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1 Allergenicity prediction of novel and modified proteins: Not a mission impossible! Development of a Random Forest allergenicity prediction model
article 2019    
Author: Westerhout, J. · Krone, T. · Snippe, A. · Babé, L. · McClain, S.U. · Ladics, G.S. · Houben, G.G. · Verhoeckx, K.C.
Keywords: Allergenicity assessment · Allergenicity prediction · Food allergy · Novel and modified proteins · Random forest · Insect protein · Protein · Allergenicity · Amino acid sequence · Biochemistry · Computer model · Data accuracy · Nonhuman · Physical chemistry · Prediction · Protein database · Risk assessment · Sensitivity and specificity · Sequence analysis
[Abstract]

2 Comparison of human IgE-binding soya bean allergenic protein Gly m I with the antigenicity profiles of calf anti-soya protein sera
article 1996    
Author: Hessing, M. · Bleeker, H. · Tsuji, H. · Ogawa, T. · Vlooswijk, R.A.A.
Keywords: Nutrition · Allergenicity · Antigenicity · Gly m Bd 30K · Gly m I (or P34) · Soya beans
[Abstract]

3 Defining the targets for the assessment of IgE-mediated allergenicity of new or modified food proteins
article 2019    
Author: Houben, G. · Blom, M. · Alvito, P. · Assuncao, R. · Crevel, R. · Faeste, C.K. · Le, T.M. · Madsen, C.B. · Remington, B. · Stroheker, T. · Vassilopoulou, E. · Verhoeckx, K. · Ayiarovska, J. · Constable, A.
Keywords: Nutrition · Food · Proteins · Allergenicity · Risk · Assessment · Life · RAPID - Risk Analysis for Products in Development
[Abstract]

4 Homologous tropomyosins from vertebrate and invertebrate: Recombinant calibrator proteins in functional biological assays for tropomyosin allergenicity assessment of novel animal foods
article 2020    
Author: Klueber, J. · Costa, J. · Randow, S. · Codreanu-Morel, F. · Verhoeckx, K. · Bindslev-Jensen, C. · Ollert, M. · Hoffmann-Sommergruber, K. · Morisset, M. · Holzhauser, T. · Kuehn, A.
Keywords: Allergenicity assessment · Basophil activation test · Chicken; rat basophil leukaemia cell mediator release · Shrimp · Shrimp allergy · Tropomyosin
[PDF] [Abstract]

5 The relevance of a digestibility evaluation in the allergenicity risk assessment of novel proteins. Opinion of a joint initiative of COST action ImpARAS and COST action INFOGEST
article 2019    
Author: Verhoeckx, K. · Bogh, K.L. · Dupont, D. · Egger, L. · Gadermaier, G. · Larre, C. · Mackie, A. · Menard, O. · Adel-Patient, K. · Picariello, G. · Portmann, R. · Smit, J. · Turner, P. · Untersmayr, E. · Epstein, M.M.
Keywords: Allergenicity risk assessment · Food allergy · Food digestion · In vitro protein digestibility tests · Novel proteins · Immunoglobulin E antibody · Intestine enzyme · Protein · Allergenicity · Allergic reaction · Biological activity · Brush border · Digestion · Human · Immune response · Immunogenicity · In vitro study · Risk assessment · Sensitization · Workshop
[PDF] [Abstract]

6 Peanut allergy: Sensitization by peanut oil-containing local therapeutics seems unlikely [4]
article 2004    
Author: Peeters, K.A.B.M. · Knulst, A.C. · Rynja, F.J. · Bruijnzeel-Koomen, C.A.F.M. · Koppelman, S.J.
Keywords: Nutrition · Food technology · arachis oil · allergenicity · animal experiment · animal model · comparative study · extraction · immunoblotting · letter · mouse · nonhuman · peanut allergy · priority journal · protein analysis · skin allergy · skin sensitization · Animals · Arachis hypogaea · Dermatologic Agents · Drug Contamination · Humans · Immunization · Peanut Hypersensitivity · Plant Oils

