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1 Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study
article 2005    
Author: Brink, M. · Weijenberg, M.P. · Goeij, A.F.P.M. de · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Bruïne, A.P. de · Goldbohm, R.A. · Brandt, P.A. van den
Keywords: Health Nutrition · Food and Chemical Risk Analysis · Colon · Meat · Rectum · Wild-type K-ras · nitrosamine · polycyclic aromatic hydrocarbon · cancer incidence · cancer patient · colon cancer · dietary intake · female · gene mutation · genetic heterogeneity · genetic risk · major clinical study · rectum cancer · wild type · Aged · Case-Control Studies · Cohort Studies · Colonic Neoplasms · Diet · DNA Mutational Analysis · Female · Genes, ras · Humans · Male · Meat · Meat Products · Middle Aged · Netherlands · Rectal Neoplasms · Risk Factors · Seafood
[PDF] [Abstract]

2 Towards understanding molecular modes of probiotic action
article 2006    
Author: Marco, M.L. · Pavan, S. · Kleerebezem, M.
Keywords: Biology · Biomedical Research · Cells · Consumer products · Food products · Genes · Health care · Animal models · Host effector molecules · Probiotic bacteria · Microorganisms · probiotic agent · bacterial colonization · bacterial strain · bacterial survival · bacterium adherence · dendritic cell · DNA microarray · follow up · food biotechnology · host resistance · human · immunomodulation · infection prevention · intestine flora · Lactobacillus acidophilus · Lactobacillus casei · nonhuman · nutrigenomics · priority journal · review · wild type · Animals · Humans · Intestinal Mucosa · Probiotics · Animalia · Bacteria (microorganisms)
[Abstract]

3 Dietary folate intake and K-ras mutations in sporadic colon and rectal cancer in the Netherlands Cohort Study
article 2005    
Author: Brink, M. · Weijenberg, M.P. · Goeij, A.F.P.M. de · Roemen, G.M.J.M. · Lentjes, M.H.F.M. · Bruïne, A.P. de · Engeland, M. van · Goldbohm, R.A. · Brandt, P.A. van den
Keywords: Health · Food and Chemical Risk Analysis · Men · Transversion · Wild-type · Women · folic acid · K ras protein · adenocarcinoma · adult · aged · article · cancer incidence · cancer risk · cohort analysis · colon cancer · confidence interval · data analysis · dietary intake · female · follow up · gene mutation · human · human tissue · major clinical study · male · Netherlands · oncogene K ras · priority journal · rectum cancer · rectum tumor · Aged · Cohort Studies · Colonic Neoplasms · Diet · DNA Mutational Analysis · Female · Folic Acid · Genes, ras · Humans · Male · Middle Aged · Mutation · Neoplasms · Netherlands · Rectal Neoplasms · Risk · Sex Factors
[Abstract]

4 Sixteen hours of fasting differentially affects hepatic and muscle insulin sensitivity in mice
article 2005    
Author: Heijboer, A.C. · Donga, E. · Voshol, P.J. · Dang, Z.C. · Havekes, L.M. · Romijn, J.A. · Corssmit, E.P.M.
Keywords: Biology · Biomedical Research · Glucose metabolism · Insulin action · Isotopes · Steatosis · Transcription factors · Glucose · Messenger RNA · Animal experiment · Animal tissue · Controlled study · Diet restriction · Fatty acid oxidation · Gene expression · Gluconeogenesis · Glucose transport · Glycogenolysis · Insulin sensitivity · Lipogenesis · Mouse · Mouse strain · Nonhuman · Skeletal muscle · Wild type · Biosynthesis · C57BL mouse · Drug effect · Genetics · Glucose blood level · Metabolism · Physiology · Time · Animals · Blood Glucose · Body Weight · Fasting · Insulin · Insulin Resistance · Liver · Male · Mice · Mice, Inbred C57BL · Muscle, Skeletal · RNA, Messenger · Time Factors · Triglycerides
[PDF] [Abstract]

