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1 Plasma clearance of urokinase-type plasminogen activator
article 1998    
Author: Kaaden, M.E. van der · Rijken, D.C. · Berkel, T.J.C. van · Kuiper, J.
Keywords: Health · urokinase receptor · blood clot lysis · drug receptor binding · endothelium cell · extracellular matrix · glycosylation · internalization · liver metabolism · nonhuman · plasma clearance · plasminogen activation · priority journal · protein isolation · review

2 Suppression of the acute inflammatory response of porcine alveolar- and liver macrophages
article 2000    
Author: Izeboud, C.A. · Monshouwer, M. · Witkamp, R.F. · Miert, A.S.J. van
Keywords: Biology · Inflammation · LPS · Macrophages · Porcine · TNF-α · animal cell · animal disease · article · immune response · liver metabolism · lung alveolus macrophage · macrophage activation · nonhuman · Animals · Cell Culture Techniques · Cytokines · Inflammation · Lipopolysaccharides · Liver · Macrophage Activation · Macrophages, Alveolar · Nitric Oxide · Reactive Oxygen Species · Receptors, Adrenergic, beta · Swine · Animalia · Mammalia · Suidae
[Abstract]

3 In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, T. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Biological marker · Boldenone · Clostebol · Estrane derivative · Ethylestrenol · Norethandrolone · Steroid · Animal tissue · Cattle · Conference paper · Controlled study · Drug abuse · Drug determination · Drug metabolism · Drug monitoring · Female · Liver · Liver cell culture · Liver metabolism · Liver microsome · Male · Model · Nonhuman · Steroid metabolism · Anabolic Agents · Animals · Biological Markers · Cattle · Cells, Cultured · Drug Residues · Estradiol · Ethylestrenol · Liver · Microsomes, Liver · Models, Biological · Norethandrolone · Predictive Value of Tests · Testosterone
[PDF] [Abstract]

4 Conjugation of isoprene monoepoxides with glutathione, catalyzed by α, μ, π and θ-class glutathione S-transferases of rat and man
article 1999    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Salmon, F.G.C. · Bladeren, P.J. van
Keywords: Nutrition · Glutathione S-transferase · Isoprene · Metabolism · Polymorphism · Cytochrome p450 · Epoxide · Epoxide hydrolase · Glutathione · Glutathione transferase · Isoprene · Conjugate · Conjugation · Controlled study · High performance liquid chromatography · Human · Liver · Liver metabolism · Mouse · Rat · Xenobiotic metabolism · Animals · Chromatography, High Pressure Liquid · Epoxy Compounds · Glutathione · Glutathione Transferase · Humans · Liver · Mice · Rats · Rats, Wistar · Species Specificity · Subcellular Fractions
[Abstract]

5 Inhibition of zaleplon metabolism by cimetidine in the human liver : in vitro studies with subcellular fractions and precision-cut liver slices
article 2002    
Author: Renwick, A.B. · Ball, S.E. · Tredger, J.M. · Price, R.J. · Walters, D.G. · Kao, J. · Scatina, J.A. · Lake, B.G.
Keywords: Nutrition · Aldehyde oxidase · Cimetidine · Cytochrome P450 3A · Reduced nicotinamide adenine dinucleotide phosphate · Zaleplon · Cell fractionation · Drug inhibition · Drug metabolism · Human · Human cell · Human tissue · In vitro study · Liver metabolism · Liver microsome · Liver slice · Acetamides · Cimetidine · Cytosol · Dose-Response Relationship, Drug · Drug Interactions · Enzyme Inhibitors · Humans · Hypnotics and Sedatives · Inhibitory Concentration 50 · Kinetics · Liver · Models, Chemical · Pyrimidines · Subcellular Fractions · Staphylococcus phage 3A
[Abstract]

