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Showing 1 to 6 of 6 found. | Sort by date

1 The use of in vitro toxicity data and physiologically based kinetic modeling to predict dose-response curves for in vivo developmental toxicity of glycol ethers in rat and man
article 2010    
Author: Louisse, J. · Jong, E. de · Sandt, J.J.M. van de · Blaauboer, B.J. · Woutersen, R.A. · Piersma, A.H. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Nutrition · Biomedical Research · Benchmark dose · Developmental toxicity · Embryonic stem cell test · Glycol ethers · Physiologically based kinetic modeling
[Abstract]

2 Combining in vitro embryotoxicity data with physiologically based kinetic (PBK) modelling to define in vivo dose-response curves for developmental toxicity of phenol in rat and human
article 2013    
Author: Strikwold, M. · Spenkelink, B. · Woutersen, R.A. · Rietjens, I.M.C.M. · Punt, A.
Keywords: Biology · Alternative for animal testing · Embryonic stem cell test (EST) · In vitro-in vivo (IVIV) extrapolation · Phenol · Physiologically based kinetic (PBK) modelling · Risk assessment · Biomedical Innovation · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 A physiologically-based kinetic model for the prediction of plasma cholesterol concentrations in the mouse
article 2011    
Author: Pas, N.C.A. van de · Woutersen, R.A. · Ommen, B. van · Rietjens, I.M.C.M. · Graaf, A.A. de
Keywords: Biology · C · CE · cholesterol · cholesteryl ester · FC · free cholesterol · HDL · high density lipoprotein · knockout · KnockOut Mouse Data Inventory of cholesterol Phenotype · ko · KOMDIP · LDL · low density lipoprotein · PBK · physiologically based kinetic · TC · total plasma cholesterol · Life · MSB - Microbiology and Systems Biology · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Prediction of in vivo developmental toxicity of all‑trans‑retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2014    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, Y.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro-in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Food and Nutrition · Healthy Living · Life Triskelion BV · RAPID - Risk Assessment Products in Developmentv ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences TNO Bedrijven

5 Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2015    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro–in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Animalia · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · RAPID - Risk Analysis for Products in Development ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Predicting individual responses to pravastatin using a physiologically based kinetic model for plasma cholesterol concentrations
article 2014    
Author: Pas, N.C.A. van de · Rullmann, J.A.C. · Woutersen, R.A. · Ommen, B. van · Rietjens, I.M.C.M. · Graaf, A.A. de
Keywords: Biology · Cholesterol · LDL · PBK modeling · Personalized medicine · Statin response · Virtual subjects · cholesterol · High density lipoprotein cholesterol · Low density lipoprotein cholesterol · Low density lipoprotein receptor · Pravastatin · Very low density lipoprotein cholesterol · Cholesterol blood level · Cholesterol synthesis · Drug effect · Drug mechanism · Human · Kinetics · Major clinical study · Monte Carlo method · Physiologically based kinetic · Protein expression · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 6 of 6 found. | Sort by date