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Showing 1 to 17 of 17 found. | Sort by date

1 Actions of metformin and statins on lipid and glucose metabolism and possible benefit of combination therapy
article 2018    
Author: Stee, M.F. van · Graaf, A.A. de · Groen, A.K.
Keywords: Biology · Atorvastatin · Combination therapy · Dyslipidemia · Glucose metabolism · Lipid metabolism · Metformin · Simvastatin · Type 2 diabetes
[PDF] [Abstract]

2 Aliskiren inhibits atherosclerosis development and improves plaque stability in APOE*3Leiden.CETP transgenic mice with or without treatment with atorvastatin
article 2012    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Hoek, A.M. van den · Havekes, L.M. · Liau, G. · Jukema, J.W. · Princen, H.M.G.
Keywords: aliskiren · APOE*3Leiden.CETP mice · atherosclerosis · atorvastatin · hypertension · plaque stability · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

3 Alirocumab inhibits atherosclerosis, improves the plaque morphology, and enhances the effects of a statin
article 2014    
Author: Kühnast, S. · Hoorn, J.W.A. van der · Pieterman, E.J. · Hoek, A.M. van den · Sasiela, W.J. · Gusarova, V. · Peyman, A. · Schäfer, H.L. · Schwahn, U. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · 3Leiden.CETP mice · APOE · Atorvastatin · Proprotein convertase subtilisin/kexin type 9 · Alirocumab · Apolipoprotein E · Atorvastatin · Bile acid · Cholesterol · Collagen · Low density lipoprotein receptor · Sterol · Triacylglycerol · Animal experiment · Animal model · Atherosclerosis · Atherosclerotic plaque · Controlled study · Disease severity · Dose response · Drug effect · Drug potentiation · Drug safety · Fat content · Female · Lipid blood level · Monocyte · Monotherapy · Mouse · Nonhuman · Protein degradation · Smooth muscle fiber · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[PDF] [Abstract]

4 Anacetrapib reduces progression of atherosclerosis, mainly by reducing non-HDL-cholesterol, improves lesion stability and adds to the beneficial effects of atorvastatin
article 2015    
Author: Kühnast, S. · Tuin, S.J.L. van der · Hoorn, J.W.A. van der · Klinken, J.B. van · Simic, B. · Pieterman, E. · Havekes, L.M. · Landmesser, U. · Lüscher, T.F. · Dijk, K.W. van · Rensen, P.C.N. · Jukema, J.W. · Princen, H.M.G.
Keywords: Biology · Anacetrapib · Atherosclerosis · Atorvastatin · Cholesteryl ester transfer protein · HDL function · HDL-cholesterol · Non-HDL-cholesterol · Apolipoprotein E3 · Atorvastatin · High density lipoprotein cholesterol · Analysis of covariance · Animal cell · Animal model · Aorta atherosclerosis · Aorta root · Atherosclerotic plaque · Cholesterol blood level · Controlled study · Diet · Disease severity · Drug efficacy · Drug potentiation · Enzyme activity · Female · In vivo study · Mouse · Nonhuman · Risk reduction · Treatment duration · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

5 Lipidomic approach to evaluate rosuvastatin and atorvastatin at various dosages: Investigating differential effects among statins
article 2008    
Author: Bergheanu, S.C. · Reijmers, T. · Zwinderman, A.H. · Bobeldijk, I. · Ramaker, R. · Liem, A.-H. · Greef, J. van der · Hankemeier, T. · Jukema, J.W.
Keywords: Biology · Atorvastatin · Cardiovascular risk · Phosphatidylcholines · Rosuvastatin · Sphingomyelins · Atorvastatin · Cholesterol · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Low density lipoprotein cholesterol · Phosphatidylcholine · Rosuvastatin · Sphingomyelin · Triacylglycerol · Adult · Aged · Article · Cardiovascular risk · Cholesterol blood level · Clinical trial · Controlled clinical trial · Controlled study · Coronary artery disease · Drug dose increase · Drug efficacy · Drug megadose · Female · Human · Lipid blood level · Lipid metabolism · Lipidomics · Liquid chromatography · Low drug dose · Major clinical study · Male · Mass spectrometry · Multicenter study · Phase 3 clinical trial · Randomized controlled trial · Therapy effect · Treatment outcome · Chromatography, Liquid · Dose-Response Relationship, Drug · Fluorobenzenes · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Lipids · Mass Spectrometry · Prospective Studies · Pyrimidines · Pyrroles · Sulfonamides
[Abstract]