6 Both lipolysis and hepatic uptake of VLDL are impaired in transgenic mice coexpressing human apolipoprotein E*3Leiden and human apolipoprotein C1
article 1996    
Author: Jong, M.C. · Dahlmans, V.E.H. · Gorp, P.J.J. van · Breuer, M.L. · Mol, M.J.T.M. · Zee, A. van der · Frants, R.R. · Hofker, M.H. · Havekes, L.M.
Keywords: Health · Transgenic mice · Triacylglycerol · Very low density lipoprotein · Animal experiment · Animal model · Atherosclerosis · Cholesterol blood level · Controlled study · Female · Lipolysis · Liver clearance · Liver metabolism · Male · Nonhuman · Protein transport · Transgenic mouse · Triacylglycerol blood level · Animals · Apolipoprotein C-I · Apolipoprotein E3 · Apolipoproteins C · Apolipoproteins E · Arteriosclerosis · Cholesterol · Cholesterol, Dietary · Gene Expression · Humans · Hyperlipoproteinemias · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Triglycerides
[Abstract]

7 In vivo and in vitro interaction of high and low molecular weight single-chain urokinase-type plasminogen activator with rat liver cells
article 1992    
Author: Kuiper, J. · Rijken, D.C. · Munk, G.A. · Berkel, T.J. van
Keywords: Biology · Biological Transport · Cells, Cultured · Embryo, Mammalian · Humans · Iodine Radioisotopes · Isoenzymes/blood · Isoenzymes/metabolism · Isoenzymes/pharmacokinetics · Kidney/enzymology · Kinetics · Liver/metabolism · Male · Metabolic Clearance Rate · Molecular Weight · Radioisotope Dilution Technique · Rats · Rats, Inbred Strains · Tissue Distribution · Urokinase-Type Plasminogen Activator/blood · Urokinase-Type Plasminogen Activator/metabolism · Urokinase-Type Plasminogen Activator/pharmacokinetics · Iodine Radioisotopes · Isoenzymes · Urokinase-Type Plasminogen Activator
[PDF] [Abstract]

8 Genetic and reproductive toxicity of butadiene and isoprene
article 2001    
Author: Anderson, D.
Keywords: Nutrition · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium · Cytogenetic effects · Isoprene · Somatic and germ cells · 1,2 epoxy 3 butene · 1,3 butadiene · butadiene diepoxide · cytochrome P450 · hypoxanthine phosphoribosyltransferase · alkalinity · biological monitoring · carcinogenesis · CHO cell · chromosome aberration · comparative study · concentration response · conference paper · cytogenetics · Drosophila melanogaster · exposure · gene translocation · genotoxicity · lethal mutant · liver metabolism · mutagenicity · nonhuman · reproductive toxicity · Salmonella typhimurium · sister chromatid exchange · spermatozoon motility · tissue distribution · Animals · Butadienes · Female · Hemiterpenes · Humans · Male · Mice · Mutagenicity Tests · Mutagens · Occupational Exposure · Ovary · Pentanes · Pregnancy · Rats · Reproduction · Testis · Animalia · Drosophila melanogaster · Melanogaster · Salmonella typhimurium · Typhimurium
[Abstract]

9 Mechanism of the slow induction of apolipoprotein A-I synthesis by retinoids in cynomolgus hepatocytes: Involvement of retinoic acid and retinoid X receptors
article 1997    
Author: Kaptein, A. · Neele, D.M. · Twisk, J. · Hendriks, H.F.J. · Kooistra, T. · Princen, H.M.G.
Keywords: Apolipoprotein A-I · Cynomolgus hepatocytes · MRNA · RAP · Receptor-selective ligands · Retinoids · RXR · Transcriptional regulation · apolipoprotein a1 · retinoic acid · retinoid x receptor · animal cell · article · lipogenesis · lipoprotein metabolism · liver cell · liver metabolism · monkey · nonhuman · transcription regulation · Animals · Apolipoprotein A-I · Benzoates · Blotting, Northern · Cells, Cultured · Female · Gene Expression Regulation · Liver · Macaca fascicularis · Male · Receptors, Retinoic Acid · Retinoid X Receptors · Retinoids · RNA, Messenger · Tetrahydronaphthalenes · Time Factors · Trans-Activation (Genetics) · Transcription Factors · Tretinoin
[PDF] [Abstract]

