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Showing 1 to 17 of 17 found. | Sort by date

1 Sensitivity of 1H NMR analysis of rat urine in relation to toxicometabonomics. Part I: Dose-dependent toxic fffects of Bromobenzene and paracetamol
article 2007    
Author: Schoonen, W.G.E.J. · Kloks, C.P.A.M. · Ploemen, J.P.H.T.M. · Horbach, G.J. · Smit, M.J. · Zandberg, P. · Mellema, J.R. · Zuylen, C.T. van · Tas, A.C. · Nesselrooij, J.H.J. van · Vogels, J.T.W.E.
Keywords: Biology · Analytical research · Biomarkers · Bromobenzene · Hepatotoxicity · Metabonomics · Necrosis · Paracetamol · Urinalysis · alanine aminotransferase · aspartate aminotransferase · biological marker · bromobenzene · paracetamol · alanine aminotransferase blood level · animal experiment · animal tissue · article · aspartate aminotransferase blood level · clinical chemistry · controlled study · diagnostic accuracy · diagnostic value · dose response · drug blood level · drug urine level · early diagnosis · histopathology · intermethod comparison · liver dysfunction · liver necrosis · liver toxicity · male · non invasive measurement · nonhuman · pattern recognition · principal component analysis · proton nuclear magnetic resonance · rat · sensitivity analysis · spectrometer · urinalysis · Acetaminophen · Alanine Transaminase · Analgesics, Non-Narcotic · Animals · Aspartate Aminotransferases · Bromobenzenes · Dose-Response Relationship, Drug · Hepatitis, Toxic · Kidney · Liver · Magnetic Resonance Spectroscopy · Necrosis · Principal Component Analysis · Rats · Rattus
[Abstract]

2 Transgenic flavonoid tomato intake reduces C-reactive protein in human C-reactive protein transgenic mice more than wild-type tomato
article 2006    
Author: Rein, D. · Schijlen, E. · Kooistra, T. · Herbers, K. · Verschuren, L. · Hall, R. · Sonnewald, U. · Bovy, A. · Kleemann, R.
Keywords: Biology · Biomedical Research · Alanine aminotransferase · C reactive protein · Cholesterol · Endothelial leukocyte adhesion molecule 1 · Fenofibrate · Fibrinogen · Flavonoid · Alanine aminotransferase blood level · Animal experiment · Animal tissue · Body weight · Cardiovascular risk · Cholesterol blood level · Controlled study · Dietary intake · Drug effect · Enzyme activity · Food intake · Male · Mouse · Nonhuman · Protein expression · Tomato · Transgenic mouse · Wild type · Alanine Transaminase · Animals · C-Reactive Protein · Cardiovascular Diseases · Cholesterol · Cholesterol, HDL · Diet · E-Selectin · Fibrinogen · Flavonoids · Fruit · Humans · Lycopersicon esculentum · Mice · Mice, Transgenic · Plants, Genetically Modified · Procetofen · Risk Factors · Lycopersicon esculentum · Mus musculus
[Abstract]

3 Salsalate attenuates diet induced non-alcoholic steatohepatitis in mice by decreasing lipogenic and inflammatory processes
article 2015    
Author: Liang, W. · Verschuren, L. · Mulder, P. · Hoorn, J.W.A. van der · Verheij, J. · Dam, A.D. van · Boon, M.R. · Princen, H.M.G. · Havekes, L.M. · Kleemann, R. · Hoek, A.M. van den
Keywords: Biology · Alanine aminotransferase · Aspartate aminotransferase · Glucose · High density lipoprotein cholesterol · Insulin · Interleukin 6 · Low density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Salsalate · Triacylglycerol · Alanine aminotransferase blood level · Animal cell · Animal experiment · Animal model · Animal tissue · Aspartate aminotransferase blood level · Body weight · Controlled study · Down regulation · Drug efficacy · Drug response · Dyslipidemia · Energy metabolism · Fatty acid oxidation · Fatty liver · Gene expression · Glucose blood level · Glycemic control · Hepatitis · Insulin blood level · Insulin resistance · Lipid metabolism · Lipogenesis · Male · Mouse · Nonalcoholic fatty liver · Nonhuman · Treatment duration · Treatment outcome · Triacylglycerol blood level · Upregulation · Weight gain · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

