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Showing 1 to 13 of 13 found. | Sort by date

1 Influence of adrenoceptor blockade on endotoxin-induced histopathological changes in murine Meth A sarcoma
article 1982    
Author: Kuper, F. · Bloksma, N. · Hofhuis, F.M. · Bruyntjes, J.P. · Willers, J.M.
Keywords: Adrenergic receptor · Endotoxin · Phenoxybenzamine · Propranolol · Animal experiment · Cell protection · Histology · Mouse · Sarcoma · Adrenergic alpha-Antagonists · Adrenergic beta-Antagonists · Animal · Endotoxins · Mice · Mice, Inbred BALB C · Mitosis · Necrosis · Sarcoma, Experimental · Support, Non-U.S. Gov't · Sympatholytics
[Abstract]

2 Integration of two-dimensional LC-MS with multivariate statistics for comparative analysis of proteomic samples
article 2006    
Author: Gaspari, M. · Verhoeckx, K.C.M. · Verheij, E.R. · Greef, J. van der
Keywords: Pharmacology · Analytical research · Computer aided software engineering · Data handling · Data processing · Mass spectrometry · Polysaccharides · Proteins · Data preprocessing · Lipopolysaccharide · Multivariate statistical analysis · Liquid chromatography · antiinflammatory agent · beta 2 adrenergic receptor · biological marker · lipopolysaccharide · peptide · propranolol · proteome · unclassified drug · zilpaterol · article · automation · comparative study · controlled study · human · human cell · information processing · liquid chromatography · macrophage · mass spectrometry · model · multivariate analysis · nanoparticle · nucleotide sequence · principal component analysis · proteomics · Adrenergic beta-Antagonists · Amino Acid Sequence · Anti-Inflammatory Agents · Biological Markers · Chromatography, Liquid · Humans · Lipopolysaccharides · Macrophages · Mass Spectrometry · Molecular Sequence Data · Multivariate Analysis · Principal Component Analysis · Propranolol · Proteome · Proteomics · Receptors, Adrenergic, beta-2 · Reproducibility of Results · Trimethylsilyl Compounds · U937 Cells
[Abstract]

3 Endotoxin-induced liver damage in rats is minimized by β2- adrenoceptor stimulation
article 2004    
Author: Izeboud, C.A. · Hoebe, K.H.N. · Grootendorst, A.F. · Nijmeijer, S.M. · Miert, A.S. van · Witkamp, R.F. · Rodenburg, R.J.T.
Keywords: Biology Pharmacology · Physiological Sciences · Adrenoceptor agonists · Cytokines · Endotoxemia · Immunopharmacology · Liver-failure · alanine aminotransferase · aspartate aminotransferase · beta adrenergic receptor · bilirubin · clenbuterol · cytokine · endotoxin · interleukin 10 · interleukin 1beta · interleukin 6 · lipopolysaccharide · propranolol · tumor necrosis factor alpha · animal model · animal tissue · article · controlled study · enzyme linked immunosorbent assay · liver failure · liver injury · male · nonhuman · rat · Adrenergic beta-Agonists · Adrenergic beta-Antagonists · Alanine Transaminase · Animals · Aspartate Aminotransferases · Clenbuterol · Endotoxins · Inflammation · Interleukin-1 · Interleukin-10 · Interleukin-6 · Lipopolysaccharides · Liver · Liver Failure · Male · Osmolar Concentration · Propranolol · Rats · Rats, Wistar · Tumor Necrosis Factor-alpha
[Abstract]

4 Monolayers of IEC-18 cells as an in vitro model for screening the passive transcellular and paracellular transport across the intestinal barrier: Comparison of active and passive transport with the human colon carcinoma Caco-2 cell line
article 2002    
Author: Versantvoort, C.H.M. · Ondrewater, R.C.A. · Duizer, E. · Sandt, J.J.M. van de · Gilde, A.J. · Groten, J.P.
Keywords: Caco-2 · Carrier-mediated transport · H+-di/tripeptide carrier · IEC-18 · Intestinal cell lines · MRP · P-Glycoprotein · acetylsalicylic acid · calcein · carrier protein · dinitrophenylglutathione · glucose derivative · glutathione derivative · glycoprotein P · glycylsarcosine · hydrocortisone · macrogol 4000 · mannitol · methylglucose · multidrug resistance protein · probenecid · propranolol · rhodamine 123 · salicylic acid · testosterone · unclassified drug · verapamil · vincristine · animal cell · article · cell membrane permeability · cell strain CACO 2 · cell transport · colon carcinoma · controlled study · drug transport · human · human cell · in vitro study · ion transport · model · nonhuman · priority journal · protein expression · rat · screening
[Abstract]

