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Showing 1 to 16 of 16 found. | Sort by date

1 Detection of titanium particles in human liver and spleen and possible health implications
article 2018    
Author: Heringa, M.B. · Peters, R.J.B. · Bleys, R.L.A.W. · Lee, M.K. van der · Tromp, P.C. · Kesteren, P.C.E. van · Eijkeren, J.C.H. van · Undas, A.K. · Oomen, A.G. · Bouwmeester, H.
Keywords: Health · Human liver · Human spleen · Nanoparticle · Quantification · Risk assessment · Sp-ICP-HRMS · Tissue level · Titanium dioxide · Environment & Sustainability · Urbanisation
[Abstract]

2 In vitro intestinal lead uptake and transport in relation to speciation
article 2003    
Author: Oomen, A.G. · Tolls, J. · Sips, A.J.A.M. · Groten, J.P.
Keywords: Biology Health · Physiological Sciences · lead · pollution exposure · article · bioavailability · cell strain CACO 2 · controlled study · first pass effect · human · human cell · intestine absorption · lead poisoning · membrane permeability · metal metabolism · priority journal · risk assessment · soil pollution · tissue level · Administration, Oral · Biological Availability · Caco-2 Cells · Digestive System · Humans · Intestinal Mucosa · Ions · Lead · Soil Pollutants
[Abstract]

3 Fluorometric determination of retinol in human tear fluid using high-performance liquid chromatography
article 1986    
Author: Speek, A.J. · Agtmaal, E.J. van · Saowakontha, S. · Schreurs, W.H.P. · Haeringen, N.J. van
Keywords: Retinol · Drug analysis · Drug determination · Drug tissue level · Fluorometry · High performance liquid chromatography · Human · Human cell · Methodology · Normal human · Tear · Visual system · Chromatography, High Pressure Liquid · Drug Stability · Evaluation Studies · Fluorometry · Human · Support, Non-U.S. Gov't · Tears · Vitamin A · Biology · Biochemistry · Medicine · Geneeskunde
[Abstract]

4 Association between toenail scandium levels and risk of acute myocardial infarction in European men: The EURAMIC and Heavy Metals Study
article 2002    
Author: Gómez-Aracena, J. · Martin-Moreno, J.M. · Riemersma, R.A. · Bode, P. · Gutiérrez-Bedmar, M. · Gorgojo, L. · Kark, J.D. · Garcia-Rodríguez, A. · Gomez-Gracia, E. · Kardinaal, A.F.M. · Aro, A. · Veer, P. van 't · Wedel, H. · Kok, F.J. · Fernández-Crehuet, J.
Keywords: Health · Physiological Sciences · Antioxidant · Heavy metals · Lycopene · Myocardial infarction · Rare earth elements · Scandium · alpha tocopherol · beta carotene · heavy metal · lycopene · mercury · oleic acid · scandium · selenium · acute heart infarction · adipose tissue · adult · alcohol consumption · article · body burden · body mass · cardiovascular risk · case control study · controlled study · coronary risk · correlation analysis · diabetes mellitus · family history · heart protection · human · hypertension · major clinical study · metal recovery · risk assessment · smoking · tissue level · toe · Biological Markers · Case-Control Studies · Humans · Male · Middle Aged · Myocardial Infarction · Nails · Risk Factors · Scandium
[Abstract]

5 Toenail selenium levels and the subsequent risk of prostate cancer: A prospective cohort study
article 2003    
Author: Brandt, P.A. van den · Zeegers, M.P.A. · Bode, P. · Goldbohm, R.A.
Keywords: Health Chemistry · Food and Chemical Risk Analysis · Alpha carotene · Alpha tocopherol · Beta cryptoxanthin · Cryptoxanthin · Lycopene · Unclassified drug · Xanthophyll · Zeaxanthin · Adult · Cancer incidence · Cancer risk · Cancer survival · Controlled study · Drug tissue level · Human tissue · Major clinical study · Multivariate analysis · Prostate cancer · Selenium toenail level · Aged · Antioxidants · Ascorbic Acid · beta Carotene · Carotenoids · Cohort Studies · Follow-Up Studies · Humans · Male · Middle Aged · Nails · Netherlands · Prospective Studies · Prostatic Neoplasms · Questionnaires · Risk Factors · Selenium · Smoking · Vitamin E · Xanthophylls
[Abstract]

