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1 Identification of modules in Aspergillus niger by gene co-expression network analysis
article 2010    
Author: Berg, R.A. van den · Braaksma, M. · Veen, D. van der · Werf, M.J. van der · Punt, P.J. · Oost, J. van der · Graaff, L.H. de
Keywords: Biology · Aspergillus niger · Co-expression · Gene co-expression network · RNA profiling · Transcription factor binding site · Transcriptional analysis
[Abstract]

2 Functions of OsDof25 in regulation of OsC4PPDK
article 2015    
Author: Zhang, Y. · Verhoeff, N.I. · Chen, Z. · Chen, S. · Wang, M. · Zhu, Z. · Ouwerkerk, P.B.F.
Keywords: Biology · Dof · OsC4PPDK · Rice · Transcription factor · Biomedical Innovation · Healthy Living · Staf · PO - Projectorganisatie · ELSS - Earth, Life and Social Sciences
[Abstract]

3 Human embryonic stem cell-derived test systems for developmental neurotoxicity: A transcriptomics approach
article 2013    
Author: Krug, A.K. · Kolde, R. · Gaspar, J.A. · Rempel, E. · Balmer, N.V. · Meganathan, K. · Vojnits, K. · Baquié, M. · Waldmann, T. · Ensenat-Waser, R. · Jagtap, S. · Evans, R.M. · Julien, S. · Peterson, H. · Zagoura, D. · Kadereit, S. · Gerhard, D. · Sotiriadou, I. · Heke, M. · Natarajan, K. · Henry, M. · Winkler, J. · Marchan, R. · Stoppini, L. · Bosgra, S. · Westerhout, J. · Verwei, M. · Vilo, J. · Kortenkamp, A. · Hescheler, J. · Hothorn, L. · Bremer, S. · Thriel, C. van · Krause, K.-H. · Hengstler, J.G. · Rahnenführer, J. · Leist, M. · Sachinidis, A.
Keywords: Biology · Alternative testing strategies · Methylmercury · Reproductive toxicity · Transcription factor · Valproic acid · Healthy Living · Life · PHS - Pharmacokinetics & Human Studies · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Time series analysis of benzo[a]pyrene-induced transcriptome changes suggests that a network of transcription factors regulates the effects on functional gene sets
article 2010    
Author: Delft, J.H.M. van · Mathijs, K. · Staal, Y.C.M. · Herwijnen, M.H.M. van · Brauers, K.J.J. · Boorsma, A. · Kleinjans, J.C.S.
Keywords: Nutrition · Biomedical Research · Carcinogen · Network · Time series · Transcription factor · Transcriptome · benzo[a]pyrene · immunoglobulin enhancer binding protein · Myc protein · serum response factor · transcription factor · transcription factor AP 1 · transcription factor E2F1 · transcriptome · amino acid metabolism · apoptosis · article · carcinogenesis · cell cycle G1 phase · cell cycle S phase · controlled study · correlation analysis · DNA adduct · DNA repair · down regulation · functional genomics · gene expression · gene regulatory network · hepatoma cell · human · human cell · lipid metabolism · named inventories, questionnaires and rating scales · proto oncogene · Short Time series Expression Miner · signal transduction · time series analysis · transcription regulation · tumor suppressor gene · upregulation
[Abstract]

5 Inhibition of glycosaminoglycan incorporation influences collagen network formation during cartilage matrix production
article 2009    
Author: Bastiaansen-Jenniskens, Y.M. · Koevoet, W. · Jansen, K.M.B. · Verhaar, J.A.N. · Groot, J. de · Vanosch, G.J.V.M.
Keywords: Biology · Biomedical Research · Cartilage matrix · Glycosaminoglycan · Cartilage cell · Cartilage degeneration · Cell culture · Concentration response · Cross linking · Alginates · Animals · Cattle · Chondrocytes · Collagen Type II · Gene Expression · Glucuronic Acid · Glycosaminoglycans · Glycosides · Hexuronic Acids · SOX9 Transcription Factor · Tissue Culture Techniques · Bovinae
[Abstract]

