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1 Percutaneous penetration studies for risk assessment
article 2000    
Author: Sartorelli, P. · Andersen, H.R. · Angerer, J. · Corish, J. · Drexler, H. · Göen, T. · Griffin, P. · Hotchkiss, S.A.M. · Larese, F. · Montomoli, L. · Perkins, J. · Schmelz, M. · Sandt, J. van de · Williams, F.
Keywords: Nutrition · Cutaneous metabolism · Diffusion cell · Guidelines · In vitro · Microdialysis · Percutaneous penetration · Regulatory toxicology · Risk assessment · Alcohol derivative · Electrolyte · Hydrocarbon · Insecticide · Macrogol derivative · Penetration enhancing agent · Pesticide · Solvent · Steroid · Surfactant · Toxic substance · Volatile agent · Diffusion · Drug penetration · Human · Membrane permeability · Microdialysis · Nonhuman · Practice guideline · Priority journal · Review · Risk assessment · Skin absorption · Skin penetration · Standardization · Xenobiotic metabolism
[Abstract]

2 Prediction of brain target site concentrations on the basis of CSF PK : impact of mechanisms of blood-to-brain transport and within brain distribution
dissertation 2014    
Author: Westerhout, J.
Keywords: Pharmacology · Pharmacokinetics · Blood-brain barrier · Systems-based pharmacokinetic modeling · Brain extracellular fluid · Cerebrospinal fluid · Microdialysis · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

3 Low efficacy adenosine A1 agonists inhibit striatal acetylcholine release in rats improving central selectivity of action
article 2003    
Author: Bueters, T.J.H. · Helden, H.P.M. van · IJzerman, A.P. · Danhof, M.
Keywords: Acetylcholine · Adenosine · Adenosine A1 receptor · Low efficacy agonist · Microdialysis · Tissue selectivity · 2' deoxy 6 n cyclopentyladenosine · 3' deoxy 6 n cyclopentyladenosine · 6 n cyclopentyladenosine · 8 butylamino 6 n cyclopentyladenosine · 8 cyclopentyltheophylline · 8 ethylamino 6 n cyclopentyladenosine · Acetylcholine · Adenosine A1 receptor agonist · Unclassified drug · Acetylcholine release · Animal experiment · Animal tissue · Cardiovascular system · Controlled study · Corpus striatum · Dose response · Drug effect · Drug efficacy · Male · Microdialysis · Nonhuman · Rat · Animals · Dose-Response Relationship, Drug · Microdialysis · Neostriatum · Rats, Wistar · Receptor, Adenosine A2B · Receptors, Purinergic P1 · Reproducibility of Results · Sensitivity and Specificity · 6 n cyclopentyladenosine, 41552-82-3 · 8 cyclopentyltheophylline, 35873-49-5 · Acetylcholine, 51-84-3, 60-31-1, 66-23-9 · Adenosine, 58-61-7; · N(6)-cyclopentyladenosine, 41552-82-3 · Receptor, Adenosine A2B · Receptors, Purinergic P1
[Abstract]

4 Increasing oxime efficacy by blood-brain barrier modulation
article 2011    
Author: Joosen, M.J.A. · Schans, M.J. van der · Dijk, C.G.M. van · Kuijpers, W.C. · Wortelboer, H.M. · Helden, H.P.M. van
Keywords: HI6 · Nerve agent · P-glycoprotein · Seizures · Tariquidar · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether · Acetylcholinesterase · Atropine · Tariquidar · Animal experiment · Animal model · Article · Blood brain barrier · Blood level · Brain blood volume · Controlled study · Convulsion · Drug effect · Drug efficacy · Drug intoxication · Drug penetration · Male · Microdialysis · Modulation · Nerve agent poisoning · Nonhuman · Priority journal · Quantitative analysis · Rat · Seizure · Rattus · 1 (4 carbamoylpyridinio) 1' (2 hydroxyiminomethylpyridinio)dimethyl ether, 34433-31-3 · Acetylcholinesterase, 9000-81-1 · Atropine, 51-55-8, 55-48-1 · Tariquidar, 206873-63-4 · Tradenames: hi 6, TNO; xr 9576, avaant · Manufacturers: TNO; avaant · Life · CBRN - CBRN Protection PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

5 Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication
article 2002    
Author: Bueters, T.J.H. · Groen, B. · Danhof, M. · IJzerman, A.P. · Helden, H.P.M. van
Keywords: Biology · Acetylcholine release · Adenosine A1 receptor · N6-Cyclopentyladenosine · Organophosphate · Adenosine A1 receptor agonist · Adenosine receptor stimulating agent · Cyclohexyladenosine · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester · Adenosine receptor · Cholinesterase · Drug derivative · N(6) cyclopentyladenosine · Organophosphate · Phosphorothioic acid derivative · Bioaccumulation · Cholinergic system · Concentration response · Controlled study · Corpus striatum · Crug efficacy · Enzyme activity · Hippocampus · Intoxication · Male · Microdialysis · Nonhuman · Rat · Reduction · Animal · Drug potentiation · Enzymology · Metabolism · Secretion · Wistar rat · Animals · Cholinesterase Inhibitors · Cholinesterases · Corpus Striatum · Male · Microdialysis · Organothiophosphorus Compounds · Parathion · Phosphoric Acid Esters · Rats · Rats, Wistar · Receptors, Purinergic P1 · Sarin · Acetylcholinesterase, 9000-81-1 · Cyclohexyladenosine, 36396-99-3 · Methylphosphonothioic acid s (2 diisopropylaminoethyl) o ethyl ester, 50782-69-9 · Parathion, 3270-86-8, 56-38-2, 597-88-6 · Sarin, 107-44-8; tabun, 77-81-6 · Acetylcholine, 51-84-3 · Adenosine, 58-61-7; · Cholinesterase Inhibitors · Cholinesterases, EC 3.1.1.8 · N(6)-cyclopentyladenosine, 41552-82-3 · Organothiophosphorus Compounds · Parathion, 56-38- · Phosphoric Acid Esters · Receptors, Purinergic P1 · Sarin, 107-44-8 · Tabun, 77-81-6 · VX, 50782-69-9
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 5 of 5 found. | Sort by date