6 Torcetrapib does not reduce atherosclerosis beyond atorvastatin and induces more proinflammatory lesions than atorvastatin
article 2008    
Author: Haan, W. de · Vries-van der Weij, J. de · Hoorn, J.W.A. van der · Gautier, T. · Hoogt, C.C. van der · Westerterp, M. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Princen, H.M.G. · Rensen, P.C.N.
Keywords: Biology · Biomedical Research · Atherosclerosis · Cholesteryl ester transfer proteins · Drugs · Lipids · Lipoproteins · Apolipoprotein E · Atorvastatin · Cholesterol · Cholesterol ester transfer protein · Collagen · High density lipoprotein cholesterol · Monocyte chemotactic protein 1 · Torcetrapib · Atherosclerosis · Cholesterol blood level · Drug activity · Evaluation · Female · Inflammation · Macrophage · Monocyte · Mouse · Nonhuman · Phenotype · Sham feeding · Statistical significance · Animals · Atherosclerosis · Cholesterol Ester Transfer Proteins · Drug Synergism · Heptanoic Acids · Inflammation · Mice · Mice, Inbred Strains · Pyrroles · Quinolines
[PDF] [Abstract]

7 Differential effects of amlodipine and atorvastatin treatment and their combination on atherosclerosis in ApoE*3-Leiden transgenic mice
article 2003    
Author: Delsing, D.J.M. · Jukema, J.W. · Wiel, M.A. van de · Emeis, J.J. · Laarse, A. van der · Havekes, L.M. · Princen, H.M.G.
Keywords: Biology · Biomedical Research · Atherosclerosis · Calcification · Calcium antagonists · Inflammation · Statins · Amlodipine · Atorvastatin · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Very low density lipoprotein cholesterol · Animal model · Animal tissue · Aorta root · Cholesterol blood level · Cholesterol diet · Controlled study · Drug effect · Inflammation · Mouse · Nonhuman · Amlodipine · Animals · Aorta, Thoracic · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Blood Pressure · Calcium Channel Blockers · Cholesterol · Cholesterol, Dietary · Drug Therapy, Combination · Female · Heptanoic Acids · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Mice · Mice, Transgenic · Pyrroles
[Abstract]

8 Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus.
article 2003    
Author: Ree, M.A. van de · Maat, M.P. de · Kluft, C. · Meinders, A.E. · Princen, H.M. · Huisman, M.V.
Keywords: Atorvastatin · Blood clotting factor 8a · Hemostatic agent · Heptanoic acid derivative · Biosynthesis · Blood · Cardiovascular disease · Clinical trial · Controlled clinical trial · Controlled study · Dose response · Double blind procedure · Non insulin dependent diabetes mellitus · Pathology · Randomized controlled trial · Time · Aged · Cardiovascular Diseases · Diabetes Mellitus, Type 2 · Dose-Response Relationship, Drug · Double-Blind Method · Factor VIIIa · Female · Fibrinogen · Hemostatics · Heptanoic Acids · Humans · Hyperlipidemias · Male · Middle Aged · Placebos · Pyrroles · Risk Factors · Time Factors · Tissue Plasminogen Activator · von Willebrand Factor
[Abstract]

