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Showing 1 to 12 of 12 found. | Sort by date

1 A pilot study to investigate effects of inulin on Caco-2 cells through in vitro metabolic fingerprinting
article 2003    
Author: Lamers, R.-J.A.N. · Wessels, E.C.H.H. · Sandt, J.J.M. van de · Venema, K. · Schaafsma, G. · Greef, J. van der · Nesselrooij, J.H.J. van
Keywords: Nutrition Packaging · Analytical research · 1H NMR spectroscopy · Metabolic fingerprinting · Biochemical marker · Cell culture · Cell metabolism · Cell strain CACO 2 · Chemical analysis · Controlled study · Experimental model · Glucose metabolism · Health status · Human cell · In vitro study · In vivo study · Laboratory test · Multivariate analysis · Nutrition · Pilot study · Proton nuclear magnetic resonance · Alanine · Analysis of Variance · Caco-2 Cells · Colon · Fermentation · Glucose · Glutamic Acid · Humans · Inulin · Ketoglutaric Acids · Lactic Acid · Magnetic Resonance Spectroscopy · Niacin · Niacinamide · Proline · Succinic Acid
[Abstract]

2 Of monkeys and men: A metabolomic analysis of static and dynamic urinary metabolic phenotypes in two species
article 2014    
Author: Saccenti, E. · Tenori, L. · Verbruggen, P. · Timmerman, M.E. · Bouwman, J. · Greef, J. van der · Luchinat, C. · Smilde, A.K.
Keywords: Biology · 1 methylhistidine · Atrolactic acid · Creatinine · Glycine · Histidine derivative · Meta hydroxyphenyl propionic acid · Phenylacetylglycine · Trimethylamine oxide · Unclassified drug · Adult · Correlational study · Female · Genetic similarity · Genetic variability · Human versus animal comparison · Male · Metabolic regulation · Metabolomics · Nonhuman · Normal human · Nuclear magnetic resonance spectroscopy · Phenotype · Phenotypic variation · Prediction · Proton nuclear magnetic resonance · Rhesus monkey · Species difference · Species diversity · Urinalysis · Urine · Young adult · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

3 Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in caco-2 cells
article 2007    
Author: Usta, M. · Wortelboer, H.M. · Vervoort, J. · Boersma, M.G. · Rietjens, I.M.C.M. · Bladeren, P.J. van · Cnubben, N.H.P.
Keywords: Biology · Toxicology and Applied Pharmacology · curcumin · glutathione transferase · adult · aged · article · atom · catalysis · cell strain CACO 2 · conjugate · drug degradation · drug excretion · drug structure · female · glutathione metabolism · human · human cell · human tissue · intestine · intestine epithelium cell · liquid chromatography · liver cytosol · male · mass spectrometry · monolayer culture · proton nuclear magnetic resonance · Adult · Aged · Caco-2 Cells · Curcumin · Cytosol · Female · Glutathione · Glutathione Transferase · Humans · Intestines · Liver · Magnetic Resonance Spectroscopy · Male · Metabolic Detoxication, Phase II · Middle Aged · Molecular Structure
[Abstract]

4 Multilevel component analysis of time-resolved metabolic fingerprinting data
article 2005    
Author: Jansen, J.J. · Hoefsloot, H.C.J. · Greef, J. van der · Timmerman, M.E. · Smilde, A.K.
Keywords: Biology · Analytical research · Biorhythms · NMR · Principal component analysis · Types of variation · Urinalysis · Data reduction · Genes · Information analysis · Nuclear magnetic resonance · Principal component analysis · Fingerprinting data · Multilevel component analysis (MCA) · Systems biology · Metabolism · Biological rhythm · Controlled study · Data analysis · Female · Genetic database · Genomics · Intermethod comparison · Male · Metabolomics · Monkey · Multilevel component analysis · Multivariate analysis · Nonhuman · Principal component analysis · Priority journal · Proton nuclear magnetic resonance · Statistical model · Urinalysis · Animalia
[Abstract]

