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Showing 1 to 17 of 17 found. | Sort by date

1 A physiologically-based pharmacokinetic (PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism
article 2000    
Author: Hissink, A.M. · Wormhoudt, L.W. · Sherratt, P.J. · Hayes, J.D. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Ethylene dibromide · Extrapolation · Glutathione S-transferase · Interindividual variation · PBPK · Risk assessment · 1,2 dibromoethane · Cytochrome P450 · Glutathione transferase · Animal experiment · Biotransformation · Controlled study · Pharmacokinetics · Prediction · Toxicity testing · Xenobiotic metabolism · Administration, Oral · Area Under Curve · Chromatography, Gas · Cytochrome P-450 Enzyme System · Glutathione Transferase · Injections, Intravenous · Models, Biological
[Abstract]

2 Retrospective detection of sulfur mustard exposure by mass spectrometric analysis of adducts to albumin and hemoglobin: An in vivo study
article 2008    
Author: Noort, D. · Fidder, A. · Degenhardt-Langelaan, C.E.A.M. · Hulst, A.G.
Keywords: Albumin · Alkylation · Animal experiment · Article · Blood analysis · Cell membrane · Chemical reaction · Controlled study · Environmental exposure · Erythrocyte · In vivo study · Nonhuman · Alkylation · Animals · Affinity chromatography · Liquid chromatography · Environmental exposure · Environmental monitoring · Injections, Intravenous · Male · Pronase · Rats · Wistar · Mass spectrometry · Electrospray ionization · Tandem mass spectrometry · Rattus · Hemoglobin 9008-02-0 · Mustard gas 505-60-2 · Biological markers · Hemoglobins · Pronase, EC 3.4.24.- · Serum albumin
[Abstract]

3 A new method to measure iron absorption from the enrichment of 57Fe and 58Fe in young erythroid cells
article 1998    
Author: Heuvel, E.G.H.M. van den · Muys, T. · Pellegrom, H. · Bruyntjes, J.P. · Dokkum, W. van · Spanhaak, S. · Schaafsma, G.
Keywords: Nutrition · Iron · Adult · Cell membrane transport · Controlled study · Erythroid cell · Female · Human · Human cell · Iron absorption · Iron kinetics · Isotope labeling · Normal human · Radioisotope distribution · Absorption · Administration, Oral · Adult · Cell Separation · Centrifugation, Zonal · Erythrocyte Aging · Erythrocytes · Female · Ferritins · Humans · Injections, Intravenous · Iron · Iron Isotopes · Isotope Labeling · Mass Spectrometry · Reticulocytes
[Abstract]

4 Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age
article 2007    
Author: Kuper, C.F. · Zijverden, M. van · Klaassen, C. · Tegelenbosch-Schouten, M. · Wolterbeek, A.P.M.
Keywords: Biology · Toxicology and Applied Pharmacology · Adult exposure · Cyclophosphamide · Cyclosporin · Fetal exposure · Peyer's patches · Rat · cyclophosphamide · cyclosporin A · animal experiment · animal tissue · article · controlled study · drug effect · female · fetotoxicity · germinal center · gestation period · immunotoxicity · lactation · lymphocyte · male · microscopy · newborn period · nonhuman · Peyer patch · pregnancy · priority journal · rat · small intestine · Wistar rat · Administration, Oral · Aging · Animals · Cell Count · Cyclophosphamide · Cyclosporine · Female · Germinal Center · Immunosuppressive Agents · Injections, Intravenous · Male · Peyer's Patches · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Animalia · Rattus · Rattus norvegicus
[Abstract]

5 Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs
article 2000    
Author: Spruit, W.E.T. · Langenberg, J.P. · Trap, H.C. · Wiel, H.J. van der · Helmich, R.B. · Helden, H.P.M. van · Benschop, H.P.
Keywords: Acetylcholinesterase inhibition · Guinea pig · Intravenous bolus · Nose-only exposure · Respiratory parameters · Stereoisomers · Toxicokinetics · Animal experiment · Animal model · Binding site · Chemical warfare · Controlled study · Drug absorption · Drug elimination · Enzyme inhibition · Gas chromatography · Guinea pig · Nonhuman · Nose mucosa · Stereoisomerism · Toxicokinetics · Acetylcholinesterase · Administration, Inhalation · Animals · Area Under Curve · Atropine · Chemical Warfare Agents · Guinea Pigs · Injections, Intravenous · Male · Stereoisomerism · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Sarin, 107-44-8
[Abstract]

