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1 Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics
article 2009    
Author: Wang, J. · Reijmers, T. · Chen, L. · Heijden, R. van der · Wang, M. · Peng, S. · Hankemeier, T. · Xu, G. · Greef, J. van der
Keywords: Biology · Physiological Sciences · Doxorubicin · FTMS · Metabolomics · Systems toxicology · UPLC-MS · Rattus
[Abstract]

2 Applications of a new subspace clustering algorithm (COSA) in medical systems biology
article 2007    
Author: Damian, D. · Orešič, M. · Verheij, E. · Meulman, J. · Friedman, J. · Adourian, A. · Morel, N. · Smilde, A. · Greef, J.
Keywords: Health · Analytical research · Biomarkers · COSA · Lipidomics · Metabolic syndrome · Metabolomics · Subspace clustering · Translational research · ZDF rats · Zucker rats · Animalia · Rattus
[Abstract]

3 Developmental toxicity study of vegetable oil-derived stanol fatty acid esters
article 1999    
Author: Slesinski, R.S. · Turnbull, D. · Frankos, V.H. · Wolterbeek, A.P.M. · Waalkens-Berendsen, D.H.
Keywords: Nutrition · Animals · Esters · Fatty Acids · Female · Fetus · Male · Phytosterols · Plant Oils · Rats · Rats, Wistar · Reproduction · Viscera · Rattus norvegicus · Sinapis arvensis
[Abstract]

4 Assessment of protein allergenicity studies in brown Norway rats
article 2002    
Author: Knippels, L.M.J. · Penninks, A.H.
Keywords: Toxicology · Allergens · Animals · Digestive System · Disease Models, Animal · Hypersensitivity · Immunoglobulin E · Male · Plants, Genetically Modified · Proteins · Rats · Animalia · Rattus norvegicus
[Abstract]

5 Beta-carotene as antioxidant
article 1996    
Author: Bast, A. · Plas, R.M. van der · Berg, H. van den · Haenen, G.R.M.M.
Keywords: Nutrition · Animals · Antioxidants · Ascorbic Acid · beta Carotene · Fats · Ferrous Compounds · Glutathione · Lipid Peroxidation · Male · Microsomes, Liver · Rats · Rats, Wistar · Vitamin A · Animalia · Rattus norvegicus
[Abstract]

6 Regulatory acceptance and use of the extended one generation reproductive toxicity study within Europe
article 2015    
Author: Schiffelers, M.J.W.A. · Blaauboer, B.J. · Bakker, W.E. · Hendriksen, C.F.M. · Krul, C.
Keywords: Barriers and drivers · EOGRTS · REACH · Regulatory acceptance and use · Reproductive toxicity testing · Animalia · Rattus · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

7 An oral sensitization model in Brown Norway rats to screen for potential allergenicity of food proteins
article 1999    
Author: Knippels, L.M.J. · Houben, G.F. · Spanhaak, S. · Penninks, A.H.
Keywords: Allergens · Animals · Antibodies · Blood Pressure · Cattle · Chickens · Dietary Proteins · Digestive System · Disease Models · Egg Proteins · Food Hypersensitivity · Humans · Immunization · Immunologic Techniques · Male · Milk Proteins · Ovalbumin · Passive Cutaneous Anaphylaxis · Rats · Inbred BN · Respiratory Function Tests · Animalia · Rattus norvegicus
[Abstract]

8 Effect of saponin on the transmucosal passage of β-lactoglobulin across the proximal small intestine of normal and β-lactoglobulin-sensitised rats
article 1997    
Author: Gee, J.M. · Wal, J.M. · Miller, K. · Atkinson, H. · Grigoriadou, F. · Wijnands, M.V.W. · Penninks, A.H. · Wortley, G. · Johnson, I.T.
Keywords: Nutrition · Allergy · Intestine · Saponin · Sensitisation · Beta lactoglobulin · Saponin · Animal experiment · Animal tissue · Controlled study · Intestine mucosa permeability · Nonhuman · Small intestine · Animals · Chymases · Histamine · Intestinal Mucosa · Jejunum · Lactoglobulins · Male · Milk Proteins · Permeability · Rats · Saponins · Serine Endopeptidases · Animalia · Gypsophila · Mammalia · Rattus norvegicus
[Abstract]

9 Correlation network analysis for data integration and biomarker selection
article 2008    
Author: Adourian, A. · Jennings, E. · Balasubramanian, R. · Hines, W.M. · Damian, D. · Plasterer, T.N. · Clish, C.B. · Stroobant, P. · McBurney, R. · Verheij, E.R. · Bobeldijk, I. · Greef, J. van der · Lindberg, J. · Kenne, K. · Andersson, U. · Hellmold, H. · Nilsson, K. · Salter, H. · Schuppe-Koistinen, I.
Keywords: Nutrition · Biological marker · Glycosyltransferase · Lipid · Ornithine · Animal · Article · Blood · Enzymology · Liver · Male · Metabolism · Rat · Systems biology · Wistar rat · Animals · Biological Markers · Glycosyltransferases · Lipids · Liver · Male · Ornithine · Rats · Rats, Wistar · Systems Biology · Animalia · Rattus · Rodentia
[PDF] [Abstract]

