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Showing 1 to 11 of 11 found. | Sort by date

1 Melphalan antitumor efficacy and hepatotoxicity: The effect of variable infusion duration in the hepatic artery
article 2003    
Author: Rothbarth, J. · Woutersen, R.A. · Sparidans, R.W. · Velde, C.J.H. van de · Mulder, G.J.
Keywords: Toxicology · Toxicology and Applied Pharmacology · melphalan · animal cell · animal experiment · animal model · animal tissue · antineoplastic activity · article · biliary tract fibrosis · body weight · colon tumor · controlled study · drug efficacy · drug infusion · drug liver level · drug tumor level · hepatic artery · high performance liquid chromatography · liver metastasis · liver perfusion · liver toxicity · nonhuman · priority journal · rat · Animals · Antineoplastic Agents, Alkylating · Disease Models, Animal · Hepatic Artery · Infusions, Intra-Arterial · Liver Neoplasms · Male · Melphalan · Neoplasm Transplantation · Rats · Treatment Outcome
[Abstract]

2 Alkylphospholipids inhibit capillary-like endothelial tube formation in vitro: Antiangiogenic properties of a new class of antitumor agents
article 2008    
Author: Zerp, S.F. · Vink, S.R. · Ruiter, G.A. · Koolwijk, P. · Peters, E. · Luit, A.H. van der · Jong, D.de · Budde, M. · Bartelink, H. · Blitterswijk, W.J. van · Verheij, M.
Keywords: Health · Alkylphospholipids · Angiogenesis · Apoptosis · Endothelial cells · In Vitro · angiogenesis inhibitor · antineoplastic agent · collagen · edelfosine · fibrin · miltefosine · perifosine · phospholipid derivative · angiogenesis · antiangiogenic activity · antineoplastic activity · aorta · apoptosis · statistical significance · umbilical vein · vascular endothelium · Alkylation · Angiogenesis Inhibitors · Animals · Antineoplastic Agents · Apoptosis · Capillaries · Cattle · Cell Line, Tumor · Cells, Cultured · Dose-Response Relationship, Drug · Endothelial Cells · Endothelium, Vascular · Humans · Indicators and Reagents · Phosphodiesterase Inhibitors · Phospholipid Ethers · Phospholipids · Phosphorylcholine · Healthy for Life · Healthy Living
[Abstract]

3 Effect of cisplatin exposure on platinum accumulation and growth inhibition in human neoplastic and normal squamous epithelial cells of the mucosa of the upper-aerodigestive tract
article 1999    
Author: Braakhuis, B.J.M. · Welters, M.J.P. · Cloos, J. · Pankras, J.E. · Smeets, S.J. · Fichtinger-Schepman, A.-M.J.
Keywords: Nutrition · Cisplatin · Head and neck · Keratinocytes · Non-malignant cells · Pt accumulation · Squamous cells · Cisplatin · Platinum · Adult · Antineoplastic activity · Cancer cell culture · Colorimetry · Controlled study · Drug accumulation · Epithelium cell · Female · Growth inhibition · Head and neck cancer · Human · Human cell · Keratinocyte · Male · Palate · Priority journal · Squamous cell · Squamous epithelium · Antineoplastic Agents · Carcinoma, Squamous Cell · Cell Division · Cisplatin · Epithelial Cells · Female · Head and Neck Neoplasms · Humans · Male · Middle Aged · Platinum · Tumor Cells, Cultured · Uvula
[Abstract]

