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1 On the antifungal mode of action of metalaxyl, an inhibitor of nucleic acid synthesis in Pythium splendens
article 1981    
Author: Kerkenaar, A.
Keywords: Biology · Metalaxyl · Mithramycin · Radioisotope · Animal experiment · Bisbenzimide h 3 · Cytotoxicity · Dna synthesis · Drug absorption · Drug mechanism · Fungus · Heredity · Histology · Lipogenesis · Metalaxyl c 14 · Nucleic acid synthesis · Oomycetes · Protein synthesis · Rna synthesis
[Abstract]

2 A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences
article 2010    
Author: Caesar, R. · Manieri, M. · Kelder, T. · Boekschoten, M. · Evelo, C. · Müller, M. · Kooistra, T. · Cinti, S. · Kleemann, R. · Drevon, C.A.
Keywords: Biology · Biomedical Research · Acetyl coenzyme A · Adenosine triphosphate citrate lyase · Androgen receptor · Carbohydrate responsive element binding protein · Fatty acid synthase · Linoleic acid · Linolenic acid · Monounsaturated fatty acid · Omega 3 fatty acid · Omega 6 fatty acid · Transcription factor · Unclassified drug · Abdominal fat · Adipocyte · Animal cell · Animal tissue · Controlled study · Down regulation · Epididymis fat · Fat intake · Fatty acid desaturation · Fatty acid synthesis · Gene expression regulation · Lipid diet · Lipid metabolism · Lipid storage · Lipidomics · Lipogenesis · Male · Microarray analysis · Mouse · Nonhuman · Spermatogenesis · Subcutaneous fat · Transcriptomics
[PDF] [Abstract]

3 Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet
article 2011    
Author: Diepen, J.A. van · Vroegrijk, I.O.C.M. · Berbée, J.F.P. · Shoelson, S.E. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N. · Voshol, P.J.
Keywords: Biology · Inflammation · Lipid metabolism · Very low-density lipoprotein · acetylsalicylic acid · apolipoprotein C1 · immunoglobulin enhancer binding protein · transcription factor RelA · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · controlled study · drug mechanism · drug targeting · enzyme inhibition · gene expression · hypertriglyceridemia · in vivo study · lipid diet · lipogenesis · lipoprotein blood level · male · metabolic syndrome X · mouse · nonhuman · priority journal · protein expression · risk factor · triacylglycerol blood level · aspirin · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: Involvement of retinoic acid and retinoid X receptors
article 1997    
Author: Kaptein, A. · Neele, D.M. · Twisk, J. · Hendriks, H.F.J. · Kooistra, T. · Princen, H.M.G.
Keywords: Apolipoprotein A-I · Cynomolgus hepatocytes · MRNA · RAP · Receptor-selective ligands · Retinoids · RXR · Transcriptional regulation · apolipoprotein a1 · retinoic acid · retinoid x receptor · animal cell · article · lipogenesis · lipoprotein metabolism · liver cell · liver metabolism · monkey · nonhuman · transcription regulation · Animals · Apolipoprotein A-I · Benzoates · Blotting, Northern · Cells, Cultured · Female · Gene Expression Regulation · Liver · Macaca fascicularis · Male · Receptors, Retinoic Acid · Retinoid X Receptors · Retinoids · RNA, Messenger · Tetrahydronaphthalenes · Time Factors · Trans-Activation (Genetics) · Transcription Factors · Tretinoin
[PDF] [Abstract]

5 Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice
article 2005    
Author: Heijboer, A.C. · Donga, E. · Voshol, P.J. · Dang, Z.C. · Havekes, L.M. · Romijn, J.A. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Glucose metabolism · Insulin action · Isotopes · Steatosis · Transcription factors · Glucose · Messenger RNA · Animal experiment · Animal tissue · Controlled study · Diet restriction · Fatty acid oxidation · Gene expression · Gluconeogenesis · Glucose transport · Glycogenolysis · Insulin sensitivity · Lipogenesis · Mouse · Mouse strain · Nonhuman · Skeletal muscle · Wild type · Biosynthesis · C57BL mouse · Drug effect · Genetics · Glucose blood level · Metabolism · Physiology · Time · Animals · Blood Glucose · Body Weight · Fasting · Insulin · Insulin Resistance · Liver · Male · Mice · Mice, Inbred C57BL · Muscle, Skeletal · RNA, Messenger · Time Factors · Triglycerides
[PDF] [Abstract]

