Repository hosted by TU Delft Library

Home · Contact · About · Disclaimer ·
 

Search results also available in MS Excel format.

Showing 1 to 20 of 21 found. Next | Sort by date

1 Beta-carotene as antioxidant
article 1996    
Author: Bast, A. · Plas, R.M. van der · Berg, H. van den · Haenen, G.R.M.M.
Keywords: Nutrition · Animals · Antioxidants · Ascorbic Acid · beta Carotene · Fats · Ferrous Compounds · Glutathione · Lipid Peroxidation · Male · Microsomes, Liver · Rats · Rats, Wistar · Vitamin A · Animalia · Rattus norvegicus
[Abstract]

2 Identification of some important metabolites of boldenone in urine and feces of cattle by gas chromatography-mass spectrometry
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Androstenedione · Boldenone · Drug metabolite · Animal tissue · Cattle · Conference paper · Drug feces level · Drug metabolism · Drug urine level · Gas chromatography · Liver cell · Liver microsome · Mass spectrometry · Nonhuman · Animals · Cells, Cultured · Feces · Gas Chromatography-Mass Spectrometry · Liver · Male · Microsomes, Liver · Testosterone
[PDF] [Abstract]

3 In vitro liver models are important tools to monitor the abuse of anabolic steroids in cattle
article 1998    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, T. · Zande, D.J.M. van der · Gelan, J. · Raus, J.
Keywords: Nutrition · Anabolic agent · Biological marker · Boldenone · Clostebol · Estrane derivative · Ethylestrenol · Norethandrolone · Steroid · Animal tissue · Cattle · Conference paper · Controlled study · Drug abuse · Drug determination · Drug metabolism · Drug monitoring · Female · Liver · Liver cell culture · Liver metabolism · Liver microsome · Male · Model · Nonhuman · Steroid metabolism · Anabolic Agents · Animals · Biological Markers · Cattle · Cells, Cultured · Drug Residues · Estradiol · Ethylestrenol · Liver · Microsomes, Liver · Models, Biological · Norethandrolone · Predictive Value of Tests · Testosterone
[PDF] [Abstract]

4 Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol
article 1996    
Author: Bessems, J.G.M. · Koppele, J.M. te · Dijk, P.A. van · Stee, L.L.P. van · Commandeur, J.N.M. · Vermeulen, N.P.E.
Keywords: Toxicology · beta naphthoflavone · cytochrome p450 · glutathione · paracetamol · paracetamol derivative · phenobarbital · animal tissue · article · controlled study · drug oxidation · liver microsome · male · nonhuman · rat · Acetaminophen · Animals · Benzoquinones · beta-Naphthoflavone · Cytochrome P-450 Enzyme System · Gas Chromatography-Mass Spectrometry · Glutathione · Imines · Kinetics · Male · Microsomes, Liver · Oxidation-Reduction · Rats · Rats, Wistar · Spectrophotometry, Ultraviolet · Animalia · Armoracia rusticana
[Abstract]

5 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

6 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

7 Differences in cytochrome P450-mediated biotransformation of 1,2- dichlorobenzene by rat and man: Implications for human risk assessment
article 1996    
Author: Hissink, A.M. · Oudshoorn, M.J. · Ommen, B. van · Haenen, G.R.M.M. · Bladeren, P.J. van
Keywords: 1,2 dichlorobenzene · ascorbic acid · cytochrome p450 · epoxide hydrolase · glutathione · glutathione transferase · isoniazid · phenobarbital · animal cell · animal experiment · article · biotransformation · conjugation · controlled study · covalent bond · human · human cell · hydrolysis · liver microsome metabolism · liver toxicity · male · nonhuman · rat · Animals · Biotransformation · Chlorobenzenes · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Humans · Insecticides · Isoenzymes · Male · Microsomes, Liver · Protein Binding · Rats · Rats, Inbred F344 · Rats, Sprague-Dawley · Rats, Wistar · Risk Assessment · Species Specificity · Spectrophotometry, Ultraviolet · Animalia · Rattus norvegicus
[Abstract]

