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1 A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches
article 2010    
Author: Scott, L. · Eskes, C. · Hoffmann, S. · Adriaens, E. · Alepée, N. · Bufo, M. · Clothier, R. · Facchini, D. · Faller, C. · Guest, R. · Harbell, J. · Hartung, T. · Kamp, H. · Varlet, B.L. · Meloni, M. · McNamee, P. · Osborne, R. · Pape, W. · Pfannenbecker, U. · Prinsen, M. · Seaman, C. · Spielmann, H. · Stokes, W. · Trouba, K. · Berghe, C.V.d. · Goethem, F.V. · Vassallo, M. · Vinardell, P. · Zuang, V.
Keywords: Biology · Alternatives · In vitro tests · Ocular irritation
[Abstract]

2 Alternative methods for skin irritation testing: the current status : ECVAM skin irritation task force report 1
article 1998    
Author: Botham, P.A. · Earl, L.K. · Fentem, J.H. · Roguet, R. · Sandt, J.J.M.
Keywords: Health · Corrosion · Human · In vitro · Irritation · Keratinocytes · Skin
[Abstract]

3 Setting an indoor air exposure limit for formaldehyde: Factors of concern
article 2008    
Author: Arts, J.H.E. · Muijser, H. · Kuper, C.F. · Woutersen, R.A.
Keywords: Health · Toxicology and Applied Pharmacology · Exposure limit · Formaldehyde · Indoor air · Sensory irritation · Air quality standard · Ambient air · Environmental exposure · Eye irritation · Nose irritation · Throat irritation · Administration, Inhalation · Air Pollutants · Carcinogens · Child · European Union · Eye · Formaldehyde · Humans · Inhalation Exposure · Irritants · No-Observed-Adverse-Effect Level · Nose · Occupational Exposure · Pharynx · Trigeminal Nerve
[Abstract]

4 Relative absorption and dermal loading of chemical substances : Consequences for risk assessment (Extended Abstract)
article 2007    
Author: Buist, H.E. · Schaafsma, G. · Sandt, J.J.M. van de
Keywords: Biology · Dermal absorption · Dermal loading · Risk assessment · Skin irritation · In vitro · In vivo · Food and Nutrition · Healthy Living

5 Eye irritation testing: The way forward : the report and recommendations of ECVAM workshop 34
article 1999    
Author: Balls, M. · Berg, N. · Bruner, L.H. · Curren, R.D. · Silva, O. de · Earl, L.K. · Esdaile, D.J. · Fentem, J.H. · Liebsch, M. · Ohno, Y. · Prinsen, M.K. · Spielmann, H. · Worth, A.P.
Keywords: Nutrition · Animal welfare · Conference paper · Drug research · Eye irritation · Good laboratory practice · Nonhuman · Practice guideline · Priority journal · Animalia

6 Inhaled formaldehyde: Evaluation of sensory irritation in relation to carcinogenicity
article 2006    
Author: Arts, J.H.E. · Rennen, M.A.J. · Heer, C.de
Keywords: Health · Toxicology and Applied Pharmacology · Benchmark dose · Carcinogenicity · Formaldehyde · Sensory irritation · formaldehyde · article · carcinogenicity · computer program · eye irritation · human · nonhuman · nose injury · nose irritation · odor · priority journal · rating scale · respiratory tract disease · sense organ · smelling · symptomatology · Administration, Inhalation · Air Pollutants · Animals · Carcinogens · Carcinoma · Eye · Formaldehyde · Humans · Inhalation Exposure · Irritants · Nasal Mucosa · No-Observed-Adverse-Effect Level · Nose Neoplasms · Occupational Exposure · Pharynx · Risk Assessment · Animalia
[Abstract]

7 Implementation challenges for designing Integrated In Vitro Testing Strategies (ITS) aiming at reducing and replacing animal experimentation
article 2012    
Author: Wever, B.de · Fuchs, H.W. · Gaca, M. · Krul, C.A.M. · Mikulowski, S. · Poth, A. · Roggen, E.L. · Vilà, M.R.
Keywords: Eye irritation · ITS · ITS design · IVTIP · Replacement · Reproductive toxicity · Testing strategies · Validation · Healthy for Life · Healthy Living · Healthy Living Life · RAPID - Risk Analysis for Products in Development · Themalijn
[Abstract]

8 Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats
article 2010    
Author: Arts, J.H.E. · Jacobs, E.J. · Kuper, C.F.
Keywords: Biology · Toxicology and Applied Pharmacology · Brown Norway rats · Respiratory allergy · Respiratory irritation · Sulfur dioxide · Trimellitic anhydride · Organisation · MSG - Modelling Simulation & Gaming · BSS - Behavioural and Societal Sciences
[Abstract]

9 The use of human keratinocytes and human skin models for predicting skin irritation: The report and recommendations of ECVAM Workshop 38
article 1999    
Author: Sandt, J. van de · Roguet, R. · Cohen, C. · Esdaile, D. · Ponec, M. · Corsini, E. · Barker, C. · Fusenig, N. · Liebsch, M. · Benford, D. · Brugerolle de · Franissinette, A. de · Fartasch, M.
Keywords: Nutrition · Irritant agent · Erythema · Experimental model · Human · Human cell · Keratinocyte · Priority journal · Skin edema · Skin function · Skin irritation · Skin sensitivity · Stratum corneum