6 Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes
article 2015    
Author: Liang, W. · Verschuren, L. · Mulder, P. · Hoorn, J.W.A. van der · Verheij, J. · Dam, A.D. van · Boon, M.R. · Princen, H.M.G. · Havekes, L.M. · Kleemann, R. · Hoek, A.M. van den
Keywords: Biology · Alanine aminotransferase · Aspartate aminotransferase · Glucose · High density lipoprotein cholesterol · Insulin · Interleukin 6 · Low density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Salsalate · Triacylglycerol · Alanine aminotransferase blood level · Animal cell · Animal experiment · Animal model · Animal tissue · Aspartate aminotransferase blood level · Body weight · Controlled study · Down regulation · Drug efficacy · Drug response · Dyslipidemia · Energy metabolism · Fatty acid oxidation · Fatty liver · Gene expression · Glucose blood level · Glycemic control · Hepatitis · Insulin blood level · Insulin resistance · Lipid metabolism · Lipogenesis · Male · Mouse · Nonalcoholic fatty liver · Nonhuman · Treatment duration · Treatment outcome · Triacylglycerol blood level · Upregulation · Weight gain · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor γ function (P465L PPARγ) in mice
article 2006    
Author: Gray, S.L. · Dalla Nora, E. · Grosse, J. · Manieri, M. · Stoeger, T. · Medina-Gomez, G. · Burling, K. · Wattler, S. · Russ, A. · Yeo, G.S.H. · Chatterjee, V.K. · O'Rahilly, S. · Voshol, P.J. · Cinti, S. · Vidal-Puig, A.
Keywords: Biology · Peroxisome proliferator activated receptor gamma · Adipose tissue · Animal cell · Animal experiment · Animal model · Animal tissue · Carbohydrate metabolism · Controlled study · Energy balance · Female · Gene expression · gene mutation · Homozygosity · Hyperphagia · Insulin resistance · Insulin sensitivity · Lipid metabolism · Lipid storage · Lipogenesis · Male · Metabolic disorder · Nonhuman · Obesity · Point mutation · Protein deficiency · Protein function · Tissue distribution · Tissue expansion · Blood · Genetics · Glucose blood level · Homozygote · Lethal gene · Metabolism · Mouse mutant · Pathology · Physiology · Adipose Tissue · Animals · Blood Glucose · Gene Expression Profiling · Genes, Lethal · Homozygote · Insulin · Insulin Resistance · Leptin · Lipid Metabolism · Mice · Mice, Obese · PPAR gamma
[Abstract]

8 Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1
article 2001    
Author: Koopmans, S.J. · Jong, M.C. · Que, I. · Dahlmans, V.E.H. · Pijl, H. · Radder, J.K. · Frölich, M. · Havekes, L.M.
Keywords: Biology · APOC1 · Hypertension · Insulin resistance · Insulin resistance syndrome · Lipoprotein · NEFA · Fatty acid · Palmitic acid · Triacylglycerol · Tritium · Very low density lipoprotein · Adipose tissue · Animal model · Animal tissue · Blood pressure · Cholesterol blood level · Clearance · Controlled study · Fatty acid metabolism · Gene overexpression · Glucose blood level · Glucose clamp technique · Glucose metabolism · Glycogen synthesis · Glycolysis · Heart rate · Hyperinsulinemia · Hyperlipidemia · Hypertension · In vivo study · Infusion · Insulin resistance · Lipid transport · Lipogenesis · Mean arterial pressure · Mouse · Nonhuman · Skeletal muscle · Transgenic mouse · Animals · Apolipoprotein C-I · Apolipoproteins C · Blood Glucose · Blood Pressure · Cholesterol · Fatty Acids, Nonesterified · Gene Expression · Glucose · Glucose Clamp Technique · Glycogen · Humans · Hyperlipidemias · Insulin · Lipid Metabolism · Liver · Mice · Mice, Transgenic · Muscle, Skeletal · Palmitic Acid · Triglycerides · Tritium
[Abstract]

9 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice
article 2006    
Author: Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M. · Nieuwenhuizen, W.F.
Keywords: Health Biology · Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acids · Sphingolipids · Steatosis · Triacylglycerol · alanine aminotransferase · amyloid · apolipoprotein E3 · cholesterol · cholesterol ester · fatty acid · messenger RNA · phytosphingosine · RNA · sphingolipid · triacylglycerol · apolipoprotein E · apolipoprotein E3 (Leidein) · very low density lipoprotein · animal experiment · animal model · animal tissue · article · cholesterol blood level · cholesterol metabolism · controlled study · diet supplementation · dose response · drug effect · drug structure · fatty liver · female · gene expression · hepatitis · lipogenesis · lipolysis · mouse · nonhuman · nutritional assessment · plasma clearance · prophylaxis · animal · blood · chemistry · cholesterol intake · enzymology · feces · genetics · intestine absorption · lipid metabolism · liver · metabolism · physiology · randomization · transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Cholesterol, Dietary · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Fatty Liver · Feces · Female · Gene Expression · Intestinal Absorption · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Random Allocation · RNA · Sphingolipids · Triglycerides
[Abstract]

