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1 Dose effects of ammonium perfluorooctanoate on Lipoprotein Metabolism in APOE*3-Leiden.CETP mice
article 2019    
Author: Pouwer, M.G. · Pieterman, E.J. · Chang, S.C. · Olsen, G.W. · Verschuren, L. · Jukema, J.W. · Princen, H.M.G.
Keywords: Health · Cholesterol · Lipoproteins · Non-HDL cholesterol · Perfluorooctanoic acid (PFOA) · Peroxisome proliferator-activated receptor (PPAR)α · Triglycerides · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

2 The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
article 2009    
Author: Hoorn, J.W.A. van der · Jukema, J.W. · Havekes, L.M. · Lundholm, E. · Camejo, G. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · 3Leiden.CETP mice · APOE · Atherogenic triad · Atherosclerosis · PPARα/γ · Tesaglitazar · 2 ethoxy 3 (4 ((4 (methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid · Alkanesulfonic acid · High density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor gamma · Phenylpropionic acid derivative · Very low density lipoprotein cholesterol · Biosynthesis · Blood · Drug potentiation · Genetics · Inflammation · Metabolism · Mouse · Mutation · Pathology · Transgenic mouse · Alkanesulfonates · Animals · Aortic Valve · Apolipoprotein E3 · Atherosclerosis · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Cholesterol, VLDL · Female · Humans · Inflammation · Mice · Mice, Transgenic · Mutation · Phenylpropionates · PPAR alpha · PPAR gamma
[Abstract]

3 Dual PPARα/γ agonist tesaglitazar reduces atherosclerosis in insulin-resistant and hypercholesterolemic ApoE*3Leiden mice
article 2006    
Author: Zadelaar, A.S.M. · Boesten, L.S.M. · Jukema, J.W. · Vlijmen, B.J.M. van · Kooistra, T. · Emeis, J.J. · Lundholm, E. · Camejo, G. · Havekes, L.M.
Keywords: Cholesterol · Inhibitors · Collagen · Immunoglobulin enhancer binding protein · Serum amyloid A · Tesaglitazar · 2 ethoxy 3 (4 ((4 (methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid · Alkanesulfonic acid · Apolipoprotein E3 (Leidein) · Biological marker · Lipoprotein · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor gamma · Phenylpropionic acid derivative · Animal cell · Animal experiment · Animal model · Animal tissue · Blood vessel wall · Cholesterol blood level · Controlled study · Diet · Enzyme activity · Monocyte · Mouse · Nonhuman · Protein blood level · Transgenic mouse · Blood · Cholesterol intake · Drug potentiation · Fat intake · Metabolism · Pathology · Pathophysiology · Alkanesulfonates · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Biological Markers · Blood Vessels · Cell Adhesion · Cholesterol · Cholesterol, Dietary · Collagen · Dietary Fats · Female · Hypercholesterolemia · Inflammation · Insulin Resistance · Lipids · Lipoproteins · Macrophages · Mice · Mice, Transgenic · Monocytes · NF-kappa B · Phenylpropionates · PPAR alpha · PPAR gamma
[Abstract]

4 Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: A randomised, crossover trial
article 2008    
Author: Joosten, M.M. · Beulens, J.W.J. · Kersten, S. · Hendriks, H.F.J.
Keywords: Biomedical Research · Adiponectin · Alcohol consumption · Gene expression · High molecular weight adiponectin · Insulin sensitivity · Lipid profile · Peroxisome proliferator-activated receptor gamma · Postmenopausal women · Alcohol · Low density lipoprotein cholesterol · Messenger RNA · Adiponectin gene · Adult · Alcohol consumption · Body mass · Cholesterol blood level · Controlled study · Correlation analysis · Gene · Gene expression · Grape juice · Homeostasis · Human experiment · Insulin resistance · Insulin sensitivity · Netherlands · Postmenopause · Protein blood level · Protein expression · Real time polymerase chain reaction · Statistical significance · Subcutaneous fat · Wine · Adiponectin · Alcohol Drinking · Cross-Over Studies · Female · Gene Expression Regulation · Humans · Insulin · Lipids · Middle Aged · Postmenopause · PPAR gamma · Random Allocation · Food and Nutrition · Healthy Living
[PDF] [Abstract]

5 Macrophage-specific inhibition of NF-κB activation reduces foam-cell formation
article 2007    
Author: Ferreira, V. · Dijk, K.W. van · Groen, A.K. · Vos, R.M. · Kaa, J. van der · Gijbels, M.J.J. · Havekes, L.M. · Pannekoek, H.
Keywords: Biology · Biomedical Research · ABCA1 mediated cholesterol efflux · Foam cell formation · Macrophage specific inhibition of NF-κB, IκBα · ox-LDL-PPARγ-CD36 "feed-forward cycle" · I kappa B kinase alpha · immunoglobulin enhancer binding protein · article · cell differentiation · cell line · cell specificity · controlled study · cytoplasm · foam cell · gene expression · human · human cell · lipid oxidation · lipid transport · monocyte · mouse · nonhuman · peritoneum cell · priority journal · protein degradation · protein expression · transgenic mouse · Animals · Antigens, CD36 · ATP-Binding Cassette Transporters · Cell Line · DNA-Binding Proteins · Foam Cells · Humans · I-kappa B Proteins · Lipoproteins, LDL · Macrophages · Mice · Mice, Inbred C57BL · NF-kappa B · PPAR gamma · Receptors, Cytoplasmic and Nuclear · Scavenger Receptors, Class A
[Abstract]