10 Dose-dependent kinetics and metabolism of 1,2-dichlorobenzene in rat : effect of pretreatment with phenobarbital
article 1996    
Author: Hissink, A.M. · Ommen, B. van · Bladeren, P.J. van
Keywords: Toxicology · Animals · Bile · Biotransformation · Chlorobenzenes · Chromatography, Gas · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Feces · Hydrolysis · Insecticides · Male · Mass Spectrometry · Phenobarbital · Rats · Rats, Wistar · Tissue Distribution · Animalia · Arene · Rattus norvegicus
[Abstract]

11 Effects of a diet high in fish oil (MaxEPA) on the formation of micronucleated erythrocytes in blood and on the number of atypical acinar cell foci induced in rat pancreas by Azaserine
article 2004    
Author: Appel, M.J. · Woutersen, R.A.
Keywords: Biology · Animals · Azaserine · Dietary Fats, Unsaturated · Docosahexaenoic Acids · Drug Combinations · Eicosapentaenoic Acid · Erythrocytes · Female · Fish Oils · Male · Micronuclei, Chromosome-Defective · Pancreatic Neoplasms · Plant Oils · Precancerous Conditions · Rats · Rats, Wistar · Animalia · Carthamus tinctorius · Helianthus · Rattus norvegicus
[Abstract]

12 Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age
article 2007    
Author: Kuper, C.F. · Zijverden, M. van · Klaassen, C. · Tegelenbosch-Schouten, M. · Wolterbeek, A.P.M.
Keywords: Biology · Toxicology and Applied Pharmacology · Adult exposure · Cyclophosphamide · Cyclosporin · Fetal exposure · Peyer's patches · Rat · cyclophosphamide · cyclosporin A · animal experiment · animal tissue · article · controlled study · drug effect · female · fetotoxicity · germinal center · gestation period · immunotoxicity · lactation · lymphocyte · male · microscopy · newborn period · nonhuman · Peyer patch · pregnancy · priority journal · rat · small intestine · Wistar rat · Administration, Oral · Aging · Animals · Cell Count · Cyclophosphamide · Cyclosporine · Female · Germinal Center · Immunosuppressive Agents · Injections, Intravenous · Male · Peyer's Patches · Pregnancy · Prenatal Exposure Delayed Effects · Rats · Rats, Wistar · Animalia · Rattus · Rattus norvegicus
[Abstract]

13 Standardisation of environmental enrichment for laboratory mice and rats: Utilisation, practicality and variation in experimental results
article 2010    
Author: Baumans, V. · Loo, P.L.P. van · Pham, T.M.
Keywords: Biology · Physiological Sciences · brain derived neurotrophic factor · animal behavior · animal care · animal experiment · animal housing · animal wellbeing · article · Bagg albino mouse · breeding · C57BL 6 mouse · controlled study · environmental enrichment · experimental animal welfare · experimental mouse · experimental rat · exploratory behavior · female · foraging behavior · knockout mouse · male · mouse · nesting · nonhuman · open field test · rat · social behavior · Sprague Dawley rat · standardization · strain difference · survival · wild type · workload · Animalia · Mus · Rattus · Rattus norvegicus · Healthy for Life · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

14 Bis(tributyltin)oxide (TBTO) decreases the food allergic response against peanut and ovalbumin in Brown Norway rats
article 2007    
Author: Jonge, J.D. de · Ezendam, J. · Knippels, L.M.J. · Odink, J. · Pourier, M.S. · Penninks, A.H. · Pieters, R. · Loveren, H. van
Keywords: Health · Toxicology and Applied Pharmacology · Bis(tributyltin)oxide · Brown Norway rat · Food allergy · Ovalbumin · Peanut · TBTO · bis(tributyltin) oxide · cytokine · immunoglobulin E · ovalbumin · proteinase · animal cell · animal experiment · animal model · article · basophil · controlled study · cytokine production · eosinophil · female · food allergy · food chain · granulocyte · immunology · immunomodulation · lymphocyte proliferation · mast cell · mesentery lymph node · nonhuman · peanut allergy · Peyer patch · priority journal · rat · risk assessment · spleen cell · Th2 cell · Adjuvants, Immunologic · Administration, Oral · Allergens · Animals · Antibody Formation · Cell Count · Cell Proliferation · Disease Models, Animal · Female · Granulocytes · Immunosuppressive Agents · Lymph Nodes · Lymphocytes · Mast Cells · Metalloendopeptidases · Ovalbumin · Peanut Hypersensitivity · Peyer's Patches · Rats · Rats, Inbred BN · Spleen · Trialkyltin Compounds · Arachis hypogaea · Rattus · Rattus norvegicus
[Abstract]

