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Showing 1 to 11 of 11 found. | Sort by date

1 Detection of salicylate and its hydroxylated adducts 2,3- and 2,5-dihydroxybenzoic acids as possible indices for in vivo hydroxyl radical formation in combination with catechol- and indoleamines and their metabolites in cerebrospinal fluid and brain tissue
article 1995    
Author: Sloot, W.N. · Gramsbergen, J.B.P.
Keywords: Biology · Animal · Biogenic Amines · Catechols · Chromatography, High Pressure Liquid · Electrochemistry · Hydroxybenzoic Acids · Hydroxyl Radical · Indoles · Magnesium · Male · Manganese Poisoning · Neostriatum · Rats · Rats, Wistar · Reference Standards · Salicylic Acid · Salicylic Acids · Spectrophotometry, Ultraviolet · Support, Non-U.S. Gov't
[Abstract]

2 The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients
article 2005    
Author: Adams, T.B. · Cohen, S.M. · Doull, J. · Feron, V.J. · Goodman, J.I. · Marnett, L.J. · Munro, I.C. · Portoghese, P.S. · Smith, R.L. · Waddell, W.J. · Wagner, B.M.
Keywords: Nutrition Toxicology · Toxicology and Applied Pharmacology · Alkoxybenzylderivatives · FEMA GRAS · Flavoring ingredients · Hydroxybenzyl derivatives · 3 ethoxy 4 hydroxybenzaldehyde · acetal · alcohol · aldehyde · anisaldehyde · benzyl derivative · butyl paraben · ester · flavoring agent · methyl 2 methoxybenzoate · piperonal · salicylic acid isopentyl ester · salicylic acid methyl ester · unclassified drug · vanillin · acute toxicity · carcinogenicity · chemical structure · concentration (parameters) · data analysis · detoxification · dog · evaluation · excretion · exposure · feeding · flavor · food analysis · food composition · food intake · food safety · genotoxicity · health care organization · human · hydrolysis · in vitro study · in vivo study · information · metabolism · mutagenesis · nonhuman · rabbit · reproduction · review · risk assessment · science · structure analysis · Alcohols · Animals · Benzyl Compounds · Flavoring Agents · Food Industry · Humans · Toxicity Tests · United States · United States Food and Drug Administration · Animalia
[Abstract]

3 Salsalate activates brown adipose tissue in mice
article 2015    
Author: Dam, A.D. van · Nahon, K.J. · Kooijman, S. · Berg, S.M. van den · Kanhai, A.A. · Kikuchi, T. · Heemskerk, M.M. · Harmelen,V. van · Lombès, M. · Hoek,A.M. van den · Winther, M.P. de · Lutgens, E. · Guigas, B. · Rensen, P.C. · Boon, M.R.
Keywords: Biology · Salicylic acid derivative · Salsalate · Administration and dosage · Adverse effects · Brown adipose tissue · Drug administration · Drug effects · Fat intake · Metabolism · Mouse · Physiology · Transgenic mouse · Adipose Tissue, Brown · Animals · Dietary Fats · Drug Administration Schedule · Glucose · Lipid Metabolism · Male · Mice · Mice, Transgenic · Obesity · Salicylates · Weight Gain · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Monolayers of IEC-18 cells as an in vitro model for screening the passive transcellular and paracellular transport across the intestinal barrier: Comparison of active and passive transport with the human colon carcinoma Caco-2 cell line
article 2002    
Author: Versantvoort, C.H.M. · Ondrewater, R.C.A. · Duizer, E. · Sandt, J.J.M. van de · Gilde, A.J. · Groten, J.P.
Keywords: Caco-2 · Carrier-mediated transport · H+-di/tripeptide carrier · IEC-18 · Intestinal cell lines · MRP · P-Glycoprotein · acetylsalicylic acid · calcein · carrier protein · dinitrophenylglutathione · glucose derivative · glutathione derivative · glycoprotein P · glycylsarcosine · hydrocortisone · macrogol 4000 · mannitol · methylglucose · multidrug resistance protein · probenecid · propranolol · rhodamine 123 · salicylic acid · testosterone · unclassified drug · verapamil · vincristine · animal cell · article · cell membrane permeability · cell strain CACO 2 · cell transport · colon carcinoma · controlled study · drug transport · human · human cell · in vitro study · ion transport · model · nonhuman · priority journal · protein expression · rat · screening
[Abstract]

