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Showing 1 to 11 of 11 found. | Sort by date

1 The in vivo rat skin photomicronucleus assay: Phototoxicity and photogenotoxicity evaluation of six fluoroquinolones
article 2012    
Author: Reus, A.A. · Usta, M. · Kenny, J.D. · Clements, P.J. · Pruimboom-Brees, I. · Aylott, M. · Lynch, A.M. · Krul, C.A.M.
Keywords: Research · ciprofloxacin · gatifloxacin · gemifloxacin · levofloxacin · lomefloxacin · methoxsalen · quinoline derived antiinfective agent · sparfloxacin · animal tissue · article · carcinogenicity · controlled study · epidermis cell · female · genotoxicity · hairless mouse · histopathology · in vitro study · in vivo study · micronucleus · micronucleus test · nonhuman · phototoxicity · priority journal · rat · single drug dose · skin · Sprague Dawley rat · Biomedical Innovation · Healthy Living · Triskelion BV · TARA - Toxicology and Risk Assessment · TNO Bedrijven
[Abstract]

2 Acute effects on brain cholecystokinin-like concentration and anxiety-like behaviour in the female rat upon a single injection of 17β-estradiol
article 2014    
Author: Holm, L. · Liang, W. · Thorsell, A. · Hilke, S.
Keywords: Biology · Anxiety · Cholecystokinin · Estrogen · Cholecystokinin · Estradiol · Amygdaloid nucleus · Animal experiment · Animal tissue · Brain region · Cingulate gyrus · Comparative study · Controlled study · Estrogen synthesis · Estrus cycle · Female · Hippocampus · Immunoreactivity · Nonhuman · Nucleus accumbens · Ovariectomy · Panic · Priority journal · Punch biopsy · Rat · Single drug dose · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Percutaneous absorption of mexoryl SX® in human volunteers: Comparison with in vitro data
article 2003    
Author: Benech-Kieffer, F. · Meuling, W.J.A. · Leclerc, C. · Roza, L. · Leclaire, J. · Nohynek, G.
Keywords: Nutrition Health · Physiological Sciences · Human skin · Mass balance · Mexoryl SX® · Percutaneous absorption · Sunscreen · carbon 14 · mexoryl sr · sulfonic acid derivative · sunscreen · terephthalylidene dicamphor sulfonic acid · unclassified drug · adult · article · blood sampling · correlation analysis · dermis · drug absorption · drug exposure · feces analysis · human · human experiment · human tissue · in vitro study · male · normal human · priority journal · radioactivity · single drug dose · skin absorption · skin surface · urinalysis · Administration, Topical · Adult · Bornanes · Camphor · Diffusion · Diffusion Chambers, Culture · Half-Life · Humans · Male · Mesylates · Skin Absorption · Sulfonic Acids · Sunscreening Agents
[Abstract]

4 Quantitative analysis of Tenecteplase in rat plasma samples using LC-MS/MS as an alternative for ELISA
article 2007    
Author: Buscher, B.A.P. · Gerritsen, H. · Schöll, I. van · Cnubben, N.H.P. · Brüll, L.P.
Keywords: Biology · Analytical research · Digestion · Liquid chromatography · Mass spectrometry · Plasma · Proteins · Quantitative analysis · Blood · Digestive system · Drug products · Enzymes · Sensitivity analysis · Internal standard · Tenecteplase · Trypsin · Chemical analysis · tenecteplase · animal experiment · article · blood sampling · controlled study · drug distribution · enzyme linked immunosorbent assay · liquid chromatography · mass spectrometry · nonhuman · priority journal · quantitative analysis · rat · single drug dose · Animals · Chromatography, Liquid · Enzyme-Linked Immunosorbent Assay · Fibrinolytic Agents · Rats · Sensitivity and Specificity · Tandem Mass Spectrometry · Tissue Plasminogen Activator · Rattus
[Abstract]

5 Pediatric Microdose Study of [14C]Paracetamol to Study Drug Metabolism Using Accelerated Mass Spectrometry: Proof of Concept
article 2014    
Author: Mooij, M.G. · Duijn, E. van · Knibbe, C.A.J. · Windhorst, A.D. · Hendrikse, N.H. · Vaes, W.H.J. · Spaans, E. · Fabriek, B.O. · Sandman, H. · Grossouw, D. · Hanff, L.M. · Janssen, P.J.J.M. · Koch, B.C.P. · Tibboel, D. · Wildt, S.N. de
Keywords: Nutrition · Carbon 14 · Drug metabolite · Paracetamol · Accelerator mass spectrometry · Blood sampling · Child · Clinical article · Drug blood level · Drug metabolism · Female · Human · Indwelling catheter · Infant · Limit of quantitation · Liquid chromatography · Male · Mass spectrometry · Maximum plasma concentration · Newborn · Open study · Pharmacokinetics · Pilot study · Preschool child · Priority journal · Single drug dose · Time to maximum plasma concentration · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

6 Desloratadine shows no effect on performance during 6 h at 8,000 ft simulated cabin altitude
article 2004    
Author: Valk, P.J.L. · Roon, D.B. van · Simons, M. · Rikken, G.
Keywords: Aviation · Aviation · Cognition · Performance · Physiology · Sleep · Vigilance · Cognitive performance · Desloratadine · H1-receptor antagonist · Antihistaminic agent · Desloratadine · Diphenhydramine · Long acting drug · Placebo · Sedative agent · Adult · Airplane crew · Airplane pilot · Alertness · Altitude · Atmospheric pressure · Clinical trial · Cognition · Controlled clinical trial · Crossover procedure · Double blind procedure · Drug effect · Eye tracking · Fatigue · Flight · Flying · Human · Interpersonal communication · Male · Measurement · Normal human · Performance · Pulse oximetry · Randomized controlled trial · Scoring system · Sedation · simulation · single drug dose · Somnolence · Task performance · Administration, Oral · Adolescent · Adult · Aerospace Medicine · Affect · Analysis of Variance · Anti-Allergic Agents · Cross-Over Studies · Diphenhydramine · Double-Blind Method · Histamine H1 Antagonists, Non-Sedating · Humans · Loratadine · Male · Oximetry · Psychomotor Performance · Sleep · Statistics, Nonparametric
[PDF] [Abstract]