7 Interlaboratory evaluation of a cow's milk allergy mouse model to assess the allergenicity of hydrolysed cow's milk based infant formulas
article 2013    
Author: Esch, B.C.A.M. van · Bilsen, J.H.M. van · Jeurink, P.V. · Garssen, J. · Penninks, A.H. · Smit, J.J. · Pieters, R.H.H. · Knippels, L.M.J.
Keywords: Biology · Allergenicity · Cow's milk allergy · Hydrolysed infant formulas · Mouse model · Safety · Sensitization · Food and Nutrition · Healthy Living · Life Triskelion BV · QS - Quality & Safety RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences TNO Bedrijven
[Abstract]

8 Evaluation of the sensitizing potential of food proteins using two mouse models
article 2016    
Author: Smit, J. · Zeeuw-Brouwer, M.L.D. · Roest, M. van · Jong, G. de · Bilsen, J. van
Keywords: Biology · Allergenic proteins · Allergenicity · Dendritic cells · Food allergy · Mouse models · Sensitization · T cells · Biomedical Innovation · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

9 Reversible denaturation of Brazil nut 2S albumin (Ber e1) and implication of structural destabilization on digestion by pepsin
article 2005    
Author: Koppelman, S.J. · Nieuwenhuizen, W.F. · Gaspari, M. · Knippels, L.M.J. · Penninks, A.H. · Knol, E.F. · Hefle, S.L. · Jongh, H.H.J.de
Keywords: Health Toxicology · Food technology · Allergenicity · Denaturation · Pepsin · Protein folding · Protein stability · albumin · guanidine · pepsin A · alkylation · allergenicity · alpha helix · article · Brazil nut · chemical procedures · circular dichroism · energy · food composition · gel electrophoresis · gel permeation chromatography · infrared spectroscopy · mass spectrometry · pH measurement · protein degradation · protein denaturation · protein folding · protein stability · protein structure · temperature dependence · Albumins · Bertholletia · Pepsin A · Plant Proteins · Protein Denaturation · Protein Precursors · Bertholletia excelsa · Ziziphus mauritiana
[Abstract]

10 Heat-induced conformational changes of Ara h 1, a major peanut allergen, do not affect its allergenic properties
article 1999    
Author: Koppelman, S.J. · Bruijnzeel-Koomen, C.A.F.M. · Hessing, M. · Jongh, H.H.J. de
Keywords: Allergen · Allergenicity · Animal cell · Conformational transition · Heat tolerance · Isoelectric point · Nonhuman · Peanut · Priority journal · Protein denaturation · Protein family · Protein folding · Protein secondary structure · Solubility · Thermostability · Adult · Allergens · Arachis hypogaea · Calorimetry, Differential Scanning · Chromatography, Gel · Circular Dichroism · Glycoproteins · Heat · Humans · Immunoglobulin E · Plant Proteins · Protein Conformation · Spectrophotometry, Ultraviolet · Animalia · Ara · Arachis hypogaea
[PDF] [Abstract]

11 Food processing and allergenicity
article 2015    
Author: Verhoeckx, K.C.M. · Vissers, Y.M. · Baumert, J.L. · Faludi, R. · Feys, M. · Flanagan, S. · Herouet-Guicheney, C. · Holzhauser, T. · Shimojo, R. · Bolt, N. van der · Wichers, H. · Kimber, I.
Keywords: Biology · Allergenicity · Allergic sensitisation · Food allergy · Food processing · IgE antibody · Allergen · Immunoglobulin E · Immunoglobulin G · cControlled study · Egg · Enzyme activity · Fermentation · Food processing · Glycation · Glycosylation · Human · Hydrolysis · Immunogenicity · Milk · Mustard · Peanut · Prevalence · Protein function · Protein intake · Review · Risk assessment · Sensitization · Soybean · Wheat · Triticum aestivum · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

12 Understanding food allergen thresholds requires careful analysis of the available clinical data
article 2015    
Author: Taylor, S.L. · Houben, G.F. · Baumert, J.L. · Crevel, R.R.W.R. · Allen, K.J. · Dubois, A.E.J. · Knulst, A.C. · Remington, B.C. · Kruizinga, A.G. · Blom, W.M. · Brooke-Taylor, S.
Keywords: Health · Allergenicity · Allergic reaction · Egg allergy · Food allergy · Food processing · Geographic origin · Hazelnut allergy · Human · Immunotherapy · Letter · Milk allergy · Patient selection · Peanut · Peanut allergy · Priority journal · Public health · Statistical model · Healthy for Life · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences

13 Continued expression of anti-soy protein antibodies in rats bred on a soy protein-free diet for one generation : the importance of dietary control in oral sensitization research
article 1998    
Author: Knippels, L.M.J. · Penninks, A.H. · Houben, G.F.
Keywords: Nutrition · Brown Norway rat · Food allergy · IgG · Oral · Sensitization · Soy protein-free diet · Allergenicity · Animal experiment · Animal tissue · Antibody production · Controlled study · Diet restriction · Food allergy · Food composition · Milk allergy · Nonhuman · Protein restriction · Sensitization · Animals · Diet · Food Hypersensitivity · Hypersensitivity · Immunoglobulin G · Mouth Mucosa · Rats · Rats, Inbred BN · Soybean Proteins
[Abstract]

14 Food allergy: What do we learn from animal models?
article 2004    
Author: Knippels, L.M.J. · Wijk, F. van · Penninks, A.H.
Keywords: Health · Toxicology and Applied Pharmacology · Allergenicity · Animal models · Food allergy · Therapy · Ara h 1 allergen · Ara h 2 allergen · Ara h 3 allergen · DNA vaccine · food allergen · fungal immunomodulatory protein · fungal protein · immunoglobulin E antibody · protein fip fve · recombinant antigen · recombinant cytokine · recombinant peanut allergen · unclassified drug · allergenicity · antigen specificity · article · bacterium · clinical research · desensitization · dog · dose response · drug activity · drug mechanism · drug research · drug screening · food allergy · genetic susceptibility · health hazard · hypothesis · immunological tolerance · immunopathogenesis · immunoprophylaxis · mouse strain · nonhuman · pathophysiology · prediction · priority journal · protein degradation · protein diet · protein intake · protein structure · publication · rat strain · review · screening test · sensitization · swine · Th1 cell · Th2 cell · Animals · Food Hypersensitivity · Humans · Immunotherapy · Interleukin-10 · Interleukin-4 · Models, Animal · T-Lymphocytes
[Abstract]

15 Assessment of protein allergenicity on the basis of immune reactivity: Animal models
article 2003    
Author: Kimber, I. · Dearman, R.J. · Penninks, A.H. · Knipples, L.M.J. · Buchanan, R.B. · Hammerberg, B. · Jackson, H.A. · Helm, R.M.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Allergy · Dog · Hazard identification · IgE · IgG · Immunogenicity · Mouse · Rat · Risk assessment · Swine · food allergen · protein · allergenicity · animal experiment · biotechnology · DNA modification · dog · food allergy · food intake · food safety · immunoreactivity · methodology · microorganism · nonhuman · priority journal · retrospective study · review · swine · world health organization · Administration, Oral · Animals · Dietary Proteins · Disease Models, Animal · Dogs · Food Hypersensitivity · Humans · Infusions, Parenteral · Mice · Mice, Inbred BALB C · Peanut Hypersensitivity · Rats · Risk Assessment · Swine · Animalia · Canis familiaris · Sus scrofa
[Abstract]

16 Subtoxic concentrations of allergenic haptens induce LC migration and maturation in a human organotypic skin explant culture model: A novel method for identifying potential contact allergens
article 2006    
Author: Lehé, C.L. · Jacobs, J.J.L. · Hua, C.M. · Courtellemont, P. · Elliott, G.R. · Das, P.K.
Keywords: Activation markers · Allergen · HOSEC · Langerhans cell · Migration · CD83 antigen · Contact allergen · Hapten · HLA DR antigen · Irritant agent · T6 antigen · Allergenicity · Antigen expression · Article · Cell maturation · Cell migration · Controlled study · Delayed hypersensitivity · Epidermis · Epidermis cell · Explant · Flow cytometry · Human · Human tissue · immunohistochemistry · Langerhans cell · Quantitative analysis · Skin biopsy · Skin culture · Upregulation · Allergens · Antigens, CD · Cell Differentiation · Cell Movement · Dermatitis, Allergic Contact · Haptens · Humans · Immunoglobulins · Langerhans Cells · Membrane Glycoproteins · Models, Biological · Skin · Tissue Culture Techniques
[Abstract]