8 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

9 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

10 Cholestrol content of the rat lens is lowered by administration of simvastatin, but not pravastatin
article 1993    
Author: Vries, A.C.J. de · Vermeer, M.A. · Bredman, J.J. · Bar, P.R. · Cohen, L.H.
Keywords: Pharmacology · 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors · hypocholesterolaemic drugs · antilipemic agent · drug derivative · hydroxymethylglutaryl coenzyme A reductase inhibitor · hypocholesterolemic agent · mevinolin · animal experiment · cholesterol metabolism · oral drug administration · biosynthesis · dose response · drug effect · enzymology · liver microsome · metabolism · organ culture · rat strain · time · Aging · Animal · Anticholesteremic Agents · Antilipemic Agents · Cholesterol · Dose-Response Relationship, Drug · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lens, Crystalline · Lovastatin · Microsomes, Liver · Organ Culture · Pravastatin · Rats · Rats, Wistar · Simvastatin · Time Factors
[Abstract]

11 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

12 Acetoxy drug : Protein transacetylase of buffalo liver - Characterization and mass spectrometry of the acetylated protein product
article 2004    
Author: Kohli, E. · Gaspari, M. · Raj, H.G. · Parmar, V.S. · Sharma, S.K. · Greef, J. van der · Kumari, R. · Gupta, G. · Seema · Khurana, P. · Tyagi, Y.K. · Watterson, A.C. · Olsen, C.E.
Keywords: Chemistry Biology · Analytical research · Acetoxy drug · MALDI-TOF · Protein acetylation · Protein mass spectrometry · Transacetylase · 7,8 diacetoxy 4 methylcoumarin · 7,8 dihydroxy 4 methylcoumarin · acyltransferase · coumarin derivative · liver enzyme · monoacetoxymonohydroxy 4 methylcoumarin · peptide derivative · trypsin · unclassified drug · acetylation · animal cell · article · buffalo · catalysis · enzyme analysis · enzyme purification · liver microsome · mass spectrometry · matrix assisted laser desorption ionization time of flight mass spectrometry · model · molecular weight · nonhuman · peptide mapping · polyacrylamide gel electrophoresis · priority journal · Acetylation · Acetyltransferases · Amino Acid Sequence · Animals · Buffaloes · Coumarins · Glutathione Transferase · Liver · Microsomes, Liver · Molecular Sequence Data · Peptides · Protein Structure, Tertiary · Proteins · Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization · Bubalus
[Abstract]

13 Liquid chromatography/tandem mass spectrometry detection of covalent binding of acetaminophen to human serum albumin
article 2007    
Author: Damsten, M.C. · Commandeur, J.N.M. · Fidder, A. · Hulst, A.G. · Touw, D. · Noort, D. · Vermeulen, N.P.E.
Keywords: Cytochrome P450 · Paracetamol · Serum albumin · Article · Biological monitoring · Covalent bond · Drug protein binding · Human · Liquid chromatography · Microsome · Priority journal · Tandem mass spectrometry · Acetaminophen · Acetylcysteine · Animals · Benzoquinones · Chromatography, Liquid · Cysteine · Humans · Imines · Microsomes, Liver · Models, Biological · Molecular Structure · Oligopeptides · Protein Binding · Rats · Reproducibility of Results · Serum Albumin · Tandem Mass Spectrometry · Chemicals · CAS: cytochrome P450, 9035-51-2 · Paracetamol, 103-90-2 · Serum albumin, 9048-46-8 · Acetaminophen, 103-90-2 · Acetylcysteine, 616-91-1 · Benzoquinones · Cysteine, 52-90-4 · Imines · N-acetyl-4-benzoquinoneimine, 50700-49-7 · Oligopeptides
[Abstract]