4 Recent methodology in the phytochemical analysis of ginseng
article 2008    
Author: Angelova, N. · Kong, H.-W. · Heijden, R. van de · Yang, S.-Y. · Choi, Y.H. · Kim, H.K. · Wang, M. · Hankemeier, T. · Greef, J. van der · Xu, G. · Verpoorte, R.
Keywords: Health · Biomedical Research · Ginsenosides · Mass spectrometry · Metabolomics · Panax ginseng · Ginseng extract · Phenol · Saponin · Analytic method · Antineoplastic activity · Biosensor · Drug absorption · Drug determination · Drug distribution · Drug efficacy · Drug excretion · Drug half life · Drug metabolism · Drug safety · Drug structure · Electrospray mass spectrometry · Enzyme linked immunosorbent assay · Fourier transform mass spectrometry · Ginseng · High performance liquid chromatography · Human · Immunoregulation · Ion cyclotron resonance mass spectrometry · Liquid chromatography · Liver protection · Mass spectrometry · Metabolomics · Near infrared reflectance spectroscopy · Nonhuman · Nuclear magnetic resonance spectroscopy · Plant root · Quality control · Review · Sensitivity analysis · Structure analysis · Systems biology · Drugs, Chinese Herbal · Ginsenosides · Mass Spectrometry · Panax · Spectroscopy, Fourier Transform Infrared · Spectroscopy, Near-Infrared · Panax ginseng
[Abstract]

5 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro
article 2005    
Author: Erk, M.J. van · Roepman, P. · Lende, T.R. van der · Stierum, R.H. · Aarts, J.M.M.J.G. · Bladeren, P.J. van · Ommen, B. van
Keywords: Health Biology · Biomedical Research · (anti-)carcinogenic mechanisms · Caco-2 · Cell proliferation · Gene expression · Quercetin · beta catenin · mitogen activated protein kinase · quercetin · T cell factor protein · antineoplastic activity · apoptosis · article · cancer cell · cell adhesion · cell cycle · cell cycle G1 phase · cell differentiation · cell interaction · cell proliferation · cell strain CACO 2 · cellular distribution · colon carcinoma · controlled study · DNA microarray · down regulation · drug activity · energy metabolism · gene expression · genetic analysis · human · human cell · in vitro study · nucleotide sequence · oncogene · signal transduction · tumor suppressor gene · unindexed sequence · upregulation · Antineoplastic Agents · Apoptosis · Caco-2 Cells · Cell Cycle · Cell Division · Colonic Neoplasms · Dose-Response Relationship, Drug · Gene Expression · Gene Expression Profiling · Gene Expression Regulation · Humans · Quercetin
[Abstract]

6 Recombinant adenoviral vectors have adjuvant activity and stimulate T cell responses against tumor cells
article 2000    
Author: Geutskens, S.B. · Eb, M.M. van der · Plomp, A.C. · Jonges, L.E. · Cramer, S.J. · Ensink, N.G. · Kuppen, P.J.K. · Hoeben, R.C.
Keywords: Cancer gene therapy · IL-2 · Recombinant adenovirus · complementary DNA · cytokine · recombinant interleukin 2 · tumor antigen · virus vector · Adenovirus · Animal cell · Animal experiment · Animal model · Antigen recognition · Antineoplastic activity · Cancer inhibition · Colorectal cancer · Controlled study · Delayed hypersensitivity · DNA transfer · Gene expression · Gene therapy · immune response · Immunotherapy · Liver metastasis · Lymphocyte activation · Nonhuman · Rat strain · T lymphocyte · Transgene · Tumor cell · Tumor regression · Virus plaque · Virus recombinant · Virus replication · Adenoviridae · Animals · Colorectal Neoplasms · Flow Cytometry · Gene Therapy · Genetic Vectors · Histocompatibility Antigens Class I · Histocompatibility Antigens Class II · Humans · Intercellular Adhesion Molecule-1 · Interleukin-2 · Liver Neoplasms, Experimental · Lymphocyte Activation · Rats · Rats, Inbred Strains · T-Lymphocytes · Tumor Cells, Cultured · Adenoviridae · Animalia · DNA viruses
[Abstract]