6 Clinical trial of doxycycline for matrix metalloproteinase-9 inhibition in patients with an abdominal aneurysm doxycycline selectively depletes aortic wall neutrophils and cytotoxic t cells
article 2009    
Author: Lindeman, J.H.N. · Abdul-Hussien, H. · Bockel, J.H. van · Wolterbeek, R. · Kleemann, R.
Keywords: Health · Aneurysm · Immunology · Inflammation · Molecular biology · Trials · Doxycycline · Gelatinase B · Granulocyte colony stimulating factor receptor · Interleukin 13 · Interleukin 6 · Interleukin 8 · Antiinfective agent · CCAAT enhancer binding protein · Enzyme inhibitor · IL6 protein, human · Transcription factor AP 1 · Transcription factor RelA · Abdominal aorta aneurysm · Aged · Cytotoxic T lymphocyte · Drug effect · Drug megadose · Drug tolerability · Enzyme inhibition · Aortic Aneurysm, Abdominal · CCAAT-Enhancer-Binding Proteins · Doxycycline · Enzyme Inhibitors · Matrix Metalloproteinase 9 · Middle Aged · Neutrophils · T-Lymphocytes, Cytotoxic · Vasculitis
[PDF] [Abstract]

7 Enhanced expression and activation of pro-inflammatory transcription factors distinguish aneurysmal from atherosclerotic aorta: IL-6- and IL-8-dominated inflammatory responses prevail in the human aneurysm
article 2008    
Author: Lindeman, J.H.N. · Abdul-Hussien, H. · Schaapherder, A.F.M. · Bockel, J.H. van · Thüsen, J.H. vonder · Roelen, D.L. · Kleemann, R.
Keywords: Health · Abdominal aortic aneurysm · Atherosclerosis · Inflammation · Interleukin · Transcription factor · CCAAT enhancer binding protein alpha · CCAAT enhancer binding protein beta · CCAAT enhancer binding protein delta · Cytokine · Gamma interferon · Interleukin 10 · Interleukin 13 · Interleukin 1alpha · Interleukin 2 · Interleukin 4 · Interleukin 6 · Interleukin 8 · Messenger RNA · Perforin · STAT3 protein · transcription factor · transcription factor AP 1 · transcription factor GATA 3 · transcription factor RelA · transcription factor T bet · tumor necrosis factor alpha · autacoid · biological marker · abdominal aorta aneurysm · adult · aged · aorta atherosclerosis · aorta wall · B lymphocyte · Cellular immunity · Clinical article · Controlled study · Cytotoxic T lymphocyte · Enzyme linked immunosorbent assay · Female · Human · Human tissue · Immunohistochemistry · Male · Medical parameters · Neutrophil · Plasma cell · Protein expression · Real time polymerase chain reaction · Th1 cell · Th2 cell · Vasa vasorum · Western blotting · Aorta valve stenosis · Biosynthesis · Differential diagnosis · Genetics · Immunology · Metabolism · Methodology · Physiology · Reverse transcription polymerase chain reaction · Aged · Aortic Aneurysm, Abdominal · Aortic Valve Stenosis · Atherosclerosis · Biological Markers · Diagnosis, Differential · Female · Gene Expression Profiling · Humans · Inflammation Mediators · Male · Middle Aged · Reverse Transcriptase Polymerase Chain Reaction · Th1 Cells · Th2 Cells · Transcription Factors
[Abstract]