5 Identification of disease- and nutrient-related metabolic fingerprints in osteoarthritic guinea pigs
article 2003    
Author: Lamers, R.-J.A.N. · Groot, J. de · Spies-Faber, E.J. · Jellema, R.H. · Kraus, V.B. · Verzijl, N. · Koppele, J.M. te · Spijksma, G.K. · Vogels, J.T.W.E. · Greef, J. van der · Nesselrooij, J.H.J. van
Keywords: Biology · Analytical research · Biomedical research · 1H NMR spectroscopy · Metabolic fingerprinting · Multivariate data analysis · Osteoarthritis · Vitamin C · ascorbic acid · biological marker · purine · animal experiment · animal model · article · controlled study · data analysis · dietary intake · disease marker · energy metabolism · guinea pig · inbred strain · male · metabolic fingerprint · metabolism · metabolite · multivariate analysis · nonhuman · nutrient · nutrition · osteoarthritis · pathophysiology · proton nuclear magnetic resonance · purine metabolism · strain difference · urinalysis · vitamin intake · Animal Nutrition Physiology · Animals · Ascorbic Acid · Diet · Dose-Response Relationship, Drug · Energy Metabolism · Guinea Pigs · Magnetic Resonance Spectroscopy · Male · Multivariate Analysis · Osteoarthritis · Peptide Mapping · Purines · Treatment Outcome · Animalia · Cavia · Cavia porcellus · Sus scrofa
[Abstract]

6 1H-NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical patterns in urines of MS patients and non-human primates with MS-like disease
article 2003    
Author: Hart, B.A. 't · Vogels, J.T.W.E. · Spijksma, G. · Brok, H.P.M. · Polman, C. · Greef, J. van der
Keywords: Biology · Analytical research · Inflammatory demyelination · MS disease markers · NMR spectroscopy · Pattern recognition · Urine · myelin protein · organic compound · glycoprotein · tritium · animal model · article · autoimmune disease · chemical composition · clinical article · controlled study · disease course · encephalomyelitis · female · human · male · marmoset · molecular recognition · multiple sclerosis · multivariate analysis · nonhuman · primate · priority journal · proton nuclear magnetic resonance · urinalysis · validation process · allergic encephalomyelitis · animal · automated pattern recognition · chemistry · comparative study · disease model · immunization · immunology · methodology · nuclear magnetic resonance spectroscopy · species difference · time · urine · Animals · Callithrix · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Female · Glycoproteins · Humans · Immunization · Magnetic Resonance Spectroscopy · Male · Multiple Sclerosis · Multivariate Analysis · Myelin Proteins · Pattern Recognition, Automated · Species Specificity · Time Factors · Tritium · Urine
[Abstract]

7 Sensitivity of 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: Dose-dependent toxic fffects of Bromobenzene and paracetamol
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.P.H.T.M. · Horbach, G.J. · Smit, M.J. · Zandberg, P. · Mellema, J.R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Biomarkers · Bromobenzene · Hepatotoxicity · Metabonomics · Necrosis · Paracetamol · Urinalysis · alanine aminotransferase · aspartate aminotransferase · biological marker · bromobenzene · paracetamol · alanine aminotransferase blood level · animal experiment · animal tissue · article · aspartate aminotransferase blood level · clinical chemistry · controlled study · diagnostic accuracy · diagnostic value · dose response · drug blood level · drug urine level · early diagnosis · histopathology · intermethod comparison · liver dysfunction · liver necrosis · liver toxicity · male · non invasive measurement · nonhuman · pattern recognition · principal component analysis · proton nuclear magnetic resonance · rat · sensitivity analysis · spectrometer · urinalysis · Acetaminophen · Alanine Transaminase · Analgesics, Non-Narcotic · Animals · Aspartate Aminotransferases · Bromobenzenes · Dose-Response Relationship, Drug · Hepatitis, Toxic · Kidney · Liver · Magnetic Resonance Spectroscopy · Necrosis · Principal Component Analysis · Rats · Rattus
[Abstract]