7 Transdermal administration of radiolabelled [14C]rotigotine by a patch formulation: A mass balance trial
article 2007    
Author: Cawello, W. · Wolff, H.M. · Meuling, W.J.A. · Horstmann, R. · Braun, M.
Keywords: Biomedical Research · carbon 14 · dopamine receptor stimulating agent · rotigotine · silicone · adult · article · clinical trial · diarrhea · dizziness · drug absorption · drug clearance · drug delivery system · drug distribution · drug elimination · drug formulation · drug metabolism · drug penetration · drug release · drug structure · drug tolerability · fatigue · human · human experiment · isotope labeling · liquid chromatography · liquid scintillation counting · male · mass balance · normal human · phase 1 clinical trial · priority journal · radioactivity · single drug dose · tandem mass spectrometry · Administration, Cutaneous · Adolescent · Adult · Carbon Radioisotopes · Chromatography, Liquid · Dopamine Agonists · Humans · Male · Middle Aged · Tandem Mass Spectrometry · Tetrahydronaphthalenes · Thiophenes
[Abstract]

8 The probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/6 mice
article 2015    
Author: Mariman, R. · Tielen, F. · Koning, F. · Nagelkerken, L.
Keywords: Biology · Flow cytometry · Host genetics · Immune modulation · Microarray · Probiotics · Chemokine receptor CCR5 · Chemokine receptor CXCR3 · Eosinophil peroxidase · Gamma interferon inducible protein 10 · Interleukin 12 receptor beta1 · Retinoid related orphan receptor gamma · Transcription factor GATA 3 · VSL3 · Adaptive immunity · Animal experiment · Colon · Controlled study · Female · Gene expression · Genetic variability · Homeostasis · Immunomodulation · Innate immunity · Intestine mucosa · Major histocompatibility complex · Mesentery lymph node · Microarray analysis · Mouse · Mouse strain · Nonhuman · Phenotype · Principal component analysis · Protein expression · Single drug dose · Small intestine · Upregulation · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

9 The effects of the fibrin-derived peptide Bβ15-42 in acute and chronic rodent models of myocardial ischemia-reperfusion
article 2007    
Author: Zacharowski, K. · Zacharowski, P.A. · Friedl, P. · Mastan, P. · Koch, A. · Boehm, O. · Rother, R.P. · Reingruber, S. · Henning, R. · Emeis, J.J. · Petzelbauer, P.
Keywords: Biology · Biomedical Research · Fibrin-derived peptide · Ischemia-reperfusion · Myocardial infarction · Preclinical study centers · CD18 antigen · Complement component C5 inhibitor · Fibrin derivative · Peptide derivative · Scavenger · Tempol · Acute heart infarction · Animal experiment · Animal model · Animal tissue · Article · Controlled study · Cytokine release · Drug effect · Heart infarction size · Heart muscle ischemia · Heart muscle reperfusion · Heart protection · Ischemic preconditioning · Leukocyte migration · Male · Nonhuman · Rat · Single drug dose · Therapy effect · Treatment outcome · Treatment response · Animals · Antigens, CD18 · Cyclic N-Oxides · Disease Models, Animal · Fibrinogen · Free Radical Scavengers · Interleukin-6 · Mice · Mice, Inbred BALB C · Models, Biological · Myocardial Infarction · Myocardial Reperfusion · Myocardium · Rats · Reperfusion Injury · Spin Labels
[Abstract]

10 CNTO736, a novel glucagon-like peptide-1 receptor agonist, ameliorates insulin resistance and inhibits very low-density lipoprotein production in high-fat-fed mice
article 2009    
Author: Parlevliet, E.T. · Schröder-van der Elst, J.P. · Corssmit, E.P.M. · Picha, K. · O'Neil, K. · Stojanovic-Susulic, V. · Ort, T. · Havekes, L.M. · Romijn, J.A. · Pijl, H.
Keywords: Biology · Biomedical Research · CNTO 736 · exendin 4 · glucagon like peptide 1 derivative · glucagon like peptide 1 receptor · very low density lipoprotein · glucagon like peptide receptor · glucagon receptor · glucagon-like peptide receptor · hybrid protein · triacylglycerol · animal experiment · animal model · chronic drug administration · controlled study · gluconeogenesis · glucose blood level · glucose transport · hyperinsulinemia · lipid diet · lipoprotein metabolism · male · mouse · nonhuman · single drug dose · animal food · blood · C57BL mouse · Cytomegalovirus · Drug effect · Drug potentiation · Fat intake · Genetics · Intravenous drug administration · Metabolism · Molecular cloning · Animal Feed · Animals · Blood Glucose · Cloning, Molecular · Cytomegalovirus · Dietary Fats · Glucose · Glucose Clamp Technique · Hyperinsulinism · Infusions, Intravenous · Insulin · Insulin Resistance · Lipoproteins, VLDL · Liver · Mice · Mice, Inbred C57BL · Promoter Regions, Genetic · Receptors, Glucagon · Recombinant Fusion Proteins · Triglycerides
[Abstract]

11 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date