6 Leptin deficiency unmasks the deleterious effects of impaired peroxisome proliferator-activated receptor γ function (P465L PPARγ) in mice
article 2006    
Author: Gray, S.L. · Dalla Nora, E. · Grosse, J. · Manieri, M. · Stoeger, T. · Medina-Gomez, G. · Burling, K. · Wattler, S. · Russ, A. · Yeo, G.S.H. · Chatterjee, V.K. · O'Rahilly, S. · Voshol, P.J. · Cinti, S. · Vidal-Puig, A.
Keywords: Biology · Peroxisome proliferator activated receptor gamma · Adipose tissue · Animal cell · Animal experiment · Animal model · Animal tissue · Carbohydrate metabolism · Controlled study · Energy balance · Female · Gene expression · gene mutation · Homozygosity · Hyperphagia · Insulin resistance · Insulin sensitivity · Lipid metabolism · Lipid storage · Lipogenesis · Male · Metabolic disorder · Nonhuman · Obesity · Point mutation · Protein deficiency · Protein function · Tissue distribution · Tissue expansion · Blood · Genetics · Glucose blood level · Homozygote · Lethal gene · Metabolism · Mouse mutant · Pathology · Physiology · Adipose Tissue · Animals · Blood Glucose · Gene Expression Profiling · Genes, Lethal · Homozygote · Insulin · Insulin Resistance · Leptin · Lipid Metabolism · Mice · Mice, Obese · PPAR gamma
[Abstract]

7 Mouse models for atherosclerosis and pharmaceutical modifiers
article 2007    
Author: Zadelaar, A.S.M. · Kleemann, R. · Verschuren, L. · Vries-van der Weij, J. de · Hoorn, J. van der · Princen, H.M. · Kooistra, T.
Keywords: Biology · Biomedical Research · ACE inhibitors · AT1 receptor antagonists · Atherosclerosis · LXR · Mouse models · Pharmaceutical drugs · PPAR · Statins · atorvastatin · avasimibe · candesartan · captopril · cholesterol acyltransferase inhibitor · dipeptidyl carboxypeptidase inhibitor · hydralazine · hydroxymethylglutaryl coenzyme A reductase inhibitor · irbesartan · losartan · ly 465608 · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · olmesartan · perindopril · peroxisome proliferator activated receptor alpha agonist · pirinixic acid · pitavastatin · pravastatin · quinapril · ramipril · rosuvastatin · simvastatin · telmisartan · temocapril · unindexed drug · valsartan · zofenopril · antihypertensive agent · antilipemic agent · apolipoprotein E · atherosclerosis · pathophysiology · sensitivity and specificity · Animals · Antihypertensive Agents · Antilipemic Agents · Apolipoproteins E · Atherosclerosis · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Dyslipidemias · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypertension · Male · Mice · Mice, Knockout · Mice, Transgenic · Sensitivity and Specificity
[Abstract]

8 Innovative pharmaceutical interventions in cardiovascular disease: Focusing on the contribution of non-HDL-C/LDL-C-lowering versus HDL-C-raisingA systematic review and meta-analysis of relevant preclinical studies and clinical trials
article 2015    
Author: Kühnast, S. · Fiocco, M. · Hoorn, J.W.A. van der · Princen, H.M.G. · Jukema, J.W.
Keywords: Biology · 3Leiden.CETP mice · ABCA1 degradation inhibitors · APOE · Apolipoprotein A-I inducer · Apolipoprotein A-I Milano · Apolipoprotein A-I mimetic · Atherosclerosis · Cardiovascular disease · CETP inhibition · Clinical outcome · Clinical trials · Delipidated HDL · Fibrates · Glitazones · Hamster · HDL-cholesterol · LCAT · LDL-cholesterol · Mouse · Myocardial infarction · Niacin · Non-HDL-cholesterol · PPAR agonists · Rabbit · Reconstituted HDL · SR-BI inhibitor · Agents affecting lipid metabolism · ATP binding cassette A1 degradation inhibitor · Cardiovascular agent · Cholesterol ester transfer protein · Cholesterol ester transfer protein inhibitor · Dalcetrapib · Fibric acid derivative · Glitazar derivative · Glitazone derivative · High density lipoprotein cholesterol · Liver X receptor agonist · Low density lipoprotein cholesterol · Nicotinic acid · Peptide derivative · Peroxisome proliferator activated receptor agonist · Placebo · Receptor blocking agent · Scavenger receptor BI inhibitor · Unclassified drug · Adverse outcome · Cardiovascular risk · Cholesterol blood level · Clinical trial (topic) · Disease association · Drug effect · Drug targeting · Heart infarction · Human · Meta analysis · Mortality · Nonhuman · Protein expression · Randomized controlled trial (topic) · Risk management · Risk reduction · Systematic review · Treatment response · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 8 of 8 found. | Sort by date