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1 Dietary sphingolipids lower plasma cholesterol and triacylglycerol and prevent liver steatosis
article 2007    
Author: Nieuwenhuizen, W.F. · Duivenvoorden, I. · Voshol, P.J. · Rensen, P.C.N. · Duyvenvoorde, W. van · Romijn, J.A. · Emeis, J.J. · Havekes, L.M.
Keywords: Food technology · APOE*3Leiden mice · Cholesterol · Free fatty acid · Sphingolipid · Steatosis · Triacylglycerol · Mus
[Abstract]

2 Transgenic mouse models to study the role of APOE in hyperlipidemia and atherosclerosis
article 1998    
Author: Hofker, M.H. · Vlijmen, B.J.M. van · Havekes, L.M.
Keywords: Health · APOE · Apolipoprotein · Cholesterol · Gene targeting · Lipoprotein · Triglyceride · Animals · Apolipoproteins E · Arteriosclerosis · Disease Models, Animal · Humans · Hyperlipidemias · Mice · Mice, Transgenic
[Abstract]

3 Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin
article 2012    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Hoek, A.M. van den · Havekes, L.M. · Liau, G. · Jukema, J.W. · Princen, H.M.G.
Keywords: aliskiren · APOE*3Leiden.CETP mice · atherosclerosis · atorvastatin · hypertension · plaque stability · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

4 Effects of probiotic Lactobacillus rhamnosus GG and Propionibacterium freudenreichii ssp. shermanii JS supplementation on intestinal and systemic markers of inflammation in ApoE*3Leiden mice consuming a high-fat diet
article 2013    
Author: Oksaharju, A. · Kooistra, T. · Kleemann, R. · Duyvenvoorde, W. van · Miettinen, M. · Lappalainen, J. · Lindstedt, K.A. · Kovanen, P.T. · Korpela, R. · Kekkonen, R.A.
Keywords: Biology · 3Leiden mice · ApoE · Inflammation · Mast cells · Probiotic bacteria · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[PDF] [Abstract]

5 Apolipoprotein E genotype status affects habitual human blood mononuclear cell gene expression and its response to fish oil intervention
article 2016    
Author: Matualatupauw, J.C. · Radonjic, M. · Rest, O. van de · Groot, L.C.P.G.M. de · Geleijnse, J.M. · Müller, M. · Afman, L.A.
Keywords: Biology · APOE4 · Fish-oil supplementation · Gene-diet interactions · Microarray · Nutrigenomics · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

6 The effect of the apolipoprotein E genotype on response to personalized dietary advice intervention: Findings from the Food4Me randomized controlled trial
article 2016    
Author: Fallaize, R. · Celis-Morales, C. · MacReady, A.L. · Marsaux, C.F.M. · Forster, H. · O'Donovan, C. · Woolhead, C. · San-Cristobal, R. · Kolossa, S. · Hallmann, J. · Mavrogianni, C. · Surwillo, A. · Livingstone, K.M. · Moschonis, G. · Navas-Carretero, S. · Walsh, M.C. · Gibney, E.R. · Brennan, L. · Bouwman, J. · Grimaldi, K. · Manios, Y. · Traczyk, I. · Drevon, C.A. · Martinez, J.A. · Daniel, H. · Saris, W.H.M. · Gibney, M.J. · Mathers, J.C. · Lovegrove, J.A.
Keywords: Biology · APOE · Dietary fat · Food4me · Nutrigenomics · Personalized nutrition · Biomedical Innovation · Healthy Living · Life · MSB - Microbiology and Systems Biology · ELSS - Earth, Life and Social Sciences
[Abstract]

7 Binding of β-VLDL to heparan sulfate proteoglycans requires lipoprotein lipase, whereas apoE only modulates binding affinity
article 1999    
Author: Beer, F. de · Hendriks, W.L. · Vark, L.C. van · Kamerling, S.W.A. · Dijk, K.W. van · Hofker, M.H. · Smelt, A.H.M. · Havekes, L.M.
Keywords: Biology · β-VLDL · apoE · Heparan sulfate proteoglycans · Lipoprotein lipase · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Binding, Competitive · Cell Line · Cholesterol, VLDL · Heparan Sulfate Proteoglycans · Iodine Radioisotopes · Lipoprotein Lipase · Macrophages · Mice · Mice, Knockout
[Abstract]