4 Vitamin A deficiency potentiates carbon tetrachloride-induced liver fibrosis in rats
article 1994    
Author: Seifert, W.F. · Bosma, A. · Brouwer, A. · Hendriks, H.F.J. · Roholl, P.J.M. · Leeuwen, R.E.W. van · Thiel van-Ruiter, G.C.F. de · Seifert-Bock, I. · Knook, D.L.
Keywords: Biology · Alanine aminotransferase · Aspartate aminotransferase · Carbon tetrachloride · Gamma glutamyltransferase · Hydroxyproline · Retinol · Retinol ester · Animal experiment · Animal model · Animal tissue · Collagen synthesis · Fibrogenesis · Liver cirrhosis · Liver fibrosis · Liver weight · Nonhuman · Retinol deficiency · Risk factor · Animal · Carbon Tetrachloride · Collagen · Female · Hydroxyproline · Liver · Liver Cirrhosis, Experimental · Rats · Rats, Inbred Strains · Retinoids · Specific Pathogen-Free Organisms · Support, Non-U.S. Gov't · Vitamin A · Vitamin A Deficiency
[Abstract]

5 Uncovering a Predictive Molecular Signature for the Onset of NASH-Related Fibrosis in a Translational NASH Mouse Model
article 2017    
Author: Koppen, A. van · Verschuren, L. · Hoek, A.M. van den · Verheij, J. · Morrison, M.C. · Li, K. · Nagabukuro, H. · Costessi, A. · Caspers, M.P.M. · Broek, T.J. van den · Sagartz, J. · Kluft, C. · Beysen, C. · Emson, C. · Gool, A.J. van · Goldschmeding, R. · Stoop, R. · Bobeldijk-Pastorova, I. · Turner, S.M. · Hanauer, G. · Hanemaaijer, R.
Keywords: Biology · ALT, alanine aminotransferase · AST, aspartate aminotransferase · DEG, differentially expressed genes; Diagnosis · ECM, extracellular matrix · HFD, high-fat diet · IPA, Ingenuity Pathway Analysis · LDLr-/-, low-density lipoprotein receptor knock out · Liver Disease; Metabolic Syndrome · NAFLD, nonalcoholic fatty liver disease · NASH, nonalcoholic steatohepatitis · Systems Biology · THBS1, thrombospontin-1 · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

6 The Netherlands twin register biobank: A resource for genetic epidemiological studies
article 2010    
Author: Willemsen, G. · Geus, E.J.C. de · Bartels, M. · Beijsterveldt, C.E.M.T. van · Brooks, A.I. · Estourgie-van Burk, G.F. · Fugman, D.A. · Hoekstra, C. · Hottenga, J.-J. · Kluft, K. · Meijer, P. · Montgomery, G.W. · Rizzu, P. · Sondervan, D. · Smit, A.B. · Spijker, S. · Suchiman, H.E.D. · Tischfield, J.A. · Lehner, T. · Slagboom, P.E. · Boomsma, D.I.
Keywords: Biology · Biomedical Research · DNA · GWAS · Mental health · Physical health · RNA · alanine aminotransferase · aspartate aminotransferase · C reactive protein · cholesterol · creatinine · fibrinogen · gamma glutamyltransferase · glucose · hemoglobin · hemoglobin A1c · high density lipoprotein cholesterol · insulin · low density lipoprotein cholesterol · triacylglycerol · adult · alanine aminotransferase blood level · article · aspartate aminotransferase blood level · basophil · blood sampling · body composition · cell line · cholesterol blood level · creatinine blood level · DNA isolation · eosinophil count · erythrocyte count · female · fibrinogen blood level · gamma glutamyl transferase blood level · gene expression · genetic epidemiology · genotype · glucose blood level · glucose metabolism · hematocrit · hemoglobin blood level · heredity · human · insulin blood level · leukocyte count · lifestyle · lipoprotein blood level · lymphocyte count · male · mean corpuscular hemoglobin · mean corpuscular volume · menstrual cycle · mental health · monocyte · Netherlands · Netherlands twin register biobank · neutrophil count · phenotype · priority journal · professional practice · register · single nucleotide polymorphism · thrombocyte count · thrombocyte volume · triacylglycerol blood level · urinalysis
[Abstract]

