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1 Involvement of human glutathione S-transferase isoenzymes in the conjugation of cyclophosphamide metabolites with glutathione
article 1994    
Author: Dirven, H.A.A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Biology · Biotransformation · Cyclophosphamide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Phosphoramide Mustards · Support, Non-U.S. Gov't
[Abstract]

2 In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plasminogen activator with rat liver cells
article 1992    
Author: Kuiper, J. · Rijken, D.C. · Munk, G.A. · Berkel, T.J. van
Keywords: Biology · Biological Transport · Cells, Cultured · Embryo, Mammalian · Humans · Iodine Radioisotopes · Isoenzymes/blood · Isoenzymes/metabolism · Isoenzymes/pharmacokinetics · Kidney/enzymology · Kinetics · Liver/metabolism · Male · Metabolic Clearance Rate · Molecular Weight · Radioisotope Dilution Technique · Rats · Rats, Inbred Strains · Tissue Distribution · Urokinase-Type Plasminogen Activator/blood · Urokinase-Type Plasminogen Activator/metabolism · Urokinase-Type Plasminogen Activator/pharmacokinetics · Iodine Radioisotopes · Isoenzymes · Urokinase-Type Plasminogen Activator
[PDF] [Abstract]

3 Inter-individual variability in the oxidation of 1,2-dibromoethane: Use of heterologously expressed human cytochrome P450 and human liver microsomes
article 1996    
Author: Wormhoudt, L.W. · Ploemen, J.H.T.M. · Waziers, I. de · Commandeur, J.N.M. · Beaune, P.H. · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Acetaldehyde · Carcinogens · Cytochrome P-450 Enzyme System · Ethylene Dibromide · Humans · Hydroxylation · Isoenzymes · Kinetics · Microsomes, Liver · Oxidation-Reduction · Structure-Activity Relationship
[Abstract]

4 Effects of consumption of Brussels sprouts on intestinal and lymphocytic glutathione S-transferases in humans
article 1995    
Author: Nijhoff, W.A. · Grubben, M.J.A.L. · Nagengast, F.M. · Jansen, J.B.M.J. · Verhagen, H. · Poppel, G. van · Peters, W.H.M.
Keywords: Biology · Adult · Brassica · Cross-Over Studies · Duodenum · Energy Intake · Enzyme Induction · Female · Glucosinolates · Glutathione · Glutathione Transferase · Human · Intestines · Isoenzymes · Lymphocytes · Male · Metabolic Detoxication, Drug · Rectum · Thiocyanates
[Abstract]

5 Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane
article 1995    
Author: Ploemen, J.H.T.M. · Wormhoudt, L.W. · Ommen, B. van · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: Biology · Class theta · Chromatography, High Pressure Liquid · Cytosol · Dinitrochlorobenzene · Epoxy Compounds · Erythrocytes · Ethylene Dibromide · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Nitrophenols · Polymorphism (Genetics) · Support, Non-U.S. Gov't · Animalia
[Abstract]

6 Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes
article 1996    
Author: Aar, E.M. van der · Buikema, D. · Commandeur, J.N.M. · Koppele, J.M. te · Ommen, B. van · Bladeren, P.J. van · Vermeulen, N.P.E.
Keywords: Nutrition · glutathione transferase · isoenzyme · nitrobenzene derivative · animal tissue · article · controlled study · enzyme kinetics · enzyme specificity · glutathione metabolism · nonhuman · rat · Animals · Chromatography, Affinity · Dinitrochlorobenzene · Glutathione Transferase · Isoenzymes · Kidney · Kinetics · Liver · Rats · Spectrophotometry, Ultraviolet · Substrate Specificity · Animalia · Felis catus
[Abstract]

7 Inhibition of rat, mouse, and human glutathione S-transferase by eugenol and its oxidation products
article 1996    
Author: Rompelberg, C.J.M. · Ploemen, J.H.T.M. · Jespersen, S. · Greef, J. van der · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · Allyl Compounds · Animals · Cytoplasm · Eugenol · Glutathione Transferase · Humans · Isoenzymes · Kidney · Liver · Male · Mice · Molecular Structure · Monophenol Monooxygenase · Phenols · Placenta · Rats · Rats, Wistar · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Animalia
[Abstract]

8 Lipoxygenase-2 oxygenates storage lipids in embryos of germinating barley
article 1997    
Author: Holtman, W.L. · Vredenbregt-Heistek, J.C. · Schmitt, N.F. · Feussner, I.
Keywords: Barley · Lipoxygenase isoenzyme · Oxygenation · Storage lipid · Isoenzyme · Lipoxygenase · Enzyme activity · Enzyme specificity · Germination · High performance liquid chromatography · Lipid oxidation · Phytochemistry · Priority journal · Chromatography, High Pressure Liquid · Germination · Hordeum · Isoenzymes · Kinetics · Lipid Metabolism · Lipids · Lipoxygenase · Substrate Specificity · Hordeum vulgare subsp. vulgare
[Abstract]

