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1 Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin
article 2008    
Author: Haan, W. de · Vries-van der Weij, J. de · Hoorn, J.W.A. van der · Gautier, T. · Hoogt, C.C. van der · Westerterp, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Atherosclerosis · Cholesteryl ester transfer proteins · Drugs · Lipids · Lipoproteins · Apolipoprotein E · Atorvastatin · Cholesterol · Cholesterol ester transfer protein · Collagen · High density lipoprotein cholesterol · Monocyte chemotactic protein 1 · Torcetrapib · Atherosclerosis · Cholesterol blood level · Drug activity · Evaluation · Female · Inflammation · Macrophage · Monocyte · Mouse · Nonhuman · Phenotype · Sham feeding · Statistical significance · Animals · Atherosclerosis · Cholesterol Ester Transfer Proteins · Drug Synergism · Heptanoic Acids · Inflammation · Mice · Mice, Inbred Strains · Pyrroles · Quinolines
[PDF] [Abstract]

2 A novel pyrroleninone cross-link from bovine dentine
article 1998    
Author: Kleter, G.A. · Damen, J.J.M. · Kettenes-Bosch, J.J. van den · Bank, R.A. · Koppele, J.M. te · Veraart, J.R. · Cate, J.M. ten
Keywords: Nutrition · Collagen · Cow · Cross-linking amino acid · Dentine · Amino acid · Hydroxylysine · Pyridinoline · Pyridone derivative · Reagent · Cattle · Chemical structure · Cross linking · Dentin · Gel permeation chromatography · Ion exchange chromatography · Nonhuman · Nuclear magnetic resonance spectroscopy · Priority journal · Amino Acids · Animals · Cattle · Chromatography, Ion Exchange · Collagen · Cross-Linking Reagents · Dentin · Electrophoresis, Capillary · Magnetic Resonance Spectroscopy · Mass Spectrometry · Molecular Structure · Pyrroles
[Abstract]

3 Analysis of coagulation cascade and endothelial cell activation during inhibition of vascular endothelial growth factor/vascular endothelial growth factor receptor pathway in cancer patients
article 2002    
Author: Kuenen, B.C. · Levi, M. · Meijers, J.C.M. · Kakkar, A.K. · Hinsbergh, V.W.M. van · Kostense, P.J. · Pinedo, H.M. · Hoekman, K.
Keywords: Angiogenesis Inhibitors · Blood Coagulation · Blood Platelets · Carcinoma, Renal Cell · Cell Division · Cell Membrane Permeability · Cell Movement · Drug Administration Schedule · Endothelium, Vascular · Fibrinolysis · Hemostasis · Indoles · Kidney Neoplasms · Melanoma · Neovascularization, Pathologic · Protein C · Proto-Oncogene Proteins · Pyrroles · Receptor Protein-Tyrosine Kinases · Receptors, Growth Factor · Receptors, Vascular Endothelial Growth Factor · Sarcoma · Thrombin · Vascular Endothelial Growth Factor Receptor-1
[Abstract]

4 Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice
article 2003    
Author: Delsing, D.J.M. · Jukema, J.W. · Wiel, M.A. van de · Emeis, J.J. · Laarse, A. van der · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Atherosclerosis · Calcification · Calcium antagonists · Inflammation · Statins · Amlodipine · Atorvastatin · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Very low density lipoprotein cholesterol · Animal model · Animal tissue · Aorta root · Cholesterol blood level · Cholesterol diet · Controlled study · Drug effect · Inflammation · Mouse · Nonhuman · Amlodipine · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Blood Pressure · Calcium Channel Blockers · Cholesterol · Cholesterol, Dietary · Drug Therapy, Combination · Female · Heptanoic Acids · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Mice · Mice, Transgenic · Pyrroles
[Abstract]

5 Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.
article 2003    
Author: Ree, M.A. van de · Maat, M.P. de · Kluft, C. · Meinders, A.E. · Princen, H.M. · Huisman, M.V.
Keywords: Atorvastatin · Blood clotting factor 8a · Hemostatic agent · Heptanoic acid derivative · Biosynthesis · Blood · Cardiovascular disease · Clinical trial · Controlled clinical trial · Controlled study · Dose response · Double blind procedure · Non insulin dependent diabetes mellitus · Pathology · Randomized controlled trial · Time · Aged · Cardiovascular Diseases · Diabetes Mellitus, Type 2 · Dose-Response Relationship, Drug · Double-Blind Method · Factor VIIIa · Female · Fibrinogen · Hemostatics · Heptanoic Acids · Humans · Hyperlipidemias · Male · Middle Aged · Placebos · Pyrroles · Risk Factors · Time Factors · Tissue Plasminogen Activator · von Willebrand Factor
[Abstract]

6 Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins
article 2008    
Author: Bergheanu, S.C. · Reijmers, T. · Zwinderman, A.H. · Bobeldijk, I. · Ramaker, R. · Liem, A.-H. · Greef, J. van der · Hankemeier, T. · Jukema, J.W.
Keywords: Biology · Atorvastatin · Cardiovascular risk · Phosphatidylcholines · Rosuvastatin · Sphingomyelins · Atorvastatin · Cholesterol · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Low density lipoprotein cholesterol · Phosphatidylcholine · Rosuvastatin · Sphingomyelin · Triacylglycerol · Adult · Aged · Article · Cardiovascular risk · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Coronary artery disease · Drug dose increase · Drug efficacy · Drug megadose · Female · Human · Lipid blood level · Lipid metabolism · Lipidomics · Liquid chromatography · Low drug dose · Major clinical study · Male · Mass spectrometry · Multicenter study · Phase 3 clinical trial · Randomized controlled trial · Therapy effect · Treatment outcome · Chromatography, Liquid · Dose-Response Relationship, Drug · Fluorobenzenes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Mass Spectrometry · Prospective Studies · Pyrimidines · Pyrroles · Sulfonamides
[Abstract]