8 Reversal of hypercholesterolemia in apolipoprotein E2 and apolipoprotein E3-Leiden transgenic mice by adenovirus-mediated gene transfer of the VLDL receptor
article 1998    
Author: Dijk, K.W. van · Vlijmen, B.J.M. van · Zee, A. van der · Hof, B. van 't · Boom, H. van der · Kobayashi, K. · Chan, L. · Havekes, L.M. · Hofker, M.H.
Keywords: Health · ApoE variants · Atherosclerosis · Gene therapy · VLDL receptor · Adenoviridae · Animals · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoproteins E · Cholesterol · Female · Gene Transfer Techniques · Humans · Hypercholesterolemia · Mice · Mice, Knockout · Mice, Transgenic · Receptors, LDL · Triglycerides
[Abstract]

9 Comment on "Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice" by Rebholz S.L. et al. Toxicol. Rep. 2016 (3) 46-54
article 2016    
Author: Princen, H.M.G. · Pouwer, M.G. · Pieterman, E.J.
Keywords: Biology · APOE*3-Leiden.CETP mice · Lipoprotein metabolism · Lipoproteins · Non-HDL-C/HDL-C · Perfluorooctanoate (PFOA) · Plasma cholesterol · Plasma triglycerides · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences

10 Genetic analysis of sex and generation differences in plasma lipid, lipoprotein, and apolipoprotein levels in adolescent twins and their parents
article 1996    
Author: Boomsma, D.I. · Kempen, H.J.M. · Gevers Leuven, J.A. · Havekes, L. · Knijff, P. de · Frants, R.R.
Keywords: Health · ApoA1 · ApoA2 · ApoB · ApoE · HDL · LDL · Adolescent · Adult · Age Distribution · Aged · Apolipoproteins · Cholesterol · Diseases in Twins · Female · Humans · Hyperlipidemias · Lipoproteins · Male · Middle Aged · Models, Genetic · Netherlands · Phenotype · Sex Distribution · Variation (Genetics)
[Abstract]

11 The AT04A vaccine against proprotein convertase subtilisin/kexin type 9 reduces total cholesterol, vascular inflammation, and atherosclerosis in APOE*3Leiden.CETP mice
article 2017    
Author: Landlinger, C. · Pouwer, M.G. · Juno, C. · Hoorn, J.W.A. van der · Pieterman, E.J. · Jukema, J.W. · Staffler, G. · Princen, H.M.G. · Galabova, G.
Keywords: Health · APOE*3Leiden.CETP mice · Anti-PCSK9 vaccine · Atherosclerosis · Systemic and vascular inflammation · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

12 Alirocumab, evinacumab, and atorvastatin triple therapy regresses plaque lesions and improves lesion composition in mice
article 2019    
Author: Pouwer, M.G. · Pieterman, E.J. · Worms, N. · Keijzer, N. · Jukema, J.W. · Gromada, J. · Gusarova, V. · Princen, H.M.G.
Keywords: APOE*3-Leiden.CETP mice · Angiopoietin-like proteins · Antibodies · Apolipoproteins · Atherosclerosis · Cardiovascular disease · Drug therapy/Hypolipidemic drugs · Macrophages / monocytes · PCSK9 · Regression · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

13 Olmesartan and pravastatin additively reduce development of atherosclerosis in APOE*3Leiden transgenic mice
article 2007    
Author: Hoorn, J.W.A. van der · Kleemann, R. · Havekes, L.M. · Kooistra, T. · Princen, H.M.G. · Jukema, J.W.
Keywords: Biology · Biomedical Research · APOE*3Leiden mice · Atherosclerosis · Combination therapy · Olmesartan · Pravastatin · T lymphocyte · transgenic mouse · Angiotensin II Type 1 Receptor Blockers · Animals · Apolipoprotein E3 · Atherosclerosis · Blood Pressure · Collagen · Diet, Atherogenic · Drug Synergism · Female · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Imidazoles · Inflammation · Lipids · Macrophages · Mice · Mice, Transgenic · Monocytes · Muscle, Smooth, Vascular · Pravastatin · Recombinant Proteins · Serum Amyloid A Protein · T-Lymphocytes · Tetrazoles
[PDF] [Abstract]