15 Respiratory irritation by trimellitic anhydride in Brown Norway and Wistar rats
article 2001    
Author: Arts, J.H.E. · Koning, M.W.de · Bloksma, N. · Kuper, C.F.
Keywords: trimellitic anhydride · animal experiment · article · breathing pattern · concentration response · controlled study · female · lung function · lung weight · nonhuman · priority journal · rat · rat strain · respiratory tract allergy · statistical analysis · Administration, Inhalation · Algorithms · Anhydrides · Animals · Female · Immunoglobulin E · Irritants · Lung · Metals · Organ Size · Particle Size · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Tract Diseases · Animalia · Rattus norvegicus
[Abstract]

16 A toxicogenomics-based parallelogram approach to evaluate the relevance of coumarin-induced responses in primary human hepatocytes in vitro for humans in vivo
article 2009    
Author: Kienhuis, A.S. · Poll, M.C.G. van de · Jong, C.H.C. de · Gottschalk, R. · Herwijnen, M. van · Boorsma, A. · Kleinjans, J.C.S. · Stierum, R.H. · Delft, J.H.M. van
Keywords: Biology · Biomedical Research · Coumarin · Gene expression profiling · Hepatotoxicity · Parallelogram approach · Primary human hepatocytes · Species difference · Toxicogenomics · Coumarin · Adult · Aged · Blood clotting · Concentration response · Controlled study · Disorders of mitochondrial functions · Down regulation · Energy consumption · Female · Gene expression profiling · Genomics · Human · Human cell · Liver cell · Liver toxicity · Male · Species difference · Toxicogenetics · Transcriptomics · Animalia · Rattus
[Abstract]

17 Retrospective detection of sulfur mustard exposure by mass spectrometric analysis of adducts to albumin and hemoglobin: An in vivo study
article 2008    
Author: Noort, D. · Fidder, A. · Degenhardt-Langelaan, C.E.A.M. · Hulst, A.G.
Keywords: Albumin · Alkylation · Animal experiment · Article · Blood analysis · Cell membrane · Chemical reaction · Controlled study · Environmental exposure · Erythrocyte · In vivo study · Nonhuman · Alkylation · Animals · Affinity chromatography · Liquid chromatography · Environmental exposure · Environmental monitoring · Injections, Intravenous · Male · Pronase · Rats · Wistar · Mass spectrometry · Electrospray ionization · Tandem mass spectrometry · Rattus · Hemoglobin 9008-02-0 · Mustard gas 505-60-2 · Biological markers · Hemoglobins · Pronase, EC 3.4.24.- · Serum albumin
[Abstract]

18 Different effects of the hypolipidemic drugs pravastatin and lovastatin on the cholesterol biosynthesis of the human ocular lens in organ culture and on the cholesterol content of the rat lens in vivo
article 1993    
Author: Vries, A.C.J. de · Cohen, L.H.
Keywords: Health · HMG-CoA reductase inhibitor · Ocular lens · Pravastatin · Vastatin · hydroxymethylglutaryl coenzyme a reductase · mevinolin · animal experiment · cholesterol synthesis · human tissue · lens · Adult · Aged · Animal · Cholesterol · Comparative Study · Fatty Acids · Human · Lens, Crystalline · Lovastatin · Middle Age · Organ Culture · Pravastatin · Rats · Rats, Wistar · Animalia · Rattus norvegicus
[Abstract]

19 Basil extract inhibits the sulfotransferase mediated formation of DNA adducts of the procarcinogen 1′-hydroxyestragole by rat and human liver S9 homogenates and in HepG2 human hepatoma cells
article 2008    
Author: Jeurissen, S.M.F. · Punt, A. · Delatour, T. · Rietjens, I.M.C.M.
Keywords: Alkenylbenzenes · DNA adducts · Estragole · Ocimum basilicum · Sulfotransferases · 1' hydroxyestragole · Animals · Anisoles · Biotransformation · Carcinoma, Hepatocellular · Cell Line, Tumor · Cell Survival · Chromatography, High Pressure Liquid · Deoxyguanosine · DNA Adducts · DNA Repair · Enzyme Inhibitors · Humans · Liver · Liver Neoplasms · Ocimum basilicum · Plant Extracts · Rats · Risk Assessment · Spectrometry, Mass, Electrospray Ionization · Subcellular Fractions · Sulfotransferases · Tetrazolium Salts · Thiazoles · Ocimum · Ocimum basilicum · Rattus
[Abstract]

20 Prediction of in vivo developmental toxicity of all-trans-retinoic acid based on in vitro toxicity data and in silico physiologically based kinetic modeling
article 2015    
Author: Louisse, J. · Bosgra, S. · Blaauboer, B.J. · Rietjens, I.M.C.M. · Verwei, M.
Keywords: Toxicology · All-trans-retinoic acid · Developmental toxicity · In vitro–in vivo extrapolation · Physiologically based kinetic modeling · Reverse dosimetry · Solid phase microextraction · Animalia · Rattus · Biomedical Innovation · Healthy Living · Life Triskelion BV · RAPID - Risk Analysis for Products in Development ARF - Analytical Research (Food) · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 79 found. Next | Sort by date