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Showing 1 to 15 of 15 found. | Sort by date

1 Studies on the production of fungal peroxidases in Aspergillus niger
article 2000    
Author: Conesa, A. · Hondel, C.A.M.J.J. van den · Punt, P.J.
Keywords: Nutrition · Botany · Fungi · Fungal enzyme · Glucan 1,4 alpha glucosidase · Hemoglobin · Lignin peroxidase · Manganese peroxidase · Messenger RNA · Peroxidase · Recombinant protein · Aspergillus niger · Enzyme activity · Enzyme purification · Enzyme release · Enzyme synthesis · Gene overexpression · Nonhuman · Nucleotide sequence · Protein expression · Protein processing · Aspergillus niger · Blotting, Northern · Blotting, Western · Ferrous Compounds · Heme · Peroxidases · Phanerochaete · Recombinant Proteins · Transformation, Genetic · Aspergillus niger · Chrysosporium · Fungi · Phanerochaete chrysosporium
[Abstract]

2 Filamentous fungi as production organisms for glycoproteins of bio-medical interest
article 1999    
Author: Maras, M. · Die, I. van · Contreras, R. · Hondel, C.A.M.J.J. van den
Keywords: Filamentous fungi · Homologous and heterologous protein secretion · N-glycosylation · O-glycosylation · Phosphorylation · Protein-linked carbohydrates · Carbohydrate · Fungal protein · Glycan · Glycoprotein · Mannose · Recombinant protein · Drug industry · Fungus · Gene fusion · Genetic engineering · Nonhuman · Priority journal · Protein secretion · Protein synthesis · Review · Biotechnology · Carbohydrate Sequence · Fungi · Glycoproteins · Glycosylation · Humans · Molecular Sequence Data · Oligosaccharides · Protein Engineering · Recombinant Proteins · Fungi · Mammalia
[Abstract]

3 In vitro stabililty of a tissue-type plasminogen activator mutant, BM 06.022, in human plasma
article 1994    
Author: Rijken, D.C. · Groeneveld, E. · Barrett-Bergshoeff, M.M.
Keywords: Biology · alpha 1 antitrypsin · alpha 2 antiplasmin · alteplase · fibrinogen · plasmin · reteplase · tissue plasminogen activator · fibrinolytic agent · proteinase inhibitor · recombinant protein · dose response · drug activity · drug half life · drug inactivation · drug stability · immunoblotting · plasma · polyacrylamide gel electrophoresis · blood · genetics · half life time · mutation · Drug Stability · Fibrinolytic Agents · Half-Life · Human · Mutation · Protease Inhibitors · Recombinant Proteins · Tissue Plasminogen Activator
[Abstract]

4 Chemically modified tetracyclines stimulate matrix metalloproteinase-s production by periodontal ligament cells
article 2006    
Author: Bildt, M.M. · Snoek-van Beurden, A.M.P. · Groot, J. de · El, B. van · Kuijpers-Jagtman, A.M. · Hoff, J.W. van den
Keywords: Biology · Biomedical Research · Chemically modified tetracyclines · Gelatin zymography · Matrix metalloproteinases · Periodontal ligament · DNA · Enzyme inhibitor · Gelatin · Gelatinase A · Gelatinase B · Recombinant protein · Tetracycline derivative · Analysis of variance · Iosynthesis · Cell culture · Chemistry · Drug antagonism · Drug effect · Human · Metabolism · Nonparametric test · Periodontal ligament · Polyacrylamide gel electrophoresis · Western blotting · Analysis of Variance · Blotting, Western · Cells, Cultured · DNA · Electrophoresis, Polyacrylamide Gel · Enzyme Inhibitors · Gelatin · Humans · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Periodontal Ligament · Recombinant Proteins · Statistics, Nonparametric · Tetracyclines
[Abstract]