5 Phenotype characterisation using integrated gene transcript, protein and metabolite profiling
article 2004    
Author: Orešič, M. · Clish, C.B. · Davidov, E.J. · Verheij, E. · Vogels, J. · Havekes, L.M. · Neumann, E. · Adourian, A. · Naylor, S. · Greef, J. van der · Plasterer, T.
Keywords: Biology · Analytical research · Biomedical research · Apolipoprotein E3 · Protein · Animal experiment · Animal tissue · Atherosclerosis · Cohort analysis · Controlled study · Disease course · Electrospray · Genetic transcription · Information processing · Liquid chromatography · Male · Mass spectrometry · Metabolite · Metabolomics · Mouse · Nonhuman · Nucleotide sequence · Onset age · Pathophysiology · Proteomics · Transgenic mouse · Wild type · Algorithms · Animals · Cells, Cultured · Computer Simulation · Gene Expression Regulation · Liver · Mass Spectrometry · Mice · Models, Biological · Peptide Mapping · Phenotype · Proteome · Signal Transduction · Systems Integration · Transcription Factors · Mus musculus
[Abstract]

6 Apolipoprotein C-I binds free fatty acids and reduces their intracellular esterification
article 2007    
Author: Westerterp, M. · Berbée, J.F.P. · Delsing, D.J.M. · Jong, M.C. · Gijbels, M.J.J. · Dahlmans, V.E.H. · Offerman, E.H. · Romijn, J.A. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Lipoprotein · Lipoprotein lipase · Skin · Triglyceride · very low density lipoprotein · animal cell · animal experiment · animal tissue · controlled study · electricity · esterification · female · in vitro study · mouse · nonhuman · phenotype · skin transplantation · wild type · Animals · Apolipoprotein C-I · Cells, Cultured · Enzyme-Linked Immunosorbent Assay · Esterification · Fatty Acids, Nonesterified · Female · Humans · Lipoproteins, VLDL · Macrophages · Male · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Oleic Acid · Phenotype · Protein Binding · Skin · Skin Abnormalities · Skin Transplantation
[PDF] [Abstract]

7 Elevated expression levels of lysyl oxidases protect against aortic aneurysm progression in Marfan syndrome
article 2015    
Author: Busnadiego, O. · Gorbenko del Blanco, D. · González-Santamaría, J. · Habashi, J.P. · Calderon, J.F. · Sandoval, P. · Bedja, D. · Guinea-Viniegra, J. · Lopez-Cabrera, M. · Rosell-Garcia, T. · Snabel, J.M. · Hanemaaijer, R. · Forteza, A. · Dietz, H.C. · Egea, G. · Rodriguez-Pascual, F.
Keywords: Biology · Aneurysm · Collagen · Extracellular matrix · Lysyl oxidases · Marfan syndrome · Transforming growth factor-β · Losartan · Oxidoreductase · Protein LOXL1 · Protein lysine 6 oxidase · Transforming growth factor beta · Unclassified drug · Animal tissue · Aorta aneurysm · Clinical article · Collagen fiber · Controlled study · Disease association · Disease course · Disease severity · Elastic fiber · Enzyme inhibition · Human tissue · Marfan syndrome · Mouse · Mouse model · Nonhuman · Prophylaxis · Protein expression · Signal transduction · Upregulation · Wild type · Animalia · Mus · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

8 Low-density lipoprotein receptor-knockout mice display impaired spatial memory associated with a decreased synaptic density in the hippocampus
article 2004    
Author: Mulder, M. · Jansen, P.J. · Janssen, B.J.A. · Berg, W.D.J. van de · Boom, H. van der · Havekes, L.M. · Kloet, R.E. de · Ramaekers, F.C.S. · Blokland, A.
Keywords: Environment · Alzheimer's disease · Apolipoprotein E · Lipid metabolism · Low-density lipoprotein receptor family · Memory · Low density lipoprotein receptor · Synaptophysin · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Controlled study · Hippocampus · Homozygosity · Knockout mouse · Maze test · Memory disorder · Mouse · Nerve ending · Nonhuman · Spatial memory · Task performance · Wild type · Working memory · Animals · Cell Count · Hippocampus · Male · Maze Learning · Memory Disorders · Mice · Mice, Inbred C57BL · Mice, Knockout · Presynaptic Terminals · Receptors, LDL · Synapses
[Abstract]