6 Transgalactooligosaccharides stimulate calcium absorption in postmenopausal women
article 2000    
Author: Heuvel, E.G.H.M. van den · Schoterman, M.H.C. · Muijs, T.
Keywords: Nutrition · Calcium absorption · Postmenopausal women · Stable isotopes · Transgalactooligosaccharides · Calcium · Oligosaccharide · Stable isotope · Bone metabolism · Calcium absorption · Calcium excretion · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Dietary intake · Double blind procedure · Female · Human · Human experiment · Isotope labeling · Normal human · Osteolysis · Postmenopause · Randomized controlled trial · Urinalysis · Administration, Oral · Aged · Calcium · Cross-Over Studies · Double-Blind Method · Female · Humans · Injections, Intravenous · Intestinal Absorption · Middle Aged · Oligosaccharides · Osteoporosis, Postmenopausal · Postmenopause · Radioactive Tracers · Spectrophotometry · Yogurt · Toscana virus
[Abstract]

7 Oligofructose stimulates calcium absorption in adolescents
article 1999    
Author: Heuvel, E.G.H.M. van den · Muys, T. · Dokkum, W. van · Schaafsma, G.
Keywords: Nutrition · Double stable- isotope technique · Male adolescents · Nondigestible oligosaccharides · Oligofructose · True calcium absorption · Calcium · Fructose · Oligosaccharide · Stable isotope · Adolescent · Calcium absorption · Calcium metabolism · Clinical research · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Dietary intake · Double blind procedure · Drug absorption · Human · Human experiment · Intravenous drug administration · Male · Normal human · Oral drug administration · Randomized controlled trial · Urinalysis · Urinary excretion · Administration, Oral · Adolescent · Analysis of Variance · Calcium · Cross-Over Studies · Double-Blind Method · Fructose · Humans · Injections, Intravenous · Intestinal Absorption · Male · Sucrose
[Abstract]

8 Thrombolytic properties in a rabbit jugular vein thrombosis model of a tissue-type plasminogen activator mutant lacking the growth factor- and kringle 1-domains
article 1992    
Author: Emeis, J.J. · Verheijen, J.H.
Keywords: Biology · Alpha 2 antiplasmin · Alteplase · Fk 2p · Gowth factor · Plasminogen · Unclassified drug · Animal experiment · Animal model · Blood clot lysis · Conference paper · Dose response · Dose time effect relation · Drug efficacy · Fibrinogen blood level · Intravenous drug administration · Mutant · Nonhuman · Protein domain · Spectrophotometry · Vein thrombosis · Animal · Comparative Study · Fibrinolysis · Infusions, Intravenous · Injections, Intravenous · Jugular Veins · Metabolic Clearance Rate · Rabbits · Recombinant Proteins · Thrombosis · Tissue Plasminogen Activator · Animalia · Oryctolagus cuniculus
[Abstract]

9 Epigallocatechin gallate (EGCG) (TEAVIGO™) does not impair nonhaem-iron absorption in man
article 2005    
Author: Ullmann, U. · Haller, J. · Bakker, G.C.M. · Brink, E.J. · Weber, P.
Keywords: Biology · Biomedical Research · Double blind · Epigallocatechin gallate (EGCG) · Green tea catechins · Iron absorption · Placebo-controlled 3-periods cross over study in man · Randomized · Epigallocatechin gallate · Ferrous ion · Iron · Placebo · Teavigo · Adult · Analysis of variance · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Dose response · Double blind procedure · Female · Human · Iron absorption · Iron storage · Malabsorption · Normal human · Priority journal · Randomized controlled trial · Statistical significance · Tea · Administration, Oral · Adolescent · Adult · Antioxidants · Camellia sinensis · Catechin · Cross-Over Studies · Dose-Response Relationship, Drug · Double-Blind Method · Drug Interactions · Female · Humans · Injections, Intravenous · Intestinal Absorption · Iron · Iron Isotopes · Middle Aged · Phytotherapy · Camellia sinensis
[Abstract]

10 Disposition of 14C-α-cyclodextrin in germ-free and conventional rats
article 2004    
Author: Ommen, B. van · Bie, A.T.H.J. de · Bär, A.
Keywords: Biology · Physiological Sciences · alpha cyclodextrin · carbon 14 · alpha cyclodextrin derivative · alpha-cyclodextrin · carbon · cyclodextrin · animal experiment · animal tissue · article · blood analysis · carcass · controlled study · dietary fiber · female · fermentation · gastrointestinal tract · germfree animal · high performance liquid chromatography · intestine flora · isotope labeling · kidney tubule excretion · lung alveolus carbon dioxide tension · male · metabolic regulation · nonhuman · priority journal · radioisotope distribution · rat · rat strain · small intestine absorption · species comparison · stomach content · animal · blood · drug detoxification · intravenous drug administration · oral drug administration · tissue distribution · urine · Wistar rat · Mammalia · Microbiota · Rattus norvegicus · Administration, Oral · alpha-Cyclodextrins · Animals · Carbon Radioisotopes · Cyclodextrins · Female · Germ-Free Life · Injections, Intravenous · Male · Metabolic Detoxication, Drug · Rats · Rats, Wistar · Tissue Distribution
[Abstract]