5 The effect of organic nitrogen sources on recombinant glucoamylase production by Aspergillus niger in chemostat culture
article 2000    
Author: Swift, R.J. · Karandikar, A. · Griffen, A.M. · Punt, P.J. · Hondel, C.A.M.J.J. van den · Robson, G.D. · Trinci, A.P.J. · Wiebe, M.G.
Keywords: Biology · Aspergillus niger · Chemostat culture · Genetic instability · Glucoamylase · Nitrogen source · Recombinant protein · Alanine · Casamino acid · DNA · Fungal DNA · Fungal enzyme · Glucan 1,4 alpha glucosidase · Glucose · Methionine · Nitro derivative · Peptone · Aspergillus niger · Chemostat · Controlled study · Culture medium · DNA methylation · Enzyme metabolism · Enzyme synthesis · Fermentation · Fungal genetics · Fungus culture · Gene loss · Morphology · Nonhuman · PH · Priority journal · Strain difference · Aspergillus niger · Culture Media · Glucan 1,4-alpha-Glucosidase · Glucose · Hydrogen-Ion Concentration · Mutation · Nitrogen · Organic Chemicals · Recombinant Proteins · Aspergillus niger
[Abstract]

6 Analysis of the role of the gene bipA, encoding the major endoplasmic reticulum chaperone protein in the secretion of homologous and heterologous proteins in black Aspergilli
article 1998    
Author: Punt, P.J. · Gemeren, I.A. van · Drint-Kuijvenhoven, J. · Hessing, J.G.M. · Muijlwijk van - Harteveld, G.M. · Beijersbergen, A. · Verrips, C.T. · Hondel, C.A.M.J.J. van den
Keywords: Nutrition · Binding protein · Chaperone · Glucan 1,4 alpha glucosidase · Recombinant protein · Aspergillus awamori · Aspergillus niger · Endoplasmic reticulum · Fungal genetics · Gene fusion · Gene overexpression · Nonhuman · Promoter region · Protein secretion · Animals · Antibody Specificity · Artificial Gene Fusion · Aspergillus · Aspergillus niger · Blotting, Northern · Blotting, Western · Cloning, Molecular · Fungal Proteins · Gene Expression Regulation, Fungal · Genes, Fungal · Glucan 1,4-alpha-Glucosidase · HSP70 Heat-Shock Proteins · Rabbits · Recombinant Fusion Proteins · Aspergillus · Aspergillus awamori · Aspergillus niger · Fungi
[Abstract]

7 Impact of apolipoprotein(a) on in vitro angiogenesis
article 2001    
Author: Schulter, V. · Koolwijk, P. · Peters, E. · Frank, S. · Hrzenjak, A. · Graier, W.F. · M. van Hinsbergh, V.W. · Kostner, G.M.
Keywords: Health · Endothelial cells · Kringle · Lp(a) · Urinary fragments · Angiostatin · Apolipoprotein A · Basic fibroblast growth factor · Fibrin · Plasminogen · Recombinant protein · Tumor necrosis factor alpha · Urokinase · Angiogenesis · Cell proliferation · Concentration (parameters) · Controlled study · Endothelium cell · Human cell · Kringle domain · Lipid analysis · Protein expression · Protein secretion · Angiogenesis Inhibitors · Apolipoproteins A · Cell Division · Cells, Cultured · Dose-Response Relationship, Drug · Endothelium, Vascular · Fibroblast Growth Factor 2 · Humans · Male · Peptide Fragments · Plasminogen Activator Inhibitor 1 · Tumor Necrosis Factor-alpha · Urinary Plasminogen Activator
[Abstract]