14 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

15 Combined Association and Linkage Analysis Applied to the APOE Locus
article 2004    
Author: Beekman, M. · Posthuma, D. · Heijmans, B.T. · Lakenberg, N. · Suchiman, H.E.D. · Snieder, H. · Knijff, P. de · Frants, R.R. · Ommen, G.J.B. van · Kluft, C. · Vogler, G.P. · Slagboom, P.E. · Boomsma, D.I.
Keywords: ApoE level · Fine-mapping · Quantitative trait locus · Twin pairs · chromosome 19 · cohort analysis · gene locus · gene mapping · genetic association · genetic linkage · genetic polymorphism · genotype · linkage analysis · lipoprotein blood level · quantitative trait locus · short tandem repeat · twins · Adolescent · Adult · Apolipoprotein E2 · Apolipoprotein E3 · Apolipoprotein E4 · Apolipoproteins E · Chromosomes, Human, Pair 19 · Cohort Studies · Female · Genotype · Humans · Linkage (Genetics) · Lod Score · Male · Netherlands · Polymorphism, Genetic · Quantitative Trait, Heritable · Genetta
[Abstract]

16 Effect of apolipoprotein E and insulin resistance on VLDL particles in combined hyperlipidemic patients
article 1996    
Author: Sijbrands, E.J.G. · Westendorp, R.G.J. · Hoffer, M.J.V. · Frants, R.R. · Meinders, A.E. · Souverijn, J.H.M. · Leuven, J.A.G. · Laarse, A. van der · Havekes, L.M. · Smelt, A.H.M.
Keywords: Biology · ApoE · Combined hyperlipidemia · Hyperinsulinemia · Particle size · VLDL · apolipoprotein e · insulin · very low density lipoprotein · adult · aged · article · clinical trial · controlled clinical trial · controlled study · diet · female · genetic analysis · heterozygosity · human · human tissue · hyperlipidemia · hypertriglyceridemia · insulin resistance · lipid analysis · major clinical study · male · priority journal · Adult · Aged · Apolipoproteins E · Cholesterol, VLDL · Fasting · Female · Humans · Hyperlipidemia, Familial Combined · Insulin · Insulin Resistance · Lipoproteins, VLDL · Male · Middle Aged · Particle Size · Triglycerides
[Abstract]

17 Uptake by J774 macrophages of very-low-density lipoproteins isolated from apoE-deficient mice is mediated by a distinct receptor and stimulated by lipoprotein lipase
article 1997    
Author: Hendriks, W.L. · Sman van der - Beer, F. de · Vlijmen, B.J.M. van · Vark, L.C. van · Hofker, M.H. · Havekes, L.M.
Keywords: Biology · apoE-deficient mice · foam cells · lipoprotein lipase · macrophages · receptor-mediated uptake · apolipoprotein a1 · apolipoprotein a4 · apolipoprotein b100 · apolipoprotein c · cholesterol ester · lipoprotein receptor · receptor protein · triacylglycerol · very low density lipoprotein · animal cell · animal experiment · animal model · atherosclerotic plaque · cell line · controlled study · foam cell · hyperlipoproteinemia type 3 · intima · lipoprotein metabolism · macrophage · mouse · nonhuman · Animals · Apolipoproteins E · Biological Transport · Cell Line · Lipoprotein Lipase · Lipoproteins, VLDL · Macrophages · Mice · Radioligand Assay · Receptors, Lipoprotein
[Abstract]