9 Alpha 2(I) collagen deficient oim mice have altered biomechanical integrity, collagen content, and collagen crosslinking of their thoracic aorta
article 2005    
Author: Pfeiffer, B.J. · Franklin, C.L. · Hsieh, F.H. · Bank, R.A. · Phillips, C.L.
Keywords: Biomechanics · Crosslinks · Oim · Type I collagen · functional group · hydroxyproline · pyridinoline · animal cell · animal model · animal tissue · artery disease · ascending aorta · biomechanics · blood vessel parameters · controlled study · descending aorta · evaluation · gene mutation · heterozygote · histology · molecule · morphological trait · mouse · mouse strain · nonhuman · osteogenesis imperfecta · priority journal · protein content · protein cross linking · protein deficiency · protein function · staining · thoracic aorta · wild type · Animals · Aorta, Thoracic · Biomechanics · Collagen · Collagen Type I · Mice · Mice, Mutant Strains · Osteogenesis Imperfecta
[Abstract]

10 The role of the Aspergillus niger furin-type protease gene in processing of fungal proproteins and fusion proteins: Evidence for alternative processing of recombinant (fusion-) proteins
article 2003    
Author: Punt, P.J. · Drint-Kuijvenhoven, A. · Lokman, B.C. · Spencer, J.A. · Jeenes, D. · Archer, D.A. · Hondel, C.A.M.J.J. van den
Keywords: Biology · Biotechnology · Filamentous fungi · Fusion-proteins · Protease · Protein processing · Protein secretion · Secretion carrier · Biotechnology · Genes · Growth kinetics · Mutagenesis · Proteins · Cleavage sites · Genetic engineering · arginine · aspergillopepsin · fungal protein · furin · glucan 1,4 alpha glucosidase · hybrid protein · lysine · protein precursor · proteinase · recombinant protein · unclassified drug · allele · amino acid composition · article · Aspergillus niger · controlled study · fungal gene · fungal strain · fungus mutant · gene deletion · gene disruption · gene function · genetic code · genetic recombination · molecular cloning · nonhuman · nucleotide sequence · priority journal · protein degradation · protein processing · wild type · Aspergillus niger · Endopeptidases · Fungal Proteins · Furin · Gene Expression Regulation, Enzymologic · Gene Expression Regulation, Fungal · Protein Processing, Post-Translational · Recombinant Fusion Proteins · Trans-Activation (Genetics) · Aspergillus · Aspergillus niger · Fungi
[Abstract]

11 LDL receptor deficiency results in decreased cell proliferation and presynaptic bouton density in the murine hippocampus
article 2007    
Author: Mulder, M. · Koopmans, G. · Wassink, G. · Mansouri, G.A. · Simard, M.-L. · Havekes, L.M. · Prickaerts, J. · Blokland, A.
Keywords: Health · Biomedical Research · Apolipoprotein E · Cholesterol · Low density lipoprotein receptor · Memory · Neurogenesis · Synaptic density · apolipoprotein E · broxuridine · cholesterol · iodine 125 · low density lipoprotein · low density lipoprotein receptor · synaptophysin · Alzheimer disease · animal cell · animal experiment · animal tissue · article · astrocytoma cell · cell proliferation · cholesterol metabolism · concentration response · controlled study · dentate gyrus · hippocampus · knockout mouse · male · memory · mouse · nerve cell plasticity · nerve fiber growth · nervous system development · neuroblastoma cell · nonhuman · pathogenesis · priority journal · spatial memory · synaptogenesis · wild type · Animals · Biological Markers · Bromodeoxyuridine · Cell Count · Cell Line, Tumor · Cell Proliferation · Cholesterol · Dentate Gyrus · Down-Regulation · Hippocampus · Humans · Male · Mice · Mice, Knockout · Neural Pathways · Neuronal Plasticity · Presynaptic Terminals · Receptors, LDL · Synaptophysin
[Abstract]