8 The role of the Aspergillus niger furin-type protease gene in processing of fungal proproteins and fusion proteins: Evidence for alternative processing of recombinant (fusion-) proteins
article 2003    
Author: Punt, P.J. · Drint-Kuijvenhoven, A. · Lokman, B.C. · Spencer, J.A. · Jeenes, D. · Archer, D.A. · Hondel, C.A.M.J.J. van den
Keywords: Biology · Biotechnology · Filamentous fungi · Fusion-proteins · Protease · Protein processing · Protein secretion · Secretion carrier · Biotechnology · Genes · Growth kinetics · Mutagenesis · Proteins · Cleavage sites · Genetic engineering · arginine · aspergillopepsin · fungal protein · furin · glucan 1,4 alpha glucosidase · hybrid protein · lysine · protein precursor · proteinase · recombinant protein · unclassified drug · allele · amino acid composition · article · Aspergillus niger · controlled study · fungal gene · fungal strain · fungus mutant · gene deletion · gene disruption · gene function · genetic code · genetic recombination · molecular cloning · nonhuman · nucleotide sequence · priority journal · protein degradation · protein processing · wild type · Aspergillus niger · Endopeptidases · Fungal Proteins · Furin · Gene Expression Regulation, Enzymologic · Gene Expression Regulation, Fungal · Protein Processing, Post-Translational · Recombinant Fusion Proteins · Trans-Activation (Genetics) · Aspergillus · Aspergillus niger · Fungi
[Abstract]

9 Microdosing of a Carbon-14 Labeled Protein in Healthy Volunteers Accurately Predicts Its Pharmacokinetics at Therapeutic Dosages
article 2015    
Author: Vlaming, M.L. · Duijn, E. van · Dillingh, M.R. · Brands, R. · Windhorst, A.D. · Hendrikse, N.H. · Bosgra, S. · Burggraaf, J. · Koning, M.C. de · Fidder, A. · Mocking, J.A. · Sandman, H. · Ligt, R.A. de · Fabriek, B.O. · Pasman, W.J. · Seinen, W. · Alves, T. · Carrondo, M. · Peixoto, C. · Peeters, P.A. · Vaes, W.H.
Keywords: Biology · Alkaline phosphatase, placental · Carbon · Glycosylphosphatidylinositol anchored protein · Isoenzyme · Recombinant protein · Area under the curve · Biological model · Clinical trial · Controlled study · Dose calculation · Double blind procedure · Half life time · Intravenous drug administration · Phase 1 clinical trial · Procedures · Randomized controlled trial · Statistical model · Administration, Intravenous · Adolescent · Adult · Alkaline Phosphatase · Area Under Curve · Carbon Radioisotopes · Double-Blind Method · Drug Dosage Calculations · GPI-Linked Proteins · Half-Life · Healthy Volunteers · Humans · Isoenzymes · Linear Models · Male · Mass Spectrometry · Metabolic Clearance Rate · Models, Biological · Netherlands · Recombinant Proteins · Young Adult · Biomedical Innovation · Healthy Living · Life Triskelion BV · MSB - Microbiology and Systems Biology ARPC - Analytical Research (Pharm & Chemistry) · ELSS - Earth, Life and Social Sciences TNO Bedrijven
[Abstract]

10 Optimization and stability of glucoamylase production by recombinant strains of Aspergillus niger in chemostat culture
article 1998    
Author: Withers, J.M. · Swift, R.J. · Wiebe, M.G. · Robson, G.D. · Punt, P.J. · Hondel, C.A.M.J.J. van den
Keywords: Nutrition · Aspergillus niger · Chemostat culture · Glucoamylase (GAM) · Protein secretion · Recombinant protein · Strain stability · Ammonium compounds · Batch cell culture · Chemostats · Genetic engineering · Glucose · Magnesium · Morphology · Phosphates · Physiology · Potassium · Sulfur compounds · Chemostat culture · Glucoamylase · Shake flask culture · Enzymes · glucan 1,4 alpha glucosidase · article · aspergillus niger · chemostat · enzyme stability · enzyme synthesis · fungus culture · fungus growth · genetic recombination · nonhuman · protein secretion · Aspergillus niger · Blotting, Western · Cell Culture Techniques · Cell Division · Culture Media · Fermentation · Glucan 1,4-alpha-Glucosidase · Glucose · Hydrogen-Ion Concentration · Polysaccharides · Recombinant Proteins · Temperature · Time Factors
[Abstract]

