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1 Effect of butylated hydroxytoluene, curcumin, propyl gallate and thiabendazole on cytochrome P450 forms in cultured human hepatocytes
article 2008    
Author: Price, R.J. · Scott, M.P. · Giddings, A.M. · Walters, D.G. · Stierum, R.H. · Meredith, C. · Lake, B.G.
Keywords: Biology · Physiological Sciences · Butylated hydroxytoluene · Curcumin · CYP induction · Cytochrome P450 (CYP) · Human hepatocytes · Propyl gallate · Thiabendazole · butylcresol · curcumin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2B6 · cytochrome P450 3A4 · ethoxyresorufin deethylase · gallic acid propyl ester · messenger RNA · tiabendazole · adult · aged · article · controlled study · enzyme activity · human · human cell · liver cell · male · Aged · Anthelmintics · Antioxidants · Butylated Hydroxytoluene · Cells, Cultured · Curcumin · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP1A2 · Cytochrome P-450 CYP3A · Cytochrome P-450 Enzyme System · Hepatocytes · Humans · Male · Middle Aged · Propyl Gallate · RNA, Messenger · Steroid Hydroxylases · Thiabendazole
[Abstract]

2 Differential maintenance of cytochrome P450 enzymes in cultured precision-cut human liver slices
article 2000    
Author: Renwick, A.B. · Watts, P.S. · Edwards, R.J. · Barton, P.T. · Guyonnet, I. · Price, R.J. · Tredger, J.M. · Pelkonen, O. · Boobis, A.R. · Lake, B.G.
Keywords: Nutrition · Apoprotein · Cytochrome P450 · Cytochrome p450 2a6 · Cytochrome P450 2B6 · Cytochrome P450 2C19 · Cytochrome p450 2c8 · Cytochrome P450 2C9 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Debrisoquine 4 hydroxylase · Dimethylnitrosamine demethylase · Ethoxyresorufin · O Deethylase · Peptide antibody · Phenacetin o deethylase · Tolbutamide methylhydroxylase · Unclassified drug · Enzyme activity · Enzyme metabolism · Human tissue · Liver cell culture · Liver slice · Protein stability · School child · Xenobiotic metabolism · Adolescent · Adult · Aged · Child · Child, Preschool · Culture Media · Culture Techniques · Cytochrome P-450 Enzyme System · Enzyme Stability · Female · Humans · Immunoblotting · Isoenzymes · Liver · Male · Microsomes, Liver · Middle Aged
[Abstract]

3 Cytochrome P450 enzyme systems in fungi
article 1998    
Author: Brink, H.M. van den · Gorcom, R.F.M. van · Hondel, C.A.M.J.J. van den · Punt, P.J.
Keywords: Nutrition · Bioconversion · Biotransformation · CPR · CYP · Cytochrome P450 · Index descriptors · Cytochrome p450 · Biotransformation · Fungal genetics · Fungus · Molecular genetics · Nonhuman · Priority journal · Review · Saccharomyces cerevisiae · Cytochrome P-450 Enzyme System · Fungi · Genes, Plant · Multigene Family · Saccharomyces cerevisiae
[Abstract]

4 Human cytochrome P450 enzyme specificity for bioactivation of safrole to the proximate carcinogen 1′-hydroxysafrole
article 2004    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Awad, H.M. · Boersma, M.G. · Brand, W. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Physiological Sciences · 1' hydroxysafrole · carcinogen · cytochrome P450 · cytochrome P450 2A6 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · safrole · unclassified drug · animal cell · article · enzyme activation · enzyme specificity · human · insect cell · microsome · nonhuman · reaction analysis · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Humans · Microsomes, Liver · Risk Assessment · Safrole · Statistics, Nonparametric · Substrate Specificity · Animalia · Insecta
[Abstract]

