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1 Comparison of dose-responses of contact allergens using the guinea pig maximization test and the local lymph node assay
article 2001    
Author: Och, F.M.M. van · Vandebriel, R.J. · Prinsen, M.K. · Jong, W.H. de · Slob, W. · Loveren, H. van
Keywords: Nutrition · Allergens · Animals · Dermatitis, Allergic Contact · Diethylamines · Dose-Response Relationship, Immunologic · Edema · Erythema · Guinea Pigs · Local Lymph Node Assay · Male · Mice · Skin · Thiram · Time Factors · Ziram
[Abstract]

2 Histopathologic approaches to detect changes indicative of immunotoxicity
article 2000    
Author: Kuper, C.F. · Harleman, J.H. · Richter-Reichelm, H.B. · Vos, J.G.
Keywords: Immunomodulation · Immunosuppression · Lymph node · Lymphoid organs · Morphology · Mucosa-associated lymphoid tissue (MALT) · Spleen · Thymus · Animal tissue · Cell structure · Histopathology · Immunomodulation · Immunotoxicity · Lymph node · Lymphoid organ · Lymphoid tissue · Nonhuman · Priority journal · Review · Spleen · Thymus · Animals · Female · Immune System · Immunosuppressive Agents · Immunotoxins · Lymphoid Tissue · Male · Rats · Animalia · Rodentia
[Abstract]

3 Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophages
article 1997    
Author: Noorman, F. · Braat, E.A.M. · Barrett-Bergshoeff, M.M. · Barbé, E. · Leeuwen, A. van · Lindeman, J. · Rijken, D.C.
Keywords: Biology · Human monocytes · KP1 · Lymph node · Biochemical marker · Dexamethasone · Lipopolysaccharide · Mannose receptor · Monoclonal antibody · Bone marrow · Cell culture · Flow cytometry · Gene expression · Immunohistochemistry · Lymph node · Skin · Technique · Thymus · Antibodies, Monoclonal · Biological Markers · Blotting, Western · Cell Differentiation · Dexamethasone · Flow Cytometry · Glucocorticoids · Humans · Immunohistochemistry · Lectins, C-Type · Lipopolysaccharides · Lymphocytes · Macrophage Activation · Macrophages · Mannose-Binding Lectins · Monocytes · Receptors, Cell Surface
[Abstract]

4 The respiratory allergen glutaraldehyde in the local lymph node assay: Sensitization by skin exposure, but not by inhalation
article 2011    
Author: Triel, J.J. van · Bree, B.W.J. van · Roberts, D.W. · Muijser, H. · Duistermaat, E. · Woutersen, R.A. · Kuper, C.F.
Keywords: Nutrition Biology · Toxicology and Applied Pharmacology · Chemical structure · Glutaraldehyde · Inhalation exposure · Local lymph node assay · Respiratory allergy · Sensitization · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Extended histopathology in immunotoxicity testing: Interlaboratory validation studies
article 2004    
Author: Germolec, D.R. · Nyska, A. · Kashon, M. · Kuper, C.F. · Portier, C. · Kommineni, C. · Johnson, K.A. · Luster, M.I.
Keywords: Biology · Physiological Sciences · Histopathology · Immunology · Immunopathology · Lymph node · Pathology · Risk assessment · Spleen · Thymus · chemical agent · analysis of variance · animal cell · animal tissue · article · cellular distribution · concentration response · controlled study · disease severity · error · experience · factorial analysis · female · germinal center · health program · histopathology · immunopathology · immunotoxicity · intermethod comparison · laboratory test · lymph node · lymphatic system disease · lymphoid tissue · medical education · medical expert · mouse · nonhuman · observer variation · organogenesis · pathologist · quantitative analysis · reproducibility · screening test · sensitivity analysis · spleen cell · thymus · tissue injury · tissue structure · toxicity testing · validation process · Allergy and Immunology · Animals · Computational Biology · Data Interpretation, Statistical · Dose-Response Relationship, Drug · Histology · Immune System · Laboratories · Models, Statistical · Reproducibility of Results · Terminology · Toxicology
[Abstract]