5 Airway morphology and function of rats following dermal sensitization and respiratory challenge with low molecular weight chemicals
article 1998    
Author: Arts, J.H.E. · Kuper, C.F. · Spoor, S.M. · Bloksma, N.
Keywords: Nutrition · 1 chloro 2,4 dinitrobenzene · Immunoglobulin e · Salicylic acid methyl ester · Trimellitic anhydride · Airway · Animal experiment · Animal model · Animal tissue · Asthma · Breathing rate · Controlled study · Histopathology · Immunoglobulin blood level · Larynx · Lung function test · Morphology · Nonhuman · Occupational asthma · Provocation test · Rat · Sensitization · Allergens · Animals · Body Weight · Bronchi · Dermatitis, Allergic Contact · Dinitrochlorobenzene · Female · Immunoglobulin E · Organ Size · Phthalic Anhydrides · Rats · Rats, Inbred BN · Rats, Wistar · Respiratory Function Tests · Respiratory Hypersensitivity · Salicylates
[Abstract]

6 A new approach to predict human intestinal absorption using porcine intestinal tissue and biorelevant matrices
article 2014    
Author: Westerhout, J. · Steeg, E. van de · Grossouw, D. · Zeijdner, E.E. · Krul, C.A.M. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Caco-2 · Food-effect · Human intestine · Intestinal absorption · InTESTine™ · Porcine intestine · Acebutolol · Atenolol · Candesartan · Cetirizine · Cimetidine · Ciprofloxacin · Diazepam · Digoxin · Famotidine · Hydrocortisone · Ibuprofen · Indometacin · Mannitol · Melagatran · Metoprolol · Mucin · Oxprenolol · Phenazone · Pindolol · Propranolol · Ranitidine · Salazosulfapyridine · Salicylic acid · Testosterone · Verapamil · Active transport · Animal tissue · CACO 2 cell line · Controlled study · Domestic pig · Drug absorption · Drug bioavailability · Drug penetration · Drug transport · Electric resistance · Ex vivo study · Female · Human · Human tissue · Intestine absorption · Intestine mucosa · Male · Nonhuman · Passive transport · Prediction · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Assessment Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Anti-inflammatory salicylate beneficially modulates pre-existing atherosclerosis through quenching of NF-κB activity and lowering of cholesterol
article 2010    
Author: Vries-van der Weij, J. de · Toet, K. · Zadelaar, A.S.M. · Wielinga, P.Y. · Kleemann, R. · Rensen, P.C.N. · Kooistra, T.
Keywords: Health · Biomedical Research · Anti-inflammatory treatment · Established lesions · Inflammation · Mouse model of atherosclerosis · NF-κB · On-top of statin treatment · Reduce further progression of atherosclerosis · Serum amyloid A (SAA) · Statin · hydroxymethylglutaryl coenzyme A reductase inhibitor · immunoglobulin enhancer binding protein · salicylic acid · serum amyloid A · STAT3 protein · animal experiment · animal model · antiinflammatory activity · aorta · article · atherosclerosis · atherosclerotic plaque · cholesterol blood level · cholesterol diet · controlled study · disease course · drug effect · female · histology · hypercholesterolemia · inflammation · liver · low fat diet · macrophage · mouse · nonhuman · priority journal · risk factor · treatment outcome
[Abstract]

8 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds
article 2010    
Author: Briel, R.J. van de · Pennings, J.L.A. · Baken, K.A. · Pronk, T.E. · Boorsma, A. · Gottschalk, R. · Loveren, H. van
Keywords: Biology · Biomedical Research · Gene profiling · HaCaT · Irritant oxidative stress · Keratinocytes · Sensitizer · 1 chloro 2,4 dinitrobenzene · 2 propanol · benzoic acid · cinnamyl alcohol · collagen type 16 · disulfiram · dodecyl sulfate sodium · eugenol · ferritin · ferrochelatase · glucose 6 phosphate dehydrogenase · glucuronosyltransferase 1A6 · glutamate cysteine ligase · glutathione reductase · heat shock protein · heme oxygenase 1 · hexane · interleukin 6 receptor · irritant agent · isoeugenol · lactic acid · mitogen activated protein kinase · nickel sulfate · phosphogluconate dehydrogenase · salicylic acid methyl ester · thioredoxin 2 · thioredoxin reductase 1 · thioredoxin reductase 2 · transcription factor Nrf2 · article · cell viability · gene control · gene expression profiling · human · human cell · human cell culture · in vitro study · keratinocyte · oxidative stress · random forest · sensitization · support vector machine
[Abstract]