7 Metabolomics in the context of systems biology: Bridging Traditional Chinese Medicine and molecular pharmacology
article 2005    
Author: Wang, M. · Lamers, R.J.A.N. · Korthout, H.A.A.J. · Nesselrooij, J.H.J. van · Witkamp, R.F. · Heijden, R. van der · Voshol, P.J. · Havekes, L.M. · Verpoorte, R. · Greef, J. van der
Keywords: Health Pharmacology · Analytical research · Metabolomics · Systems biology · Traditional Chinese Medicine (TCM) · 5' methoxyhdnocarpin · Alanine aminotransferase · Alkaloid · Apolipoprotein E · Berberine · Biflavonoid · Bilobalide · Cannabidiol · Cannabis · Chaconine · Cholesterol · Flavonoid · Ginkgo biloba extract · Ginkgolide · Glucoside · Herbaceous agent · Insulin · Low density lipoprotein · Plant extract · Prodrug · Salicylic acid · Saligenin · Saponin · Solanine · Tetrahydrocannabinol · Triacylglycerol · Unclassified drug · Very low density lipoprotein · Alanine aminotransferase blood level · Animal experiment · Animal model · Atherosclerosis · Bark · Blood flow · Chinese medicine · Clinical pharmacology · Controlled study · Data analysis · DNA microarray · Drug effect · Drug efficacy · Drug potentiation · Drug research · Drug safety · Drug targeting · Female · Ginkgo biloba · Headache · Herbal medicine · High performance liquid chromatography · Human · Human experiment · Insulin resistance · Insulin sensitivity · Ion cyclotron resonance mass spectrometry · Lipid metabolism · Liver function · Male · Mass spectrometry · Medicinal plant · Metabolic syndrome X · Metabolite · Molecular pharmacology · Nonhuman · Nuclear magnetic resonance spectroscopy · Pain · Phytotherapy · Plant leaf · Proton nuclear magnetic resonance · Rat · Thin layer chromatography · Traditional medicine · Willow · Drugs, Chinese Herbal · Humans · Pharmacology · Phytotherapy
[Abstract]

8 Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice, a translational model for atherosclerosis
article 2014    
Author: Gierman, L.M. · Kühnast, S. · Koudijs, A. · Pieterman, E.J. · Kloppenburg, M. · Osch, G.J.V.M. van · Stojanovic-Susulic, V. · Huizinga, T.W.J. · Princen, H.M.G. · Zuurmond. A.M.
Keywords: Biology · Alanine aminotransferase · Apolipoprotein E · Atorvastatin · Cholesterol ester transfer protein · Endothelial leukocyte adhesion molecule 1 · Etimibe · Monocyte chemotactic protein 1 · Serum amyloid A · Very low density lipoprotein · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Cholesterol intake · Controlled study · Female · Knee osteoarthritis · Mouse · Nonhuman · Priority journal · Transgenic mouse · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

9 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

10 Effect of type of alcoholic beverages on carbohydrate-deficient transferrin, sialic acid, and liver enzymes
article 2003    
Author: Sillanaukee, P. · Gaag, M.S. van der · Sierksma, A. · Hendriks, H.F.J. · Strid, N. · Pönniö, M. · Nikkari, S.T.
Keywords: Health · Physiological Sciences · Alcoholic Beverages · Markers of Alcohol Use Disorders · Moderate Drinking · alanine aminotransferase · alcohol · aspartate aminotransferase · carbohydrate deficient transferrin · gamma glutamyltransferase · liver enzyme · sialic acid · water · adult · alcohol consumption · alcoholic beverage · alcoholism · article · beer · clinical trial · controlled clinical trial · controlled study · crossover procedure · disease marker · drinking behavior · enzyme blood level · gin · human · iron metabolism · male · meal · normal human · priority journal · randomized controlled trial · wine · Adult · Alanine Transaminase · Alcoholic Beverages · Analysis of Variance · Aspartate Aminotransferases · Beer · Biological Markers · gamma-Glutamyltransferase · Humans · Liver · Male · Middle Aged · N-Acetylneuraminic Acid · Transferrin · Wine
[Abstract]

11 Effect of moderate alcohol consumption on fetuin-A levels in men and women: Post-hoc analyses of three open-label randomized crossover trials
article 2014    
Author: Joosten, M.M. · Schrieks, I.C. · Hendriks, H.F.J.
Keywords: Biology · Alcohol consumption · Fetuin-A · Insulin sensitivity · Liver enzymes · Type 2 diabetes mellitus · Adiponectin · Alanine aminotransferase · Alcohol · Alkaline phosphatase · Aspartate aminotransferase · Fatty acid · Gamma glutamyltransferase · Glucose · High density lipoprotein cholesterol · Insulin · Low density lipoprotein cholesterol · Triacylglycerol · Adult · Beer · Blood sampling · Concentration (parameters) · Controlled study · Crossover procedure · Female · Grape juice · Human · Insulin sensitivity · Intervention study · Male · Open study · Orange juice · Post hoc analysis · Postmenopause · Premenopause · Priority journal · Randomized controlled trial · Sex difference · Vodka · White wine · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