14 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

15 Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes
article 2009    
Author: Treijtel, N. · Eijkeren, J.C.H.v. · Nijmeijer, S. · Greef de - Sandt, I.C.J. van der · Freidig, A.P.
Keywords: Health · Biomedical Research · HIV-protease inhibitors · Metabolism · P-Glycoprotein · Rat hepatocytes · rat liver microsomes · Sandwich-culture · cyclosporin A · drug metabolite · glycoprotein P · ketoconazole · proteinase inhibitor · ritonavir · saquinavir · testosterone derivative · valspodar · verapamil · animal cell · article · cell culture · controlled study · drug clearance · drug excretion · drug metabolism · drug transport · Human immunodeficiency virus 1 · hydroxylation · intrahepatic bile duct · liver cell · liver metabolism · male · microsome · nonhuman · rat · sandwich culture · Animals · Biological Transport, Active · Cell Culture Techniques · Cell Survival · Cells, Cultured · Cyclosporine · Cyclosporins · Dose-Response Relationship, Drug · Hepatocytes · HIV Protease Inhibitors · Ketoconazole · Male · Metabolic Clearance Rate · Microsomes, Liver · Rats · Rats, Wistar · Ritonavir · Saquinavir · Human immunodeficiency virus 1 · Rattus
[Abstract]

16 Comparison of three different in vitro mutation assays used for the investigation of cytochrome P450-mediated mutagenicity of nitro-polycyclic aromatic hydrocarbons
article 2000    
Author: Kappers, W.A. · Och, F.M.M. van · Groene, E.M. de · Horbach, G.J.
Keywords: Nutrition · Acetyltransferase · Amestest · AminoPAHs · Cytochrome P450 · HPRT · Mutagenicity · NIH/3T3 cells · NitroPAHs · Shuttle vector · V79 cells · Cytochrome P450 · Polycyclic aromatic hydrocarbon · Animal cell · Cell strain 3T3 · Controlled study · Enzyme activity · Gene locus · In vitro study · Mouse · Mutagenicity · Nonhuman · Priority journal · Reaction analysis · Reporter gene · Shuttle vector · 3T3 Cells · Animals · Cell Line · Cell Survival · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Enzyme Inhibitors · Ethyl Methanesulfonate · Fluorenes · Humans · Hypoxanthine Phosphoribosyltransferase · Ketoconazole · Lac Operon · Mice · Microsomes, Liver · Mutagenicity Tests · Mutagens · Mutation · Polycyclic Hydrocarbons, Aromatic · Pyrenes · Rats · Recombinant Fusion Proteins · Salmonella typhimurium · Theophylline · Animalia · Cricetinae · Cricetulus griseus · Eukaryota · Salmonella typhimurium · Typhimurium
[Abstract]

17 Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
article 1998    
Author: Bessems, J.G.M. · Groot, M.J. de · Baede, E.J. · Koppele, J.M. te · Vermeulen, N.P.E.
Keywords: Nutrition · Analgesic agent · Cytochrome p450 · Horseradish peroxidase · Hydrogen peroxide · Paracetamol · Reduced nicotinamide adenine dinucleotide phosphate · Analgesia · Animal experiment · Animal tissue · Biotransformation · Catalysis · Drug metabolism · Electron spin resonance · Enzyme activity · Liver microsome · Male · Nonhuman · Oxidation · Rat · Acetaminophen · Animals · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP2B1 · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Electron Spin Resonance Spectroscopy · Free Radicals · Horseradish Peroxidase · Hydrogen · Male · Microsomes, Liver · NADP · Oxidation-Reduction · Rats · Rats, Wistar · Thermodynamics · Animalia · Armoracia rusticana · Rickettsia sp. PAR
[Abstract]