9 Cholesteryl ester transfer protein inhibition: Effect on reverse cholesterol transport?
article 2006    
Author: Rensen, P.C.N. · Havekes, L.M.
Keywords: Biology · Biomedical Research · 2 methylpropanethioic acid s [2 [1 (2 ethylbutyl)cyclohexylcarboxamido]phenyl] ester · Atorvastatin · Cholesterol ester transfer protein inhibitor · Fibric acid derivative · High density lipoprotein cholesterol · Hydroxymethylglutaryl coenzyme A reductase inhibitor · Nicotinic acid · Torcetrapib · Atherosclerosis · Cholesterol transport · Clinical trial · Drug efficacy · Drug mechanism · Dyslipidemia · Editorial · Ischemic heart disease · Nonhuman · Plasma clearance · Protein expression · Reverse cholesterol transport · Animals · Biological Transport · Cardiovascular Diseases · Carrier Proteins · Cholesterol Ester Transfer Proteins · Cholesterol Esters · Cholesterol, HDL · Glycoproteins · Humans · Lipid Metabolism · Lipoproteins, HDL · Rabbits · Risk Factors
[Abstract]

10 Osteoarthritis development is induced by increased dietary cholesterol and can be inhibited by atorvastatin in APOE*3Leiden.CETP mice, a translational model for atherosclerosis
article 2014    
Author: Gierman, L.M. · Kühnast, S. · Koudijs, A. · Pieterman, E.J. · Kloppenburg, M. · Osch, G.J.V.M. van · Stojanovic-Susulic, V. · Huizinga, T.W.J. · Princen, H.M.G. · Zuurmond. A.M.
Keywords: Biology · Alanine aminotransferase · Apolipoprotein E · Atorvastatin · Cholesterol ester transfer protein · Endothelial leukocyte adhesion molecule 1 · Etimibe · Monocyte chemotactic protein 1 · Serum amyloid A · Very low density lipoprotein · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Cholesterol blood level · Cholesterol intake · Controlled study · Female · Knee osteoarthritis · Mouse · Nonhuman · Priority journal · Transgenic mouse · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

11 Systems biology, connectivity and the future of medicine
article 2005    
Author: Greef, J. van der
Keywords: Biology · Analytical research · Disease progression · Disease system fingerprints · Diseases · Drug perturbations · Drugs · Medicine · Patient treatment · Reversed-pharmacology · Systems biology · Systems pathology · Systems pharmacology · Systems-based combinatorial-therapies approach · Biology · Diseases · Drug therapy · Pathology · Pharmacokinetics · Disease system fingerprints · Pharmacology · Systems biology · Drug products · amlodipine plus atorvastatin · berberine · biological marker · fluticasone propionate plus salmeterol · ginseng extract · glibenclamide plus metformin · article · asthma · bioinformatics · biostatistics · cardiovascular disease · clinical protocol · disease course · drug design · drug industry · drug research · human · hypercholesterolemia · in vivo study · medicine · metabolic syndrome X · methodology · molecular biology · non insulin dependent diabetes mellitus · nonhuman · quality control · quality of life · Cell Physiology · Drug Design · Models, Biological · Pharmaceutical Preparations · Pharmacology · Pharmacology, Clinical · Systems Biology · Panax ginseng
[Abstract]

12 Atorvastatin accelerates clearance of lipoprotein remnants generated by activated brown fat to further reduce hypercholesterolemia and atherosclerosis
article 2017    
Author: Hoeke, G. · Wang, Y. · Dam, A.D. van · Mol, M. · Gart, E. · Klop, H.G. · Berg, S.M. van den · Pieterman, E.H. · Princen, H.M.G. · Groen, A.K. · Rensen, P.C.N. · Berbée, J.F.P. · Boon, M.R.
Keywords: Biology · Atherosclerosis · Brown adipose tissue · Hypercholesterolemia · Cholesterol metabolism · Lipid and lipoprotein metabolism · 5 [2 [[2 (3 chlorophenyl) 2 hydroxyethyl]amino]propyl] 1,3 benzodioxole 2,2 dicarboxylic acid · Atorvastatin · Cholesterol · Fatty acid · High density lipoprotein cholesterol · Lipoprotein · Proprotein convertase 9 · Triacylglycerol · Animal experiment · Animal model · Animal tissue · Atherosclerosis · Brown adipose tissue · Cholesterol blood level · Controlled study · Drug effect · Drug potentiation · Energy expenditure · Female · Gene expression · Hypercholesterolemia · Lipid composition · Lipid liver level · Lipid metabolism · Lipid oxidation · Lipid transport · Lipoprotein metabolism · Mouse · Nonhuman · Triacylglycerol blood level · Western diet · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · EELS - Earth, Environmental and Life Sciences
[Abstract]