6 Application of physiologically based toxicokinetic modelling to study the impact of the exposure scenario on the toxicokinetics and the behavioural effects of toluene in rats
article 2003    
Author: Asperen, J. van · Rijcken, W.R.P. · Lammers, J.H.C.M.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Peak exposure · Physiologically based toxicokinetic modelling · Rat · Toluene · toluene · animal experiment · area under the curve · article · behavior · blood level · brain level · concentration response · controlled study · exposure · male · model · nonhuman · prediction · priority journal · rat · reliability · task performance · tissue level · toxicokinetics · visual discrimination · Administration, Inhalation · Animals · Behavior, Animal · Brain · Discrimination Learning · Dose-Response Relationship, Drug · Inhalation Exposure · Models, Biological · Rats · Toluene · Visual Perception
[Abstract]

7 Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage
article 2012    
Author: Vos, P.A.J.M. · Degroot, J. · Barten-Van Rijbroek, A.D. · Zuurmond, A.-M. · Bijlsma, J.W.J. · Mastbergen, S.C. · Lafeber, F.P.J.G.
Keywords: Health · canine · non-enzymatic glycation · osteoarthritis · pentosidine · proteoglycan · advanced glycation end product · carbohydrate · pentosidine · proteoglycan · ribose · threose · unclassified drug · animal cell · animal experiment · animal model · animal tissue · article · bone turnover · cartilage · cartilage cell · cartilage injury · controlled study · experimental dog · female · histopathology · in vivo study · joint degeneration · knee surgery · nonhuman · osteoarthritis · priority journal · synovitis · tissue level · Healthy for Life · Healthy Living · Life · MHR - Metabolic Health Research PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

8 Pharmacokinetics of cisplatin with and without amifostine in tumour- bearing nude mice
article 1998    
Author: Korst, A.E.C. · Boven, E. · Sterre, M.L.T. van der · Fichtinger-Schepman, A.M.J. · Vijgh, W.J.F. van der
Keywords: Nutrition · Amifostine · Cisplatin · Ethyol · Pharmacokinetics · WR-2721 · Amifostine · Cisplatin · Dna · Animal cell · Animal experiment · Animal model · Animal tissue · Area under the curve · Article · Bone marrow · Controlled study · Dna adduct · Drug blood level · Drug tissue level · Female · Human · Human tissue · Intraperitoneal drug administration · Intravenous drug administration · Kidney · Liver · Mouse · Nonhuman · Nude mouse · Ovary cancer · Pharmacokinetics · Priority journal · Tumor xenograft · Amifostine · Animals · Antineoplastic Agents · Cisplatin · Drug Combinations · Drug Synergism · Female · Humans · Kidney · Liver · Mice · Neoplasm Transplantation · Ovarian Neoplasms · Platinum · Radiation-Protective Agents · Transplantation, Heterologous
[Abstract]

9 Enhancement of tissue-type plasminogen activator levels by retinoids in rat tissues in vivo
article 1992    
Author: Kooistra, T. · Bennekum, A.M. van · Hendriks, H.F.J. · Brouwer, A. · Roholl, P.J.M. · Emeis, J.J.
Keywords: Health · antiplasmin · fibrinogen · isotretinoin · plasminogen · plasminogen activator · plasminogen activator inhibitor · plasminogen activator inhibitor 1 · retinoic acid · retinoid · retinol · retinol acetate · retinol palmitate · tissue plasminogen activator · urokinase · von willebrand factor · animal experiment · animal tissue · blood level · conference paper · controlled study · fibrinogen blood level · intragastric drug administration · nonhuman · retinol deficiency · tissue level · Animal · Female · Immunoenzyme Techniques · Isotretinoin · Kidney · Plasminogen Activator Inhibitor 1 · Rats · Rats, Inbred BN · Time Factors · Tissue Plasminogen Activator · Tretinoin · Urinary Plasminogen Activator · Vitamin A · Vitamin A Deficiency · Animalia

10 Feasibility of SPECT-CT imaging to study the pharmacokinetics of antisense oligonucleotides in a mouse model of Duchenne muscular dystrophy
article 2017    
Author: Steeg, E. van de · Läppchen, T. · Aguilera, B. · Jansen, H.T. · Muilwijk, D. · Vermue, R. · Hoorn, J.W. van der · Donato, K. · Rossin, R. · Visser, P.C. de · Vlaming, M.L.H.
Keywords: Nutrition · SPECT imaging · Antisense oligonucleotides · RNA-based therapeutics · Duchenne muscular dystrophy · Antisense oligonucleotides · Antisense oligonucleotide i 123 · Antisense oligonucleotide in 111 · Indium 111 · Iodine 123 · Tracer · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Drug distribution · Drug half life · Drug tissue level · Drug uptake · In vivo study · Male · Mouse · Mouse model · Nonhuman · Single photon emission computed tomography-computed tomography · Skeletal muscle · Target tissue · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