10 An analysis of human response to the irritancy of acetone vapors
article 2002    
Author: Arts, J.H.E. · Mojet, J. · Gemert, L.J. van · Emmen, H.H. · Lammers, J.H.C.M. · Marquart, J. · Woutersen, R.A. · Feron, V.J.
Keywords: Chemistry Health · (neuro)behavior · Acetone · Adaptation · Chemosensory aspects · Habituation · Irritancy · Irritation · acetone · irritant agent · adaptation · adult · analytic method · animal experiment · chemosensitivity · controlled study · eye irritation · habituation · human · human experiment · male · mouse · nonhuman · normal human · occupational exposure · odor · questionnaire · review · vapor · Acetone · Adolescent · Adult · Aged · Animals · Female · Humans · Irritants · Male · Middle Aged · Occupational Exposure · Odors · Sensory Thresholds · Smell · Animalia
[PDF] [Abstract]

11 The isolated chicken eye test as a suitable in vitro method for determining the eye irritation potential of household cleaning products
article 2009    
Author: Schutte, K. · Prinsen, M.K. · McNamee, P.M. · Roggeband, R.
Keywords: Toxicology · Alternative testing method · CEET · Chicken enucleated eye test · Eye irritation · Household cleaning products · ICE · In vitro test methods · Isolated chicken eye test · Low volume eye test · LVET · citric acid · detergent · domestic chemical · fluorescein · animal tissue · article · chicken · classification · controlled study · cornea · cornea edema · cornea opacity · corrosion · eye irritation · female · in vitro study · industry · isolated organ · male · marketing · nonhuman · packaging · priority journal · safety
[Abstract]

12 Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration
article 2006    
Author: Jacobs, J.J.L. · Lehé, C.L. · Hasegawa, H. · Elliott, G.R. · Das, P.K.
Keywords: Contact allergy · Langerhans cell · Maturation · Migration · Skin irritation · CD83 antigen · Chemokine receptor CCR7 · Contact allergen · Irritant agent · T6 antigen · Article · Cell count · Cell maturation · Cell migration · Contact allergy · Contact sensitization · Controlled study · Dendritic cell · Explant · Human · Human tissue · Hypersensitivity reaction · Immunohistochemistry · Immunopathology · Langerhans cell · Lymph node · Quantitative analysis · Skin allergy · Skin culture · Skin irritation · Allergens · Cell Differentiation · Cell Movement · Dermatitis, Contact · Dermatitis, Occupational · Female · Humans · Irritants · Langerhans Cells · Lymph Nodes · Skin · Skin Irritancy Tests · Tissue Culture Techniques
[Abstract]

13 Safety evaluation of β-glucanase derived from Trichoderma reesei: Summary of toxicological data
article 1995    
Author: Coenen, T.M.M. · Schoenmakers, A.C.M. · Verhagen, H.
Keywords: Toxicology · barlican · beta glucan hydrolase · unclassified drug · animal experiment · article · chicken · chronic toxicity · controlled study · eye irritation · female · guinea pig · male · mutagenicity · nonhuman · rabbit · rat · skin irritation · skin sensitization · Administration, Oral · Animal · Animal Feed · beta-Glucosidase · Biological Products · Chickens · CHO Cells · Dermatitis, Contact · Environmental Exposure · Female · Food Additives · Guinea Pigs · Hamsters · Lethal Dose 50 · Male · Mutagenicity Tests · No-Observed-Adverse-Effect Level · Rabbits · Rats · Rats, Wistar · Salmonella typhimurium · Toxicity Tests · Trichoderma · Animalia · Cavia porcellus · Gallus gallus · Hypocrea jecorina · Oryctolagus cuniculus · Sus scrofa · Trichoderma
[Abstract]

14 Relative absorption and dermal loading of chemical substances: Consequences for risk assessment
article 2009    
Author: Buist, H.E. · Schaafsma, G. · Sandt, J.J.M. van de
Keywords: Chemistry · Food and Chemical Risk Analysis · Dermal absorption · Dermal loading · In vitro · In vivo · Risk assessment · Skin irritation · 1 methyl 2 pyrrolidinone · 2 ethoxyethanol · aminolevulinic acid · aminolevulinic acid hexyl ester · aminolevulinic acid methyl ester · atrazine · azinphos methyl · benzo[a]pyrene · benzoic acid · catechol · chemical compound · disulfoton · flurbiprofen · hexachlorobenzene · hydrocortisone · ibuprofen · iprodione · malathion · mevinphos · naloxone · parathion · pentachlorophenol · pesticide · phosmet · pyrene · testosterone · triclosan · trimethylamine · volatile agent · zinc chloride · article · health hazard · human · in vitro study · in vivo study · molecular weight · nonhuman · priority journal · risk assessment · skin absorption · skin irritation
[Abstract]