8 Non-invasive measurement of brain damage in a primate model of multiple sclerosis
article 2004    
Author: T Hart, B.A. · Vogels, J. · Bauer, J. · Brok, H.P.M. · Blezer, E.
Keywords: Biology Health · Analytical research · myelin · allergic encephalomyelitis · brain injury · chemometric analysis · demyelination · diagnostic imaging · human · immunopathology · marmoset · multiple sclerosis · neurologic disease · neuropathology · non invasive measurement · nonhuman · nuclear magnetic resonance imaging · nuclear magnetic resonance spectroscopy · pattern recognition · positron emission tomography · proton nuclear magnetic resonance · review · urinalysis · white matter · X ray analysis · Animals · Animals, Outbred Strains · Antigens, CD · Biological Markers · Brain · Callithrix · CD4-Positive T-Lymphocytes · Chronic Disease · Demyelinating Diseases · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Genes, MHC Class II · Humans · Magnetic Resonance Imaging · Magnetic Resonance Spectroscopy · Mice · Multiple Sclerosis · Myelin Basic Proteins · Myelin-Associated Glycoprotein · T-Lymphocytes, Cytotoxic · Th2 Cells · Animalia · Callithrix · Callithrix jacchus · marmosets · Primates · Rodentia
[Abstract]

9 Uniform procedure of 1H NMR analysis of rat urine and toxicometabonomics Part II : Comparison of NMR profiles classification of hepatotoxicity
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.-P.H.T.M. · Smit, M.J. · Zandberg, P. · Horbach, G.J. · Mellema, J.-R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Cholestasis · Hepatotoxicity · Metabonomics · Necrosis · NMR · Steatosis · Urinalysis · 1 naphthyl isothiocyanate · biological marker · bromobenzene · carbon tetrachloride · chlorpromazine · ethinylestradiol · ibuprofen · iproniazid · isoniazid · methyltestosterone · mianserin · paracetamol · phenobarbital · placebo · tetracycline · thioacetamide · animal experiment · animal tissue · article · controlled study · diagnostic accuracy · diagnostic value · drug blood level · drug urine level · early diagnosis · fatty liver · histopathology · intermethod comparison · intrahepatic cholestasis · liver necrosis · liver toxicity · male · nonhuman · pattern recognition · prediction · principal component analysis · proton nuclear magnetic resonance · rat · urinalysis · Animals · Biological Markers · Cholestasis · Fatty Liver · Hepatitis, Toxic · Liver · Magnetic Resonance Spectroscopy · Male · Necrosis · Pattern Recognition, Automated · Principal Component Analysis · Rats · Rats, Wistar · Urine · Animalia · Rattus
[Abstract]

10 Protein adduct formation by glucuronide metabolites of permethrin
article 2008    
Author: Noort, D. · Zuylen, A. van · Fidder, A. · Ommen, B. van · Hulst, A.G.
Keywords: Nutrition · 3 (2,2 dichlorovinyl) 2,2 dimethylcyclopropane 1 carboxylic acid · 3 phenoxybenzoic acid · Albumin · Amino acid · Benzoic acid derivative · Carboxylic acid derivative · Glucuronide · Lysine derivative · Peptide · Permethrin · Pronase · Article · Biological monitoring · Chemical structure · Complex formation · Covalent bond · Crug conjugation · Enzyme synthesis · Liquid chromatography · Metabolite · Protein adduct · Protein binding · Proton nuclear magnetic resonance · Radioactivity · Synthesis · Tandem mass spectrometry · Chromatography, High Pressure Liquid · Environmental Monitoring · Glucuronides · Humans · Insecticides · Lysine · Magnetic Resonance Spectroscopy · Microsomes, Liver · Permethrin · Pesticide Residues · Protein Binding · Serum Albumin · Spectrometry, Mass, Electrospray Ionization · Tandem Mass Spectrometry · Chemicals · 3 phenoxybenzoic acid, 3739-38-6 · Amino acid, 65072-01-7 · Permethrin, 51877-74-8, 52645-53-1 · Pronase, 9036-06-0 · Glucuronides · Insecticides · Lysine, 56-87-1 · Permethrin, 52645-53-1 · Pesticide residues · Serum albumin
[Abstract]