5 Generic solid phase extraction-liquid chromatography-tandem mass spectrometry method for fast determination of drugs in biological fluids
article 2003    
Author: Schellen, A. · Ooms, B. · Lagemaat, D. van de · Vreeken, R. · Dongen, W.D. van
Keywords: Drugs Pharmacology · Analytical research · Drug analysis · Generic method · Body fluids · Drug products · Mass spectrometers · Solid phase extraction · High performance liquid chromatography · caffeine · carbamazepine · paclitaxel · paracetamol · procainamide · propranolol · ranitidine · sulfadiazine · sulfamerazine · theobromine · theophylline · accuracy · article · controlled study · drug blood level · drug determination · high performance liquid chromatography · human · linear system · physical chemistry · priority journal · quantitative analysis · solid phase extraction · tandem mass spectrometry · technique · time · Chromatography, High Pressure Liquid · Humans · Mass Spectrometry · Pharmaceutical Preparations · Reproducibility of Results · Sensitivity and Specificity · Spectrophotometry, Ultraviolet
[Abstract]

6 A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
article 2014    
Author: Westerhout, J. · Steeg, E. van de · Grossouw, D. · Zeijdner, E.E. · Krul, C.A.M. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Caco-2 · Food-effect · Human intestine · Intestinal absorption · InTESTine™ · Porcine intestine · Acebutolol · Atenolol · Candesartan · Cetirizine · Cimetidine · Ciprofloxacin · Diazepam · Digoxin · Famotidine · Hydrocortisone · Ibuprofen · Indometacin · Mannitol · Melagatran · Metoprolol · Mucin · Oxprenolol · Phenazone · Pindolol · Propranolol · Ranitidine · Salazosulfapyridine · Salicylic acid · Testosterone · Verapamil · Active transport · Animal tissue · CACO 2 cell line · Controlled study · Domestic pig · Drug absorption · Drug bioavailability · Drug penetration · Drug transport · Electric resistance · Ex vivo study · Female · Human · Human tissue · Intestine absorption · Intestine mucosa · Male · Nonhuman · Passive transport · Prediction · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

7 In vitro models for the prediction of in vivo performance of oral dosage forms
article 2014    
Author: Kostewicz, E.S. · Abrahamsson, B. · Brewster, M. · Brouwers, J. · Butler, J. · Carlert, S. · Dickinson, P.A. · Dressman, J. · Holm, R. · Klein, S. · Mann, J. · McAllister, M. · Minekus, M. · Muenster, U. · Müllertz, A. · Verwei, M. · Vertzoni, M. · Weitschies, W. · Augustijns, P.
Keywords: Biology · Biorelevant · In vitro evaluation · In vivo biopharmaceutical performance · Innovative Medicines Initiative (IMI) · Oral Biopharmaceutical Tools (OrBiTo) · Oral drug formulations · Albendazole · Amprenavir · Bile acid · Celecoxib · Cinnarizine · Cyclodextrin · Danazol · Diclofenac · Dipyridamole · Excipient · Gelucire · Ketoconazole · Loviride · Montelukast · Octanol · Propranolol · Saquinavir · Controlled drug release · Drug absorption · Drug bioavailability · Drug development · Drug dosage form · Drug formulation · Drug penetration · Drug solubility · Gastrointestinal motility · Human · Hydrodynamics · In vitro study · In vivo study · Lipolysis · Nonhuman · Precipitation · Prediction · Priority journal · Quality control · Review · Simulation · Tablet disintegration · Food and Nutrition · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Toxicogenomics directory of chemically exposed human hepatocytes
article 2014    
Author: Grinberg, M. · Stöber, R.M. · Edlund, K. · Rempel, E. · Godoy, P. · Reif, R. · Widera, A. · Madjar, K. · Schmidt-Heck, W. · Marchan, R. · Sachinidis, A. · Spitkovsky, D. · Hescheler, J. · Carmo, H. · Arbo, M.D. · Water, B. van de · Wink, S. · Vinken, M. · Rogiers, V. · Escher, S. · Hardy, B. · Mitic, D. · Myatt, G. · Waldmann, T. · Mardinoglu, A. · Damm, G. · Seehofer, D. · Nüssler, A. · Weiss, T.S. · Oberemm, A. · Lampen, A. · Schaap, M.M. · Luijten, M. · van Steeg, H. · Thasler, W.E. · Kleinjans, J.C.S. · Stierum, R.H. · Leist, M. · Rahnenführer, J. · Hengstler, J.G.
Keywords: Biology · Bioinformatics · Biomarker identification · Cirrhosis · Hepatocellular cancer · Hepatotoxicity · In vivo validation · SEURAT-1 · Steatosis · Toxicotranscriptomics · Unsupervised clustering · allyl alcohol · biological marker · chemical compound · cytochrome P450 1A1 · cytochrome P450 3A4 · galactosamine · isoniazid · ketoconazole · liver protein · paracetamol · propranolol · thyroid hormone · transcription factor · triazolam · valproic acid · binding site · cell stress · data base · down regulation · fatty liver · gene expression · gene ontology · human · liver cell · liver cell carcinoma · liver cirrhosis · liver disease · microarray analysis · mutation · nonalcoholic fatty liver · quantitative analysis · real time polymerase chain reaction · RNA extraction · toxicogenomics · transcriptomics · upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

