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Showing 1 to 18 of 18 found. | Sort by date

1 Toxicological evaluation of chemical mixtures
article 2002    
Author: Feron, V.J. · Groten, J.P.
Keywords: Nutrition · Air Pollutants · Animals · Drug Interactions · Food · Humans · Models, Statistical · Public Health · Toxicology · Water Supply · Xenobiotics
[Abstract]

2 Feminization of male carp
article 1996    
Author: Gimeno, S. · Gerritsen, A. · Bowmer, T. · Komen, H.
Keywords: Toxicology · industrial chemical · animal tissue · article · carp · environmental exposure · feminization · male · nonhuman · priority journal · spermatogenesis · tissue section · Animals · Carps · Estradiol · Female · Feminization · Fish Diseases · Male · Phenols · Sex Differentiation · Xenobiotics · Animalia · Cyprinus carpio

3 Toxicology of chemical mixtures : challenges for today and the future
article 1995    
Author: Feron, V.J. · Groten, J.P. · Jonker, D. · Cassee, F.R. · Bladeren, P.J. van
Keywords: Toxicology · Administration, Inhalation · Administration, Oral · Aldehydes · Animals · Drug Interactions · Hazardous Substances · Kidney Diseases · Organ Specificity · Rats · Rats, Wistar · Research Design · Risk Assessment · Toxicity Tests · Xenobiotics · Animalia · Complex mixtures · Defined · Standard setting · Study designs
[Abstract]

4 Toxicology of chemical mixtures: International perspective
article 1998    
Author: Feron, V.J. · Cassee, F.R. · Groten, J.P.
Keywords: Nutrition · Data analysis · Europe · Japan · Mixtures · Research programs · Risk assessment · Strategies · Study designs · Aldehyde · Heterocyclic amine · Mycotoxin · Pesticide · Petroleum derivative · Solvent · Toxic substance · Volatile organic compound · Airborne particle · Conference paper · Environmental exposure · Europe · Exhaust gas · Food contamination · Foundry · Fume · Health hazard · Human · Indoor air pollution · Japan · priority journal · quantitative structure activity relation · risk assessment · Animals · Drug Interactions · Humans · Toxicology · World Health · Xenobiotics
[Abstract]

5 Effect of fatty acids and the aqueous diffusion barrier on the uptake and transport of polychlorinated biphenyls in Caco-2 cells
article 1996    
Author: Dulfer, W.J. · Groten, J.P. · Govers, H.A.J.
Keywords: Nutrition · Enterocytes · Lipoproteins · Metabolism · Triglyceride · Xenobiotics · Bile salt · Fatty acid · Polychlorinated biphenyl · Aqueous solution · Cancer cell culture · Cell transport · Diffusion · Fat intake · Human · Human cell · Hydrophobicity · Intestine cell · Micelle · Permeability barrier · Priority journal · Solubility · Xenobiotic metabolism · Biological Transport · Caco-2 Cells · Cell Polarity · Diffusion · Fatty Acids · Humans · Polychlorinated Biphenyls · Solubility · Water
[PDF] [Abstract]

6 Glutathione conjugation as a bioactivation reaction
article 2000    
Author: Bladeren, P.J. van
Keywords: Nutrition · Bioactivation · Glutathione conjugates · Glutathione S-transferases · Cysteine · Glutathione · Glutathione transferase · Lyase · Catalysis · Chemical binding · Chemical reaction · Chromosomal localization · Conjugation · Covalent bond · Detoxification · Enzyme activation · Enzyme activity · Enzyme induction · Enzyme inhibition · Enzyme mechanism · Gene location · Genetic polymorphism · Human · Nonhuman · Protein expression · Reaction analysis · Reduction · Animals · Biotransformation · Carbon-Sulfur Lyases · Enzyme Induction · Glutathione · Glutathione Transferase · Humans · Metabolic Detoxication, Drug · Oxidation-Reduction · Xenobiotics
[Abstract]

7 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

8 Toxicological evaluation and risk assessment of chemical mixtures
article 1998    
Author: Cassee, F.R. · Groten, J.P. · Bladeren, P.J. van · Feron, V.J.
Keywords: Nutrition · Combination toxicology · Complex mixtures · Isoboles · Physiologically based toxicokinetic modeling · Response surface analysis · Simple mixtures · Weight of evidence approach · Chemical compound · Chemical analysis · Dose response · Drug mechanism · Drug potentiation · Environmental exposure · Review · Risk assessment · Toxin analysis · Animals · Drug Interactions · Drug Synergism · Guidelines · International Cooperation · Male · Models, Biological · Models, Statistical · No-Observed-Adverse-Effect Level · Rats · Risk Assessment · Xenobiotics
[Abstract]