11 Toxicogenomics of bromobenzene hepatotoxicity: A combined transcriptomics and proteomics approach
article 2003    
Author: Heijne, W.H.M. · Stierum, R.H. · Slijper, M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Toxicology Health · Physiological Sciences · Bromobenzene · cDNA microarray · Hepatotoxicity · Proteomics · Toxicogenomics · Transcriptomics · alpha glutamylcysteine synthetase · bromobenzene · cathepsin L · enzyme · epoxide hydrolase · glutathione · glutathione transferase · heme oxygenase · messenger RNA · peroxiredoxin · proteasome · unclassified drug · animal experiment · animal model · animal tissue · article · controlled study · enzyme activity · enzyme induction · enzyme regulation · enzyme subunit · gene control · gene expression · gene identification · gene induction · genomics · glutathione metabolism · liver toxicity · lysosome · male · nonhuman · nucleotide sequence · oxidative stress · priority journal · protein content · protein degradation · protein depletion · protein expression · protein synthesis · proteomics · rat · RNA analysis · tissue level · unindexed sequence · weight reduction · Animals · Bromobenzenes · Liver · Male · Oligonucleotide Array Sequence Analysis · Pharmacogenetics · Proteomics · Rats · Rats, Wistar · Transcription, Genetic
[Abstract]

12 Determinants of p,p'-dichlorodiphenyldichloroethane (DDE) concentration in adipose tissue in women from five European cities
article 1999    
Author: Sanz-Gallardo, M.I. · Guallar, E. · Veer, P. van 't · Longnecker, M.P. · Strain, J.J. · Martin, B.C. · Kardinaal, A.F.M. · Fernández-Crehuet, J. · Thamm, M. · Kohlmeier, L. · Kok, F.J. · Martín-Moreno, J.M.
Keywords: 1,1 dichloro 2,2 bis(4 chlorophenyl)ethylene · antioxidant · arachidic acid · biological marker · fatty acid · retinol · adipose tissue · adult · aged · article · breast cancer · cancer risk · city · controlled study · Europe · female · fish · food chain · food contamination · food intake · human · human tissue · major clinical study · postmenopause · priority journal · regression analysis · tissue level · Adipose Tissue · Aged · Antioxidants · Cross-Sectional Studies · Dichlorodiphenyl Dichloroethylene · Diet · Environmental Exposure · Environmental Monitoring · Europe · Fatty Acids · Female · Food Contamination · Humans · Insecticides · Linear Models · Middle Aged · Multivariate Analysis · Postmenopause · Questionnaires · Risk Factors · Urban Health
[Abstract]

13 Age-related accumulation of Maillard reaction products in human articular cartilage collagen
article 2000    
Author: Verzijl, N. · Groot, J. de · Oldehinkel, E. · Bank, R.A. · Thorpe, S.R. · Baynes, J.W. · Bayliss, M.T. · Bijlsma, J.W.J. · Lafeber, F.P.J.G. · TeKoppele, J.M.
Keywords: Health Biology · Biomedical Research · Advanced glycation end product · Aging · Cross-linking · N(ε)-(carboxymethyl)lysine · Pentosidine · advanced glycation end product · arginine · collagen · collagenase · hydroxylysine · lysine · n carboxyethyllysine · n carxobymethyllysine · pentosidine · unclassified drug · adolescent · adult · age · aged · aging · amino acid composition · article · articular cartilage · bioaccumulation · child · color · controlled study · fluorescence · human · human tissue · priority journal · protein cross linking · protein degradation · protein glycosylation · skin · tensile strength · tissue level · Adolescent · Adult · Age Factors · Aged · Aged, 80 and over · Aging · Arginine · Cartilage, Articular · Child · Child, Preschool · Collagen · Collagenases · Cross-Linking Reagents · Female · Femur · Glycosylation End Products, Advanced · Humans · Lysine · Maillard Reaction · Male · Middle Aged · Skin · Spectrometry, Fluorescence
[Abstract]