13 Effect of garlic powder on C-reactive protein and plasma lipids in overweight and smoking subjects
article 2006    
Author: Doorn, M.B.A. van · Espirito Santo, S.M. · Meijer, P. · Kamerling, I.M. · Schoemaker, R.C. · Dirsch, V. · Vollmar, A. · Haffner, T. · Gebhardt, R. · Cohen, A.F. · Princen, H.M. · Burggraaf, J.
Keywords: Biomedical Research · CRP · Endothelial function · atorvastatin · biological marker · C reactive protein · garlic extract · low density lipoprotein cholesterol · placebo · printanor · triacylglycerol · tumor necrosis factor alpha · abdominal discomfort · cardiovascular disease · cardiovascular risk · cell function · cholesterol blood level · clinical trial · controlled clinical trial · controlled study · double blind procedure · drug effect · inflammation · lipid blood level · lipid metabolism · major clinical study · obesity · patient compliance · protein blood level · randomized controlled trial · side effect · smoking · triacylglycerol blood level · unspecified side effect · Adult · Aged · Analysis of Variance · Anticholesteremic Agents · Biological Markers · C-Reactive Protein · Cholesterol · Cholesterol, HDL · Cholesterol, LDL · Double-Blind Method · Endothelium · Female · Garlic · Heptanoic Acids · Humans · Lipids · Male · Middle Aged · Overweight · Plant Extracts · Powders · Pyrroles · Smoking · Triglycerides · Allium sativum
[Abstract]

14 Atorvastatin increases HDL cholesterol by reducing CETP expression in cholesterol-fed APOE*3-Leiden.CETP mice
article 2008    
Author: Haan, W. de · Hoogt, C.C. van der · Westerterp, M. · Hoekstra, M. · Dallinga-Thie, G.M. · Princen, H.M.G. · Romijn, J.A. · Jukema, J.W. · Havekes, L.M. · Rensen, P.C.N.
Keywords: Health · CETP · High-density lipoprotein · HMGCoA reductase · Statin · Transgenic mice · ABC transporter A1 · apolipoprotein A1 · apolipoprotein E3 · atorvastatin · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · messenger RNA · phospholipid transfer protein · scavenger receptor BI · very low density lipoprotein · very low density lipoprotein cholesterol · animal experiment · animal model · article · cholesterol blood level · cholesterol diet · controlled study · drug effect · gene expression · hypercholesterolemia · lipoprotein blood level · lipoprotein metabolism · male · mouse · nonhuman · priority journal · protein expression · transgenic mouse · Animals · Apolipoprotein E3 · Cholesterol Ester Transfer Proteins · Cholesterol, Dietary · Cholesterol, HDL · Cholesterol, VLDL · Dose-Response Relationship, Drug · Female · Gene Expression · Heptanoic Acids · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypercholesterolemia · Liver · Male · Mice · Mice, Inbred C57BL · Mice, Transgenic · Pyrroles · RNA, Messenger
[Abstract]

15 Mouse models for atherosclerosis and pharmaceutical modifiers
article 2007    
Author: Zadelaar, A.S.M. · Kleemann, R. · Verschuren, L. · Vries-van der Weij, J. de · Hoorn, J. van der · Princen, H.M. · Kooistra, T.
Keywords: Biology · Biomedical Research · ACE inhibitors · AT1 receptor antagonists · Atherosclerosis · LXR · Mouse models · Pharmaceutical drugs · PPAR · Statins · atorvastatin · avasimibe · candesartan · captopril · cholesterol acyltransferase inhibitor · dipeptidyl carboxypeptidase inhibitor · hydralazine · hydroxymethylglutaryl coenzyme A reductase inhibitor · irbesartan · losartan · ly 465608 · n (2,2,2 trifluoroethyl) n [4 [2,2,2 trifluoro 1 hydroxy 1 (trifluoromethoxy)ethyl]phenyl]benzenesulfonamide · olmesartan · perindopril · peroxisome proliferator activated receptor alpha agonist · pirinixic acid · pitavastatin · pravastatin · quinapril · ramipril · rosuvastatin · simvastatin · telmisartan · temocapril · unindexed drug · valsartan · zofenopril · antihypertensive agent · antilipemic agent · apolipoprotein E · atherosclerosis · pathophysiology · sensitivity and specificity · Animals · Antihypertensive Agents · Antilipemic Agents · Apolipoproteins E · Atherosclerosis · Disease Models, Animal · Dose-Response Relationship, Drug · Drug Administration Schedule · Dyslipidemias · Humans · Hydroxymethylglutaryl-CoA Reductase Inhibitors · Hypertension · Male · Mice · Mice, Knockout · Mice, Transgenic · Sensitivity and Specificity
[Abstract]