12 Endotoxin-induced liver damage in rats is minimized by β2- adrenoceptor stimulation
article 2004    
Author: Izeboud, C.A. · Hoebe, K.H.N. · Grootendorst, A.F. · Nijmeijer, S.M. · Miert, A.S. van · Witkamp, R.F. · Rodenburg, R.J.T.
Keywords: Biology Pharmacology · Physiological Sciences · Adrenoceptor agonists · Cytokines · Endotoxemia · Immunopharmacology · Liver-failure · alanine aminotransferase · aspartate aminotransferase · beta adrenergic receptor · bilirubin · clenbuterol · cytokine · endotoxin · interleukin 10 · interleukin 1beta · interleukin 6 · lipopolysaccharide · propranolol · tumor necrosis factor alpha · animal model · animal tissue · article · controlled study · enzyme linked immunosorbent assay · liver failure · liver injury · male · nonhuman · rat · Adrenergic beta-Agonists · Adrenergic beta-Antagonists · Alanine Transaminase · Animals · Aspartate Aminotransferases · Clenbuterol · Endotoxins · Inflammation · Interleukin-1 · Interleukin-10 · Interleukin-6 · Lipopolysaccharides · Liver · Liver Failure · Male · Osmolar Concentration · Propranolol · Rats · Rats, Wistar · Tumor Necrosis Factor-alpha
[Abstract]

13 Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels : a randomized, diet-controlled intervention study
article 2002    
Author: Sierksma, A. · Gaag, M.S. van der · Kluft, C. · Hendriks, H.F.J.
Keywords: Nutrition · Alcohol · Atherosclerosis · C-reactive protein · Fibrinogen · Inflammation · Acetylsalicylic acid · Acute phase protein · Alanine aminotransferase · Aspartate aminotransferase · Estradiol · Follitropin · Gamma glutamyltransferase · Glucose · Hemoglobin · High density lipoprotein cholesterol · Low density lipoprotein cholesterol · Paracetamol · Triacylglycerol · Adult · Alcohol consumption · Antiinflammatory activity · Cardiovascular risk · Cigarette smoking · Clinical trial · Controlled clinical trial · Controlled study · Crossover procedure · Diet therapy · Fibrinogen blood level · Food composition · Human experiment · Netherlands · Postmenopause · Protein blood level · Randomized controlled trial · Alcohol Drinking · Beer · C-Reactive Protein · Cardiovascular Diseases · Cholesterol, HDL · Cross-Over Studies · Diet · Female · Humans · Liver · Male · Middle Aged · Postmenopause · Triglycerides
[Abstract]

14 Heterogeneous expression of cholesterol 7α-hydroxylase and sterol 27- hydroxylase genes in the rat liver lobulus
article 1995    
Author: Twisk, J. · Hoekman, M.F.M. · Mager, W.H. · Moorman, A.F.M. · Boer, P.A.J. de · Scheja, L. · Princen, H.M.G. · Gebhardt, R.
Keywords: Health · 3 hydroxy 3 methylglutaryl coenzyme a · alanine aminotransferase · cholesterol 7alpha monooxygenase · colestipol · glutamate ammonia ligase · glyceraldehyde 3 phosphate dehydrogenase · messenger rna · pyruvate kinase · sterol 27 hydroxylase · unclassified drug · animal cell · animal experiment · bile acid synthesis · controlled study · enterohepatic circulation · enzyme isolation · enzyme localization · gene expression · in situ hybridization · liver metabolism · sterol analysis · Animal · Biological Markers · Blotting, Northern · Cell Separation · Cholesterol 7-alpha-Hydroxylase · Colestipol · Cytochrome P-450 Enzyme System · Gene Expression Regulation, Enzymologic · In Situ Hybridization · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Steroid Hydroxylases · Support, Non-U.S. Gov't · Tissue Distribution · Transcription, Genetic
[Abstract]