9 Kinetic characteristics of acidic and alkaline ceramidase in human epidermis
article 2007    
Author: Houben, E. · Uchida, Y. · Nieuwenhuizen, W.F. · Paepe, K. de · Vanhaecke, T. · Holleran, W.M. · Rogiers, V.
Keywords: Nutrition · Food technology · Ceramidase · Epidermis · Kinetic parameters · acylsphingosine deacylase · enzyme inhibitor · ethanolamine derivative · isoenzyme · adult · article · enzyme activity · enzyme analysis · enzyme assay · enzyme inhibition · enzyme kinetics · enzyme substrate · enzymology · epidermis · female · human · human tissue · isoenzyme analysis · isotope labeling · normal human · nucleotide sequence · priority journal · zymography · Adult · Amidohydrolases · Enzyme Repression · Epidermis · Female · Humans · Hydrogen-Ion Concentration · Isoenzymes · Kinetics · Middle Aged · Skin Absorption
[Abstract]

10 Effects of consumption of Brussels sprouts on plasma and urinary glutathione S-transferase class-α and -π in humans
article 1995    
Author: Nijhoff, W.A. · Mulder, T.P.J. · Verhagen, H. · Poppel, G. van · Peters, W.H.M.
Keywords: glucosinolate · glutathione transferase · adult · article · Brassica · controlled study · diet · enzyme blood level · enzyme linked immunosorbent assay · female · human · male · priority journal · sex difference · urine level · vegetable · Adult · Biological Markers · Brassica · Cross-Over Studies · Diet · Enzyme Induction · Female · Glucosinolates · Glutathione Transferase · Human · Isoenzymes · Male · Sex Factors · Vegetables
[Abstract]

11 Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases
article 1995    
Author: Dirven, H.A.A.M. · Megens, L. · Oudshoorn, M.J. · Dingemanse, M.A. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione transferase · Ifosfamide · Cancer chemotherapy · Drug conjugation · Drug detoxification · Drug resistance · Enzyme activity · Human · Human tissue · Leukemia · Lymphoma · Solid tumor · Antineoplastic Agents, Alkylating · Biotransformation · Chromatography, High Pressure Liquid · Drug Resistance, Neoplasm · Glutathione · Glutathione Transferase · Human · Ifosfamide · Isoenzymes · Magnetic Resonance Spectroscopy · Metabolic Detoxication, Drug · Spectrometry, Mass, Fast Atom Bombardment · Support, Non-U.S. Gov't
[Abstract]

12 The role of human glutathione S-transferase isoenzymes in the formation of glutathione conjugates of the alkylating cytostatic drug thiotepa
article 1995    
Author: Dirven, H.A.A.M. · Dictus, E.L.J.T. · Broeders, N.L.H.L. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione reductase · Tepa · Thiotepa · Conformational transition · Drug conformation · Drug conjugation · Drug protein binding · Drug resistance · Enzyme activity · Priority journal · Chromatography, High Pressure Liquid · Female · Glutathione · Glutathione Transferase · Human · Isoenzymes · Kinetics · Liver · Magnetic Resonance Spectroscopy · Placenta · Pregnancy · Support, Non-U.S. Gov't · Thiotepa
[Abstract]

13 GSTP1-1 stereospecifically catalyzes glutathione conjugation of ethacrynic acid
article 1998    
Author: Iersel, M.L.P.S. van · Lipzig, M.M.H. van · Rietjens, I.M.C.M. · Vervoort, J. · Bladeren, P.J. van
Keywords: EA, ethacrynic acid · Ethacrynic acid · Glutathione S-transferase · Stereoselectivity · Etacrynic acid · Glutathione · Glutathione transferase · Multidrug resistance protein · Chemical reaction · Conjugate · Controlled study · Diastereoisomer · Drug conjugation · Enzyme mechanism · Glutathione metabolism · Human cell · Melanoma cell · Nuclear magnetic resonance spectroscopy · Stereochemistry · Amino Acid Substitution · Ethacrynic Acid · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Point Mutation · Stereoisomerism · Substrate Specificity · Tumor Cells, Cultured
[PDF] [Abstract]

14 14-3-3 proteins interact with a 13-lipoxygenase, but not with a 9-lipoxygenase
article 2000    
Author: Holtman, W.L. · Roberts, M.R. · Oppedijk, B.J. · Testerink, C. · Zeijl, M.J. van · Wang, M.
Keywords: Interaction · 13 lipoxygenase · 9 lipoxygenase · lipoxygenase · unclassified drug · barley · enzyme purification · enzyme substrate complex · germination · immunoprecipitation · nucleotide sequence · protein family · protein phosphorylation · surface plasmon resonance · Western blotting · 14-3-3 Proteins · Antibodies, Monoclonal · Chemistry, Physical · Escherichia coli · Hordeum · Immunosorbent Techniques · Isoenzymes · Lipoxygenase · Proteins · Recombinant Proteins · Surface Plasmon Resonance · Tyrosine 3-Monooxygenase · Hordeum vulgare subsp. vulgare
[PDF] [Abstract]

