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Showing 1 to 19 of 19 found. | Sort by date

1 Statistical designs in combination toxicology: A matter of choice
article 1996    
Author: Schoen, E.D.
Keywords: Aldehydes · Animals · Dose-Response Relationship, Drug · Drug Interactions · Drug Synergism · Models, Statistical · Predictive Value of Tests · Rats · Research Design · Toxicology
[Abstract]

2 Survival of aerosolized bacteriophage phiX174 in air containing ozone olefin mixtures
article 1977    
Author: Mik, G. de · Groot, I. de · Gerbrandy, J.L.F.
Keywords: Biology · Bacteriophage · Escherichia coli · In vitro study · Microorganism · Theoretical study · Virus inactivation · Aerosols · Air Microbiology · Alkenes · Chemistry · Coliphages · DNA Viruses · Drug Synergism · Ozone
[Abstract]

3 Influence of single and multiple doses of amifostine on the efficacy and the pharmacokinetics of carboplatin in mice
article 1997    
Author: Korst, A.E.C. · Boven, E. · Sterre, M.L.T. van der · Fichtinger-Schepman, A.M.J. · Vijgh, W.J.F. van der
Keywords: Amifostine · Anti-tumour activity · Carboplatin · Hypothermia · Pharmacokinetics · Amifostine · Animals · Antineoplastic Agents · Body Temperature · Carboplatin · DNA Adducts · Drug Administration Schedule · Drug Synergism · Female · Humans · Mice · Mice, Nude · Neoplasm Transplantation · Ovarian Neoplasms · Platinum · Radiation-Protective Agents · Transplantation, Heterologous
[PDF] [Abstract]

4 Effects of flavonoid mixtures on the transport of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through Caco-2 monolayers: An in vitro and kinetic modeling approach to predict the combined effects on transporter inhibition
article 2008    
Author: Schutte, M.E. · Boersma, M.G. · Verhallen, D.A.M. · Groten, J.P. · Rietjens, I.M.C.M.
Keywords: ABC transporters · Caco-2 · Flavonoids · Kinetic modeling · Mixtures · PhIP · 2 amino 1 methyl 6 phenylimidazo[4,5 b]pyridine · Biological Transport, Active · Caco-2 Cells · Carcinogens · Drug Synergism · Flavonoids · Humans · Imidazoles · Models, Biological
[Abstract]

5 Effect of cigarette-smoke condensate and norharman on the induction of SCEs by direct and indirect mutagens in CHO cells
article 1986    
Author: Rutten, A.A.J.J.L. · Wilmer, J.W.G.M.
Keywords: Nutrition · 2 Aminoanthracene · 2 Fluorenylamine · Benzo[a]pyrene · Beta carboline · Cyclophosphamide · Fluorenylacetohydroxamic acid · Methylnitronitrosoguanidine · Mitomycin c · N (2 fluorenyl)acetamide · Tobacco smoke · Animal cell · Cell culture · Chemical mutagenesis · Cho cell · Cigarette smoking · Drug efficacy · Drug interaction · Female genital system · Heredity · In vitro study · Methodology · Mutagen testing · Nonhuman · Priority journal · Sister chromatid exchange · Synergism · Topical drug administration · Alkaloids · Animal · Cell Line · Drug Synergism · Hamsters · Harmine · Mutagenicity Tests · Mutagens · Plants, Toxic · Sister Chromatid Exchange · Smoke · Support, Non-U.S. Gov't · Tobacco · Biology · cytology · celleer

6 Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin
article 2008    
Author: Haan, W. de · Vries-van der Weij, J. de · Hoorn, J.W.A. van der · Gautier, T. · Hoogt, C.C. van der · Westerterp, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Atherosclerosis · Cholesteryl ester transfer proteins · Drugs · Lipids · Lipoproteins · Apolipoprotein E · Atorvastatin · Cholesterol · Cholesterol ester transfer protein · Collagen · High density lipoprotein cholesterol · Monocyte chemotactic protein 1 · Torcetrapib · Atherosclerosis · Cholesterol blood level · Drug activity · Evaluation · Female · Inflammation · Macrophage · Monocyte · Mouse · Nonhuman · Phenotype · Sham feeding · Statistical significance · Animals · Atherosclerosis · Cholesterol Ester Transfer Proteins · Drug Synergism · Heptanoic Acids · Inflammation · Mice · Mice, Inbred Strains · Pyrroles · Quinolines
[PDF] [Abstract]

