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1 Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?
article 2015    
Author: Mesens, N. · Crawfordb, A.D. · Menke, A. · Hung, P.D. · Goethem, F. van · Nuyts, R. · Hansen, E. · Wolterbeek, A. · Gompel, J. van · Witte, P. de · Esguerra, C.V.
Keywords: Nutrition · Zebrafish larvae · Screening assay · Lfabp10a · Hepatotoxicity · DILI · Alpidem · Amiodarone · Bosentan · Buspirone · Diclofenac · Fatty acid binding protein · Fatty acid binding protein 10a · Glycogen · Ketorolac · Nefazodone · Paracetamol · Reactive oxygen metabolite · Rosiglitazone · Tacrine · Tamoxifen · Tetracycline · Troglitazone · Unclassified drug · Zolpidem · Adult · Animal tissue · Cell vacuole · Cholestasis · Circulation · Concentration response · Controlled study · Drug safety · Female · Glycogen analysis · Heart rate · Histology · Histopathology · In situ hybridization · Larval stage · Liver cell · Liver level · Liver size · Liver toxicity · Male · Mitochondrial membrane · Mitochondrial toxicity · Molecular cloning · Nonhuman · Protein expression · Steatosis · Toxicity testing · Zebra fish · Danio rerio · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

2 Sustained activation of the mammalian target of rapamycin nutrient sensing pathway is associated with hepatic insulin resistance, but not with steatosis, in mice
article 2006    
Author: Korsheninnikova, E. · Zon, G.C.M. van der · Voshol, P.J. · Janssen, G.M. · Havekes, L.M. · Grefhorst, A. · Kuipers, F. · Reijngoud, D.-J. · Romijn, J.A. · Ouwens, D.M. · Maassen, J.A.
Keywords: Biology · Biomedical Research · Hepatic steatosis · High-fat feeding · Nutrient sensing · Enzyme inhibitor · Glucose · Hydroxymethylglutaryl coenzyme A reductase kinase · Mammalian target of rapamycin · Protein kinase B · Protein S6 · S6 kinase · Tetradecylglycidic acid · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Diabetic obesity · Diabetogenesis · Enzyme activation · Glucose clamp technique · Hyperinsulinemia · Insulin resistance · Lipid diet · Liver homogenate · Liver mitochondrion · Mitochondrial membrane · Nonhuman · Nutrient concentration · Nutrient content · Protein blood level · Protein induction · Protein phosphorylation · Protein synthesis · Protein targeting · Species comparison · 1-Phosphatidylinositol 3-Kinase · Animals · Blood Glucose · Dietary Fats · DNA, Mitochondrial · Electron Transport Complex IV · Fatty Acids · Fatty Liver · Insulin · Insulin Resistance · Leucine · Liver · Male · Mice · Mice, Inbred C57BL · Phosphorylation · Protein Kinases · Ribosomal Proteins
[Abstract]

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