15 Approaches to induce and elicit respiratory allergy: Impact of route and intensity of exposure
article 2003    
Author: Arts, J.H.E. · Kuper, C.F.
Keywords: Toxicology Health · Toxicology and Applied Pharmacology · Airway irritation · Respiratory allergy · Route and intensity of exposure · allergen · irritant agent · allergic reaction · biosafety · conference paper · environmental factor · exposure · heredity · human · inhalation test · nonhuman · prediction · priority journal · respiratory tract allergy · risk assessment · risk management · sensitization · standardization · Administration, Cutaneous · Administration, Inhalation · Allergens · Animals · Dose-Response Relationship, Drug · Predictive Value of Tests · Respiratory System · Animalia
[Abstract]

16 A Toolkit for Dermal Risk Assessment: Toxicological Approach for Hazard Characterization
article 2003    
Author: Schuhmacher-Wolz, U. · Kalberlah, F. · Oppl, R. · Hemmen, J.J. van
Keywords: Chemistry Health · Food and Chemical Risk Analysis · Dermal · Exposure · Hazard assessment · Occupational · Hazardous materials · Health risks · Risk assessment · Skin · Toxicity · Intrinsic toxicity (IT) scores · Occupational risks · Controlled study · Drowsiness · Hazard assessment · Health hazard · Liver injury · Occupational exposure · Occupational health · Skin defect · Skin irritation · Skin penetration · Hazardous Substances · Humans · Models, Theoretical · Occupational Exposure · Skin Absorption
[Abstract]

17 Sensory irritation to mixtures of formaldehyde, acrolein, and acetaldehyde in rats
article 1996    
Author: Cassee, F.R. · Arts, J.H.E. · Groten, J.P. · Feron, V.J.
Keywords: Acetaldehyde · Acrolein · Formaldehyde · Rat · Sensory irritation · acetaldehyde · acrolein · formaldehyde · animal experiment · animal model · article · breathing rate · chemical interaction · controlled study · inhalation · lung toxicity · male · model · nonhuman · priority journal · rat · Acetaldehyde · Acrolein · Animals · Drug Combinations · Formaldehyde · Irritants · Male · Rats · Rats, Wistar · Respiration
[Abstract]

18 Toxicokinetics and metabolism
article 2005    
Author: Coecke, S. · Blaauboer, B.J. · Elaut, G. · Freeman, S. · Freidig, A. · Gensmantel, N. · Hoet, P. · Kapoulas, V.M. · Ladstetter, B. · Langley, G. · Leahy, D. · Mannens, G. · Meneguz, A. · Monshouwer, M. · Nemery, B. · Pelkonen, O. · Pfaller, W. · Prieto, P. · Proctor, N. · Rogiers, V. · Rostami-Hodjegan, A. · Sabbioni, E. · Steiling, W. · Sandt, J.J.M. van de
Keywords: Toxicology · Food and Chemical Risk Analysis · cosmetic · acute toxicity · artificial membrane · bioavailability · biotransformation · carcinogenicity · cell line · cell strain CACO 2 · computer model · concentration response · electric resistance · eye irritation · genotoxicity · human · metabolism · nonhuman · phototoxicity · plasma protein binding · practice guideline · priority journal · reproductive toxicity · review · skin absorption · skin sensitization · species difference · toxicokinetics · validation process · Animals · Biotransformation · Consumer Product Safety · Cosmetics · Drug Administration Routes · European Union · Humans

19 Implementation and evaluation of the fluorescent tracer technique in greenhouse exposure studies
article 1998    
Author: Bierman, E.P.B. · Brouwer, D.H. · Hemmen, J.J. van
Keywords: Nutrition · Air quality · Greenhouses · Health hazards · Industrial hygiene · Pesticides · Risk assessment · Dermal exposure · Fluorescent tracer technique · Occupational risks · Fluorescent dye · Propoxur · Tinopal · Tracer · Unclassified drug · Agricultural worker · Fluorescence · Greenhouse effect · Human · Image analysis · Occupational hazard · Priority journal · Protective clothing · Risk assessment · Skin irritation · Agriculture · Fluorescence · Humans · Image Processing, Computer-Assisted · Occupational Exposure · Skin
[Abstract]

20 Human volunteer study with PGME: Eye irritation during vapour exposure
article 2003    
Author: Emmen, H.H. · Muijser, H. · Arts, J.H.E. · Prinsen, M.K.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Human volunteer study · Propylene glycol monomethyl ether · Subjective symptoms · Propanediol derivative · Propylene glycol methyl ether · Unclassified drug · Clinical article · Clinical feature · Clinical trial · Conference paper · Conjunctiva · Controlled clinical trial · Controlled study · Cornea · Double blind procedure · Exposure · Eye irritation · Eyelid reflex · Follow up · Intestine muscle · Muscle cramp · Myalgia · Odor · Perception · Priority journal · Shivering · Skin · Throat · Toxicity testing · Vapor · Adult · Double-Blind Method · Eye · Eye Diseases · Humans · Irritants · Male · Propylene Glycols · Volatilization
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 28 found. Next | Sort by date