17 Workshop overview : Approaches to the assessment of the allergenic potential of food from genetically modified crops
article 2003    
Author: Ladics, G.S. · Holsapple, M.P. · Astwood, J.D. · Kimber, I. · Knippels, L.M.J. · Helm, R.M. · Dong, W.
Keywords: Biology Health · Toxicology and Applied Pharmacology · allergen · food allergen · gene product · allergenicity · allergic reaction · bioinformatics · digestion · exposure · food allergy · food safety · genetic analysis · genetically modified crop · human · hypersensitivity reaction · in vitro study · in vivo study · medical research · nonhuman · nucleotide sequence · physical chemistry · prick test · reproducibility · review · risk assessment · risk factor · validation process · workshop · Animals · Disease Models, Animal · Food Hypersensitivity · Food, Genetically Modified · Mice · Mice, Inbred BALB C · Plant Proteins · Rats · Rats, Inbred BN · Rodentia
[Abstract]

18 Oral sensitization to food proteins: A Brown Norway rat model
article 1998    
Author: Knippels, L.M.J. · Penninks, A.H. · Spanhaak, S. · Houben, G.F.
Keywords: Nutrition · Brown Norway · DTH · Food allergy · IgE · IgG · Oral · Ovalbumin · Rat · Immunoglobulin e · Immunoglobulin g · Ovalbumin · Allergenicity · Allergy · Animal model · Article · Controlled study · Delayed hypersensitivity · Food allergy · Food intake · Nonhuman · Passive skin anaphylaxis · Priority journal · Protein analysis · Rat · Sensitization · Administration, Oral · Animals · Disease Models, Animal · Enzyme-Linked Immunosorbent Assay · Food Hypersensitivity · Hypersensitivity, Delayed · Immunoglobulin E · Immunoglobulin G · Male · Ovalbumin · Passive Cutaneous Anaphylaxis · Rats · Rats, Inbred BN
[Abstract]

19 Approaches to assess IgE mediated allergy risks (sensitization and cross-reactivity) from new or modified dietary proteins
article 2018    
Author: Remington, B. · Broekman, H.C.H. · Blom, W.M. · Capt, A. · Crevel, R.W.R. · Dimitrov, I. · Faeste, C.K. · Fernandez-Canton, R. · Giavi, S. · Houben, G.F. · Glenn, K.C. · Madsen, C.B. · Kruizinga, A.K. · Constable, A.
Keywords: Nutrition · Allergen · Hazard analysis · IgE · Novel proteins · Risk assessment · Sensitization · Immunoglobulin E · Allergenicity · Antigen binding · Basophil activation test · Bioinformatics · Clinical study · Computer model · Cross reaction · DNA modification · Enzymatic degradation · Exposure · Food allergy · Health hazard · Human · Immunogenicity · In vitro study · In vivo study · Methodology · Nonhuman · Outcome assessment · Prick test · Protein analysis · Protein intake · Review · Risk factor · Food and Nutrition · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

20 Assessment of the allergic potential of food protein extracts and proteins on oral application using the Brown Norway rat model
article 2003    
Author: Knippels, L.M.J. · Penninks, A.H.
Keywords: Toxicology · Toxicology and Applied Pharmacology · Allergic potential · Brown Norway rats · Challenge effects · Egg-white proteins · Food allergy · Food proteins · IgE · Milk proteins · Oral sensitization · Ovalbumin · Passive cutaneous anaphylaxis · adjuvant · egg white · food allergen · immunoglobulin E · immunoglobulin G · ovalbumin · allergenicity · animal experiment · animal model · antibody response · antigen specificity · breathing rate · controlled study · feeding · food allergy · immune response · intestine mucosa permeability · male · milk allergy · nonhuman · peanut allergy · priority journal · protein intake · protein purification · provocation test · rat · rat strain · review · risk assessment · sensitization · symptomatology · systolic blood pressure · Administration, Oral · Allergens · Animals · Disease Models, Animal · Egg Proteins · Food Hypersensitivity · Humans · Immunoglobulin E · Immunoglobulin G · Male · Milk Proteins · Rats · Animalia · Arachis hypogaea · Rattus norvegicus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 27 found. Next | Sort by date