7 4-Week oral toxicity study of a combination of eight chemicals in rats: Comparison with the toxicity of the individual compounds
article 1990    
Author: Jonker, D. · Woutersen, R.A. · Bladeren, P.J. van · Til, H.P. · Feron, V.J.
Keywords: dioctyltin dichloride · hemoglobin · loperamide · lysinoalanine · metaldehyde · mirex · potassium nitrite · sodium metabisulfite · stannous chloride · unclassified drug · animal experiment · article · drug mixture · female · kidney mass · male · nonhuman · priority journal · rat · toxicity · Administration, Oral · Animal · Blood · Body Weight · Drug Synergism · Drug Toxicity · Eating · Female · Male · Organ Weight · Pharmaceutical Preparations · Rats · Rats, Inbred Strains · Support, Non-U.S. Gov't · Animalia · Rattus norvegicus
[Abstract]

8 Toxicological evaluation and risk assessment of chemical mixtures
article 1998    
Author: Cassee, F.R. · Groten, J.P. · Bladeren, P.J. van · Feron, V.J.
Keywords: Nutrition · Combination toxicology · Complex mixtures · Isoboles · Physiologically based toxicokinetic modeling · Response surface analysis · Simple mixtures · Weight of evidence approach · Chemical compound · Chemical analysis · Dose response · Drug mechanism · Drug potentiation · Environmental exposure · Review · Risk assessment · Toxin analysis · Animals · Drug Interactions · Drug Synergism · Guidelines · International Cooperation · Male · Models, Biological · Models, Statistical · No-Observed-Adverse-Effect Level · Rats · Risk Assessment · Xenobiotics
[Abstract]

9 Toxicity of mixtures of nephrotoxicants with similar or dissimilar mode of action
article 1996    
Author: Jonker, D. · Woutersen, R.A. · Feron, V.J.
Keywords: Toxicology · Hexachlorobutadiene · Limonene · Lysinoalanine · Mercuric chloride · Tetrachloroethylene · Trichloroethylene · Animal experiment · Animal model · Chemical interaction · Controlled study · Drug mixture · Nephrotoxicity · Nonhuman · Sex difference · Administration, Oral · Animals · Body Weight · Butadienes · Carcinogens · Chlorofluorocarbons · Cyclohexenes · Dose-Response Relationship, Drug · Drug Synergism · Female · Fungicides, Industrial · Kidney Tubules, Proximal · Lysinoalanine · Male · Mercuric Chloride · Organ Size · Random Allocation · Rats · Rats, Wistar · Solvents · Specific Pathogen-Free Organisms · Terpenes · Tetrachloroethylene · Trichloroethylene
[Abstract]

10 Dietary fish oil (MaxEPA) enhances pancreatic carcinogenesis in azaserine-treated rats
article 1996    
Author: Appel, M.J. · Woutersen, R.A.
Keywords: Nutrition · Animals · Anticarcinogenic Agents · Azaserine · Body Weight · Carcinogens · Cell Division · Cocarcinogenesis · Dietary Fats, Unsaturated · Docosahexaenoic Acids · Drug Combinations · Drug Synergism · Eating · Eicosapentaenoic Acid · Fatty Acids · Fatty Acids, Omega-3 · Female · Fish Oils · Liver · Organ Size · Pancreatic Neoplasms · Precancerous Conditions · Pregnancy · Prostaglandins · Rats · Rats, Wistar
[PDF] [Abstract]

11 Interaction of reteplase with heparin. A comparison between reteplase and alteplase
article 1996    
Author: Rijken, D.C. · Jie, A.F.H.
Keywords: Biology · Alteplase · BM 06.022 · Fibrinolysis · Heparin · Plasminogen activation · Reteplase · Thrombolysis · Tissue-type plasminogen activator · alteplase · heparin · reteplase · article · blood clot lysis · controlled study · drug interaction · fibrinolysis · plasminogen activation · priority journal · Amidohydrolases · Anticoagulants · Drug Synergism · Enzyme Activation · Fibrinolytic Agents · Glycosylation · Heparin · Humans · Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase · Plasminogen · Plasminogen Activators · Protein Binding · Recombinant Proteins · Sepharose · Tissue Plasminogen Activator
[Abstract]