6 The respiratory local lymph node assay as a tool to study respiratory sensitizers
article 2008    
Author: Arts, J.H.E. · Jong, W.H. de · Triel, J.J. van · Schijf, M.A. · Klerk, A. de · Loveren, H. van · Kuper, C.F.
Keywords: Health · Toxicology and Applied Pharmacology · Contact allergy · LLNA · Potency · Respiratory allergy · Sensitizers · 1 chloro 2,4 dinitrobenzene · allergen · formaldehyde · hexamethylene diisocyanate · isophorone · oxazolone · phthalic anhydride · salicylic acid methyl ester · trimellitic anhydride · airway · animal experiment · article · cell proliferation · concentration response · contact allergy · controlled study · histopathology · local lymph node assay · male · molecular weight · mouse · nonhuman · respiratory tract allergy · respiratory tract examination · skin sensitization · toxicity testing · Animals · Body Weight · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Local Lymph Node Assay · Male · Mass Spectrometry · Mice · Mice, Inbred BALB C · Organ Size · Particle Size · Respiratory System · Mus
[Abstract]

7 Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis
article 2015    
Author: Kooijman, S. · Meurs, I. · Stoep, M. van der · Habets, K.L. · Lammers, B. · Berbée, J.F.P. · Havekes, L.M. · Eck, M. van · Romijn, J.A. · Korporaal, S.J.A. · Rensen, P.C.N.
Keywords: Biology · Alpha7 nicotinic acetylcholine receptor · Atherosclerosis · Bone marrow transplantation · Inflammation · Platelets · Bungarotoxin receptor · C reactive protein · Tumor necrosis factor alpha · Animal experiment · Animal model · Atherogenic diet · Controlled study · Disease course · Leukocyte · Mesentery lymph node · Mouse · Nonhuman · Peritoneum · Spleen · Thrombocyte activation · Thrombocyte function · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure
article 2009    
Author: Jong, W.H. de · Arts, J.H.E. · Klerk, A. de · Schijf, M.A. · Ezendam, J. · Kuper, C.F. · Loveren, H. van
Keywords: Biology · Toxicology and Applied Pharmacology · Cytokine profiles · Inhalation exposure · Lymph node responses · Sensitizers · Skin exposure · 1 chloro 2,4 dinitrobenzene · concanavalin A · formaldehyde · gamma interferon · hexamethylene diisocyanate · interleukin 10 · interleukin 4 · isophorone · oxazolone · phthalic anhydride · salicylic acid methyl ester · toluene diisocyanate · trimellitic anhydride · animal cell · animal experiment · animal model · article · cell proliferation · cell suspension · concentration (parameters) · contact sensitivity · controlled study · cytokine production · ex vivo study · hypersensitivity reaction · inhalation · lymphadenectomy · lymphatic drainage · male · mouse · nonhuman · priority journal · protein induction · respiratory tract allergy · Administration, Cutaneous · Allergens · Animals · Biological Markers · Cell Proliferation · Cells, Cultured · Cytokines · Dermatitis, Allergic Contact · Dose-Response Relationship, Drug · Inhalation Exposure · Interferon-gamma · Interleukin-10 · Interleukin-4 · Local Lymph Node Assay · Lymph Nodes · Male · Mice · Mice, Inbred BALB C · Models, Animal · Respiratory Hypersensitivity · Animalia · Mus
[Abstract]

9 Repeated dose oral toxicological evaluation of concentrated barley β-glucan in CD-1 mice including a recovery phase
article 2003    
Author: Delaney, B. · Carlson, T. · Zheng, G.-H. · Hess, R. · Knutson, N. · Frazer, S. · Ostergren, K. · Zijverden, M. van · Knippels, L. · Jonker, D. · Penninks, A.
Keywords: Toxicology Biology · Toxicology and Applied Pharmacology · beta glucan · animal experiment · animal tissue · article · barley · controlled study · evaluation · female · hematological parameters · histopathology · immunoreactivity · lymph node · lymphoid organ · male · mouse · nonhuman · oat · organ weight · toxicity testing · Animal Feed · Animals · Diet · Dietary Fiber · Dose-Response Relationship, Drug · Drug Administration Schedule · Female · Glucans · Hematologic Tests · Hordeum · Lymphoid Tissue · Male · Mice · Mice, Inbred Strains · Toxicity Tests · Animalia · Avena · Hordeum vulgare subsp. vulgare
[Abstract]