9 Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments
article 2008    
Author: Arts, J.H.E. · Muijser, H. · Jonker, D. · Sandt, J.J.M. van de · Bos, P.M.J. · Feron, V.J.
Keywords: Health · Chemicals · Guidelines · Hazard · Inhalation · OECD · Reach · Toxicity · acute toxicity · animal testing alternative · article · health hazard · inhalation · nonhuman · practice guideline · risk assessment · safety · toxicity · Animal Testing Alternatives · Animals · European Union · Government Regulation · Guidelines as Topic · Inhalation Exposure · Risk Assessment · Tissue Culture Techniques · Toxicity Tests · Xenobiotics · Animalia
[Abstract]

10 Improving the applicability of (Q)SARs for percutaneous penetration in regulatory risk assessment.
article 2008    
Author: Bouwman, T. · Cronin, M.T. · Bessems, J.G. · Sandt, J.J. van de
Keywords: Health · xenobiotic agent · article · biological model · chemistry · drug effect · European Union · government regulation · human · legal aspect · physiology · prediction and forecasting · quantitative structure activity relation · risk assessment · skin absorption · European Union · Government Regulation · Humans · Models, Biological · Predictive Value of Tests · Quantitative Structure-Activity Relationship · Risk Assessment · Skin Absorption · Xenobiotics
[Abstract]

11 Safety evaluation of chemical mixtures and combinations of chemical and non-chemical stressors
article 2004    
Author: Jonker, D. · Freidig, A.P. · Groten, J.P. · Hollander, A.E.M.de · Stierum, R.H. · Woutersen, R.A. · Feron, V.J.
Keywords: Chemistry Biology · Toxicology and Applied Pharmacology · Combination toxicology · Cumulative risk assessment · chemical agent · bioinformatics · cold stress · environmental exposure · genomics · health hazard · heat stress · human · immobilization stress · indoor air pollution · microorganism · noise · nonhuman · rat · review · risk assessment · safety · stress · toxicokinetics · toxicology · traffic · Dose-Response Relationship, Drug · Drug Interactions · Environmental Exposure · Humans · Models, Statistical · Risk Assessment · Safety · Sequence Analysis, Protein · Structure-Activity Relationship · Toxicology · Xenobiotics
[Abstract]

12 General aspects of immunotoxicology including validation issues
article 2006    
Author: Frieke Kuper, C.
Keywords: Biology · Toxicology and Applied Pharmacology · Immunopathology · Organ sampling · Validation · allergy · article · autoimmune disease · histology · histopathology · human · immunotoxicity · immunotoxicology · lymphoid cell · lymphoid organ · lymphoid tissue · sensitivity and specificity · thymus · toxicology · validation study · Animals · Immune System · Immunosuppressive Agents · Lymphoid Tissue · Reproducibility of Results · Toxicity Tests · Xenobiotics
[Abstract]

13 Comparison of five incubation systems for rat liver slices using functional and viability parameters
article 1997    
Author: Olinga, P. · Groen, K. · Hof, I.H. · Kanter, R. de · Koster, H.J. · Leeman, W.R. · Rutten, A.A.J.J.L. · Twillert, K. van · Groothuis, G.M.M.
Keywords: Incubation system · Rat liver slices · Vaibility · Lidocaine · Phenazone · Testosterone · Animal tissue · Cell viability · Controlled study · Culture medium · Drug metabolism · Incubation time · Liver microsome metabolism · Liver slice · Nonhuman · Preservation · Animals · Energy Metabolism · L-Lactate Dehydrogenase · Liver · Male · Organ Culture Techniques · Potassium · Rats · Rats, Wistar · Xenobiotics · Animalia
[Abstract]

14 Increased bioactivation of dihaloalkanes in rat liver due to induction of class Theta glutathione S-transferase T1-1
article 1998    
Author: Sherratt, P.J. · Manson, M.M. · Thomson, A.M. · Hissink, E.A.M. · Neal, G.E. · Bladeren, P.J. van · Green, T. · Hayes, J.D.
Keywords: Nutrition · 3 indolemethanol · Alkane derivative · Antineoplastic agent · Cytochrome p450 · Glutathione transferase · Liver enzyme · Messenger rna · Phenobarbital · Animal tissue · Cancer prevention · Chemoprophylaxis · Controlled study · Cytoplasm · Diet · Enzyme subunit · Female · Immunoblotting · Male · Nonhuman · Priority journal · Rat · Animals · Anticarcinogenic Agents · Biotransformation · Carcinogens · Dietary Supplements · Enzyme Induction · Female · Glutathione Transferase · Humans · Hydrocarbons, Brominated · Isoenzymes · Liver · Male · Methylene Chloride · Phenobarbital · Rats · Rats, Inbred F344 · Sex Characteristics · Xenobiotics · Animalia
[Abstract]

