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Showing 1 to 8 of 8 found. | Sort by date

1 Fenofibrate increases HDL-cholesterol by reducing cholesteryl ester transfer protein expression
article 2007    
Author: Hoogt, C.C. van der · Haan, W. de · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Romijn, J.A. · Princen, H.M.G. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · Biomedical Research · Fibrate · High density lipoprotein · Peroxisome proliferator-activated receptor α · Transgenic mice · apolipoprotein E · cholesterol ester transfer protein · fenofibrate · high density lipoprotein cholesterol · very low density lipoprotein · animal experiment · cholesterol transport · controlled study · drug mechanism · food intake · gene expression · lipid metabolism · mouse · nonhuman · priority journal · protein expression · protein function · steady state · transgene · Animals · Antilipemic Agents · Apolipoproteins B · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Gene Expression · Humans · Liver · Male · Mice · Mice, Transgenic · Procetofen · RNA, Messenger
[PDF] [Abstract]

2 Induction of atherosclerotic plaque rupture in apolipoprotein E-/- mice after adenovirus-mediated transfer of p53
article 2002    
Author: Thüsen, J.H. von der · Vlijmen, B.J.M. van · Hoeben, R.C. · Kockx, M.M. · Havekes, L.M. · Berkel, T.J.C. van · Biessen, E.A.L.
Keywords: Health · Carotid arteries · Genes · Muscle · Adenovirus vector · Apolipoprotein E · Beta galactosidase · Phenylephrine · Protein p53 · Animal experiment · Animal model · Atherogenesis · Atherosclerotic plaque · Carotid artery · Cell death · Controlled study · Gene overexpression · Genetic transfection · Knockout mouse · Mouse · Nonhuman · Rupture · Smooth muscle fiber · Thrombosis · Transgene · Tumor suppressor gene · Adenoviridae · Animals · Apolipoproteins E · Apoptosis · Arteriosclerosis · beta-Galactosidase · Biological Markers · Carotid Artery Diseases · Cell Division · Genetic Vectors · Immunohistochemistry · Mice · Mice, Knockout · Muscle, Smooth, Vascular · Transfection · Tumor Suppressor Protein p53
[Abstract]

3 Assessment of the safety of foods derived from genetically modified (GM) crops
article 2004    
Author: König, A. · Cockburn, A. · Crevel, R.W.R. · Debruyne, E. · Grafstroem, R. · Hammerling, U. · Kimber, I. · Knudsen, I. · Kuiper, H.A. · Peijnenburg, A.A.C.M. · Penninks, A.H. · Poulsen, M. · Schauzu, M. · Wal, J.M.
Keywords: Nutrition Safety · Toxicology and Applied Pharmacology · Allergy · Food · Genetic engineering · Genetic manipulation · Genetic modification · Molecular characterisation · Novel foods · Plant biotechnology · Plant metabolism · Recombinant proteins · Regulation · Risk analysis · Safety assessment · Toxicology · Transgenic crops · Agronomic trait · Analytic method · Conference paper · DNA sequence · DNA vector · Food analysis · Food safety · Gene insertion · Genetically modified crop · Geographic distribution · Human · Molecular biology · Nonhuman · Nutrition · Phenotype · Practice guideline · Risk assessment · Toxicity testing · Transgene · Animals · Consumer Product Safety · Food Analysis · Food Supply · Food, Genetically Modified · Genetic Engineering · Humans · International Cooperation · Plants, Genetically Modified · Risk Assessment · Safety
[Abstract]

4 Formation and persistence of O6-ethylguanine in genomic and transgene DNA in liver and brain of λlacZ transgenic mice treated with N-ethyl-N-nitrosourea
article 1996    
Author: Mientjes, E.J. · Hochleitner, K. · Luiten-Schuite, A. · Delft, J.H.M. van · Thomale, J. · Berends, F. · Rajewsky, M.F. · Lohman, P.H.M. · Baan, R.A.
Keywords: Toxicology · 6 o alkylguanine dna alkyltransferase · dna · ethylnitrosourea · guanine derivative · 6 ethylguanine · 6-ethylguanine · 7 ethylguanine · 7-ethylguanine · DNA · drug derivative · guanine · mutagenic agent · animal experiment · animal tissue · article · brain · controlled study · dna adduct · dna repair · enzyme inhibition · female · immunoblotting · liver · mouse · mutagenicity · nonhuman · priority journal · transgene · transgenic mouse · animal · bacteriophage lambda · biosynthesis · DNA repair · drug effect · genetics · genome · lactose operon · metabolism · mutagen testing · physiology · polymerase chain reaction · sensitivity and specificity · Animals · Bacteriophage lambda · Brain · DNA · DNA Repair · Ethylnitrosourea · Female · Genome · Guanine · Immunoblotting · Lac Operon · Liver · Mice · Mice, Transgenic · Mutagenicity Tests · Mutagens · Polymerase Chain Reaction · Sensitivity and Specificity
[Abstract]