15 Two novel, putatively cell wall-associated and glycosylphosphatidylinositol-anchored α-glucanotransferase enzymes of Aspergillus niger
article 2007    
Author: Kaaij, R.M. van der · Yuan, X.L. · Franken, A. · Ram, A.F.J. · Punt, P.J. · Maarel, M.J.E.C. van der · Dijkhuizen, L.
Keywords: Biology · Food technology · 4 alpha glucanotransferase · 4 alpha-glucanotransferase · fungal protein · glycogen debranching enzyme · glycosylphosphatidylinositol · hybrid protein · isoenzyme · maltooligosaccharides · oligosaccharide · unclassified drug · amino acid sequence · article · Aspergillus niger · cell wall · chemistry · classification · cytology · enzymology · genetics · metabolism · molecular genetics · nucleotide sequence · phylogeny · sequence alignment · sequence homology · Amino Acid Sequence · Aspergillus niger · Base Sequence · Cell Wall · Fungal Proteins · Glycogen Debranching Enzyme System · Glycosylphosphatidylinositols · Isoenzymes · Molecular Sequence Data · Oligosaccharides · Phylogeny · Recombinant Fusion Proteins · Sequence Alignment · Sequence Homology, Amino Acid · Aspergillus niger
[Abstract]

16 In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate
article 1996    
Author: Ploemen, J.-P.H.T.M. · Iersel, M.L.P.S. van · Wormhoudt, L.W. · Commandeur, J.N.M. · Vermeulen, N.P.E. · Bladeren, P.J. van
Keywords: diethyldithiocarbamate · disulfiram · gl utathion e · glutathione S-transferases · in vitro · inhibition · 1 chloro 2,4 dinitrobenzene · 1,2 epoxy 3 (4 nitrophenoxy)propane · aldehyde dehydrogenase inhibitor · diethyldithiocarbamic acid · disulfiram · dithiothreitol · glutathione transferase · isoenzyme · thiol · unclassified drug · article · controlled study · drug metabolism · enzyme inactivation · enzyme inhibition · enzyme purification · enzyme substrate · human · nonhuman · priority journal · rat · reduction · Animals · Disulfiram · Dithiothreitol · Ditiocarb · Glutathione · Glutathione Transferase · Humans · Isoenzymes · Rats · Spectrophotometry, Ultraviolet · Time Factors
[Abstract]

17 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

18 Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
article 1999    
Author: Iersel, M.L.P.S. van · Cnubben, N.H.P. · Smink, N. · Koeman, J.H. · Bladeren, P.J. van
Keywords: Nutrition · Cells · Glutathione S-transferases · Inhibition · Metabolism · Prostaglandin A2 · 1 chloro 2,4 dinitrobenzene · Glutathione · Glutathione transferase · Prostaglandin a2 · Glutathione transferase P1 · GSTP1 protein, human · Isoenzyme · Prostaglandin A · Prostaglandin A2 · Biotransformation · Cell function · Cell metabolism · Cell proliferation · Controlled study · Cytotoxicity · Enzyme activity · Enzyme modification · Human · Human cell · Melanoma cell · Priority journal · Cell culture · Drug antagonism · Melanoma · Metabolism · Biotransformation · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Prostaglandins A · Tumor Cells, Cultured
[Abstract]

19 Molecular characterization of two lipoxygenases from barley
article 1999    
Author: Mechelen, J.R. van · Schuurink, R.C. · Smits, M. · Graner, A. · Douma, A.C. · Sedee, N.J.A. · Schmitt, N.F. · Valk, B.E.
Keywords: Barley · Chromosomal mapping · Grain dormancy · Hordeum distichum · Jasmonate (jasmonic acid) · Lipoxygenase (LOX) · Chromosomal localization · Complementary DNA · Dormancy · Gene locus · Germination · Lipoxygenase · Messenger RNA · Restriction fragment length polymorphism · Sequence homology · Southern blotting · Amino Acid Sequence · Antibodies, Monoclonal · Base Sequence · Chromosomes · Cloning, Molecular · Gene Dosage · Gene Expression · Genes, Plant · Germination · Hordeum · Isoenzymes · Lipoxygenase · Molecular Sequence Data · Physical Chromosome Mapping · Polymorphism, Restriction Fragment Length · Recombinant Proteins · RNA, Messenger · Sequence Analysis · Sequence Homology, Amino Acid · Embryophyta · Hordeum · Hordeum vulgare subsp. vulgare · Loxa
[Abstract]

20 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 26 found. Next | Sort by date