10 Skin irritants and contact sensitizers induce Langerhans cell migration and maturation at irritant concentration
article 2006    
Author: Jacobs, J.J.L. · Lehé, C.L. · Hasegawa, H. · Elliott, G.R. · Das, P.K.
Keywords: Contact allergy · Langerhans cell · Maturation · Migration · Skin irritation · CD83 antigen · Chemokine receptor CCR7 · Contact allergen · Irritant agent · T6 antigen · Article · Cell count · Cell maturation · Cell migration · Contact allergy · Contact sensitization · Controlled study · Dendritic cell · Explant · Human · Human tissue · Hypersensitivity reaction · Immunohistochemistry · Immunopathology · Langerhans cell · Lymph node · Quantitative analysis · Skin allergy · Skin culture · Skin irritation · Allergens · Cell Differentiation · Cell Movement · Dermatitis, Contact · Dermatitis, Occupational · Female · Humans · Irritants · Langerhans Cells · Lymph Nodes · Skin · Skin Irritancy Tests · Tissue Culture Techniques
[Abstract]

11 Migration of human antigen-presenting cells in a human skin graft onto nude mice model after contact sensitization
article 1995    
Author: Hoefakker, S. · Balk, H.P. · Boersma, W.J.A. · Joost, T. van · Notten, W.R.F. · Claassen, E.
Keywords: Biology · Contact allergen · HLA DR antigen · Interleukin 1alpha · Interleukin 1beta · Rhodamine b · Tumor necrosis factor alpha · Adult · Animal experiment · Animal model · Antigen presenting cell · Cell migration · Controlled study · Dendritic cell · Immunohistochemistry · Keratinocyte · Lymph node · Mouse · Nonhuman · skin transplantation · Xenograft · Adult · Animal · Cell Movement · Cytokines · Dendritic Cells · Dermatitis, Contact · Epidermis · Female · Human · Immunoenzyme Techniques · Lymph Nodes · Mice · Mice, Inbred BALB C · Skin Transplantation · Time Factors · Transplantation, Heterologous
[Abstract]

12 Histopathology of a spontaneously developing mast cell sarcoma in a Wistar rat
article 1996    
Author: Baselmans, A.H.C. · Kuijpers, M.H.M. · Dijk, J.E. van
Keywords: Toxicology · blood basophilia · eosinophilic granulocytes · eyelid · intracytoplasmatic granules · Mast cell tumor · metachromasia · animal model · animal tissue · article · basophil · cancer diagnosis · eosinophil · female · histopathology · immunohistochemistry · male · nonhuman · priority journal · rat · sarcoma · animal · animal disease · case report · eye · eyelid tumor · leukocyte count · liver tumor · lymph node metastasis · metastasis · pathology · rodent disease · ultrastructure · Wistar rat · Animalia · Exophthalmus · Rattus norvegicus · Animals · Eye · Eyelid Neoplasms · Female · Leukocyte Count · Liver Neoplasms · Lymphatic Metastasis · Mast-Cell Sarcoma · Rats · Rats, Wistar · Rodent Diseases
[Abstract]

13 Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats
article 2007    
Author: Jonge, J.D. de · Ezendam, J. · Knippels, L.M.J. · Odink, J. · Pourier, M.S. · Penninks, A.H. · Pieters, R. · Loveren, H. van
Keywords: Health · Toxicology and Applied Pharmacology · Bis(tributyltin)oxide · Brown Norway rat · Food allergy · Ovalbumin · Peanut · TBTO · bis(tributyltin) oxide · cytokine · immunoglobulin E · ovalbumin · proteinase · animal cell · animal experiment · animal model · article · basophil · controlled study · cytokine production · eosinophil · female · food allergy · food chain · granulocyte · immunology · immunomodulation · lymphocyte proliferation · mast cell · mesentery lymph node · nonhuman · peanut allergy · Peyer patch · priority journal · rat · risk assessment · spleen cell · Th2 cell · Adjuvants, Immunologic · Administration, Oral · Allergens · Animals · Antibody Formation · Cell Count · Cell Proliferation · Disease Models, Animal · Female · Granulocytes · Immunosuppressive Agents · Lymph Nodes · Lymphocytes · Mast Cells · Metalloendopeptidases · Ovalbumin · Peanut Hypersensitivity · Peyer's Patches · Rats · Rats, Inbred BN · Spleen · Trialkyltin Compounds · Arachis hypogaea · Rattus · Rattus norvegicus
[Abstract]