11 Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: Involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes
article 1995    
Author: Claassen, I.J.T.M. · Osterhaus, A.D.M.E. · Claassen, E.
Keywords: Biology · Fluorescence · Immune-stimulating complex · Macrophages · Marginal zone · carbocyanine · iscom · virus antigen · animal experiment · animal tissue · antigen detection · antigen presenting cell · article · b lymphocyte · dendritic cell · female · fluorescence microscopy · immunization · immunogenicity · liver · lymph node · macrophage · mouse · nonhuman · ovary follicle cell · priority journal · rabies virus · spleen · Animal · Antibodies, Monoclonal · Antigen Presentation · Antigens, Viral · B-Lymphocytes · Carbocyanines · Dendritic Cells · Female · Fluorescent Dyes · Immunization · Injections, Intramuscular · Injections, Intraperitoneal · Injections, Intravenous · ISCOMs · Liver · Lymphocyte Activation · Macrophages · Metals · Mice · Mice, Inbred BALB C · Microscopy, Fluorescence · Pharmacokinetics · Rabies virus · Spleen
[Abstract]

12 Thalidomide inhibits UVB-induced mouse keratinocyte apoptosis by both TNF-α-dependent and TNF-α-independent pathways
article 2003    
Author: Lu, K.Q. · Brenneman, S. · Burns Jr., R. · Vink, A. · Gaines, E. · Haake, A. · Gaspari, A.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · α-N-phthalimido-glutarimide · Mouse model · Photoprotection · Sunburn cell · Ultraviolet light · antiinflammatory agent · apoptosis inhibitor · cell DNA · cyclobutane derivative · cytokine · dimer · drug vehicle · messenger RNA · pyrimidine derivative · recombinant tumor necrosis factor alpha · thalidomide · tumor necrosis factor alpha · animal cell · animal experiment · animal model · animal tissue · antiinflammatory activity · apoptosis · article · biosynthesis · bolus injection · cell assay · cell death · controlled study · cytokine production · DNA damage · dose response · drug blood level · drug mechanism · drug megadose · female · histopathology · hypothesis · immunostimulation · in vitro study · keratinocyte · low drug dose · monocyte · mouse · newborn · nick end labeling · nonhuman · photosensitivity disorder · priority journal · radiation dose · radiation exposure · radiation injury · ribonuclease protection assay · skin · skin biopsy · skin lupus erythematosus · steady state · sunburn · ultraviolet B radiation · Animals · Anti-Inflammatory Agents, Non-Steroidal · Apoptosis · Disease Models, Animal · Dose-Response Relationship, Drug · Erythema · Female · Injections, Intravenous · Keratinocytes · Mice · Mice, Inbred BALB C · RNA, Messenger · Thalidomide · Tumor Necrosis Factor-alpha · Ultraviolet Rays
[Abstract]

13 Tolerization of an established αb-crystallin-reactive T-cell response by intravenous antigen
article 2007    
Author: Verbeek, R. · Mark, K. van der · Wawrousek, E.F. · Plomp, A.C. · Noort, J.M. van
Keywords: Biology · Biomedical Research · αB-crystallin · Autoimmunity · Multiple sclerosis · T cells · Tolerance · alpha crystallin · alphab crystallin · antibody · autoantigen · Freund adjuvant · ovalbumin · epitope · gamma interferon · immunoglobulin G · recombinant protein · animal cell · animal experiment · antibody blood level · antibody response · antigen specificity · article · cellular immunity · controlled study · delayed hypersensitivity · dose response · drug dose comparison · drug efficacy · immune response · immunization · immunological tolerance · immunoregulation · mouse · multiple sclerosis · nonhuman · priority journal · protein deficiency · T lymphocyte activation · animal · biosynthesis · cell culture · dendritic cell · immunology · intravenous drug administration · lymphocyte activation · T lymphocyte subpopulation · time · alpha-Crystallin B Chain · Animals · Autoantigens · Cells, Cultured · Dendritic Cells · Dose-Response Relationship, Immunologic · Epitopes · Hypersensitivity, Delayed · Immune Tolerance · Immunoglobulin G · Injections, Intravenous · Interferon Type II · Lymphocyte Activation · Mice · Multiple Sclerosis · Recombinant Proteins · T-Lymphocyte Subsets · Time Factors
[Abstract]