16 No effects of atorvastatin (10 mg/d or 80 mg/d) on nitric oxide, prostacyclin, thromboxane and oxidative stress in type 2 diabetes mellitus patients of the DALI study
article 2015    
Author: Tsikas, D. · Pham, V.V. · Suchy, M.T. · Ree, M.A. van de · Huisman, M.V. · Frölich, J.C. · Princen, H.M.G.
Keywords: Biology · 8-iso-Prostaglandin F2α · Carbonic anhydrase · Cardiovascular disease · Diabetes mellitus type 2 · Nitric oxide · Oxidative stress · Prostacyclin · Statins · Thromboxane · 2,3 dinor 6 oxoprostaglandin F1 alpha · 2,3 dinorthromboxane B2 · 8 isoprostaglandin F2 alpha · Atorvastatin · Carbonate dehydratase · Cholesterol · Nitrate · Nitric oxide · Nitrite · Placebo · Prostacyclin · Prostaglandin synthase · Thromboxane · Thromboxane A2 · Adult · Aged · Antioxidant activity · Biosynthesis · Cholesterol metabolism · Controlled study · Dose response · Double blind procedure · Drug effect · Drug treatment failure · Dyslipidemia · Female · Heart protection · Lipid peroxidation · Lipolysis · Major clinical study · Male · Mass fragmentography · Middle aged · Non insulin dependent diabetes mellitus · Oxidative stress · Randomized controlled trial · Tandem mass spectrometry · Treatment duration · Urine level · Biomedical Innovation · Healthy Living · Life · MHR - Metabolic Health Research · ELSS - Earth, Life and Social Sciences
[Abstract]

17 Effect of low dose atorvastatin versus diet-induced cholesterol lowering on atherosclerotic lesion progression and inflammation in apolipoprotein E*3-Leiden transgenic mice
article 2005    
Author: Verschuren, L. · Kleemann, R. · Offerman, E.H. · Szalai, A.J. · Emeis, S.J. · Princen, H.M.G. · Kooistra, T.
Keywords: Biology · Biomedical Research · Growth factors · Lipids · Lipoprotein metabolism · Pathophysiology · C reactive protein · Cholesterol · Gelatinase B · Macrophage migration inhibition factor · Plasminogen activator inhibitor 1 · Vascular cell adhesion molecule 1 · Animal cell · Animal experiment · animal model · Antiinflammatory activity · Aorta arch · Cholesterol blood level · Cholesterol diet · Controlled study · Dietary intake · Disease activity · Disease course · Disease severity · Inflammation · Lipoprotein metabolism · Low drug dose · Macrophage · Monocyte · Mouse · Nonhuman · Pathophysiology · Protein expression · Smooth muscle fiber · Transgenic mouse · Treatment outcome · Amyloid A protein · Apolipoprotein E3 · Atorvastatin · Animals · Anticholesteremic Agents · Aorta · Apolipoprotein E3 · Apolipoproteins E · Arteriosclerosis · Biological Markers · C-Reactive Protein · Cholesterol · Diet · Diet, Atherogenic · Drug Administration Schedule · Female · Heptanoic Acids · Inflammation · Male · Mice · Mice, Transgenic · Pyrroles · Serum Amyloid A Protein
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date