5 Human cytochrome P450 enzyme specificity for the bioactivation of estragole and related alkenylbenzenes
article 2007    
Author: Jeurissen, S.M.F. · Punt, A. · Boersma, M.G. · Bogaards, J.J.P. · Fiamegos, Y.C. · Schilter, B. · Bladeren, P.J. van · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxyestragole · alkenylbenzene derivative · alpha naphthoflavone · benzene derivative · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2D6 · cytochrome P450 2E1 · estragole · methyleugenol · safrole · article · enzyme specificity · human · human cell · hydroxylation · liver microsome · phenotype · protein expression · Anisoles · Biotransformation · Chromatography, High Pressure Liquid · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Hydroxylation · Microsomes, Liver · Safrole · Substrate Specificity
[Abstract]

6 Human cytochrome P450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1′-hydroxymethyleugenol
article 2006    
Author: Jeurissen, S.M.F. · Bogaards, J.J.P. · Boersma, M.G. · Horst, J.P.F. ter · Awad, H.M. · Fiamegos, Y.C. · Beek, T.A. van · Alink, G.M. · Sudhölter, E.J.R. · Cnubben, N.H.P. · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · 1' hydroxymethyleugenol · barbituric acid derivative · carcinogen · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · methyleugenol · unclassified drug · article · carcinogenicity · concentration (parameters) · enzyme activation · enzyme kinetics · enzyme specificity · enzyme substrate · human · hydroxylation · incubation time · insect cell · lifestyle · liver microsome · nonhuman · sensitivity analysis · smoking · Aryl Hydrocarbon Hydroxylases · Benzoflavones · Biotransformation · Carcinogens · Cell Line · Cytochrome P-450 CYP1A2 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Eugenol · Flavoring Agents · Humans · Kinetics · Microsomes, Liver · Mixed Function Oxygenases · Recombinant Proteins · Risk Assessment · Sulfaphenazole · Insecta
[Abstract]

7 Characterization of human cytochrome P450s involved in the bioactivation of tri-Ortho-Cresyl phosphate (ToCP)
article 2015    
Author: Reinen, J. · Nematollahi, L. · Fidder, A. · Vermeulen, N.P.E. · Noort, D. · Commandeur, J.N.M.
Keywords: Toxicology · Cytochrome P450 1A2 · Cytochrome P450 2C18 · Cytochrome P450 2D6 · Cytochrome P450 3A4 · Cytochrome P450 3A5 · Organophosphorus compound · Unclassified drug · Animal cell · Biotransformation · Cholinesterase inhibition · Controlled study · Enzyme inactivation · Humans · human cell · Hydrolysis · IC50 · In vitro study · Liver microsome · Liver microsome metabolism · Neurotoxicity · Nonhuman · Rats · Acetylcholinesterase, 9000-81-1 · Cholinesterase, 9001-08-5 · cytochrome P450, 9035-51-2 · Cytochrome P450 3A4, 329736-03-0 · Cytochrome P450 3A5, 336874-97-6 · Tri ortho cresyl phosphate, 78-30-8 · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

8 The biotransformation of isoprene and the two isoprene monoepoxides by human cytochrome P450 enzymes, compared to mouse and rat liver microsomes
article 1996    
Author: Bogaards, J.J.P. · Venekamp, J.C. · Bladeren, P.J. van
Keywords: Cytochrome P-450 · Isoprene · Metabolism · cyclohexane oxide · cytochrome p450 · cytochrome p450 isoenzyme · epoxide hydrolase · isoprene · animal experiment · article · controlled study · enzyme activity · enzyme specificity · epoxidation · human · human tissue · liver microsome metabolism · mouse · nonhuman · rat · species difference · xenobiotic metabolism · Animals · Biotransformation · Butadienes · Cyclohexanes · Cyclohexenes · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Enzyme Inhibitors · Epoxide Hydrolases · Epoxy Compounds · Hemiterpenes · Humans · Hydrolysis · Mice · Microsomes, Liver · Oxidation-Reduction · Pentanes · Rats · Rats, Wistar · Species Specificity
[Abstract]

