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1 Interaction of digitalis-like compounds with liver uptake transporters NTCP, OATP1B1, and OATP1B3
article 2014    
Author: Gozalpour, E. · Greupink, R. · Wortelboer, H.M. · Bilos, A. · Schreurs, M. · Russel, F.G.M. · Koenderink, J.B.
Keywords: Biology Pharmacology · Bufadienolides · Cardenolides · Cell transport · Convallatoxin · Digitalis-like compounds · Dihydroouabain · Drug-induced toxicity · NTCP · OATP1B1 · OATP1B3 · Ouabagenin · Ouabain · Cardiac glycoside · Convallatoxin · Cymarin · Dehydroouabain · Digitoxigenin · Digitoxin · Digoxigenin · Digoxin · Dihydroouabain · Estradiol 17 glucuronide · Gitoxigenin · Hydroxyl group · Ouabagenin · Ouabain · Peruvoside · Plant glycoside · Proscillaridin · Sodium bile acid cotransporter · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Strophanthidin · Strophanthidol · Sugar · Taurocholic acid · Unclassified drug · Animal cell · Chemical structure · CHO cell line · Controlled study · Drug interaction · Drug uptake · Embryo · Human · Human cell · IC 50 · Kidney cell · Liquid chromatography · Mass spectrometry · Nonhuman · Food and Nutrition · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

2 Predicting carrier-mediated hepatic disposition of rosuvastatin in man by scaling from individual transfected cell-lines in vitro using absolute transporter protein quantification and PBPK modeling.
article 2014    
Author: Bosgra, S. · Steeg, E. van de · Vlaming, M.L. · Verhoeckx, K.C. · Huisman, M.T. · Verwei, M. · Wortelboer, H.M.
Keywords: Biology · Transporter · Hepatic disposition · Transfected cell-lines · Protein abundance · LC–MS · Hepatic disposition · OATP · PBPK model · Polymorphisms · Protein abundance · Transfected cell-lines · Drug carrier · Organic anion transporter B · Rosuvastatin · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Controlled study · Drug clearance · Drug disposition · Drug transport · Enterohepatic circulation · Gene overexpression · Genetic transfection · Genetic variability · HEK293 cell line cell tissue · In vitro study · In vivo study · Intrinsic clearance · Liquid chromatography · Liver · Liver cell · Model · Outer membrane · Physiology based pharmacokinetic model · Prediction · Protein analysis · Simulation · Single drug dose · Tandem mass spectrometry · Food and Nutrition · Healthy Living · Life · RAPID - Risk Assessment Products in Development MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Generation of Bayesian prediction models for OATP-mediated drug-drug interactions based on inhibition screen of OATP1B1, OATP1B1∗15 and OATP1B3
article 2015    
Author: Steeg, E. van de · Venhorst, J. · Jansen, H.T. · Nooijen, I.H.G. · Degroot, J. · Wortelboer, H.M. · Vlaming, M.L.H.
Keywords: Biology · Bayesian prediction model · Computational modeling · Drugdrug interaction · OATP · Polymorphisms · Transporter · Abamectin · Acemetacin · Atazanavir · Bromocriptine mesilate · Clarithromycin · Clobetasol propionate · Dihydroergocristine methanesulfonate · Dipyridamole · Docetaxel · Estradiol · Fluindostatin · Fosinopril · Losartan · Mifepristone · Nicardipine · Olmesartan · Pranlukast · Pyrantel embonate · Rapamycin · Rifampicin · Rifamycin · Salazosulfapyridine · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B1 15 · Solute carrier organic anion transporter 1B3 · Suramin · Telmisartan · Tibolone · Troglitazone · Unclassified drug · Unindexed drug · Bayesian learning · Controlled study · Drug protein binding · HEK293 cell line · Human cell · Nucleotide sequence · Prediction · Priority journal · Protein expression · Tandem mass spectrometry · Ultra performance liquid chromatography · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Proteomics of human liver membrane transporters: a focus on fetuses and newborn infants
article 2018    
Author: Groen, B.D. van · Steeg, E. van de · Mooij, M.G. · Lipzig, M.M.H. van · Koning, B.A.E. de · Verdijk, R.M. · Wortelboer, H.M. · Gaedigk, R. · Bi, C. · Leeder, S. · Schaik, R.H.N. van · Rosmalen, J. van · Tibboel, D. · Vaes, W.H. · Wildt, S.N. de
Keywords: Biology · Liver · Ontogeny · Pediatrics · Proteomics · Transporters · Bile salt export pump · Breast cancer resistance protein · Glucose transporter 1 · Monocarboxylate transporter 1 · Multidrug resistance associated protein 1 · Multidrug resistance associated protein 2 · Multidrug resistance associated protein 3 · Multidrug resistance protein 1 · Organic anion transporter B · Organic cation transporter 1 · RNA · Sodium bile acid cotransporter · Solute carrier organic anion transporter 1A1 · Solute carrier organic anion transporter 1B1 · Solute carrier organic anion transporter 1B3 · Cohort analysis · Controlled study · Female · Fetus · Fetus liver · Genetic variability · Genotype · Human · Human tissue · Infant · Liquid chromatography-mass spectrometry · Liver membrane · Major clinical study · Male · Membrane transport · MRNA expression level · Newborn · Pilot study · Prematurity · Protein expression · Protein expression level · Proteomics · RNA sequence · Single nucleotide polymorphism
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 4 of 4 found. | Sort by date