapolation (IVIVE) · Interindividual differences · Monte Carlo simulation · PBK or PBPK modelling · UGT · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

2 Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2014    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, Y.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro-in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Food and Nutrition · Healthy Living · Life Triskelion BV · RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven

3 Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2015    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro–in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Animalia · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · RAPID - Risk Analysis for Products in Development ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Interpreting in vitro developmental toxicity test battery results: The consideration of toxicokinetics
article 2015    
Author: Bosgra, S. · Westerhout, J.
Keywords: Toxicology · In vitro test battery · In vitro-in vivo extrapolation · Protein binding · TK modeling · Toxicokinetics · 2 ethylhexanoic acid · Ammonium derivative · Cyclosporin A · Diethylstilbestrol · Endosulfan · Gluphosinate ammonium · Hexanoic acid derivative · Methoxyacetic acid · Methylhexanoic acid · Methylmercuric chloride · Phthalic acid 2 ethylhexyl monoester · Retinoic acid · Unclassified drug · Valproic acid · Animal experiment · Clinical observation · Controlled study · Developmental toxicity · In vitro study · In vivo study · Mouse · Mouse defense test battery · Nonhuman · Predictive value · Protein binding · Quantitative analysis · Rat · Reproductive toxicity · Risk assessment · Simulation · Toxicokinetics · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 4 of 4 found. | Sort by date