14 The effect of the food matrix on In Vivo immune responses to purified peanut allergens
article 2005    
Author: Wijk, F. van · Nierkens, S. · Hassing, I. · Feijen, M. · Koppelman, S.J. · Jong, G.A.H. de · Pieters, R. · Knippels, L.M.J.
Keywords: Nutrition Toxicology · Food technology · Food matrix · Immunogenicity · Mouse model · Peanut allergens · allergen · cholera toxin · cytokine · immunoglobulin E · allergenicity · animal cell · animal experiment · antigen presenting cell · antigen purification · article · assay · cell count · controlled study · cytokine production · feeding · female · food allergy · foot pad · immune response · immunogenicity · immunoreactivity · immunostimulation · in vivo study · lymph node · mouse · mouse strain · nonhuman · peanut · Allergens · Animals · Antigens, CD · Antigens, CD80 · Antigens, CD86 · Arachis hypogaea · Cholera Toxin · Cytokines · Dietary Fats · Female · Glycoproteins · Immunoglobulin E · Immunoglobulin G · Intercellular Adhesion Molecule-1 · Lymph Nodes · Membrane Glycoproteins · Mice · Mice, Inbred BALB C · Mice, Inbred C3H · Peanut Hypersensitivity · Plant Proteins · Ara · Arachis hypogaea
[Abstract]

15 The probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/6 mice
article 2015    
Author: Mariman, R. · Tielen, F. · Koning, F. · Nagelkerken, L.
Keywords: Biology · Flow cytometry · Host genetics · Immune modulation · Microarray · Probiotics · Chemokine receptor CCR5 · Chemokine receptor CXCR3 · Eosinophil peroxidase · Gamma interferon inducible protein 10 · Interleukin 12 receptor beta1 · Retinoid related orphan receptor gamma · Transcription factor GATA 3 · VSL3 · Adaptive immunity · Animal experiment · Colon · Controlled study · Female · Gene expression · Genetic variability · Homeostasis · Immunomodulation · Innate immunity · Intestine mucosa · Major histocompatibility complex · Mesentery lymph node · Microarray analysis · Mouse · Mouse strain · Nonhuman · Phenotype · Principal component analysis · Protein expression · Single drug dose · Small intestine · Upregulation · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride-sensitized brown Norway rats
article 2008    
Author: Arts, J.H.E. · Schijf, M.A. · Kuper, C.F.
Keywords: Biology · Toxicology and Applied Pharmacology · silicon dioxide · trimellitic anhydride · animal experiment · animal model · animal tissue · article · biochemistry · breathing pattern · brown Norway rat · cell infiltration · controlled study · eosinophil · female · histopathology · inflammation · laryngeal inflammation · laryngeal ulceration · larynx disorder · liver weight · lung edema · lung function · lung lavage · lung weight · lymph node · lymphocyte count · macrophage · neutrophil · nonhuman · priority journal · rat · respiratory tract allergy · squamous cell metaplasia · tidal volume · Allergens · Animals · Body Weight · Drug Administration Schedule · Female · Immunoglobulin E · Liver · Lung · Lymph Nodes · Organ Size · Phthalic Anhydrides · Rats · Respiratory Function Tests · Silicon Dioxide · Animalia · Rattus norvegicus
[Abstract]

17 Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134
article 2008    
Author: Nolte-'t Hoen, E.N.M. · Boot, E.P.J. · Wagenaar-Hilbers, J.P.A. · Bilsen, J.H.M. van · Arkesteijn, G.J.A. · Storm, G. · Everse, L.A. · Eden, W. van · Wauben, M.H.M.
Keywords: Biology · FoxP3 · Immune regulation · Kinetics · Lymph nodes · CD134 antigen · interleukin 2 receptor alpha · transcription factor FOXP3 · animal cell · animal experiment · animal model · arthritis · article · CD25+ T lymphocyte · CD4+ T lymphocyte · cell activation · cell differentiation · cell proliferation · controlled study · effector cell · lymph node · male · memory T lymphocyte · nonhuman · phenotype · priority journal · protein analysis · protein expression · protein function · protein isolation · protein localization · rat · regulatory T lymphocyte · Animals · Arthritis, Experimental · Disease Models, Animal · Disease Progression · Forkhead Transcription Factors · Interleukin-2 Receptor alpha Subunit · Male · Rats · Rats, Inbred Lew · Receptors, OX40 · T-Lymphocytes, Regulatory · Rattus
[Abstract]