9 Effect of thiabendazole on some rat hepatic xenobiotic metabolising enzymes
article 2004    
Author: Price, R.J. · Scott, M.P. · Walters, D.G. · Stierum, R.H. · Groten, J.P. · Meredith, C. · Lake, B.G.
Keywords: Nutrition · Physiological Sciences · 1-chloro-2,4-dinitrobenzene · BHT · Butylated hydroxytoluene · CDNB · CH · Cumene hydroperoxide · CYP · Cytochrome P450 · DCNB · Enzyme induction · GSH S-transferase · Rat liver · Thiabendazole · Xenobiotic metabolism · apoprotein · butylcresol · cytochrome P450 1A · cytochrome P450 1A1 · cytochrome P450 1A2 · cytochrome P450 2B · cytochrome P450 2B1 · cytochrome P450 2B2 · glutathione transferase · messenger RNA · tiabendazole · animal cell · animal experiment · article · controlled study · dose response · drug megadose · enzyme activation · enzyme activity · enzyme induction · enzyme metabolism · enzyme substrate · liver microsome metabolism · liver mitochondrion · liver weight · male · nonhuman · nucleotide sequence · protein blood level · rat · xenobiotic metabolism · Acyltransferases · Administration, Oral · Animals · Antinematodal Agents · Antioxidants · Butylated Hydroxytoluene · Cytochrome P-450 Enzyme System · Dose-Response Relationship, Drug · Glutathione Transferase · Liver · Male · Rats · Rats, Sprague-Dawley · RNA, Messenger · Thiabendazole
[Abstract]

10 Rapid metabolism of retinoic acid by cultured human vascular endothelial cells as compared to the human hepatoma cell line HepG2
article 1996    
Author: Lansink, M. · Blaner, W.S. · Kooistra, T.
Keywords: Biology · cytochrome p450 · retinoic acid · conference paper · hepatoma cell · human · human cell · metabolic rate · vascular endothelium · vitamin metabolism
[Abstract]

11 Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450
article 1998    
Author: Bessems, J.G.M. · Groot, M.J. de · Baede, E.J. · Koppele, J.M. te · Vermeulen, N.P.E.
Keywords: Nutrition · Analgesic agent · Cytochrome p450 · Horseradish peroxidase · Hydrogen peroxide · Paracetamol · Reduced nicotinamide adenine dinucleotide phosphate · Analgesia · Animal experiment · Animal tissue · Biotransformation · Catalysis · Drug metabolism · Electron spin resonance · Enzyme activity · Liver microsome · Male · Nonhuman · Oxidation · Rat · Acetaminophen · Animals · Cytochrome P-450 CYP1A1 · Cytochrome P-450 CYP2B1 · Cytochrome P-450 CYP2E1 · Cytochrome P-450 Enzyme System · Electron Spin Resonance Spectroscopy · Free Radicals · Horseradish Peroxidase · Hydrogen · Male · Microsomes, Liver · NADP · Oxidation-Reduction · Rats · Rats, Wistar · Thermodynamics · Animalia · Armoracia rusticana · Rickettsia sp. PAR
[Abstract]

12 The novel antifungal agent PLD-118 is neither metabolized by liver microsomes nor inhibits cytochrome P450 in vitro
article 2005    
Author: Parnham, M.J. · Bogaards, J.J.P. · Schrander, F. · Schut, M.W. · Orešković, K. · Mildner, B.
Keywords: Health Pharmacology · Physiological Sciences · Cytochrome P450 · Metabolism · PLD-118 · 2 amino 4 methylenecyclopentanecarboxylic acid · alpha naphthoflavone · amino acid · antifungal agent · bufuralol · chlorzoxazone · coumarin · cytochrome P450 · cytochrome P450 1A2 · cytochrome P450 2A6 · cytochrome P450 2B6 · cytochrome P450 2C19 · cytochrome P450 2C9 · cytochrome P450 2D6 · cytochrome P450 2E1 · cytochrome P450 3A · diclofenac · diethyldithiocarbamic acid · ethoxyresorufin · ketoconazole · mephenytoin · monoclonal antibody · monoclonal antibody 2B6 · quinidine · reduced nicotinamide adenine dinucleotide phosphate · resorufin · sulfaphenazole · testosterone · umbelliferone · unclassified drug · unindexed drug · analytic method · animal tissue · article · candidiasis · concentration response · controlled study · derivatization · dog · drug structure · enzyme assay · enzyme inhibition · enzyme stability · enzyme substrate · fluorescence analysis · high performance liquid chromatography · human · human tissue · in vitro study · liver homogenate · liver microsome metabolism · nonhuman · rat · structure analysis · Administration, Oral · Animals · Antifungal Agents · Chemistry, Pharmaceutical · Cycloleucine · Cytochrome P-450 Enzyme System · Dogs · Drug Evaluation, Preclinical · Humans · Microsomes, Liver · Rats · Ribosomal Proteins
[Abstract]