11 Generation of a recombinant apolipoprotein E variant with improved biological functions: Hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia
article 2005    
Author: Kypreos, K.E. · Dijk, K.W. van · Havekes, L.M. · Zannis, V.I.
Keywords: Biology · Biomedical Research · Amino acids · Biochemistry · Cholesterol · Genes · Molecular biology · Mutagenesis · Alanines · Apolipoprotein E (apoE) · High density lipoprotein (HDL) · Ultracentrifugation analysis · Proteins · High density lipoprotein · Leucine · Lipoprotein lipase · Phenylalanine · Recombinant apolipoprotein E · Recombinant protein · Triacylglycerol · Tryptophan · Unclassified drug · Valine · Very low density lipoprotein · Adenovirus · Amino acid substitution · Animal experiment · Carboxy terminal sequence · Controlled study · Density gradient centrifugation · Electron microscopy · Gene transfer · Human cell · Hydrophobicity · Hyperlipidemia · Hypertriglyceridemia · Mouse · Mutation · Nonhuman · Protein expression · Protein function · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Hypertriglyceridemia · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Mutagenesis, Site-Directed · Mutation, Missense · Peptide Fragments · Recombinant Proteins · Transgenes · Triglycerides
[PDF] [Abstract]

12 Tolerization of an established αb-crystallin-reactive T-cell response by intravenous antigen
article 2007    
Author: Verbeek, R. · Mark, K. van der · Wawrousek, E.F. · Plomp, A.C. · Noort, J.M. van
Keywords: Biology · Biomedical Research · αB-crystallin · Autoimmunity · Multiple sclerosis · T cells · Tolerance · alpha crystallin · alphab crystallin · antibody · autoantigen · Freund adjuvant · ovalbumin · epitope · gamma interferon · immunoglobulin G · recombinant protein · animal cell · animal experiment · antibody blood level · antibody response · antigen specificity · article · cellular immunity · controlled study · delayed hypersensitivity · dose response · drug dose comparison · drug efficacy · immune response · immunization · immunological tolerance · immunoregulation · mouse · multiple sclerosis · nonhuman · priority journal · protein deficiency · T lymphocyte activation · animal · biosynthesis · cell culture · dendritic cell · immunology · intravenous drug administration · lymphocyte activation · T lymphocyte subpopulation · time · alpha-Crystallin B Chain · Animals · Autoantigens · Cells, Cultured · Dendritic Cells · Dose-Response Relationship, Immunologic · Epitopes · Hypersensitivity, Delayed · Immune Tolerance · Immunoglobulin G · Injections, Intravenous · Interferon Type II · Lymphocyte Activation · Mice · Multiple Sclerosis · Recombinant Proteins · T-Lymphocyte Subsets · Time Factors
[Abstract]

13 Protective and therapeutic role for αB-crystallin in autoimmune demyelination
article 2007    
Author: Ousman, S.S. · Tomooka, B.H. · Noort, J.M. van · Wawrousek, E.F. · O'Conner, K. · Hafler, D.A. · Sobel, R.A. · Robinson, W.H. · Steinman, L.
Keywords: Biomedical Research · caspase 3 · cytokine · gamma interferon · interleukin 12p40 · interleukin 17 · interleukin 2 · recombinant alphab crystallin · recombinant protein · tumor necrosis factor · antibody · brain · gene · immune response · immune system · nervous system disorder · rodent · allergic encephalomyelitis · animal cell · animal experiment · animal model · animal tissue · apoptosis · article · astrocyte · central nervous system · cerebrospinal fluid · controlled study · cytokine release · demyelination · female · gene function · human · immune response · immune system · macrophage · mouse · multiple sclerosis · myelin sheath · nick end labeling · nonhuman · priority journal · T lymphocyte · Th1 cell · wild type · alpha-Crystallin B Chain · Animals · Apoptosis · Astrocytes · Caspase 3 · Encephalomyelitis, Autoimmune, Experimental · Humans · Inflammation · Macrophages · MAP Kinase Signaling System · Mice · Multiple Sclerosis · Myelin Sheath · Neuroglia · Neuroprotective Agents · NF-kappa B · T-Lymphocytes, Helper-Inducer · Mus
[Abstract]