18 Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
article 2000    
Author: Renwick, A.B. · Watts, P.S. · Edwards, R.J. · Barton, P.T. · Guyonnet, I. · Price, R.J. · Tredger, J.M. · Pelkonen, O. · Boobis, A.R. · Lake, B.G.
Keywords: Nutrition · Apoprotein · Cytochrome P450 · Cytochrome p450 2a6 · Cytochrome P450 2B6 · Cytochrome P450 2C19 · Cytochrome p450 2c8 · Cytochrome P450 2C9 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Debrisoquine 4 hydroxylase · Dimethylnitrosamine demethylase · Ethoxyresorufin · O Deethylase · Peptide antibody · Phenacetin o deethylase · Tolbutamide methylhydroxylase · Unclassified drug · Enzyme activity · Enzyme metabolism · Human tissue · Liver cell culture · Liver slice · Protein stability · School child · Xenobiotic metabolism · Adolescent · Adult · Aged · Child · Child, Preschool · Culture Media · Culture Techniques · Cytochrome P-450 Enzyme System · Enzyme Stability · Female · Humans · Immunoblotting · Isoenzymes · Liver · Male · Microsomes, Liver · Middle Aged
[Abstract]

19 Protein adduct formation by glucuronide metabolites of permethrin
article 2008    
Author: Noort, D. · Zuylen, A. van · Fidder, A. · Ommen, B. van · Hulst, A.G.
Keywords: Nutrition · 3 (2,2 dichlorovinyl) 2,2 dimethylcyclopropane 1 carboxylic acid · 3 phenoxybenzoic acid · Albumin · Amino acid · Benzoic acid derivative · Carboxylic acid derivative · Glucuronide · Lysine derivative · Peptide · Permethrin · Pronase · Article · Biological monitoring · Chemical structure · Complex formation · Covalent bond · Crug conjugation · Enzyme synthesis · Liquid chromatography · Metabolite · Protein adduct · Protein binding · Proton nuclear magnetic resonance · Radioactivity · Synthesis · Tandem mass spectrometry · Chromatography, High Pressure Liquid · Environmental Monitoring · Glucuronides · Humans · Insecticides · Lysine · Magnetic Resonance Spectroscopy · Microsomes, Liver · Permethrin · Pesticide Residues · Protein Binding · Serum Albumin · Spectrometry, Mass, Electrospray Ionization · Tandem Mass Spectrometry · Chemicals · 3 phenoxybenzoic acid, 3739-38-6 · Amino acid, 65072-01-7 · Permethrin, 51877-74-8, 52645-53-1 · Pronase, 9036-06-0 · Glucuronides · Insecticides · Lysine, 56-87-1 · Permethrin, 52645-53-1 · Pesticide residues · Serum albumin
[Abstract]

20 17α-Ethyl-5β-estrane-3α,17β-diol, a biological marker for the abuse of norethandrolone and ethylestrenol in slaughter cattle
article 1999    
Author: Puymbroeck, M. van · Kuilman, M.E.M. · Maas, R.F.M. · Witkamp, R.F. · Leyssens, L. · Miert, A.S.J.P.A.M. van · Hendriks, L. · Zande, D.J.M. van der · Adriaensens, P. · Jacobs, M.-P. · Raus, J.
Keywords: Nutrition · 17α-Ethyl-5β-estrane-3α,17β-diol · Ethylestrenol · Norethandrolone · Steroids · Biological marker · Ethylestrenol · Norethandrolone · 17Alpha ethyl 5 xi estrane 3 xi,17 beta diol · Drug derivative · Drug residue · Estradiol · Animal experiment · Animal tissue · Article · Biotransformation · Cattle · Drug abuse · Drug metabolism · Drug monitoring · Feces · Female · Intramuscular drug administration · Liver · Liver cell culture · Male · Nonhuman · Priority journal · Reduction · Urine · Animal · Animal husbandry · Chemistry · High performance liquid chromatography · Liver microsome · Mass fragmentography · Nuclear magnetic resonance spectroscopy · Sensitivity and specificity · Standard · Thin layer chromatography · Ultraviolet spectrophotometry · Biological Markers · Cattle · Chromatography, High Pressure Liquid · Chromatography, Thin Layer · Drug Residues · Estradiol · Ethylestrenol · Gas Chromatography-Mass Spectrometry · Magnetic Resonance Spectroscopy · Male · Microsomes, Liver · Norethandrolone · Reference Standards · Sensitivity and Specificity · Spectrophotometry, Ultraviolet
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 21 found. Next | Sort by date