13 Xanthobacter sp. C20 contains a novel bioconversion pathway for limonene
article 2000    
Author: Werf, M.J. van der · Keijzer, P.M. · Schaft, P.H. van der
Keywords: Biology · Cytochrome P-450 · Limonene-8,9-epoxide · Oxidation · Stereospecificity · Terpene bioconversion · Bacteria · Biopolymers · Carbon · Cell culture · Enzyme inhibition · Reaction kinetics · Cyclohexane · Cytochrome · Limonene · Bioconversion · cytochrome P450 · limonene · limonene 8,9 epoxide · terpene · unclassified drug · article · bacterium identification · bacterium isolation · biotransformation · enantiomer · nonhuman · nuclear magnetic resonance spectroscopy · priority journal · reaction analysis · river · sediment · stereoisomerism · Xanthobacter · Cyclohexanes · Cyclohexenes · Cytochrome P-450 Enzyme System · Food Microbiology · Ginger · Industrial Microbiology · Menthol · Monoterpenes · Oxidation-Reduction · Plants, Medicinal · Stereoisomerism · Terpenes · Xanthobacter · Xanthobacter sp.
[PDF] [Abstract]

14 Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling
article 2000    
Author: Bogaards, J.J.P. · Hissink, E.M. · Briggs, M. · Weaver, R. · Jochemsen, R. · Jackson, P. · Bertrand, M. · Bladeren, P. van
Keywords: Nutrition · Cytochrome P450 · Interindividual variation · Metabolism · Physiologically based pharmacokinetic modeling · Agomelatine · Bufuralol · Chlorzoxazone · Coumarin · Cytochrome P450 · Diclofenac · Ethoxyresorufin · Mephenytoin · Testosterone · Clinical trial · Controlled clinical trial · Controlled study · Drug blood level · Enzyme kinetics · Food drug interaction · Genetic polymorphism · Human · Human cell · Human experiment · Human tissue · Liver microsome · Male · Model · Normal human · Phase 1 clinical trial · Phenotype · Priority journal · Acetamides · Cell Line · Cytochrome P-450 Enzyme System · Humans · Hypnotics and Sedatives · Isoenzymes · Kinetics · Microsomes, Liver · Models, Biological · Pharmaceutical Preparations · Pharmacokinetics · Recombinant Proteins · Transfection
[Abstract]

15 Increased resistance to 14α-demethylase inhibitors (DMIs) in Aspergillus niger by coexpression of the Penicillium italicum eburicol 14α-demethylase (cyp51) and the A. Niger cytochrome P450 reductase (cprA) genes
article 1996    
Author: Brink, H.J.M. van den · Nistelrooy, H.J.G.M. van · Waard, M.A. de · Hondel, C.A.M.J.J. van den · Gorcom, R.F.M. van
Keywords: Biology · Ergosterol · NADPH cytochrome P450 reductase · Sterol 14α-demethylation inhibitors · Drug products · Fungicides · Genes · Demethylase inhibitors (DMI) · Gene encoding · Genetic engineering · Cytochrome p450 reductase · Reduced nicotinamide adenine dinucleotide phosphate ferrihemoprotein reductase · Enzyme synthesis · Fungal genetics · Nonhuman · Penicillium · Priority journal · Aspergillus niger · Cytochrome P-450 Enzyme System · Drug Resistance, Microbial · Enzyme Inhibitors · Gene Expression Regulation, Fungal · NADH, NADPH Oxidoreductases · NADPH-Ferrihemoprotein Reductase · Oxidoreductases · Penicillium · Recombinant Proteins · Transformation, Genetic · Aspergillus niger · Fungi · Penicillium · Penicillium italicum
[Abstract]

