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1 Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.
article 2005    
Author: Cnubben, N.H. · Wortelboer, H.M. · Zanden, J.J. van · Rietjens, I.M. · Bladeren, P.J. van
Keywords: Health Pharmacology · Physiological Sciences · ABC transporter · cyclosporin derivative · dibenzo[a,d]cycloheptene derivative · glycoprotein P · quinoline derivative · valspodar · zosuquidar · drug antagonism · drug design · drug effect · genetics · human · metabolism · multidrug resistance · review · RNA interference · transport at the cellular level · ATP-Binding Cassette Transporters · Biological Transport · Cyclosporins · Dibenzocycloheptenes · Drug Design · Drug Resistance, Multiple · Humans · P-Glycoproteins · Quinolines · RNA Interference
[Abstract]

2 Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
article 2006    
Author: Kitayama, K. · Nakai, D. · Kono, K. · Hoop, A.G. van der · Kurata, H. · Wit, E.C. de · Cohen, L.H. · Inaba, T. · Kohama, T.
Keywords: Biology · Apical sodium-dependent bile acid transporter · Cholesterol · Enterohepatic circulation · Hamster · Hypocholesterolemic agent · Monkey · Carbon 14 · Cholesterol · High density lipoprotein cholesterol · Ileum apical bile acid transporter inhibitor · Phospholipid · Piperidine derivative · R 146224 · Taurocholic acid · Triacylglycerol · Tritium · Unclassified drug · Bile acid · Carrier protein · Cotransporter · Organic anion transporter · Quinoline derivative · Sodium · Sodium bile acid cotransporter · Sodium-bile acid cotransporter · Absorption · Animal experiment · Animal tissue · Bile duct fistula · Bile flow · Cholesterol blood level · Cholesterol esterification · Concentration response · Controlled study · Diet · Dose response · Drug mechanism · Embryo · Feeding · Human cell · Hypercholesterolemia · Hypolipemia · Inhibition kinetics · Time · Triacylglycerol blood level · Urinary excretion · Biosynthesis · Blood · Cell line · Drug antagonism · Drug effect · Genetics · In vitro study · Macaca · Metabolism · Physiology · Sprague Dawley rat · Syrian hamster · Animals · Anticholesteremic Agents · Bile Acids and Salts · Cell Line · Cholesterol · Cricetinae · Humans · Ileum · Macaca fascicularis · Male · Membrane Transport Proteins · Mesocricetus · Organic Anion Transporters, Sodium-Dependent · Piperidines · Quinolines · Rats · Rats, Sprague-Dawley · Sodium · Symporters · Taurocholic Acid
[Abstract]

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