18 Antigen detection in vivo after immunization with different presentation forms of rabies virus antigen: Involvement of marginal metallophilic macrophages in the uptake of immune-stimulating complexes
article 1995    
Author: Claassen, I.J.T.M. · Osterhaus, A.D.M.E. · Claassen, E.
Keywords: Biology · Fluorescence · Immune-stimulating complex · Macrophages · Marginal zone · carbocyanine · iscom · virus antigen · animal experiment · animal tissue · antigen detection · antigen presenting cell · article · b lymphocyte · dendritic cell · female · fluorescence microscopy · immunization · immunogenicity · liver · lymph node · macrophage · mouse · nonhuman · ovary follicle cell · priority journal · rabies virus · spleen · Animal · Antibodies, Monoclonal · Antigen Presentation · Antigens, Viral · B-Lymphocytes · Carbocyanines · Dendritic Cells · Female · Fluorescent Dyes · Immunization · Injections, Intramuscular · Injections, Intraperitoneal · Injections, Intravenous · ISCOMs · Liver · Lymphocyte Activation · Macrophages · Metals · Mice · Mice, Inbred BALB C · Microscopy, Fluorescence · Pharmacokinetics · Rabies virus · Spleen
[Abstract]

19 The accuracy of extended histopathology to detect immunotoxic chemicals
article 2004    
Author: Germolec, D.R. · Kashon, M. · Nyska, A. · Kuper, C.F. · Portier, C. · Kommineni, C. · Johnson, K.A. · Luster, M.I.
Keywords: Biology · Toxicology and Applied Pharmacology · B6C3F1 mice · Extended histopathology · Immunotoxicity · Safety Assessment · Screening tests · 2',3' dideoxyadenosine · 2,3,7,8 tetrachlorodibenzo para dioxin · 2,4 diaminotoluene · 4 nitrotoluene · aldicarb · chemical agent · didanosine · drug vehicle · gallium arsenide · immunosuppressive agent · oxymetholone · ribavirin · thalidomide · accuracy · analytical error · animal experiment · animal model · animal tissue · article · body weight · chemical analysis · controlled study · correlation analysis · disease severity · female · health program · histopathology · immune system · immunological procedures · immunotoxicity · incidence · intermethod comparison · leukocyte count · lymph node · lymphoid tissue · mouse · nonhuman · organ weight · pathologist · plaque forming cell · prediction · scoring system · sensitivity analysis · spleen · thymus · toxicity testing · toxicology · Animals · Body Weight · Dose-Response Relationship, Drug · Endpoint Determination · False Positive Reactions · Hemolytic Plaque Technique · Immune System · Immunity, Cellular · Lymph Nodes · Lymphocyte Count · Mice · Mice, Inbred Strains · Organ Size · Organ Specificity · Predictive Value of Tests · Reproducibility of Results · Spleen · Thymus Gland · Toxicity Tests · Vehicles
[Abstract]

20 The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
article 2008    
Author: Kuper, C.F. · Stierum, R.H. · Boorsma, A. · Schijf, M.A. · Prinsen, M. · Bruijntjes, J.P. · Bloksma, N. · Arts, J.H.E.
Keywords: Health · Dinitrochlorobenzene · LLNA · MCP-1 · MIP1-beta · Respiratory allergy · Skin allergy · 1 chloro 2,4 dinitrobenzene · CD4 antigen · immunoglobulin G · macrophage inflammatory protein 1beta · monocyte chemotactic protein 1 · monocyte chemotactic protein 3 · thymus and activation regulated chemokine · animal experiment · animal model · animal tissue · article · controlled study · female · lung function · lung lavage · lung parenchyma · male · microarray analysis · nonhuman · Norway · nucleotide sequence · priority journal · rat · respiratory tract allergy · skin allergy · skin irritation · skin sensitization · Th2 cell · upregulation · Administration, Cutaneous · Allergens · Animals · Dermatitis, Allergic Contact · Dinitrochlorobenzene · Female · Immunoglobulin E · Immunoglobulin G · Inhalation Exposure · Irritants · Local Lymph Node Assay · Lung · Lymph Nodes · Male · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Hypersensitivity · Th2 Cells · Animalia · Rattus · Rattus norvegicus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 24 found. Next | Sort by date