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1 Feasibility of SPECT-CT imaging to study the pharmacokinetics of antisense oligonucleotides in a mouse model of Duchenne muscular dystrophy
article 2017    
Author: Steeg, E. van de · Läppchen, T. · Aguilera, B. · Jansen, H.T. · Muilwijk, D. · Vermue, R. · Hoorn, J.W. van der · Donato, K. · Rossin, R. · Visser, P.C. de · Vlaming, M.L.H.
Keywords: Nutrition · SPECT imaging · Antisense oligonucleotides · RNA-based therapeutics · Duchenne muscular dystrophy · Antisense oligonucleotides · Antisense oligonucleotide i 123 · Antisense oligonucleotide in 111 · Indium 111 · Iodine 123 · Tracer · Unclassified drug · Animal experiment · Animal model · Animal tissue · Controlled study · Drug distribution · Drug half life · Drug tissue level · Drug uptake · In vivo study · Male · Mouse · Mouse model · Nonhuman · Single photon emission computed tomography-computed tomography · Skeletal muscle · Target tissue · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

2 GIT1 Mediates Thrombin Signaling in Endothelial Cells: Role in Turnover of RhoA-Type Focal Adhesions
article 2004    
Author: Nieuw Amerongen, G.P. van · Natarajan, K. · Yin, G. · Hoefen, R.J. · Osawa, M. · Haendeler, J. · Ridley, A.J. · Fujiwara, K. · Hinsbergh, V.W.M. van · Berk, B.C.
Keywords: Biology · Biomedical Research · Contractility · Endothelium · Focal adhesion kinase · Thrombin · 4 (1 aminoethyl) n (4 pyridyl)cyclohexanecarboxamide · antisense oligonucleotide · focal adhesion kinase · G protein coupled receptor kinase · G protein coupled receptor kinase interacting protein · GIT1 protein · guanosine triphosphatase · protein tyrosine kinase · Rho kinase · RhoA guanine nucleotide binding protein · thrombin · unclassified drug · vinculin · Adenovirus · animal cell · article · cell migration · cell shape · cell structure · cellular distribution · controlled study · depletion · endothelium cell · enzyme activation · enzyme metabolism · enzyme phosphorylation · enzyme substrate · focal adhesion · genetic transfection · human · human cell · membrane permeability · negative feedback · nonhuman · priority journal · protein function · protein localization · protein phosphorylation · protein protein interaction · protein transport · regulatory mechanism · signal transduction · umbilical vein · Adaptor Proteins, Signal Transducing · Amides · Animals · Aorta · Cattle · Cell Cycle Proteins · Cell Size · Cells, Cultured · Endothelial Cells · Endothelium, Vascular · Enzyme Inhibitors · Feedback, Biochemical · Focal Adhesion Kinase 1 · Focal Adhesion Protein-Tyrosine Kinases · Focal Adhesions · GTPase-Activating Proteins · Humans · Oligodeoxyribonucleotides, Antisense · Phosphoproteins · Phosphorylation · Protein Processing, Post-Translational · Protein Transport · Protein-Tyrosine Kinases · Proto-Oncogene Proteins pp60(c-src) · Pyridines · rac GTP-Binding Proteins · rhoA GTP-Binding Protein · RNA, Small Interfering · Signal Transduction · Thrombin · Transduction, Genetic · Transfection · Umbilical Veins · Vinculin
[Abstract]

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