12 Cost-effectiveness of pharmacogenomics in clinical practice: A case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe
article 2006    
Author: Akker-van Marle, M.E. van den · Gurwitz, D. · Detmar, S.B. · Enzing, C.M. · Hopkins, M.M. · Gutierrez De Mesa, E. · Ibarreta, D.
Keywords: Health · Antineoplastic Agents · Cost-Benefit Analysis · Europe · Genotype · Humans · Leukemia, Lymphocytic, Acute · Methyltransferases · Models, Economic · Pharmacogenetics · 6-mercaptopurine · Acute lymphoblastic leukemia · Adverse drug reactions · Cost-effectiveness analysis · Drug-metabolizing enzymes · Germany · Ireland · Netherlands · Pharmacogenetics · Thiopurine drugs · Thiopurine methyltransferase (TMPT) · United Kingdom · Azathioprine · Drug metabolizing enzyme · Mercaptopurine · Thiopurine methyltransferase · Acute lymphoblastic leukemia · Anorexia · Blood toxicity · Bone marrow suppression · Calculation · Case study · Clinical practice · Cytopenia · Diarrhea · Drug dose regimen · Drug fatality · Drug hypersensitivity · Enteritis · Enzyme activity · Enzyme deficiency · Europe · Graft rejection · Health care quality · Health survey · Heterozygosity · Homozygosity · Hospital cost · Infection · Interview · Leukopenia · Nausea · Pancreatitis · Phenotype · Polymerase chain reaction · Sensitivity and specificity · Sepsis · United Kingdom · Vomiting · Wild type
[Abstract]

13 Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato
article 2006    
Author: Rein, D. · Schijlen, E. · Kooistra, T. · Herbers, K. · Verschuren, L. · Hall, R. · Sonnewald, U. · Bovy, A. · Kleemann, R.
Keywords: Biology · Biomedical Research · Alanine aminotransferase · C reactive protein · Cholesterol · Endothelial leukocyte adhesion molecule 1 · Fenofibrate · Fibrinogen · Flavonoid · Alanine aminotransferase blood level · Animal experiment · Animal tissue · Body weight · Cardiovascular risk · Cholesterol blood level · Controlled study · Dietary intake · Drug effect · Enzyme activity · Food intake · Male · Mouse · Nonhuman · Protein expression · Tomato · Transgenic mouse · Wild type · Alanine Transaminase · Animals · C-Reactive Protein · Cardiovascular Diseases · Cholesterol · Cholesterol, HDL · Diet · E-Selectin · Fibrinogen · Flavonoids · Fruit · Humans · Lycopersicon esculentum · Mice · Mice, Transgenic · Plants, Genetically Modified · Procetofen · Risk Factors · Lycopersicon esculentum · Mus musculus
[Abstract]