8 β1 integrins regulate chondrogenesis and rock signaling in adipose stem cells
article 2008    
Author: Lu, Z.F. · Doulabi, B.Z. · Huang, C.L. · Bank, R.A. · Helder, M.N.
Keywords: Health · Biomedical Research · β1 integrins · Adipose tissue · Cell shape · Chondrogenesis · Mesenchymal stem cells · Rock signaling · beta1 integrin · collagen type 10 · collagen type 2 · transcription factor Sox9 · transforming growth factor beta1 · DNA binding protein · high mobility group protein · immunoglobulin G · Rho kinase · sox-9 transcription factor · SOX6 protein, human · transcription factor · adipocyte · article · cell interaction · chondrogenesis · collagen 2 gene · collagen x gene · controlled study · down regulation · extracellular matrix · gene · gene expression · human · human cell · human tissue · priority journal · protein function · rock 1 gene · rock 2 gene · signal transduction · Sox9 gene · adipose tissue · cell shape · culture medium · cytology · drug antagonism · drug effect · gene expression regulation · genetics · physiology · stem cell · Adipose Tissue · Antigens, CD29 · Cell Shape · Chondrogenesis · Collagen Type II · Collagen Type X · Culture Media · DNA-Binding Proteins · Gene Expression · Gene Expression Regulation, Developmental · High Mobility Group Proteins · Humans · Immunoglobulin G · rho-Associated Kinases · Stem Cells · Transcription Factors · Transforming Growth Factor beta1 · Healthy for Life · Healthy Living
[Abstract]

9 Glycolipid-dependent sorting of melanosomal from lysosomal membrane proteins by lumenal determinants
article 2008    
Author: Groux-Degroote, S. · Dijk, S.M. van · Wolthoorn, J. · Neumann, S. · Theos, A.C. · Mazière, A.M. de · Klumperman, J. · Meer, G. van · Sprong, H.
Keywords: Biology · Adaptor complex · Glycosphingolipids · Lysosomal protein · Melanosomal enzyme · Melanosome assembly · Protein sorting · Secretory lysosome · chimeric protein · glucosylceramide · glycolipid · glycosphingolipid · lysosome associated membrane protein 1 · lysosome associated membrane protein 2 · membrane protein · monophenol monooxygenase · transcription factor · transcription factor ap 3 · tyrosinase related protein 1 · article · biogenesis · cell surface · cellular distribution · controlled study · Golgi complex · human · human cell · intracellular transport · lysosome · melanocyte · melanosome · priority journal · protein localization · protein targeting · protein transport · Animals · Cell Line, Tumor · Lysosome-Associated Membrane Glycoproteins · Melanocytes · Melanoma · Melanosomes · Mice · Monophenol Monooxygenase · Oxidoreductases · Protein Structure, Tertiary · Protein Transport · Transfection
[Abstract]

10 Key Inflammatory Processes in Human NASH Are Reflected in Ldlr−/−.Leiden Mice: A Translational Gene Profiling Study
article 2018    
Author: Morrison, M.C. · Kleemann, R. · Koppen, A. van · Hanemaaijer, R. · Verschuren, L.
Keywords: Biology · Liver · NASH, · Inflammation · Molecular · Gene expression · Translational · Mouse · Human · Translational · Cytokine · Growth factor · Transcription factor · Animal experiment · Animal model · Controlled study · Extracellular matrix · Gene expression profiling · Human tissue · Inflammation · Lipid diet · Lipid metabolism · Liver biopsy · Mouse · Nonalcoholic fatty liver · Nonhuman · Transcriptomics · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

11 Genistein reduces tumor necrosis factor α-induced plasminogen activator inhibitor-1 transcription but not urokinase expression in human endothelial cells
article 1994    
Author: Hinsbergh, V.W.M. van · Vermeer, M. · Koolwijk, P. · Grimbergen, J. · Kooistra, T.
Keywords: Health · bacterium lipopolysaccharide · daidzein · genistein · herbimycin a · plasminogen activator · protein tyrosine phosphatase · transcription factor · tumor necrosis factor alpha · tyrphostin · urokinase · vanadic acid · cell migration · endothelium cell · enzyme activation · enzyme inhibition · fibrinolysis · genetic transcription · human cell · mitogenesis · plasminogen activation · priority journal · signal transduction · Cells, Cultured · Endothelium, Vascular · Fibroblast Growth Factor 2 · Genistein · Human · In Vitro · Isoflavones · Plasminogen Activator Inhibitor 1 · Protein-Tyrosine Kinase · Receptors, Tumor Necrosis Factor · Signal Transduction · Support, Non-U.S. Gov't · Tissue Plasminogen Activator · Tumor Necrosis Factor · Urinary Plasminogen Activator
[Abstract]