10 Hepatic low-density lipoprotein receptor-related protein deficiency in mice increases atherosclerosis independent of plasma cholesterol
article 2004    
Author: Espirito Santo, S.M.S. · Pires, N.M.M. · Boesten, L.S.M. · Gerritsen, G. · Bovenschen, N. · Dijk, K.W. van · Jukema, J.W. · Princen, H.M.G. · Bensadoun, A. · Li, W.P. · Herz, J. · Havekes, L.M. · Vlijmen, B.J.M. van
Keywords: Blood clotting factor 8 · Cholesterol · Ligand · Lipoprotein lipase · Liver protein · Low density lipoprotein receptor · Low density lipoprotein receptor related protein · Tissue plasminogen activator · Triacylglycerol · Von Willebrand factor · Animal experiment · Animal model · Animal tissue · Atherogenesis · Cholesterol blood level · Controlled study · Hyperlipoproteinemia type 3 · Liver function · Liver metabolism · Mouse · Nonhuman · Protein deficiency · Triacylglycerol blood level · Animals · Aorta · Apolipoproteins E · Arteriosclerosis · Blood Coagulation Factors · Cholesterol · LDL-Receptor Related Protein 1 · Lipids · Liver · Male · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL
[Abstract]

11 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

12 Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Mager, W.H. · Moorman, A.F.M. · Boer, P.A.J. de · Scheja, L. · Princen, H.M.G. · Gebhardt, R.
Keywords: Health · 3 hydroxy 3 methylglutaryl coenzyme a · alanine aminotransferase · cholesterol 7alpha monooxygenase · colestipol · glutamate ammonia ligase · glyceraldehyde 3 phosphate dehydrogenase · messenger rna · pyruvate kinase · sterol 27 hydroxylase · unclassified drug · animal cell · animal experiment · bile acid synthesis · controlled study · enterohepatic circulation · enzyme isolation · enzyme localization · gene expression · in situ hybridization · liver metabolism · sterol analysis · Animal · Biological Markers · Blotting, Northern · Cell Separation · Cholesterol 7-alpha-Hydroxylase · Colestipol · Cytochrome P-450 Enzyme System · Gene Expression Regulation, Enzymologic · In Situ Hybridization · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Tissue Distribution · Transcription, Genetic
[Abstract]

13 Ghrelin differentially affects hepatic and peripheral insulin sensitivity in mice
article 2006    
Author: Heijboer, A.C. · Hoek, A.M. van den · Parlevliet, E.T. · Havekes, L.M. · Romijn, J.A. · Pijl, H. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Animal models · GHRP-6 · Glucose metabolism · Gut hormone · Hyperinsulinaemic- euglycaemic clamp technique · Insulin resistance · Tracer methodology · Deoxyglucose · Desoctanoylghrelin · Ghrelin · Growth hormone secretagogue receptor · Growth hormone secretagogue receptor stimulating agent · Histidyl dextro tryptophylalanyltryptophyl dextro phenylalanyllysinamide · Peptide derivative · Unclassified drug · Adipose tissue · Adolescent · Body weight · Controlled study · Food intake · Glucogenesis · Glucose clamp technique · Glucose metabolism · Hormone action · Hyperinsulinemia · Insulin sensitivity · Isotope dilution assay · Liver metabolism · Mouse · Muscle metabolism · Nonhuman · Animals · Body Weight · Glucose · Hepatocytes · Insulin · Male · Mice · Mice, Inbred C57BL · Peptide Hormones
[Abstract]

14 Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Wortelboer, H. · Herwijnen, M. van · Gottschalk, R. · Jong, C.H.C. de · Boorsma, A. · Paules, R.S. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Toxicology · Biotechnology · Acetaminophen · Gene expression profiling · Hepatocyte-based in vitro models · Interspecies extrapolation · Liver injury · T-profiler · oxidoreductase · paracetamol · adult · aged · animal cell · animal experiment · animal model · animal tissue · article · biological activity · cell function · chemical analysis · controlled study · energy consumption · enzyme activity · female · gene expression profiling · gene repression · human · human cell · human tissue · human versus animal comparison · in vitro study · in vivo study · liver cell · liver metabolism · liver mitochondrion · liver toxicity · male · nonhuman · rat · species comparison · toxicogenetics · Acetaminophen · Adult · Aged · Analgesics, Non-Narcotic · Animals · Cell Survival · Cells, Cultured · Female · Hepatitis, Toxic · Hepatocytes · Humans · In Situ Hybridization · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Rats, Wistar · RNA · Species Specificity · Toxicogenetics · Rattus · Rodentia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 14 of 14 found. | Sort by date