14 Branching mutants of Aspergillus oryzae with improved amylase and protease production on solid substrates
article 2005    
Author: Biesebeke, R. te · Record, E. · Biezen, N. van · Heerikhuisen, M. · Franken, A. · Punt, P.J. · Hondel, C.A.M.J.J. van den
Keywords: Biology · Biotechnology · Enzyme kinetics · Enzymes · Fermentation · Growth kinetics · Hydrolysis · Microorganisms · Substrates · Yeast · Amylase · Branching mutants · Hydrolytic enzymes · Solid substrates · Mutagenesis · amylase · carrier protein · glucan 1,4 alpha glucosidase · phosphatidylglycerol · phosphatidylinositol · proteinase · fungus · gene expression · protein · allele · article · Aspergillus oryzae · enzyme activity · enzyme synthesis · fermentation · fungal biomass · fungal genetics · fungal strain · fungus growth · fungus hyphae · fungus mutant · genetic code · hydrolysis · microscopy · nonhuman · protein secretion · seed kernel · solid · sporogenesis · wheat · wild type · Amylases · Aspergillus oryzae · Biomass · Fungal Proteins · Gene Deletion · Glucan 1,4-alpha-Glucosidase · Hyphae · Morphogenesis · Mutagenesis, Insertional · Mutation · Peptide Hydrolases · Phospholipid Transfer Proteins · Spores, Fungal · Triticum · Aspergillus oryzae · Fungi · Triticum aestivum
[Abstract]

15 CD36 deficiency increases insulin sensitivity in muscle, but induces insulin resistance in the liver in mice
article 2003    
Author: Goudriaan, J.R. · Dahlmans, V.E.H. · Teusink, B. · Ouwens, D.M. · Febbraio, M. · Maassen, J.A. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acid transport · Glucose metabolism · Hepatic steatosis · Hyperinsulinemic clamp · CD36 antigen · fatty acid · glucose · protein kinase B · triacylglycerol · unclassified drug · animal experiment · animal model · animal tissue · controlled study · enzyme activation · enzyme deficiency · fatty acid blood level · glucose blood level · glucose transport · hyperinsulinemia · insulin sensitivity · male · mouse · muscle · nonhuman · spontaneously hypertensive rat · triacylglycerol blood level · Western blotting · wild type · Animals · Antigens, CD36 · Blood Glucose · Body Weight · Eating · Gene Deletion · Insulin · Insulin Resistance · Lipids · Liver · Mice · Mice, Inbred C57BL · Muscle, Skeletal · Rats · Signal Transduction · Triglycerides · Tritium
[PDF] [Abstract]

16 CD36 deficiency in mice impairs lipoprotein lipase-mediated triglyceride clearance
article 2005    
Author: Goudriaan, J.R. · oer, M.A.M. den · Rensen, P.C.N. · Febbraio, M. · Kuipers, F. · Romijn, J.A. · Havekes, L.M. · Voshol, P.J.
Keywords: Biology · Biomedical Research · Fatty acid transport · Free fatty acids · Postprandial lipid metabolism · Transgenic mice · Triglyceride hydrolysis · CD36 antigen · Glycerol · Heparin · Triacylglycerol · Very low density lipoprotein · Animal experiment · Animal tissue · Body fat · CD36 deficiency · Controlled study · Enzyme inhibition · Enzyme metabolism · Half life time · In vitro study · Isotope labeling · Lipid metabolism · Mouse · Nonhuman · Protein deficiency · Protein function · Protein hydrolysis · Transgenic mouse · Tiacylglycerol blood level · Wild type · Animals · Antigens, CD36 · Eating · Fatty Acids, Nonesterified · Female · Intestinal Absorption · Lipoprotein Lipase · Lipoproteins, VLDL · Liver · Male · Mice · Mice, Inbred C57BL · Triglycerides
[PDF] [Abstract]

17 Human CD46-transgenic mice in studies involving replication-incompetent adenoviral type 35 vectors
article 2006    
Author: Verhaagh, S. · Jong, E. de · Goudsmit, J. · Lecollinet, S. · Gillissen, G. · Vries, M. de · Leuven, K. van · Que, I. · Ouwehand, K. · Mintardjo, R. · Weverling, G.J. · Radošević, K. · Richardson, J. · Eloit, M. · Lowik, C. · Quax, P. · Havenga, M.
Keywords: Biology · Biomedical Research · Adenovirus vector · Beta galactosidase · CD8 antigen · Gag protein · Luciferase · Membrane cofactor protein · Simian immunodeficiency virus vaccine · Animal cell · Animal experiment · Antigen expression · Antigen function · Camera · CD8+ T lymphocyte · Cellular immunity · Controlled study · Dendritic cell · Drug potency · Drug safety · Female · Gene expression · Human adenovirus · Imaging system · Kidney cell · Lung alveolus epithelium · Male · Mouse · Mouse strain · Muscle cell · Nonhuman · Receptor affinity · Transgenic mouse · Viral gene delivery system · Virus replication · Wild type · Adenoviruses, Human · Animals · Antigens, CD46 · Genetic Vectors · Humans · Mice · Mice, Transgenic · Virus Replication · Adenoviridae · Animalia · Human adenovirus · Mus musculus · Simian immunodeficiency virus
[Abstract]