7 Tissue inhibitor of metalloproteinase-3 expression from an oncolytic adenovirus inhibits matrix metalloproteinase activity in vivo without affecting antitumor efficacy in malignant glioma
article 2005    
Author: Lamfers, M.L.M. · Gianni, D. · Tung, C.H. · Idema, S. · Schagen, F.H.E. · Carette, J.E. · Quax, P.H.A. · Beusechem, V.W. van · Top, W.P. van der · Dirven, C.M.F. · Chiocca, E.A. · Gerritsen, W.R.
Keywords: Biomedical Research · oncolytic adenovirus · oncolytic virus · tissue inhibitor of metalloproteinase 3 · Adenovirus · animal experiment · animal model · animal tissue · antineoplastic activity · article · cancer cell culture · cancer model · cancer survival · cell proliferation · cell strain HEK293 · controlled study · culture medium · drug efficacy · enzyme activity · enzyme inhibition · female · gene deletion · gene expression · gene insertion · gene transfer · glioblastoma · glioma cell · human · human cell · mouse · nonhuman · priority journal · protein expression · survival time · transgene · tumor xenograft · Adenoviridae · Animals · Cell Growth Processes · Cell Line, Tumor · Gene Transfer Techniques · Glioma · Humans · Matrix Metalloproteinase 2 · Mice · Mice, Nude · Tissue Inhibitor of Metalloproteinase-3 · Virus Replication · Xenograft Model Antitumor Assays
[Abstract]

8 The role of cyclooxygenase in n-6 and n-3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE2 synthesis and cytotoxicity in human colorectal carcinoma cell lines
article 2003    
Author: Dommels, Y.E.M. · Haring, M.M.G. · Keestra, N.G.M. · Alink, G.M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Biology · Analytical research · 5 (4 fluorophenyl) 1 [(4 methylsulfonyl)phenyl] 3 trifluoromethylpyrazole · 5,8,11,14,17 icosapentaenoic acid · acetylsalicylic acid · alpha tocopherol · antioxidant · arachidonic acid · ascorbic acid · carbene · celecoxib · cyclooxygenase 2 inhibitor · docosahexaenoic acid · indometacin · interleukin 1beta · linoleic acid · malonaldehyde · nonsteroid antiinflammatory agent · omega 3 fatty acid · omega 6 fatty acid · prostaglandin E2 · prostaglandin synthase · antineoplastic activity · cancer cell · cell growth · cell proliferation · colon cancer · colorectal carcinoma · controlled study · cytotoxicity · drug effect · drug mechanism · enzyme activation · enzyme activity · fatty acid synthesis · growth inhibition · human · human cell · hypothesis · incubation time · lipid peroxidation · priority journal · review · signal transduction · Antioxidants · Caco-2 Cells · Cell Division · Colorectal Neoplasms · Cyclooxygenase Inhibitors · Dinoprostone · Fatty Acids, Omega-3 · Fatty Acids, Omega-6 · Fatty Acids, Unsaturated · HT29 Cells · Humans · Lipid Peroxidation · Prostaglandin-Endoperoxide Synthases
[Abstract]

9 Fiber-chimeric adenoviruses expressing fibers from serotype 16 and 50 improve gene transfer to human pancreatic adenocarcinoma
article 2009    
Author: Kuhlmann, K.F.D. · Geer, M.A. van · Bakker, C.T. · Dekker, J.E.M. · Havenga, M.J.E. · Oude Elferink, R.P.J. · Gouma, D.J. · Bosma, P.J. · Wesseling, J.G.
Keywords: Biology · Biomedical Research · Adenovirus · Fiber-chimeric · Pancreatic cancer · Serotype · adenovirus vector · bacterial enzyme · coxsackie virus and adenovirus receptor · cytosine deaminase · flucytosine · green fluorescent protein · red fluorescent protein · virus DNA · virus fiber protein · Adenovirus fiber gene · Adenovirus fiber knob 5 · Adenovirus type 16 · Adenovirus type 50 · antineoplastic activity · article · bacterial gene · cancer cell culture · cell viability · controlled study · cytosine deaminase gene · drug cytotoxicity · drug efficacy · drug mechanism · drug specificity · fiber chimeric human adenovirus 5 · gene directed enzyme prodrug therapy · gene expression · gene targeting · human · Human adenovirus · Human adenovirus 5 · human cell · human tissue · liver cell culture · molecular cloning · nonhuman · pancreas adenocarcinoma · priority journal · protein domain · protein expression · suicide gene · viral gene delivery system · virus fiber · virus gene · Adenoviridae · Cell Line · Cell Line, Tumor · Flow Cytometry · Gene Therapy · Genetic Vectors · Green Fluorescent Proteins · Humans · Pancreatic Neoplasms · Polymerase Chain Reaction · Recombinant Fusion Proteins · Recombination, Genetic · Transduction, Genetic · Viral Envelope Proteins · Adenoviridae
[Abstract]