14 Effect of eicosapentaenoic acid, an omega-3 polyunsaturated fatty acid, on UVR-related cancer risk in humans. An assessment of early genotoxic markers
article 2003    
Author: Rhodes, L.E. · Shahbakhti, H. · Azurdia, R.M. · Moison, R.M.W. · Steenwinkel, M.J.S.T. · Homburg, M.I. · Dean, M.P. · McArdle, F. · Beijersbergen van Henegouwen, G.M.J. · Epe, B. · Vink, A.A.
Keywords: Health Nutrition · Physiological Sciences · 8 hydroxydeoxyguanosine · alpha tocopherol · antioxidant · ascorbic acid · glutathione · icosapentaenoic acid · monounsaturated fatty acid · oleic acid · omega 3 fatty acid · protein p53 · adult · aged · cancer risk · clinical trial · comet assay · controlled clinical trial · controlled study · DNA damage · DNA strand breakage · dose response · double blind procedure · drug bioavailability · drug structure · drug tissue level · epidermis cell · erythema · female · flatulence · genotoxicity · human · human experiment · human tissue · immunohistochemistry · lipid peroxidation · male · normal human · oxidative stress · peripheral lymphocyte · photooxidation · photosensitivity · priority journal · protein expression · randomized controlled trial · review · skin cancer · skin carcinogenesis · sunburn · ultraviolet radiation · Adult · Aged · Ascorbic Acid · Biological Availability · Dietary Supplements · DNA · DNA Damage · DNA Repair · Double-Blind Method · Eicosapentaenoic Acid · Female · Genetic Markers · Glutathione · Humans · Lipid Peroxidation · Lymphocytes · Male · Middle Aged · Neoplasms, Radiation-Induced · Oleic Acid · Skin · Skin Neoplasms · Tumor Suppressor Protein p53 · Ultraviolet Rays · Vitamin E
[Abstract]

15 A physiologically based pharmacokinetic (PB/PK) model for multiple exposure routes for soman in multiple species
article 2006    
Author: Sweeney, R.E. · Langenberg, J.P. · Maxwell, D.M.
Keywords: Toxicology · Acetylcholinesterase · Carboxylesterase · Enzyme · Soman · Adipose tissue · Allometry · Animal experiment · Animal tissue · Arterial blood · Blood flow velocity · BLood level · Body weight · Breathing rate · Computer language · Computer simulation · Controlled study · Exposure · Guinea pig · In vitro study · Kidney perfusion · LD 50 · Liver perfusion · Lung perfusion · Male · Marmoset · Metabolism · Nonhuman · Partition coefficient · Priority journal · Provocation test · Rat · Regression analysis · Sensitivity analysis · Stereoisomerism · Tidal volume · Tissue level · Toxicokinetics · Venous blood · Administration, Inhalation · Animals · Callithrix · Chemical Warfare Agents · Cholinesterase Inhibitors · Computer Simulation · Guinea Pigs · Injections, Intravenous · Injections, Subcutaneous · Male · Models, Biological · Rats · Rats, Wistar · Animalia · Cavia porcellus · Marmosets · Acetylcholinesterase, 9000-81-1 · Carboxylesterase, 59536-71-9, 83380-83-0, 9016-18-6, 9028-01-7 · Soman, 96-64-0 · Chemical warfare agents · Cholinesterase inhibitors
[Abstract]

16 Disposition of [14C]γ-cyclodextrin in germ-free and conventional rats
article 1998    
Author: Bie, A.T.H.J. de · Ommen, B. van · Bär, A.
Keywords: Nutrition · Carbon 14 · Carbon dioxide · Drug metabolite · Gamma cyclodextrin · Carbon · Cyclodextrin · Gamma cyclodextrin derivative · Gamma-cyclodextrin · Animal experiment · Animal tissue · Carcass · Controlled study · Dose response · Drug bile level · Drug blood level · Drug disposition · Drug feces level · Drug identification · Drug metabolism · Drug saliva level · Drug tissue level · Drug urine level · Female · Gastrointestinal tract · Germfree animal · High performance liquid chromatography · Intravenous drug administration · Isotope labeling · Male · Nonhuman · Oral drug administration · Priority journal · Rat · Animal · Animal food · Bile · Breath analysis · Chemistry · Comparative study · Digestive system · Feces · Intestine absorption · Metabolism · Wistar rat · Administration, Oral · Animal Feed · Animals · Breath Tests · Carbon Dioxide · Carbon Radioisotopes · Cyclodextrins · Digestive System · Feces · Female · gamma-Cyclodextrins · Germ-Free Life · Injections, Intravenous · Intestinal Absorption · Male · Rats · Rats, Wistar
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 16 of 16 found. | Sort by date