7 Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects
article 2006    
Author: Doorn, M.B.A. van · Espirito Santo, S.M. · Meijer, P. · Kamerling, I.M. · Schoemaker, R.C. · Dirsch, V. · Vollmar, A. · Haffner, T. · Gebhardt, R. · Cohen, A.F. · Princen, H.M. · Burggraaf, J.
Keywords: Biomedical Research · CRP · Endothelial function · atorvastatin · biological marker · C reactive protein · garlic extract · low density lipoprotein cholesterol · placebo · printanor · triacylglycerol · tumor necrosis factor alpha · abdominal discomfort · cardiovascular disease · cardiovascular risk · cell function · cholesterol blood level · clinical trial · controlled clinical trial · controlled study · double blind procedure · drug effect · inflammation · lipid blood level · lipid metabolism · major clinical study · obesity · patient compliance · protein blood level · randomized controlled trial · side effect · smoking · triacylglycerol blood level · unspecified side effect · Adult · Aged · Analysis of Variance · Anticholesteremic Agents · Biological Markers · C-Reactive Protein · Cholesterol · Cholesterol, HDL · Cholesterol, LDL · Double-Blind Method · Endothelium · Female · Garlic · Heptanoic Acids · Humans · Lipids · Male · Middle Aged · Overweight · Plant Extracts · Powders · Pyrroles · Smoking · Triglycerides · Allium sativum
[Abstract]

8 Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
article 2005    
Author: Verschuren, L. · Kleemann, R. · Offerman, E.H. · Szalai, A.J. · Emeis, S.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Biomedical Research · Growth factors · Lipids · Lipoprotein metabolism · Pathophysiology · C reactive protein · Cholesterol · Gelatinase B · Macrophage migration inhibition factor · Plasminogen activator inhibitor 1 · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · animal model · Antiinflammatory activity · Aorta arch · Cholesterol blood level · Cholesterol diet · Controlled study · Dietary intake · Disease activity · Disease course · Disease severity · Inflammation · Lipoprotein metabolism · Low drug dose · Macrophage · Monocyte · Mouse · Nonhuman · Pathophysiology · Protein expression · Smooth muscle fiber · Transgenic mouse · Treatment outcome · Amyloid A protein · Apolipoprotein E3 · Atorvastatin · Animals · Anticholesteremic Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Biological Markers · C-Reactive Protein · Cholesterol · Diet · Diet, Atherogenic · Drug Administration Schedule · Female · Heptanoic Acids · Inflammation · Male · Mice · Mice, Transgenic · Pyrroles · Serum Amyloid A Protein
[Abstract]

9 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
article 2008    
Author: Haan, W. de · Hoogt, C.C. van der · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Princen, H.M.G. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · CETP · High-density lipoprotein · HMGCoA reductase · Statin · Transgenic mice · ABC transporter A1 · apolipoprotein A1 · apolipoprotein E3 · atorvastatin · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · messenger RNA · phospholipid transfer protein · scavenger receptor BI · very low density lipoprotein · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · cholesterol diet · controlled study · drug effect · gene expression · hypercholesterolemia · lipoprotein blood level · lipoprotein metabolism · male · mouse · nonhuman · priority journal · protein expression · transgenic mouse · Animals · Apolipoprotein E3 · Cholesterol Ester Transfer Proteins · Cholesterol, Dietary · Cholesterol, HDL · Cholesterol, VLDL · Dose-Response Relationship, Drug · Female · Gene Expression · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypercholesterolemia · Liver · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Pyrroles · RNA, Messenger
[Abstract]

10 Evidence for anti-inflammatory activity of statins and PPARα activators in human C-reactive protein transgenic mice in vivo and in cultured human hepatocytes in vitro
article 2004    
Author: Kleemann, R. · Verschuren, L. · Rooij, B.J. de · Lindeman, J. · Maat, M.M.de · Szalai, A.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biomedical Research · Antilipemic agent · C reactive protein · CCAAT enhancer binding protein · Cholesterol · Fenofibrate · Hydroxymethylglutaryl coenzyme A reductase inhibitor · I kappa B alpha · Immunoglobulin enhancer binding protein · Interleukin 1beta · Peroxisome proliferator activated receptor agonist · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor alpha agonist · Pirinixic acid · Protein p50 · Unclassified drug · Animal experiment · Animal model · Animal tissue · Antiinflammatory activity · Atherogenesis · Atherosclerosis · Cardiovascular risk · Cell culture · Cholesterol blood level · Controlled study · Hepatoma cell · Human cell · Inflammation · Liver cell · Mouse · Nonhuman · Transgenic mouse · Animals · C-Reactive Protein · Carcinoma, Hepatocellular · CCAAT-Enhancer-Binding Proteins · Cell Line, Tumor · Cholesterol · Down-Regulation · Gene Expression · Hepatocytes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · I-kappa B Proteins · Interleukin-1 · Male · Mice · Mice, Transgenic · NF-kappa B · NF-kappa B p50 Subunit · Pyrroles · Receptors, Cytoplasmic and Nuclear · Simvastatin · Transcription Factors · Up-Regulation
[Abstract]

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Showing 1 to 10 of 10 found. | Sort by date