12 Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice
article 2007    
Author: Hoorn, J.W.A. van der · Kleemann, R. · Havekes, L.M. · Kooistra, T. · Princen, H.M.G. · Jukema, J.W.
Keywords: Biology · Biomedical Research · APOE*3Leiden mice · Atherosclerosis · Combination therapy · Olmesartan · Pravastatin · T lymphocyte · transgenic mouse · Angiotensin II Type 1 Receptor Blockers · Animals · Apolipoprotein E3 · Atherosclerosis · Blood Pressure · Collagen · Diet, Atherogenic · Drug Synergism · Female · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Imidazoles · Inflammation · Lipids · Macrophages · Mice · Mice, Transgenic · Monocytes · Muscle, Smooth, Vascular · Pravastatin · Recombinant Proteins · Serum Amyloid A Protein · T-Lymphocytes · Tetrazoles
[PDF] [Abstract]

13 Mixtures and interactions
article 2000    
Author: Groten, J.P.
Keywords: Nutrition · Additivity · Disinfection by-products · Interactions · Risk assessment of chemical mixtures · Statistical designs · Synergism · Toxicology of chemical mixtures · Drinking water · Chemical composition · Conference paper · Disinfection · Environmental exposure · Health hazard · Human · Nonhuman · Public health · Risk assessment · Toxicity · Drug Interactions · Humans · Risk Assessment · Water Pollutants, Chemical · Water Supply · Animalia
[Abstract]

14 Statistically designed experiments in a tiered approach to screen mixtures of Fusarium mycotoxins for possible interactions
article 2002    
Author: Tajima, O. · Schoen, E.D. · Feron, V.J. · Groten, J.P.
Keywords: Central composite design · Full factorial design · Fusarium mycotoxins · Interaction · Joint action · Tiered approach · Fumonisin B1 · Mycotoxin · Nivalenol · T 2 toxin · Vomitoxin · Zearalenone · Animal cell · Bioassay · Controlled study · Diagnostic test · Fungal strain · Fusarium · Mouse · Nonhuman · Racemic mixture · Screening · Statistical analysis · Algorithms · Animals · Cell Line · DNA · Dose-Response Relationship, Drug · Drug Synergism · Fusarium · Linear Models · Mice · Mycotoxins · Nucleic Acid Synthesis Inhibitors · Fusarium · Zea
[Abstract]

15 A comparison of the oximes HS-6 and HI-6 in the therapy of soman intoxication in rodents
article 1978    
Author: Kepner, L.A. · Wolthuis, O.L.
Keywords: Biology · Atropine · Cholinesterase reactivator · Oxime · Soman · 1 (3 carbamoylpyridinio) 1 (2 hydroximinoethylpyridinio)dimethyl ether · Animal experiment · Breathing · Drug comparison · Drug intoxication · Drug response · Intoxication · Intraperitoneal drug administration · Mouse · Muscle · Musculoskeletal system · Neuromuscular transmission · Organophosphate poisoning · Rat · Respiratory system · Subcutaneous drug administration · Animal · Atropine · Comparative Study · Drug Synergism · Female · Male · Mice · Neuromuscular Junction · Organophosphorus Compounds · Oximes · Rats · Rats, Inbred Strains · Respiration · Soman
[Abstract]

16 Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation
article 2007    
Author: Staal, Y.C.M. · Hebels, D.G.A.J. · Herwijnen, M.H.M. van · Gottschalk, R.W.H. · Schooten, F.J. van · Delft, J.H.M. van
Keywords: Toxicology and Applied Pharmacology · benzo[a]pyrene · benzo[b]fluoranthene · dibenz[a,h]anthracene · dibenzo[a,l]pyrene · fluoranthene · phenanthrene derivative · polycyclic aromatic hydrocarbon · apoptosis · article · carcinogenesis · carcinogenicity · cell cycle · cell strain HepG2 · controlled study · DNA adduct · exposure · gene expression · hepatoma cell · human · human cell · nucleotide sequence · priority journal · unindexed sequence · Air Pollutants · Apoptosis · Cell Cycle · Cell Line, Tumor · DNA Adducts · Drug Antagonism · Drug Synergism · Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Humans · Polycyclic Hydrocarbons, Aromatic
[Abstract]