5 No effect of C-reactive protein on early atherosclerosis development in apolipoprotein E*3-Leiden/human C-reactive protein transgenic mice
article 2005    
Author: Trion, A. · Maat, M.P.M. de · Jukema, J.W. · Laarse, A. van der · Maas, M.C. · Offerman, E.H. · Havekes, L.M. · Szalai, A.J. · Princen, H.M.G. · Emeis, J.J.
Keywords: Biology · Biomedical Research · Atherosclerosis · C-reactive protein · Inflammation · Mouse · Transgene · Acute phase protein · Apolipoprotein E3 Leiden · Biological marker · C reactive protein · Cholesterol · Unclassified drug · Animal experiment · Animal model · Animal tissue · Atherogenesis · Blood sampling · Cardiovascular risk · Cholesterol blood level · Cholesterol diet · Controlled study · Enzyme linked immunosorbent assay · Experimental model · Histopathology · Hypercholesterolemia · Immunohistochemistry · Inflammation · Mouse strain · Nonhuman · Pathophysiology · Protein blood level · Protein expression · Protein function · Transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Atherosclerosis · Biological Markers · Body Weight · C-Reactive Protein · Cholesterol · Early Diagnosis · Eating · Endothelium, Vascular · Female · Humans · Hypercholesterolemia · Male · Mice · Mice, Transgenic · Monocytes · Risk Factors · Severity of Illness Index
[Abstract]

6 Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells
article 2000    
Author: Geutskens, S.B. · Eb, M.M. van der · Plomp, A.C. · Jonges, L.E. · Cramer, S.J. · Ensink, N.G. · Kuppen, P.J.K. · Hoeben, R.C.
Keywords: Cancer gene therapy · IL-2 · Recombinant adenovirus · complementary DNA · cytokine · recombinant interleukin 2 · tumor antigen · virus vector · Adenovirus · Animal cell · Animal experiment · Animal model · Antigen recognition · Antineoplastic activity · Cancer inhibition · Colorectal cancer · Controlled study · Delayed hypersensitivity · DNA transfer · Gene expression · Gene therapy · immune response · Immunotherapy · Liver metastasis · Lymphocyte activation · Nonhuman · Rat strain · T lymphocyte · Transgene · Tumor cell · Tumor regression · Virus plaque · Virus recombinant · Virus replication · Adenoviridae · Animals · Colorectal Neoplasms · Flow Cytometry · Gene Therapy · Genetic Vectors · Histocompatibility Antigens Class I · Histocompatibility Antigens Class II · Humans · Intercellular Adhesion Molecule-1 · Interleukin-2 · Liver Neoplasms, Experimental · Lymphocyte Activation · Rats · Rats, Inbred Strains · T-Lymphocytes · Tumor Cells, Cultured · Adenoviridae · Animalia · DNA viruses
[Abstract]

7 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma
article 2005    
Author: Lamfers, M.L.M. · Gianni, D. · Tung, C.H. · Idema, S. · Schagen, F.H.E. · Carette, J.E. · Quax, P.H.A. · Beusechem, V.W. van · Top, W.P. van der · Dirven, C.M.F. · Chiocca, E.A. · Gerritsen, W.R.
Keywords: Biomedical Research · oncolytic adenovirus · oncolytic virus · tissue inhibitor of metalloproteinase 3 · Adenovirus · animal experiment · animal model · animal tissue · antineoplastic activity · article · cancer cell culture · cancer model · cancer survival · cell proliferation · cell strain HEK293 · controlled study · culture medium · drug efficacy · enzyme activity · enzyme inhibition · female · gene deletion · gene expression · gene insertion · gene transfer · glioblastoma · glioma cell · human · human cell · mouse · nonhuman · priority journal · protein expression · survival time · transgene · tumor xenograft · Adenoviridae · Animals · Cell Growth Processes · Cell Line, Tumor · Gene Transfer Techniques · Glioma · Humans · Matrix Metalloproteinase 2 · Mice · Mice, Nude · Tissue Inhibitor of Metalloproteinase-3 · Virus Replication · Xenograft Model Antitumor Assays
[Abstract]

8 Prolonged in vivo gene silencing by electroporation-mediated plasmid delivery of small interfering RNA
article 2007    
Author: Eefting, D. · Grimbergen, J.M. · Vries, M.R. de · Weel, V. van · Kaijzel, E.L. · Que, I. · Moon, R.T. · Löwik, C.W. · Bockel, J.H. van · Quax, P.H.A.
Keywords: Biology · Biomedical Research · double stranded RNA · histidine · luciferase · oligonucleotide · plasmid vector · small interfering RNA · toll like receptor 4 · uridine · animal cell · animal experiment · article · bioluminescence · controlled study · electroporation · gastrocnemius muscle · gene expression · gene function · gene repression · gene silencing · human · human cell · immune response · in vivo gene transfer · in vivo study · male · mouse · nonhuman · nonviral gene delivery system · protein expression · restenosis · RNA interference · transgene · treatment planning · tumor · viral gene delivery system · Animals · Cattle · Cell Line, Transformed · Cell Transformation, Viral · Electroporation · Feasibility Studies · Gene Silencing · Genes, Reporter · Humans · Hypoxanthine Phosphoribosyltransferase · Lipopolysaccharides · Luciferases · Luminescent Measurements · Male · Mice · Mice, Inbred Strains · Muscle, Skeletal · NIH 3T3 Cells · Plasmids · RNA Interference · RNA, Messenger · RNA, Small Interfering · Time Factors · Toll-Like Receptor 4 · Murinae
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 8 of 8 found. | Sort by date