10 Do aberrant crypt foci have predictive value for the occurrence of colorectal tumours? Potential of gene expression profiling in tumours
article 2004    
Author: Wijnands, M.V.W. · Erk, M.J. van · Doornbos, R.P. · Krul, C.A.M. · Woutersen, R.A.
Keywords: Biology · Analytical research · AC, aberrant crypt · ACF, aberrant crypt focus · AIN, American Institute of Nutrition · ANOVA, analysis of variance · AOM, azoxymethane · BIT, benzyl isothiocyanate · CA2, carbonic anhydrase II · CDK4, cyclin-dependent kinase 4 · cDNA, complementary DNA · benzyl isothiocyanate · curcumin · rutoside · animal experiment · animal model · animal tissue · antineoplastic activity · article · carcinogenesis · colorectal tumor · controlled study · correlation analysis · crypt cell · dietary intake · disease marker · drug effect · gene expression profiling · intestine crypt · male · nonhuman · oncogene · prediction · protein expression · rat · scoring system · statistical significance · time series analysis · wheat bran · Animals · Anticarcinogenic Agents · Body Weight · Colorectal Neoplasms · Diet · DNA Primers · DNA, Complementary · Eating · Energy Metabolism · Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Intestinal Mucosa · Male · Predictive Value of Tests · Rats · Rats, Inbred F344 · Reverse Transcriptase Polymerase Chain Reaction · RNA, Neoplasm · Survival Analysis · Tissue Inhibitor of Metalloproteinase-1 · Tumor Markers, Biological · Triticum aestivum
[Abstract]

11 Of the major phenolic acids formed during human microbial fermentation of tea, citrus, and soy flavonoid supplements, only 3,4-dihydroxyphenylacetic acid has antiproliferative activity
article 2006    
Author: Gao, K. · Xu, A. · Krul, C.A.M. · Venema, K. · Liu, Y. · Niu, Y. · Lu, J. · Bensoussan, L. · Seeram, N.P. · Heber, D. · Henning, S.M.
Keywords: Health · Biomedical Research · Antiproliferative activity · Colonic fermentation · Flavonoids · Phenolic acids · 3 (4 hydroxy 3 methoxyphenyl)propionic acid · 3 hydroxyphenyl acetic acid · 3,4 dihydroxyphenylacetic acid · 4 hydroxyphenyl acetic acid · dihydro meta coumaric acid · flavonoid · genistein · hippuric acid · homovanillic acid · naringenin · phenol derivative · phloroglucinolcarboxylic acid · rutoside · theaflavin · unclassified drug · antineoplastic activity · bacterial flora · cancer cell · citrus fruit · colon adenocarcinoma · colon flora · comparative study · concentration response · conference paper · controlled study · dialysate · diet supplementation · fermentation · gas chromatography · high performance liquid chromatography · human · human cell · human experiment · in vitro study · intestine cell · mass spectrometry · microbial metabolism · nonhuman · normal human · prostate adenocarcinoma · sample · statistical significance · tea · 3,4-Dihydroxyphenylacetic Acid · Adult · Citrus · Colon · Fermentation · Flavonoids · Humans · Phenylacetates · Tea · Bacteria (microorganisms) · Camellia sinensis · Citrus
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 11 of 11 found. | Sort by date