9 In search of secreted protein biomarkers for the anti-inflammatory effect of β2-adrenergic receptor agonists: Application of DIGE technology in combination with multivariate and univariate data analysis tools
article 2005    
Author: Verhoeckx, K.C.M. · Gaspari, M. · Bijlsma, S. · Greef, J. van der · Witkamp, R.F. · Doornbos, R.P. · Rodenburg, R.J.T.
Keywords: Pharmacology · Analytical research · β2-adrenergic receptor · Difference gel electrophoresis · Macrophage inflammatory protein-1β · Multivariate data analysis · Partial least squares discriminant analysis · Principal component analysis · Zilpaterol · adenylate kinase · beta 2 adrenergic receptor · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · biological marker · butyryl cyclic AMP · clenbuterol · endotoxin · Escherichia coli lipopolysaccharide · formoterol · forskolin · heat shock protein · macrophage inflammatory protein 1alpha · macrophage inflammatory protein 1beta · phosphoglycerate mutase · propranolol · prostaglandin E2 · proteome · salbutamol · unclassified drug · zilpaterol · adrenergic system · analytic method · antiinflammatory activity · article · controlled study · data analysis · discriminant analysis · human · human cell · inflammation · liquid chromatography · macrophage · mass spectrometry · multivariate analysis · nucleotide sequence · principal component analysis · priority journal · protein expression · protein secretion · proteomics · statistical analysis · two dimensional difference gel electrophoresis · two dimensional gel electrophoresis · Adrenergic Agonists · Adrenergic beta-Antagonists · Anti-Inflammatory Agents · Biological Markers · Cluster Analysis · Down-Regulation · Electrophoresis, Gel, Two-Dimensional · Enzyme-Linked Immunosorbent Assay · Humans · Immunoassay · Inflammation · Lipopolysaccharides · Macrophage Inflammatory Protein-1 · Macrophages · Mass Spectrometry · Monocytes · Multivariate Analysis · Principal Component Analysis · Propranolol · Proteome · Proteomics · Receptors, Adrenergic, beta-2 · Statistics · Trimethylsilyl Compounds · U937 Cells · Up-Regulation · Escherichia coli
[Abstract]

10 Inhibitory effects of the β2-adrenergic receptor agonist zilpaterol on the LPS-induced production of TNF-α in vitro and in vivo
article 2005    
Author: Verhoeckx, K.C.M. · Doornbos, R.P. · Greef, J. van der · Witkamp, R.F. · Rodenburg, R.J.T.
Keywords: Biology Pharmacology · Analytical research · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · alprenolol · atenolol · bacterium lipopolysaccharide · beta 1 adrenergic receptor blocking agent · beta 2 adrenergic receptor blocking agent · beta 2 adrenergic receptor stimulating agent · clenbuterol · cyclic AMP · formoterol · isoprenaline · propranolol · salbutamol · tumor necrosis factor alpha · unclassified drug · zilpaterol · animal experiment · antiinflammatory activity · article · cattle · cell strain U937 · controlled study · cytokine production · dose response · drug effect · drug receptor binding · drug structure · human · human cell · inflammation · macrophage · male · nonhuman · priority journal · rat · rat strain · Adrenergic beta-Agonists · Animals · Cattle · Cyclic AMP · Dose-Response Relationship, Drug · Escherichia coli · Humans · Immunologic Factors · Lipopolysaccharides · Macrophage Activation · Male · Rats · Rats, Wistar · Trimethylsilyl Compounds · Tumor Necrosis Factor-alpha · U937 Cells · Animalia · Bacteria (microorganisms) · Bos taurus · Rattus norvegicus
[Abstract]