14 A fungal biofilm reactor based on metal structured packing improves the quality of a Gla::GFP fusion protein produced by Aspergillus oryzae
article 2015    
Author: Zune, Q. · Delepierre, A. · Gofflot, S. · Bauwens, J. · Twizere, J.C. · Punt, P.J. · Francis, F. · Toye, D. · Bawin, T. · Delvigne, F.
Keywords: Nutrition · Fungal biofilm · Bioreactor · Scale-up · Recombinant protein · Antigen-antibody reactions · Aspergillus · Biofilms · Biomass · Bioreactors · Electrophoresis · Enzyme activity · Fermentation · Fungi · Metabolites · Physiology · Recombinant proteins · Shear stress · Comparative analysis · Extracellular medium · Green fluorescent protein · Physiological mechanisms · Secondary metabolites · Solid-state fermentation · Submerged fermentation · Proteins · Amylase · Glucan 1,4 alpha glucosidase · Glucoamylase green fluorescent protein fusion protein · Green fluorescent protein · Hybrid protein · Unclassified drug · Fermentation · Fungus · Metal · Physiological response · Protein · Qualitative analysis · Recirculating system · Recombination · Secondary metabolite · Alkalinization · Amino acid sequence · Aspergillus niger · Aspergillus oryzae · Autolysis · Biofilm reactor · Biotransformation · Carbon source · Controlled study · Enzyme activity · Extracellular space · Fungal biomass · Fungal colonization · Fungus culture · Fungus growth · Glucose intake · Hydrolysis · Immersion · Immunodetection · Nonhuman · PH measurement · Protein analysis · Shear stress · Solid state fermentation · Submerged fermentation · Western blotting · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

15 Calcium measurements in living filamentous fungi expressing codon-optimized aequorin
article 2004    
Author: Nelson, G. · Kozlova-Zwinderman, O. · Collis, A.J. · Knight, M.R. · Fincham, J.R.S. · Stanger, C.P. · Renwick, A. · Hessing, J.G.M. · Punt, P.J. · Hondel, C.A.M.J.J. van den · Read, N.D.
Keywords: Biology · Biotechnology · Aequorin · Calcimycin · Calcium · Calcium channel · Calcium channel blocking agent · Calcium channel stimulating agent · Cation · Chelating agent · Cyclopiazonic acid · Ethylene glycol 1,2 bis(2 aminophenyl) ether n,n,n',n' tetraacetic acid · Recombinant protein · 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid · Drug derivative · Egtazic acid · Enzyme inhibitor · Indole derivative · Ionophore · Aspergillus awamori · Aspergillus niger · Codon · Concentration (parameters) · Controlled study · Fungus · Measurement · Neurospora crassa · Nonhuman · Osmotic stress · Physical chemistry · Priority journal · Protein expression · Signal transduction · Stimulus · Stimulus response · Aspergillus · Calcium signaling · Cytology · Genetics · Mechanical stress · Metabolism · Molecular genetics · Nucleotide sequence · Osmotic pressure · Physiology · Sequence alignment · Aspergillus · Aspergillus awamori · Aspergillus niger · Fungi · Neurospora · Neurospora crassa · Aequorin · Aspergillus · Base Sequence · Calcimycin · Calcium · Calcium Channel Blockers · Calcium Signaling · Chelating Agents · Codon · Egtazic Acid · Enzyme Inhibitors · Indoles · Ionophores · Molecular Sequence Data · Neurospora crassa · Osmotic Pressure · Recombinant Proteins · Sequence Alignment · Stress, Mechanical
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 15 of 15 found. | Sort by date