14 Toxicokinetics of the nerve agent (±)-VX in anesthetized and atropinized hairless guinea pigs and marmosets after intravenous and percutaneous administration
article 2003    
Author: Schans, M.J. van der · Lander, B.J. · Wiel, H. van der · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Chiral HPLC · Hairless guinea pigs · Intravenous · Marmosets · Percutaneous · Persistence · Stereospecificity · Toxicokinetics · Treatment · Carbamic acid · Oxime · Volatile agent · Anesthesia · Animal experiment · Animal model · Bioavailability · Blood level · Dose response · Enantiomer · Guinea pig · Intoxication · Marmoset · Nonhuman · Primate · Toxicokinetics · Administration, Topical · Anesthesia · Animals · Atropine · Callithrix · Chemical Warfare Agents · Chromatography, Gas · Chromatography, High Pressure Liquid · Electrochemistry · Injections, Intravenous · Kinetics · Lethal Dose 50 · Male · Muscarinic Antagonists · Organothiophosphorus Compounds · Stereoisomerism · Animalia · Cavia · Cavia porcellus · Primates · Sus scrofa · Acetylcholinesterase, 9000-81-1 · Carbamic acid, 463-77-4 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Sarin, 107-44-8 · Soman, 96-64-0 · Acetylcholinesterase, EC 3.1.1.7 · Atropine, 51-55-8 · Chemical warfare agents · Muscarinic antagonists · Organothiophosphorus compounds · VX, 50782-69-9
[Abstract]

15 Retrospective detection of exposure to nerve agents: Analysis of phosphofluoridates originating from fluoride-induced rectivation of phospylated BuChE
article 2004    
Author: Schans, M.J. van der · Polhuijs, M. · Dijk, C. van · Degenhardt, C.E.A.M. · Pleijsier, K. · Langenberg, J.P. · Benschop, H.P.
Keywords: Biology · Biomarker · Biomonitoring · Butyryl cholinesterase · Fluoride ions · Lexposure · Nerve agents · Organophosphates · Reactivation · Retrospective detection · Cholinesterase · Cholinesterase inhibitor · Cyclosarin · Fluoride · Nerve gas · Organophosphate · Paraoxon · Parathion · Phosphorus derivative · Sarin · Soman · Tabun · Unclassified drug · Biological monitoring · Biological warfare · Chemical structure · Concentration (parameters) · Environmental exposure · Enzyme activation · Enzyme active site · Enzyme inhibition · Gas chromatography · Half life time · Human · Nonhuman · pH · Priority journal · Retrospective study · Rhesus monkey · Animals · Butyrylcholinesterase · Chemical Warfare Agents · Cholinesterase Inhibitors · Cholinesterase Reactivators · Gas chromatography · Female · Fluorides · Half-Life · Humans · Injections, Intravenous · Macaca mulatta · Male · Organophosphorus compounds · Paraoxon · Reference standards · Time factors · Macaca mulatta · Cholinesterase, 9001-08-5 · Cyclosarin, 329-99-7 · Fluoride, 16984-48-8 · Paraoxon, 311-45-5 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8 · Soman, 96-64-0 · Tabun, 77-81-6 · Butyrylcholinesterase, EC 3.1.1.- · Chemical warfare agents · Cholinesterase inhibitors · Cholinesterase reactivators · Fluorides · Organophosphorus compounds
[Abstract]

16 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

17 Disposition of [14C]γ-cyclodextrin in germ-free and conventional rats
article 1998    
Author: Bie, A.T.H.J. de · Ommen, B. van · Bär, A.
Keywords: Nutrition · Carbon 14 · Carbon dioxide · Drug metabolite · Gamma cyclodextrin · Carbon · Cyclodextrin · Gamma cyclodextrin derivative · Gamma-cyclodextrin · Animal experiment · Animal tissue · Carcass · Controlled study · Dose response · Drug bile level · Drug blood level · Drug disposition · Drug feces level · Drug identification · Drug metabolism · Drug saliva level · Drug tissue level · Drug urine level · Female · Gastrointestinal tract · Germfree animal · High performance liquid chromatography · Intravenous drug administration · Isotope labeling · Male · Nonhuman · Oral drug administration · Priority journal · Rat · Animal · Animal food · Bile · Breath analysis · Chemistry · Comparative study · Digestive system · Feces · Intestine absorption · Metabolism · Wistar rat · Administration, Oral · Animal Feed · Animals · Breath Tests · Carbon Dioxide · Carbon Radioisotopes · Cyclodextrins · Digestive System · Feces · Female · gamma-Cyclodextrins · Germ-Free Life · Injections, Intravenous · Intestinal Absorption · Male · Rats · Rats, Wistar
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date