15 Nutritional effects of alkali treated soyprotein in rats
article 1974    
Author: Beek, L. van · Feron, V.J. · Groot, A.P. de
Keywords: ketone body · protein · alanine aminotransferase blood level · alkaline phosphatase blood level · aspartate aminotransferase blood level · body weight · dose response · drug response · erythrocyte count · feeding behavior · glucosuria · growth · histology · kidney · kidney calcification · leukocyte count · microscopy · oral drug administration · organ · proteinuria · rat · sex · sex difference · soybean · theoretical study · urine · urine ph · Alanine Transaminase · Alkaline Phosphatase · Animal · Animal Nutrition · Aspartate Aminotransferases · Body Weight · Comparative Study · Dietary Proteins · Female · Hydrogen-Ion Concentration · Kidney · Male · Nephrocalcinosis · Organ Weight · Phosphorus · Rats · Sex Factors · Soybeans · Vegetable Proteins · production · technology · food · Medicine · Geneeskunde · Health · Gezondheid · Dietetics · Voedingsleer
[Abstract]

16 Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: A combined transcriptomics and metabolomics analysis
article 2007    
Author: Kleemann, R. · Verschuren, L. · Erk, M.J. van · Nikolsky, Y. · Cnubben, N.H.P. · Verheij, E.R. · Smilde, A.K. · Hendriks, H.F.J. · Zadelaar, A.S.M. · Smith, G.J. · Kaznacheev, V. · Nikolskaya, T. · Melnikov, A. · Hurt-Camejo, E. · Greef, J. van der · Ommen, B. van · Kooistra, T.
Keywords: Analytical research · Biomedical research · alanine aminotransferase · aspartate aminotransferase · cholesterol · endothelial leukocyte adhesion molecule 1 · gamma interferon · high density lipoprotein · hydroxymethylglutaryl coenzyme A reductase · immunoglobulin enhancer binding protein · interleukin 1 · low density lipoprotein · peroxisome proliferator activated receptor alpha · platelet derived growth factor · protein p53 · retinoid X receptor · retinoid X receptor alpha · serum amyloid A · Smad3 protein · STAT1 protein · STAT3 protein · STAT5 protein · sterol regulatory element binding protein 1 · sterol regulatory element binding protein 2 · transcription factor FKHR · transcription factor Sp1 · transcription factor YY1 · triacylglycerol · tumor necrosis factor alpha · very low density lipoprotein · alanine aminotransferase blood level · animal experiment · animal model · animal tissue · article · aspartate aminotransferase blood level · atherosclerosis · cholesterol blood level · cholesterol diet · cholesterol intake · controlled study · diet supplementation · female · gene control · genetic transcription · hepatitis · hypercholesterolemia · lipid metabolism · metabolomics · mouse · nonhuman · pathophysiology · protein blood level · stress · transcription regulation · transcriptomics · triacylglycerol blood level · upregulation · animal · biological model · diet · disease model · gene expression regulation · inflammation · liver · metabolism · pathology · systems biology · Mus · Animals · Atherosclerosis · Cholesterol, Dietary · Diet · Disease Models, Animal · Female · Gene Expression Regulation · Inflammation · Lipid Metabolism · Liver · Metabolism · Mice · Models, Biological · Systems Biology · Transcription, Genetic
[Abstract]

17 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis in APOE*3Leiden mice
article 2006    
Author: Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M. · Nieuwenhuizen, W.F.
Keywords: Health Biology · Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acids · Sphingolipids · Steatosis · Triacylglycerol · alanine aminotransferase · amyloid · apolipoprotein E3 · cholesterol · cholesterol ester · fatty acid · messenger RNA · phytosphingosine · RNA · sphingolipid · triacylglycerol · apolipoprotein E · apolipoprotein E3 (Leidein) · very low density lipoprotein · animal experiment · animal model · animal tissue · article · cholesterol blood level · cholesterol metabolism · controlled study · diet supplementation · dose response · drug effect · drug structure · fatty liver · female · gene expression · hepatitis · lipogenesis · lipolysis · mouse · nonhuman · nutritional assessment · plasma clearance · prophylaxis · animal · blood · chemistry · cholesterol intake · enzymology · feces · genetics · intestine absorption · lipid metabolism · liver · metabolism · physiology · randomization · transgenic mouse · Animals · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Cholesterol, Dietary · Dose-Response Relationship, Drug · Fatty Acids, Nonesterified · Fatty Liver · Feces · Female · Gene Expression · Intestinal Absorption · Lipid Metabolism · Lipolysis · Lipoproteins, VLDL · Liver · Mice · Mice, Transgenic · Random Allocation · RNA · Sphingolipids · Triglycerides
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date