11 Xenobiotic metabolism in human skin and 3D human skin reconstructs: A review
article 2007    
Author: Gibbs, S. · Sandt, J.J.M. van de · Merk, H.F. · Lockley, D.J. · Pendlington, R.U. · Pease, C.K.
Keywords: Biology · 3D skin reconstructs · Cytochrome P450 · IDO expression · In vitro skin absorption · Microarray · Peptidases · 1 chloro 2,4 dinitrobenzene · 2 nitro 1,4 phenylenediamine · 4 aminophenol · alcohol dehydrogenase · aldehyde dehydrogenase · alpha tocopherol · atrazine · azo reductase · carnitine · cinnamaldehyde · cinnamyl alcohol · clobetasol propionate · cytochrome P450 · esterase · hydrogen peroxide · messenger RNA · nicotinic acid ethyl ester · oxygenase · phenylenediamine · propoxur · propranolol · resorufin · retinoic acid · retinol palmitate · T 2 toxin · toxic substance · triclosan · triolein · unindexed drug · xenobiotic agent · biotransformation · chemical carcinogenesis · environmental exposure · enzyme assay · ex vivo study · human · immunohistochemistry · in vitro study · nonhuman · Northern blotting · occupational exposure · protein expression · protein function · review · skin absorption · skin allergy · skin cancer · skin carcinogenesis · skin inflammation · skin sensitization · skin toxicity · toxicokinetics · Western blotting · xenobiotic metabolism · Biotransformation · Humans · Models, Biological · Skin · Xenobiotics
[Abstract]

12 Pharmacological modulation of the endotoxin-induced increase in plasminogen activator inhibitor activity in rats
article 1992    
Author: Emeis, J.J. · Hoogen, C.M. van den
Keywords: 2 (3,4 dihydro 3,4 dioxo 1 naphthylamino)benzoic acid methyl ester · 2,3 diethyl 4 methoxy 1 naphthol acetate · 3 [3 tert butylthio 1 (4 chlorobenzyl) 5 isopropyl 2 indolyl] 2,2 dimethylpropionic acid · 3 amino 1 (3 trifluoromethylphenyl) 2 pyrazoline · Acetylsalicylic acid · Argipressin[1 (3,3 cyclopentamethylene 3 mercaptopropionic acid) 2 (2 methyltyrosine)] · Cycloheximide · Dexamethasone · Diltiazem · Endotoxin · Forskolin · Ginkgolide b · Heparin · Hirudin · Indometacin · Isobutylmethylxanthine · Mepyramine maleate · n (3 phenoxy 3 phenylallyl)acetohydroxamic acid · n [3 (3 phenoxyphenyl)allyl]acetohydroxamic acid · n(g) nitroarginine methyl ester · Naloxone · Phentolamine · Phentolamine mesylate · Propranolol · Unclassified drug · Verapamil · Animal experiment · Controlled study · Fibrinolysis · Intraperitoneal drug administration · Intravenous drug administration · Nonhuman · Oral drug administration · Pharmacology · 1-Methyl-3-isobutylxanthine · Animal · Aspirin · BW-755C · Dose-Response Relationship, Drug · Enzyme Activation · Indomethacin · Lipopolysaccharides · Male · Plasminogen Activator Inhibitor 1 · Rats · Rats, Wistar · Tissue Plasminogen Activator
[Abstract]

13 Development of an on-line high performance liquid chromatography detection system for human cytochrome P450 1A2 inhibitors in extracts of natural products
article 2007    
Author: Jeurissen, S.M.F. · Claassen, F.W. · Havlik, J. · Bouwmans, E.E. · Cnubben, N.H.P. · Sudhölter, E.J.R. · Rietjens, I.M.C.M. · Beek, T.A. van
Keywords: Biomedical Research · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · Bioassay · Cytology · Enzyme inhibition · Fluorescence · Metabolites · Screening · Methoxyresorufin-O-demethylase · Mixture analysis · On-line detection · P450 1A2 inhibitors · High performance liquid chromatography · basil extract · cytochrome P450 1A2 · cytochrome P450 1A2 inhibitor · cytochrome P450 inhibitor · fluvoxamine · furafylline · kava extract · methoxyresorufin · naringenin · natural product · plant extract · propranolol · resorufin · resorufin derivative · tacrine · article · assay · basil · demethylation · fluorescence · high performance liquid chromatography · metabolite · methoxyresorufin O demethylation assay · minimum detectable amount · online analysis · parameter · priority journal · screening · Biological Products · Chromatography, High Pressure Liquid · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Humans · Inhibitory Concentration 50 · Kava · Methanol · Ocimum basilicum · Online Systems · Oxidoreductases · Plant Extracts · Spectrometry, Fluorescence · Spectrophotometry, Ultraviolet · Ocimum basilicum · Piper methysticum
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date