18 The dual PPARα/γ agonist tesaglitazar blocks progression of pre-existing atherosclerosis in APOE*3Leiden.CETP transgenic mice
article 2009    
Author: Hoorn, J.W.A. van der · Jukema, J.W. · Havekes, L.M. · Lundholm, E. · Camejo, G. · Rensen, P.C.N. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · 3Leiden.CETP mice · APOE · Atherogenic triad · Atherosclerosis · PPARα/γ · Tesaglitazar · 2 ethoxy 3 (4 ((4 (methylsulfonyloxy)phenethyl)oxy)phenyl)propanoic acid · Alkanesulfonic acid · High density lipoprotein cholesterol · Peroxisome proliferator activated receptor alpha · Peroxisome proliferator activated receptor gamma · Phenylpropionic acid derivative · Very low density lipoprotein cholesterol · Biosynthesis · Blood · Drug potentiation · Genetics · Inflammation · Metabolism · Mouse · Mutation · Pathology · Transgenic mouse · Alkanesulfonates · Animals · Aortic Valve · Apolipoprotein E3 · Atherosclerosis · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Cholesterol, VLDL · Female · Humans · Inflammation · Mice · Mice, Transgenic · Mutation · Phenylpropionates · PPAR alpha · PPAR gamma
[Abstract]

19 Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF)
article 2006    
Author: Burger-Kentischer, A. · Göbel, H. · Kleemann, R. · Zernecke, A. · Bucala, R. · Leng, L. · Finkelmeier, D. · Geiger, G. · Schaefer, H.E. · Schober, A. · Weber, C. · Brunner, H. · Rütten, H. · Ihling, C. · Bernhagen, J.
Keywords: Biology · Biomedical Research · ApoE-/- · Inflammation · MIF · Apontaneous atherosclerosis · apolipoprotein E · CD40 ligand · Fibrinogen · Gelatinase A · Immunoglobulin G · Intercellular adhesion molecule 1 · Interleukin 12 · Interleukin 6 · Macrophage migration inhibition factor · Monoclonal antibody · Neutralizing antibody · Stress activated protein kinase · Transcription factor · Tumor necrosis factor · Animal experiment · Animal model · Animal tissue · Atherosclerotic plaque · Controlled study · Foam cell · Heart valve · Macrophage · Mediator release · Mouse · Nonhuman · Protein expression · Animals · Antibodies, Monoclonal · Aorta, Thoracic · Aortitis · Apolipoproteins E · Atherosclerosis · CD40 Ligand · Disease Models, Animal · Follow-Up Studies · Gene Expression · Immunologic Factors · Intercellular Adhesion Molecule-1 · Interleukin-12 · Macrophage Migration-Inhibitory Factors · Matrix Metalloproteinase 2 · Mice · Mice, Inbred C57BL · Polymerase Chain Reaction · RNA · Tumor Necrosis Factor-alpha
[Abstract]

20 Generation of a recombinant apolipoprotein E variant with improved biological functions: Hydrophobic residues (LEU-261, TRP-264, PHE-265, LEU-268, VAL-269) of apoE can account for the apoE-induced hypertriglyceridemia
article 2005    
Author: Kypreos, K.E. · Dijk, K.W. van · Havekes, L.M. · Zannis, V.I.
Keywords: Biology · Biomedical Research · Amino acids · Biochemistry · Cholesterol · Genes · Molecular biology · Mutagenesis · Alanines · Apolipoprotein E (apoE) · High density lipoprotein (HDL) · Ultracentrifugation analysis · Proteins · High density lipoprotein · Leucine · Lipoprotein lipase · Phenylalanine · Recombinant apolipoprotein E · Recombinant protein · Triacylglycerol · Tryptophan · Unclassified drug · Valine · Very low density lipoprotein · Adenovirus · Amino acid substitution · Animal experiment · Carboxy terminal sequence · Controlled study · Density gradient centrifugation · Electron microscopy · Gene transfer · Human cell · Hydrophobicity · Hyperlipidemia · Hypertriglyceridemia · Mouse · Mutation · Nonhuman · Protein expression · Protein function · Animals · Apolipoproteins E · Cholesterol · Female · Humans · Hypertriglyceridemia · Lipoproteins, HDL · Lipoproteins, VLDL · Liver · Mice · Mice, Knockout · Mutagenesis, Site-Directed · Mutation, Missense · Peptide Fragments · Recombinant Proteins · Transgenes · Triglycerides
[PDF] [Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 25 found. Next | Sort by date