16 Isolation and molecular characterisation of the gene encoding eburicol 14α-demethylase (CYP51) from Penicillium italicum
article 1996    
Author: Nistelrooy, J.G.M. van · Brink, J.M. van den · Kan, J.A.L. van · Gorcom, R.F.M. van · Waard, M.A. de
Keywords: Biology · 14α-demethylase · Cytochrome P450 · Fungicides · Penicillium italicum · Sterol biosynthesis inhibitors · Cytochrome p450 isoenzyme · Enilconazole · Etaconazole · Fenarimol · Fungicide · Unclassified drug · Article · Controlled study · Gene isolation · Genetic analysis · Molecular cloning · Molecular genetics · Nonhuman · Penicillium · Priority journal · Sterol synthesis · Yeast · Amino Acid Sequence · Base Sequence · Blotting, Northern · Cloning, Molecular · Cytochrome P-450 Enzyme System · DNA Primers · Fungal Proteins · Fungicides, Industrial · Genes, Fungal · Lanosterol · Molecular Sequence Data · Oxidoreductases · Penicillium · Pyrimidines · Restriction Mapping · Sequence Analysis, DNA · Sequence Homology, Amino Acid
[Abstract]

17 Human cytochrome P450 enzyme selectivities in the oxidation of chlorinated benzenes
article 1995    
Author: Bogaards, J.J.P. · Ommen, B. van · Wolf, C.R. · Bladeren, P.J. van
Keywords: Toxicology · Cell Line · Chlorobenzenes · Chlorzoxazone · Chromatography, Gas · Cytochrome P-450 Enzyme System · Ethanolamines · Human · Oxazines · Oxidation-Reduction · Substrate Specificity · Testosterone · Transfection
[Abstract]

18 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

19 Effect of fumonisin B1 on rat hepatic P450 system
article 2000    
Author: Spotti, M. · Maas, R.F.M. · Nijs, C.M. de · Fink-Gremmels, J.
Keywords: Nutrition · Cytochrome P450 · Fumonisin B1 · Liver · Rat · Cytochrome P450 3A · Dimethylnitrosamine demethylase · Fumonisin B1 · Isoenzyme · Pentoxyresorufin dealkylase · Phenacetin o deethylase · Protein kinase · Sphingolipid · Animal model · Body weight · Controlled study · Enzyme activity · Growth retardation · Male · Metabolism · Nonhuman · Oral drug administration · Priority journal · Rat
[Abstract]

20 Characterization of cytochrome P450 isoenzymes in primary cultures of pig hepatocytes
article 1998    
Author: Monshouwer, M. · Klooster, G.A.E. van 't · Nijmeijer, S.M. · Witkamp, R.F. · Miert, A.S.J.P.A.M. van
Keywords: Nutrition · Cytochrome P450 · Hepatocytes · Induction · Pig · Apoprotein · Beta naphthoflavone · Complementary DNA · Cytochrome p450 isoenzyme · Dexamethasone · Ethoxyresorufin deethylase · Ethylmorphine n demethylase · Messenger RNA · Oxygenase · Phenobarbital · Rifampicin · Animal cell · Controlled study · Enzyme activity · Enzyme analysis · Enzyme induction · Liver cell culture · Nonhuman · RNA analysis · RNA hybridization · Swine · Xenobiotic metabolism
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 20 of 63 found. Next | Sort by date