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1 Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants
article 2018    
Author: Groen, B.D. van · Steeg, E. van de · Mooij, M.G. · Lipzig, M.M.H. van · Koning, B.A.E. de · Verdijk, R.M. · Wortelboer, H.M. · Gaedigk, R. · Bi, C. · Leeder, S. · Schaik, R.H.N. van · Rosmalen, J. van · Tibboel, D. · Vaes, W.H. · Wildt, S.N. de
Keywords: Biology · Liver · Ontogeny · Pediatrics · Proteomics · Transporters · Bile salt export pump · Breast cancer resistance protein · Glucose transporter 1 · Monocarboxylate transporter 1 · Multidrug resistance associated protein 1 · Multidrug resistance associated protein 2 · Multidrug resistance associated protein 3 · Multidrug resistance protein 1 · Organic anion transporter B · Organic cation transporter 1 · RNA · Sodium bile acid cotransporter · Solute carrier organic anion transporter 1A1 · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Cohort analysis · Controlled study · Female · Fetus · Fetus liver · Genetic variability · Genotype · Human · Human tissue · Infant · Liquid chromatography-mass spectrometry · Liver membrane · Major clinical study · Male · Membrane transport · MRNA expression level · Newborn · Pilot study · Prematurity · Protein expression · Protein expression level · Proteomics · RNA sequence · Single nucleotide polymorphism
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2 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
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