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1 Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
article 2006    
Author: Kitayama, K. · Nakai, D. · Kono, K. · Hoop, A.G. van der · Kurata, H. · Wit, E.C. de · Cohen, L.H. · Inaba, T. · Kohama, T.
Keywords: Biology · Apical sodium-dependent bile acid transporter · Cholesterol · Enterohepatic circulation · Hamster · Hypocholesterolemic agent · Monkey · Carbon 14 · Cholesterol · High density lipoprotein cholesterol · Ileum apical bile acid transporter inhibitor · Phospholipid · Piperidine derivative · R 146224 · Taurocholic acid · Triacylglycerol · Tritium · Unclassified drug · Bile acid · Carrier protein · Cotransporter · Organic anion transporter · Quinoline derivative · Sodium · Sodium bile acid cotransporter · Sodium-bile acid cotransporter · Absorption · Animal experiment · Animal tissue · Bile duct fistula · Bile flow · Cholesterol blood level · Cholesterol esterification · Concentration response · Controlled study · Diet · Dose response · Drug mechanism · Embryo · Feeding · Human cell · Hypercholesterolemia · Hypolipemia · Inhibition kinetics · Time · Triacylglycerol blood level · Urinary excretion · Biosynthesis · Blood · Cell line · Drug antagonism · Drug effect · Genetics · In vitro study · Macaca · Metabolism · Physiology · Sprague Dawley rat · Syrian hamster · Animals · Anticholesteremic Agents · Bile Acids and Salts · Cell Line · Cholesterol · Cricetinae · Humans · Ileum · Macaca fascicularis · Male · Membrane Transport Proteins · Mesocricetus · Organic Anion Transporters, Sodium-Dependent · Piperidines · Quinolines · Rats · Rats, Sprague-Dawley · Sodium · Symporters · Taurocholic Acid
[Abstract]

2 Bile duct proliferation associated with bile salt-induced hypercholeresis in Mdr2 P-glycoprotein-deficient mice
article 2005    
Author: Hulzebos, C.V. · Voshol, P.J. · Wolters, H. · Kruit, J.K. · Ottenhof, R. · Groen, A.K. · Stellaard, F. · Verkade, H.J. · Kuipers, F.
Keywords: Bile flow · Bile formation · Bile salt synthesis · Cholangiocyte · Cholate kinetics · Cholehepatic shunt · beta actin · bile salt · binding protein · carrier protein · chenodeoxycholic acid · cholic acid · deoxycholic acid · glycoprotein P · ileal bile salt binding protein · lithocholic acid · messenger RNA · multidrug resistance protein 2 · multidrug resistance protein 3 · muricholic acid · tauroursodeoxycholic acid · unclassified drug · animal experiment · animal model · animal tissue · bile acid synthesis · cell proliferation · controlled study · dilution · immunohistochemistry · in vivo study · intestine mucosa · intrahepatic bile duct · kinetics · liver parenchyma · male · mouse · nonhuman · nucleotide sequence · protein analysis · protein deficiency · protein expression · upregulation · Western blotting · wild type · Animals · Bile Acids and Salts · Bile Duct Diseases · Bile Ducts · Carrier Proteins · Cell Division · Cholates · Deuterium · Gallbladder · Intestines · Membrane Glycoproteins · Mice · Mice, Mutant Strains · Organic Anion Transporters, Sodium-Dependent · P-Glycoproteins · Phospholipids · RNA, Messenger · Symporters
[Abstract]

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