12 Aspirin reduces hypertriglyceridemia by lowering VLDL-triglyceride production in mice fed a high-fat diet
article 2011    
Author: Diepen, J.A. van · Vroegrijk, I.O.C.M. · Berbée, J.F.P. · Shoelson, S.E. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N. · Voshol, P.J.
Keywords: Biology · Inflammation · Lipid metabolism · Very low-density lipoprotein · acetylsalicylic acid · apolipoprotein C1 · immunoglobulin enhancer binding protein · transcription factor RelA · triacylglycerol · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · controlled study · drug mechanism · drug targeting · enzyme inhibition · gene expression · hypertriglyceridemia · in vivo study · lipid diet · lipogenesis · lipoprotein blood level · male · metabolic syndrome X · mouse · nonhuman · priority journal · protein expression · risk factor · triacylglycerol blood level · aspirin · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

13 A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences
article 2010    
Author: Caesar, R. · Manieri, M. · Kelder, T. · Boekschoten, M. · Evelo, C. · Müller, M. · Kooistra, T. · Cinti, S. · Kleemann, R. · Drevon, C.A.
Keywords: Biology · Biomedical Research · Acetyl coenzyme A · Adenosine triphosphate citrate lyase · Androgen receptor · Carbohydrate responsive element binding protein · Fatty acid synthase · Linoleic acid · Linolenic acid · Monounsaturated fatty acid · Omega 3 fatty acid · Omega 6 fatty acid · Transcription factor · Unclassified drug · Abdominal fat · Adipocyte · Animal cell · Animal tissue · Controlled study · Down regulation · Epididymis fat · Fat intake · Fatty acid desaturation · Fatty acid synthesis · Gene expression regulation · Lipid diet · Lipid metabolism · Lipid storage · Lipidomics · Lipogenesis · Male · Microarray analysis · Mouse · Nonhuman · Spermatogenesis · Subcutaneous fat · Transcriptomics
[PDF] [Abstract]

14 Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: A combined transcriptomics and metabolomics analysis
article 2007    
Author: Kleemann, R. · Verschuren, L. · Erk, M.J. van · Nikolsky, Y. · Cnubben, N.H.P. · Verheij, E.R. · Smilde, A.K. · Hendriks, H.F.J. · Zadelaar, A.S.M. · Smith, G.J. · Kaznacheev, V. · Nikolskaya, T. · Melnikov, A. · Hurt-Camejo, E. · Greef, J. van der · Ommen, B. van · Kooistra, T.
Keywords: Analytical research · Biomedical research · alanine aminotransferase · aspartate aminotransferase · cholesterol · endothelial leukocyte adhesion molecule 1 · gamma interferon · high density lipoprotein · hydroxymethylglutaryl coenzyme A reductase · immunoglobulin enhancer binding protein · interleukin 1 · low density lipoprotein · peroxisome proliferator activated receptor alpha · platelet derived growth factor · protein p53 · retinoid X receptor · retinoid X receptor alpha · serum amyloid A · Smad3 protein · STAT1 protein · STAT3 protein · STAT5 protein · sterol regulatory element binding protein 1 · sterol regulatory element binding protein 2 · transcription factor FKHR · transcription factor Sp1 · transcription factor YY1 · triacylglycerol · tumor necrosis factor alpha · very low density lipoprotein · alanine aminotransferase blood level · animal experiment · animal model · animal tissue · article · aspartate aminotransferase blood level · atherosclerosis · cholesterol blood level · cholesterol diet · cholesterol intake · controlled study · diet supplementation · female · gene control · genetic transcription · hepatitis · hypercholesterolemia · lipid metabolism · metabolomics · mouse · nonhuman · pathophysiology · protein blood level · stress · transcription regulation · transcriptomics · triacylglycerol blood level · upregulation · animal · biological model · diet · disease model · gene expression regulation · inflammation · liver · metabolism · pathology · systems biology · Mus · Animals · Atherosclerosis · Cholesterol, Dietary · Diet · Disease Models, Animal · Female · Gene Expression Regulation · Inflammation · Lipid Metabolism · Liver · Metabolism · Mice · Models, Biological · Systems Biology · Transcription, Genetic
[Abstract]