17 Pharmacokinetics of cisplatin with and without amifostine in tumour- bearing nude mice
article 1998    
Author: Korst, A.E.C. · Boven, E. · Sterre, M.L.T. van der · Fichtinger-Schepman, A.M.J. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Ethyol · Pharmacokinetics · WR-2721 · Amifostine · Cisplatin · Dna · Animal cell · Animal experiment · Animal model · Animal tissue · Area under the curve · Article · Bone marrow · Controlled study · Dna adduct · Drug blood level · Drug tissue level · Female · Human · Human tissue · Intraperitoneal drug administration · Intravenous drug administration · Kidney · Liver · Mouse · Nonhuman · Nude mouse · Ovary cancer · Pharmacokinetics · Priority journal · Tumor xenograft · Amifostine · Animals · Antineoplastic Agents · Cisplatin · Drug Combinations · Drug Synergism · Female · Humans · Kidney · Liver · Mice · Neoplasm Transplantation · Ovarian Neoplasms · Platinum · Radiation-Protective Agents · Transplantation, Heterologous
[Abstract]

18 Membrane-type matrix metalloproteinase-mediated angiogenesis in a fibrin-collagen matrix
article 2003    
Author: Collen, A. · Hanemaaijer, R. · Lupu, F. · Quax, P.H.A. · Lent, N. van · Grimbergen, J. · Peters, E. · Koolwijk, P. · Hinsbergh, V.W.M. van
Keywords: Biology · Biomedical Research · Adenoviridae · Aprotinin · Cells, Cultured · Collagen · Culture Media · Defective Viruses · Drug Synergism · Endothelial Growth Factors · Endothelium, Vascular · Fibrin · Fibroblast Growth Factor 2 · Genetic Vectors · Heart Diseases · Humans · Intercellular Signaling Peptides and Proteins · Lymphokines · Matrix Metalloproteinase 1 · Matrix Metalloproteinase 2 · Matrix Metalloproteinases, Membrane-Associated · Metalloendopeptidases · Neovascularization, Pathologic · Neovascularization, Physiologic · Phenylalanine · Protease Inhibitors · Thiophenes · Thrombosis · Tissue Inhibitor of Metalloproteinase-1 · Tissue Inhibitor of Metalloproteinase-3 · Transduction, Genetic · Tumor Necrosis Factor-alpha · Vascular Endothelial Growth Factor A · Vascular Endothelial Growth Factors
[Abstract]

19 Transcriptomics analysis of interactive effects of benzene, trichloroethylene and methyl mercury within binary and ternary mixtures on the liver and kidney following subchronic exposure in the rat
article 2007    
Author: Hendriksen, P.J.M. · Freidig, A.P. · Jonker, D. · Thissen, U. · Bogaards, J.J.P. · Mumtaz, M.M. · Groten, J.P. · Stierum, R.H.
Keywords: Biology · Analytical research · Biomedical research · Benzene · Mercury · Microarrays · Mixtures · Toxicogenomics · Trichloroethylene · benzene · biological marker · messenger RNA · methylmercury · trichloroethylene · animal experiment · animal tissue · apoptosis · article · Ccng1 gene · cell proliferation · cell viability · controlled study · gene · gene expression profiling · gene induction · id2 gene · liver toxicity · long term exposure · male · MDM2 gene · microarray analysis · nephrotoxicity · NFKB1 gene · nonhuman · Nr2f6 gene · rat · stress · tissue specificity · tnfrsf1a gene · toxicogenetics · transcriptomics · Animals · Benzene · Cell Survival · Drug Interactions · Drug Synergism · Environmental Pollutants · Gene Expression Profiling · Gene Expression Regulation · Kidney · Liver · Male · Methylmercury Compounds · No-Observed-Adverse-Effect Level · Oligonucleotide Array Sequence Analysis · Rats · Rats, Inbred F344 · RNA, Messenger · Toxicity Tests · Trichloroethylene · Rattus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 19 of 19 found. | Sort by date