15 Use of factorial designs in combination toxicity studies
article 1996    
Author: Groten, J.P. · Schoen, E.D. · Feron, V.J.
Keywords: Toxicology · Acetylsalicylic acid · Butylated hydroxyanisole · Cadmium · Calcium · Chemical agent · Dichloromethane · Formaldehyde · Iron · Loperamide · Magnesium · Manganese · Mineral · Phosphorus · Phthalic acid bis(2 ethylhexyl) ester · Phthalic acid derivative · Phthalic acid ester · Polycyclic aromatic hydrocarbon · Selenium · Sermine · Sannous chloride · Tace element · Zinc · Animal experiment · Bioaccumulation · Carcinogenic activity · Chemical interaction · Controlled study · Drug mixture · Economic aspect · Factorial analysis · Administration, Oral · Alanine Transaminase · Analysis of Variance · Animals · Aspartate Aminotransferases · Body Weight · Cadmium · Drug Interactions · Kidney · Liver · Male · Minerals · Models, Chemical · Rats · Rats, Wistar · Toxicology · Xenobiotics
[Abstract]

16 Health risks associated with inhaled nasal toxicants
article 2001    
Author: Feron, V.J. · Arts, J.H.E. · Kuper, C.F. · Slootweg, P.J. · Woutersen, R.A.
Keywords: 1,2 dibromo 3 chloropropane · 1,2 dibromoethane · 1,2 epoxy 3 butene · acetaldehyde · acrylonitrile · benzene · bis(chloromethyl) ether · chromium · dimethyl sulfate · dimethylnitrosamine · epichlorohydrin · formaldehyde · hempa · hydrazine · nickel · phosphodiesterase inhibitor · propylene oxide · vinyl acetate · adaptation · air pollution · cancer risk · carcinogenesis · cell proliferation · dosimetry · drug exposure · dust · health hazard · human · immunopathology · inhalation · neuroendocrinology · neurogenic inflammation · neurotoxicity · nose carcinoma · occupational exposure · paranasal sinus · review · risk assessment · smoking · tissue injury · trigeminal nerve disease · Animals · Dose-Response Relationship, Drug · Hazardous Substances · Humans · Inflammation · Inhalation Exposure · Nasal Cavity · Nose Diseases · Nose Neoplasms · Particle Size · Risk Factors · Xenobiotics
[Abstract]

17 International issues on human health effects of exposure to chemical mixtures
article 2002    
Author: Feron, V.J. · Cassee, F.R. · Groten, J.P. · Vliet, P.W. van · Zorge, J.A. van
Keywords: Airports · Classification · Flavors · Irritants · Mathematics · Mixtures · Models · Statistics · Toxicogenomics · Toxicology · Drinking water · Environmental chemical · Flavoring agent · Food additive · Volatile organic compound · Air pollutant · Airborne particle · Airport · Ambient air · Computer prediction · Computer program · Disease association · Ecotoxicology · Environmental exposure · Environmental health · Experimental design · Food intake · Gene expression · Health hazard · Health status · Human · Mathematical model · Nose cancer · Particle size · Pattern recognition · Population exposure · Priority journal · Public health · Research · Review · Risk assessment · Water treatment · Air Pollutants · Computer Simulation · Drug Interactions · Environment · Food Additives · Gene Expression Profiling · Humans · Models, Theoretical · Public Health · Risk Assessment · Safety · Xenobiotics
[Abstract]

18 Xenobiotic metabolism in human skin and 3D human skin reconstructs: A review
article 2007    
Author: Gibbs, S. · Sandt, J.J.M. van de · Merk, H.F. · Lockley, D.J. · Pendlington, R.U. · Pease, C.K.
Keywords: Biology · 3D skin reconstructs · Cytochrome P450 · IDO expression · In vitro skin absorption · Microarray · Peptidases · 1 chloro 2,4 dinitrobenzene · 2 nitro 1,4 phenylenediamine · 4 aminophenol · alcohol dehydrogenase · aldehyde dehydrogenase · alpha tocopherol · atrazine · azo reductase · carnitine · cinnamaldehyde · cinnamyl alcohol · clobetasol propionate · cytochrome P450 · esterase · hydrogen peroxide · messenger RNA · nicotinic acid ethyl ester · oxygenase · phenylenediamine · propoxur · propranolol · resorufin · retinoic acid · retinol palmitate · T 2 toxin · toxic substance · triclosan · triolein · unindexed drug · xenobiotic agent · biotransformation · chemical carcinogenesis · environmental exposure · enzyme assay · ex vivo study · human · immunohistochemistry · in vitro study · nonhuman · Northern blotting · occupational exposure · protein expression · protein function · review · skin absorption · skin allergy · skin cancer · skin carcinogenesis · skin inflammation · skin sensitization · skin toxicity · toxicokinetics · Western blotting · xenobiotic metabolism · Biotransformation · Humans · Models, Biological · Skin · Xenobiotics
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 18 of 18 found. | Sort by date