15 Exposure to bisphenol A, but not phthalates, increases spontaneous diabetes type 1 development in NOD mice
article 2015    
Author: Bodin, J. · Kocbach Bølling, A. · Wendt, A. · Eliasson, L. · Becher, R. · Kuper, F. · Løvik, M. · Nygaard, U.C.
Keywords: Toxicology · Bisphenol A · Diabetes mellitus type 1 · Immunotoxicity · Insulitis · NOD mice · Phthalates · Prenatal exposure · 4,4' isopropylidenediphenol · Caspase 3 · CD68 antigen · Gamma interferon · Glucose · Insulin · Interleukin 10 · Interleukin 4 · Interleukin 6 · Nitric oxide · Phthalic acid · Testosterone · Transcription factor FOXP3 · Tumor necrosis factor alpha · Animal cell · Animal experiment · Animal model · Animal tissue · Blood glucose monitoring · Controlled study · Cytokine release · Environmental exposure · Flow cytometry · Histopathology · Immunocytochemistry · Immunohistochemistry · Incidence · Insulin dependent diabetes mellitus · Insulin release · Lymphocytic infiltration · Male · Mouse · Pancreas islet · Phagocytosis · Regulatory T lymphocyte · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

16 Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models
article 2015    
Author: Schmeits, P.C.J. · Schaap, M.M. · Luijten, M. · Someren, E. van · Boorsma, A. · Loveren, H. van · Peijnenburg, A.A.C.M. · Hendriksen, P.J.M.
Keywords: Biology · C57BL/6 · CTLL-2 · Cyclosporine A · Interspecies comparison · Splenocytes · Interleukin 2 · Messenger RNA · Transcription factor Nrf2 · Animal cell · Animal experiment · Cell cycle regulation · Controlled study · Cytotoxic T lymphocyte · Down regulation · Endoplasmic reticulum stress · HepG2 cell line · Human · Human cell · Immune response · Immunotoxicity · In vitro study · In vivo study · Jurkat cell line · Male · Mouse · Nonhuman · Dpleen cell · T lymphocyte activation · Thymoma cell line · Transcriptomics · Unfolded protein response · Upregulation · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

17 The probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/6 mice
article 2015    
Author: Mariman, R. · Tielen, F. · Koning, F. · Nagelkerken, L.
Keywords: Biology · Flow cytometry · Host genetics · Immune modulation · Microarray · Probiotics · Chemokine receptor CCR5 · Chemokine receptor CXCR3 · Eosinophil peroxidase · Gamma interferon inducible protein 10 · Interleukin 12 receptor beta1 · Retinoid related orphan receptor gamma · Transcription factor GATA 3 · VSL3 · Adaptive immunity · Animal experiment · Colon · Controlled study · Female · Gene expression · Genetic variability · Homeostasis · Immunomodulation · Innate immunity · Intestine mucosa · Major histocompatibility complex · Mesentery lymph node · Microarray analysis · Mouse · Mouse strain · Nonhuman · Phenotype · Principal component analysis · Protein expression · Single drug dose · Small intestine · Upregulation · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