18 Circulating insulin stimulates fatty acid retention in white adipose tissue via KATP channel activation in the central nervous System only in insulin-sensitive mice
article 2011    
Author: Coomans, C.P. · Geerling, J.J. · Guigas, B. · Hoek, A.M. van den · Parlevliet, E.T. · Ouwens, D.M. · Pijl, H. · Voshol, P.J. · Rensen, P.C.N. · Havekes, L.M. · Romijn, J.A.
Keywords: Health Biology · Brain · Brown adipose tissue · Insulin resistance · Lipid metabolism · Lipoprotein lipase · Triglycerides · adenosine triphosphate sensitive potassium channel · CD36 antigen · cyclic AMP · fatty acid · insulin · leptin · serum albumin · tolbutamide · triacylglycerol · animal experiment · animal model · animal tissue · brown adipose tissue · central nervous system · channel gating · controlled study · drug administration route · drug distribution · drug half life · drug targeting · fatty acid metabolism · fatty acid retention · hormone action · hyperinsulinemia · insulin action · insulin sensitivity · male · mouse · nonhuman · signal transduction · white adipose tissue · wild type · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

19 Standardisation of environmental enrichment for laboratory mice and rats: Utilisation, practicality and variation in experimental results
article 2010    
Author: Baumans, V. · Loo, P.L.P. van · Pham, T.M.
Keywords: Biology · Physiological Sciences · brain derived neurotrophic factor · animal behavior · animal care · animal experiment · animal housing · animal wellbeing · article · Bagg albino mouse · breeding · C57BL 6 mouse · controlled study · environmental enrichment · experimental animal welfare · experimental mouse · experimental rat · exploratory behavior · female · foraging behavior · knockout mouse · male · mouse · nesting · nonhuman · open field test · rat · social behavior · Sprague Dawley rat · standardization · strain difference · survival · wild type · workload · Animalia · Mus · Rattus · Rattus norvegicus · Healthy for Life · Healthy Living · Life · QS - Quality & Safety · EELS - Earth, Environmental and Life Sciences
[Abstract]

20 Body Mass Index and von Hippel-Lindau Gene Mutations in Clear-cell Renal Cancer: Results of the Netherlands Cohort Study on Diet and Cancer
article 2010    
Author: Smits, K.M. · Schouten, L.J. · Hudak, E. · Verhage, B. · Dijk, B.A.C. van · Hulsbergen - Kaa, C.A. van de · Goldbohm, R.A. · Oosterwijk, E. · Brandt, P.A. van den
Keywords: Health · Leefomgeving en gezondheid · Body Mass Index · Clear-cell Renal Cancer · VHL Mutations · von Hippel Lindau protein · adult · age · article · body mass · cancer risk · clear cell carcinoma · cohort analysis · controlled study · diet · female · gene mutation · human · kidney cancer · major clinical study · male · Netherlands · priority journal · prospective study · risk factor · weight gain · wild type · Adult · Body Mass Index · Carcinoma, Renal Cell · Cohort Studies · Confidence Intervals · Diet · Female · Humans · Kidney Neoplasms · Male · Middle Aged · Mutation · Netherlands · Nutritional Status · Risk Factors · von Hippel-Lindau Disease · Young Adult
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 28 found. Next | Sort by date