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1 Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
article 2006    
Author: Verwei, M. · Burgsteden, J.A. van · Krul, C.A.M. · Sandt, J.J.M. van de · Freidig, A.P.
Keywords: Biology · Biomedical Research · Alternative test method · Developmental toxicity · Embryonic stem cells · PBPK model · 2 ethoxyethanol · 2 methoxyethanol · acetic acid derivative · ethoxyacetic acid · fluorouracil · methotrexate · methoxyacetic acid · retinoic acid · unclassified drug · animal cell · article · computer model · controlled study · embryo · embryo development · embryonic stem cell · embryotoxicity · exposure · metabolism · mouse · nonhuman · prediction · priority journal · risk assessment · rodent · Animal Testing Alternatives · Animals · Cell Line · Cell Survival · Dose-Response Relationship, Drug · Embryo · Mice · Models, Biological · Predictive Value of Tests · Rats · Risk Assessment · Stem Cells · Teratogens · Toxicity Tests · Rodentia
[Abstract]

2 Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents. III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data
article 2007    
Author: Hissink, A.M. · Krüse, J. · Kulig, B.M. · Verwei, M. · Muijser, H. · Salmon, F. · Leenheers, L.H. · Owen, D.E. · Lammers, J.H.C.M. · Freidig, A.P. · McKee, R.H.
Keywords: Biology · Toxicology and Applied Pharmacology · Central nervous system effects · Cross-species extrapolation · n-Decane · Occupational exposure limits · PBPK model · Toxicokinetics · Trimethyl benzene · White spirit · 1,2,4 trimethylbenzene · decane · hydrocarbon · organic solvent · stoddard solvent · unclassified drug · adult · animal experiment · article · behavior · blood analysis · brain · central nervous system · cognition · controlled study · exposure · human · human experiment · in vitro study · lung alveolus · male · nonhuman · partition coefficient · priority journal · rat · toxicokinetics · validation study · Adult · Alkanes · Aniline Compounds · Animals · Behavior, Animal · Body Weight · Brain · Dose-Response Relationship, Drug · Humans · Hydrocarbons · Male · Models, Animal · Models, Biological · Rats · Rats, Wistar · Solvents · Time Factors · Tissue Distribution · Animalia · Rattus
[Abstract]

3 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

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