9 The respiratory local lymph node assay as a tool to study respiratory sensitizers
article 2008    
Author: Arts, J.H.E. · Jong, W.H. de · Triel, J.J. van · Schijf, M.A. · Klerk, A. de · Loveren, H. van · Kuper, C.F.
Keywords: Health · Toxicology and Applied Pharmacology · Contact allergy · LLNA · Potency · Respiratory allergy · Sensitizers · 1 chloro 2,4 dinitrobenzene · allergen · formaldehyde · hexamethylene diisocyanate · isophorone · oxazolone · phthalic anhydride · salicylic acid methyl ester · trimellitic anhydride · airway · animal experiment · article · cell proliferation · concentration response · contact allergy · controlled study · histopathology · local lymph node assay · male · molecular weight · mouse · nonhuman · respiratory tract allergy · respiratory tract examination · skin sensitization · toxicity testing · Animals · Body Weight · Chromatography, High Pressure Liquid · Dose-Response Relationship, Drug · Local Lymph Node Assay · Male · Mass Spectrometry · Mice · Mice, Inbred BALB C · Organ Size · Particle Size · Respiratory System · Mus
[Abstract]

10 Contact and respiratory sensitizers can be identified by cytokine profiles following inhalation exposure
article 2009    
Author: Jong, W.H. de · Arts, J.H.E. · Klerk, A. de · Schijf, M.A. · Ezendam, J. · Kuper, C.F. · Loveren, H. van
Keywords: Biology · Toxicology and Applied Pharmacology · Cytokine profiles · Inhalation exposure · Lymph node responses · Sensitizers · Skin exposure · 1 chloro 2,4 dinitrobenzene · concanavalin A · formaldehyde · gamma interferon · hexamethylene diisocyanate · interleukin 10 · interleukin 4 · isophorone · oxazolone · phthalic anhydride · salicylic acid methyl ester · toluene diisocyanate · trimellitic anhydride · animal cell · animal experiment · animal model · article · cell proliferation · cell suspension · concentration (parameters) · contact sensitivity · controlled study · cytokine production · ex vivo study · hypersensitivity reaction · inhalation · lymphadenectomy · lymphatic drainage · male · mouse · nonhuman · priority journal · protein induction · respiratory tract allergy · Administration, Cutaneous · Allergens · Animals · Biological Markers · Cell Proliferation · Cells, Cultured · Cytokines · Dermatitis, Allergic Contact · Dose-Response Relationship, Drug · Inhalation Exposure · Interferon-gamma · Interleukin-10 · Interleukin-4 · Local Lymph Node Assay · Lymph Nodes · Male · Mice · Mice, Inbred BALB C · Models, Animal · Respiratory Hypersensitivity · Animalia · Mus
[Abstract]

11 Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology
article 2005    
Author: Wang, M. · Lamers, R.J.A.N. · Korthout, H.A.A.J. · Nesselrooij, J.H.J. van · Witkamp, R.F. · Heijden, R. van der · Voshol, P.J. · Havekes, L.M. · Verpoorte, R. · Greef, J. van der
Keywords: Health Pharmacology · Analytical research · Metabolomics · Systems biology · Traditional Chinese Medicine (TCM) · 5' methoxyhdnocarpin · Alanine aminotransferase · Alkaloid · Apolipoprotein E · Berberine · Biflavonoid · Bilobalide · Cannabidiol · Cannabis · Chaconine · Cholesterol · Flavonoid · Ginkgo biloba extract · Ginkgolide · Glucoside · Herbaceous agent · Insulin · Low density lipoprotein · Plant extract · Prodrug · Salicylic acid · Saligenin · Saponin · Solanine · Tetrahydrocannabinol · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Alanine aminotransferase blood level · Animal experiment · Animal model · Atherosclerosis · Bark · Blood flow · Chinese medicine · Clinical pharmacology · Controlled study · Data analysis · DNA microarray · Drug effect · Drug efficacy · Drug potentiation · Drug research · Drug safety · Drug targeting · Female · Ginkgo biloba · Headache · Herbal medicine · High performance liquid chromatography · Human · Human experiment · Insulin resistance · Insulin sensitivity · Ion cyclotron resonance mass spectrometry · Lipid metabolism · Liver function · Male · Mass spectrometry · Medicinal plant · Metabolic syndrome X · Metabolite · Molecular pharmacology · Nonhuman · Nuclear magnetic resonance spectroscopy · Pain · Phytotherapy · Plant leaf · Proton nuclear magnetic resonance · Rat · Thin layer chromatography · Traditional medicine · Willow · Drugs, Chinese Herbal · Humans · Pharmacology · Phytotherapy
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date