11 Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology
article 2005    
Author: Wang, M. · Lamers, R.J.A.N. · Korthout, H.A.A.J. · Nesselrooij, J.H.J. van · Witkamp, R.F. · Heijden, R. van der · Voshol, P.J. · Havekes, L.M. · Verpoorte, R. · Greef, J. van der
Keywords: Health Pharmacology · Analytical research · Metabolomics · Systems biology · Traditional Chinese Medicine (TCM) · 5' methoxyhdnocarpin · Alanine aminotransferase · Alkaloid · Apolipoprotein E · Berberine · Biflavonoid · Bilobalide · Cannabidiol · Cannabis · Chaconine · Cholesterol · Flavonoid · Ginkgo biloba extract · Ginkgolide · Glucoside · Herbaceous agent · Insulin · Low density lipoprotein · Plant extract · Prodrug · Salicylic acid · Saligenin · Saponin · Solanine · Tetrahydrocannabinol · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Alanine aminotransferase blood level · Animal experiment · Animal model · Atherosclerosis · Bark · Blood flow · Chinese medicine · Clinical pharmacology · Controlled study · Data analysis · DNA microarray · Drug effect · Drug efficacy · Drug potentiation · Drug research · Drug safety · Drug targeting · Female · Ginkgo biloba · Headache · Herbal medicine · High performance liquid chromatography · Human · Human experiment · Insulin resistance · Insulin sensitivity · Ion cyclotron resonance mass spectrometry · Lipid metabolism · Liver function · Male · Mass spectrometry · Medicinal plant · Metabolic syndrome X · Metabolite · Molecular pharmacology · Nonhuman · Nuclear magnetic resonance spectroscopy · Pain · Phytotherapy · Plant leaf · Proton nuclear magnetic resonance · Rat · Thin layer chromatography · Traditional medicine · Willow · Drugs, Chinese Herbal · Humans · Pharmacology · Phytotherapy
[Abstract]

12 Evaluation of metabolite profiles as biomarkers for the pharmacological effects of thiazolidinediones in type 2 diabetes mellitus patients and healthy volunteers
article 2007    
Author: Doorn, M. van · Vogels, J. · Tas, A. · Hoogdalem, E.J. van · Burggraaf, J. · Cohen, A. · Greef, J. van der
Keywords: Biology · Analytical research · Biomarkers · Diabetes · Metabolomics · Metabonomics · NMR · 2,4 thiazolidinedione derivative · alanine · aromatic amino acid · biological marker · branched chain amino acid · citric acid · glutamic acid · glutamine · hippuric acid · lipid · phosphoenolpyruvate · placebo · rosiglitazone · adult · aged · amino acid blood level · amino acid urine level · article · clinical article · clinical trial · controlled clinical trial · controlled study · diabetic patient · double blind procedure · drug effect · drug mechanism · evaluation · female · finger dermatoglyphics · gender · human · lipid blood level · male · metabolic disorder · metabolite · metabolomics · multivariate analysis · non insulin dependent diabetes mellitus · plasma · priority journal · proton nuclear magnetic resonance · randomized controlled trial · urinalysis · volunteer · Adult · Aged · Biological Markers · Blood Glucose · Diabetes Mellitus, Type 2 · Double-Blind Method · Female · Humans · Hypoglycemic Agents · Magnetic Resonance Spectroscopy · Male · Middle Aged · Principal Component Analysis · Thiazolidinediones
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 12 of 12 found. | Sort by date