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1 Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes
article 2004    
Author: Price, R.J. · Scott, M.P. · Walters, D.G. · Stierum, R.H. · Groten, J.P. · Meredith, C. · Lake, B.G.
Keywords: Nutrition · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · BHT · Butylated hydroxytoluene · CDNB · CH · Cumene hydroperoxide · CYP · Cytochrome P450 · DCNB · Enzyme induction · GSH S-transferase · Rat liver · Thiabendazole · Xenobiotic metabolism · apoprotein · butylcresol · cytochrome P450 1A · cytochrome P450 1A1 · cytochrome P450 1A2 · cytochrome P450 2B · cytochrome P450 2B1 · cytochrome P450 2B2 · glutathione transferase · messenger RNA · tiabendazole · animal cell · animal experiment · article · controlled study · dose response · drug megadose · enzyme activation · enzyme activity · enzyme induction · enzyme metabolism · enzyme substrate · liver microsome metabolism · liver mitochondrion · liver weight · male · nonhuman · nucleotide sequence · protein blood level · rat · xenobiotic metabolism · Acyltransferases · Administration, Oral · Animals · Antinematodal Agents · Antioxidants · Butylated Hydroxytoluene · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Glutathione Transferase · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Thiabendazole
[Abstract]

2 Parallelogram approach using rat-human In vitro and rat in vivo toxicogenomics predicts acetaminophen-induced hepatotoxicity in humans
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Wortelboer, H. · Herwijnen, M. van · Gottschalk, R. · Jong, C.H.C. de · Boorsma, A. · Paules, R.S. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Toxicology · Biotechnology · Acetaminophen · Gene expression profiling · Hepatocyte-based in vitro models · Interspecies extrapolation · Liver injury · T-profiler · oxidoreductase · paracetamol · adult · aged · animal cell · animal experiment · animal model · animal tissue · article · biological activity · cell function · chemical analysis · controlled study · energy consumption · enzyme activity · female · gene expression profiling · gene repression · human · human cell · human tissue · human versus animal comparison · in vitro study · in vivo study · liver cell · liver metabolism · liver mitochondrion · liver toxicity · male · nonhuman · rat · species comparison · toxicogenetics · Acetaminophen · Adult · Aged · Analgesics, Non-Narcotic · Animals · Cell Survival · Cells, Cultured · Female · Hepatitis, Toxic · Hepatocytes · Humans · In Situ Hybridization · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Rats, Wistar · RNA · Species Specificity · Toxicogenetics · Rattus · Rodentia
[Abstract]

3 Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
article 2006    
Author: Korsheninnikova, E. · Zon, G.C.M. van der · Voshol, P.J. · Janssen, G.M. · Havekes, L.M. · Grefhorst, A. · Kuipers, F. · Reijngoud, D.-J. · Romijn, J.A. · Ouwens, D.M. · Maassen, J.A.
Keywords: Biology · Biomedical Research · Hepatic steatosis · High-fat feeding · Nutrient sensing · Enzyme inhibitor · Glucose · Hydroxymethylglutaryl coenzyme A reductase kinase · Mammalian target of rapamycin · Protein kinase B · Protein S6 · S6 kinase · Tetradecylglycidic acid · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Diabetic obesity · Diabetogenesis · Enzyme activation · Glucose clamp technique · Hyperinsulinemia · Insulin resistance · Lipid diet · Liver homogenate · Liver mitochondrion · Mitochondrial membrane · Nonhuman · Nutrient concentration · Nutrient content · Protein blood level · Protein induction · Protein phosphorylation · Protein synthesis · Protein targeting · Species comparison · 1-Phosphatidylinositol 3-Kinase · Animals · Blood Glucose · Dietary Fats · DNA, Mitochondrial · Electron Transport Complex IV · Fatty Acids · Fatty Liver · Insulin · Insulin Resistance · Leucine · Liver · Male · Mice · Mice, Inbred C57BL · Phosphorylation · Protein Kinases · Ribosomal Proteins
[Abstract]

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