18 Role of c-Jun and proximal phorbol 12-myristate-13-acetate-(PMA)-responsive elements in the regulation of basal and PMA-stimulated plasminogen-activator inhibitor-1 gene expression in HepG2
article 1996    
Author: Arts, J. · Grimbergen, J. · Bosma, P.J. · Rahmsdorf, H.J. · Kooistra, T.
Keywords: Biology · Activator protein-1 · Gene expression · Hepatocytes · Phorbol-12 myristate-13-acetate-responsive element · Plasminogen-activator inhibitor 1 · antisense oligodeoxynucleotide · messenger rna · phorbol 13 acetate 12 myristate · plasminogen activator inhibitor 1 · article · cell strain hepg2 · controlled study · gene expression regulation · gene induction · human · human cell · oncogene c fos · oncogene c jun · priority journal · Base Sequence · Binding Sites · Cell Line · Culture Media · Cycloheximide · Gene Expression Regulation · Genes, fos · Genes, jun · Humans · Kinetics · Oligonucleotides, Antisense · Plasminogen Activator Inhibitor 1 · Protein Synthesis Inhibitors · Proto-Oncogene Proteins c-fos · Proto-Oncogene Proteins c-jun · RNA, Messenger · Tetradecanoylphorbol Acetate · Transcription Factor AP-1
[Abstract]

19 Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)
article 2006    
Author: Burger-Kentischer, A. · Göbel, H. · Kleemann, R. · Zernecke, A. · Bucala, R. · Leng, L. · Finkelmeier, D. · Geiger, G. · Schaefer, H.E. · Schober, A. · Weber, C. · Brunner, H. · Rütten, H. · Ihling, C. · Bernhagen, J.
Keywords: Biology · Biomedical Research · ApoE-/- · Inflammation · MIF · Apontaneous atherosclerosis · apolipoprotein E · CD40 ligand · Fibrinogen · Gelatinase A · Immunoglobulin G · Intercellular adhesion molecule 1 · Interleukin 12 · Interleukin 6 · Macrophage migration inhibition factor · Monoclonal antibody · Neutralizing antibody · Stress activated protein kinase · Transcription factor · Tumor necrosis factor · Animal experiment · Animal model · Animal tissue · Atherosclerotic plaque · Controlled study · Foam cell · Heart valve · Macrophage · Mediator release · Mouse · Nonhuman · Protein expression · Animals · Antibodies, Monoclonal · Aorta, Thoracic · Aortitis · Apolipoproteins E · Atherosclerosis · CD40 Ligand · Disease Models, Animal · Follow-Up Studies · Gene Expression · Immunologic Factors · Intercellular Adhesion Molecule-1 · Interleukin-12 · Macrophage Migration-Inhibitory Factors · Matrix Metalloproteinase 2 · Mice · Mice, Inbred C57BL · Polymerase Chain Reaction · RNA · Tumor Necrosis Factor-alpha
[Abstract]

20 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds
article 2010    
Author: Briel, R.J. van de · Pennings, J.L.A. · Baken, K.A. · Pronk, T.E. · Boorsma, A. · Gottschalk, R. · Loveren, H. van
Keywords: Biology · Biomedical Research · Gene profiling · HaCaT · Irritant oxidative stress · Keratinocytes · Sensitizer · 1 chloro 2,4 dinitrobenzene · 2 propanol · benzoic acid · cinnamyl alcohol · collagen type 16 · disulfiram · dodecyl sulfate sodium · eugenol · ferritin · ferrochelatase · glucose 6 phosphate dehydrogenase · glucuronosyltransferase 1A6 · glutamate cysteine ligase · glutathione reductase · heat shock protein · heme oxygenase 1 · hexane · interleukin 6 receptor · irritant agent · isoeugenol · lactic acid · mitogen activated protein kinase · nickel sulfate · phosphogluconate dehydrogenase · salicylic acid methyl ester · thioredoxin 2 · thioredoxin reductase 1 · thioredoxin reductase 2 · transcription factor Nrf2 · article · cell viability · gene control · gene expression profiling · human · human cell · human cell culture · in vitro study · keratinocyte · oxidative stress · random forest · sensitization · support vector machine
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 30 found. Next | Sort by date