10 Characterization of anti-inflammatory compounds using transcriptions, proteomics, and metabolics in combination with multivariate data analysis
article 2004    
Author: Verhoeckx, K.C.M. · Bijlsma, S. · Jespersen, S. · Ramaker, R. · Verheij, E.R. · Witkamp, R.F. · Greef, J. van der · Rodenburg, R.J.T.
Keywords: Pharmacology Health · 2-D gel electrophoresis · Anti-inflammatory drugs · Metabolomics · Micro-array · Multivariate data analysis · Principal component discriminant analysis · 4 (4 fluorophenyl) 2 (4 methylsulfinylphenyl) 5 (4 pyridyl)imidazole · Antiinflammatory agent · Beta 2 adrenergic receptor stimulating agent · Clenbuterol · Dexamethasone · Formoterol · Lipopolysaccharide · Salbutamol · Unclassified drug · Zilpaterol · Antiinflammatory activity · controlled study · Data analysis · DNA microarray · Drug determination · Gel electrophoresis · Genetic transcription · Human · Human cell · Lipogenesis · Liquid chromatography · Mass spectrometry · Metabolism · Methodology · Molecule · Monocyte · Multivariate analysis · Priority journal · Protein expression · Proteomics · Adrenergic beta-Agonists · Anti-Inflammatory Agents · Cell Line, Tumor · Electrophoresis, Gel, Two-Dimensional · Gas Chromatography-Mass Spectrometry · Humans · Lipids · Lipopolysaccharides · Macrophage Activation · Macrophages · Multivariate Analysis · Oligonucleotide Array Sequence Analysis · Proteome · Receptors, Adrenergic, beta-2 · RNA, Messenger
[Abstract]

11 Cholesterol 7α-Hydroxylase Deficiency in Mice on an APOE*3-Leiden Background Impairs Very-Low-Density Lipoprotein Production
article 2004    
Author: Post, S.M. · Groenendijk, M. · Solaas, K. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Bile acid biosynthesis · Cholesterol 7α-hydroxylase · SREBP-1 · Bile acid · Cholesterol · Cholesterol 7alpha monooxygenase · Cholesterol ester · Cytochrome P450 isoenzyme · Messenger RNA · Sterol · Sterol regulatory element binding protein 1 · Unclassified drug · Very low density lipoprotein · Vitamin · Acyltransferase · Alpha tocopherol · Apolipoprotein E3 (Leidein) · Dgat1 protein, mouse · Diacylglycerol acyltransferase · Retinol · Animal experiment · Animal model · Animal tissue · Antioxidant activity · Bile acid synthesis · Catalysis · Cholesterol blood level · Cholesterol metabolism · Controlled study · Enzyme deficiency · Feces level · Gene · Gene expression · Hyperlipidemia · Knockout mouse · Lipid diet · Lipid metabolism · Lipogenesis · Lipoprotein synthesis · Nonhuman · Srebf1 gene · Triacylglycerol blood level · Atherogenic diet · Biosynthesis · Blood · Cross breeding · Feces · Genetics · Metabolism · Mouse mutant · Physiology · Acyltransferases · Animals · Apolipoprotein E3 · Apolipoproteins B · Apolipoproteins E · Bile Acids and Salts · Cholesterol 7-alpha-Hydroxylase · Cholesterol Esters · Crosses, Genetic · Diacylglycerol O-Acyltransferase · Diet, Atherogenic · Feces · Female · Hyperlipoproteinemia Type III · Ketone Bodies · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Knockout · RNA, Messenger · Sterols · Triglycerides · Vitamin A · Vitamin E
[Abstract]

12 Fenofibrate increases very low density lipoprotein triglyceride production despite reducing plasma triglyceride levels in APOE*3-Leiden.CETP mice
article 2010    
Author: Bijland, S. · Pieterman, E.J. · Maas, A.C.E. · Hoorn, J.W.A. van der · Erk, M.J. van · Klinken, J.B. van · Havekes, L.M. · Dijk, K.W. van · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Apolipoprotein B (apoB) · Emulsion particles · Fenofibrate · Hepatic genes · Kinetic study · Lipoprotein lipase · Lipoprotein metabolism · Male mouse · Mouse models · Palmitic acid · Peroxisome proliferator-activated receptor · Plasma cholesterol · Plasma triglycerides · Production rates · Skeletal muscle · Very low density lipoproteins · White adipose tissues · Acids · Cytology · Emulsification · Fatty acids · Gene expression · Glycerol · Liver · Mammals · Nutrition · Plasmas · Acetyl coenzyme A acetyltransferase · Acyl coenzyme A desaturase 1 · Acyl coenzyme A oxidase · Apolipoprotein A4 · Apolipoprotein B · Apolipoprotein B messenger RNA editing enzyme catalytic polypeptide 1 · Apolipoprotein C1 · Apolipoprotein C2 · Apolipoprotein C3 · Apolipoprotein E3 · Blood clotting factor 5 Leiden · Carnitine palmitoyltransferase I · Cholesterol · Cholesterol ester transfer protein · Diacylglycerol acyltransferase 1 · Diacylglycerol acyltransferase 2 · Fas antigen · Fatty acid · Fatty acid binding protein 2 · Fenofibrate · Lipoprotein lipase · Palmitic acid · Sterol regulatory element binding protein 1a · Sterol regulatory element binding protein 1c · Triacylglycerol · Triolein · Tritium · Animal experiment · Controlled study · Emulsion · Enzyme activity · Esterification · Food intake · Gene expression profiling · Lipid transport · Lipogenesis · Lipoprotein synthesis · Liver parenchyma · Nnhuman · Skeletal muscle · Treatment duration · Treatment outcome · Animals · Apolipoproteins B · Lipid Metabolism · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Transgenic · Procetofen · Triglycerides · Biomedical Innovation · Healthy Living
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date