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Showing 1 to 17 of 17 found. | Sort by date

1 Elimination kinetics and molecular reaction mechanisms of cyclosarin (GF) by an oxime substituted β-cyclodextrin derivative in vitro
article 2015    
Author: Kranawetvogl, A. · Müller, S. · Kubik, S. · Spruit, W.E.T. · Thiermann, H. · Worek, F. · Noort, D. · Reiter, G.
Keywords: Chemistry · Covalent conjugate · Detoxification · Organophosphorus compound · Supramolecular scavenger · β-cyclodextrin · Observation, Weapon & Protection Systems · CBRN - CBRN Protection · TS - Technical Sciences
[Abstract]

2 A glutathione S-transferase with activity towards cis-1,2- dichloroepoxyethane is involved in isoprene utilization by Rhodococcus sp. strain AD45
article 1998    
Author: Hylckama Vlieg, J.E.T. van · Kingma, J. · Wijngaard, A.J. van den · Janssen, D.B.
Keywords: Nutrition · 1,2 dichloroepoxyethane · Ethylene · Glutathione transferase · Industrial chemical · Isoprene · Unclassified drug · Biodegradation · Dechlorination · Detoxification · Enzyme activity · Enzyme isolation · Kinetics · Nonhuman · Biodegradation, Environmental · Butadienes · Epoxy Compounds · Glutathione Transferase · Hemiterpenes · Oxidation-Reduction · Pentanes · Rhodococcus · Negibacteria · Rhodococcus sp.
[PDF] [Abstract]

3 A physiologically based biokinetic (PBBK) model for estragole bioactivation and detoxification in rat
article 2008    
Author: Punt, A. · Freidig, A.P. · Delatour, T. · Scholz, G. · Boersma, M.G. · Schilter, B. · Bladeren, P.J. van · Rietjens, I.M.C.M.
Keywords: Biology · Biomedical Research · Bioactivation · Detoxification · Estragole · In vitro · PBPK · Rat · 1' hydroxyestragole glucuronide · 1' sulfooxyestragole · Benzene derivative · Chavicol · Estragole · Glucuronide · Phenol derivative · Unclassified drug · Animal tissue · Arterial blood · Body fat · Controlled study · Detoxification · In vitro study · Kinetics · Liver · Nonhuman · Partition coefficient · Rat · Tissue perfusion · Venous blood · Allyl Compounds · Animals · Anisoles · Carcinogens · Dose-Response Relationship, Drug · Female · Glucuronides · Kidney · Lung · Male · Metabolic Detoxication, Drug · Models, Biological · Phenols · Rats · Rats, Sprague-Dawley · Rats, Wistar · Sulfones · Tissue Distribution · Rattus · Food and Nutrition · Healthy Living
[Abstract]

4 Evaluation of the intestinal absorption of deoxynivalenol and nivalenol by an in vitro gastrointestinal model, and the binding efficacy of activated carbon and other adsorbent materials
article 2004    
Author: Avantaggiato, G. · Havenaar, R. · Visconti, A.
Keywords: Biology Health · Physiological Sciences · Activated carbon · Deoxynivalenol · DON · Gas chromatography · Gastrointestinal · GC · GI · High performance liquid chromatography · HPLC · Mycotoxin detoxification · NIV · Nivalenol · TIM · Gastrointestinal model · ZEA · Zearalenone · activated carbon · adsorbent · mycotoxin · nivalenol · trichothecene derivative · vomitoxin · zearalenone · animal experiment · animal tissue · article · binding affinity · calculation · commercial phenomena · controlled study · detoxification · dynamics · evaluation · food contamination · Fusarium · gastrointestinal tract · in vitro study · intestine absorption · isotherm · jejunum · model · nonhuman · pH · screening · simulation · small intestine absorption · swine · wheat · Adsorption · Animals · Charcoal · Food Contamination · Hydrogen-Ion Concentration · Intestinal Absorption · Intestine, Small · Models, Biological · Swine · Trichothecenes · Fusarium · Triticum aestivum
[Abstract]

5 Assessment of the multi-mycotoxin-binding efficacy of a carbon/aluminosilicate-based product in an in vitro gastrointestinal model
article 2007    
Author: Avantaggiato, G. · Havenaar, R. · Visconti, A.
Keywords: Biology · Biomedical Research · Aflatoxins · Fumonisins, deoxynivalenol · Mycotoxin binders · Mycotoxin detoxification · Mycotoxins · Ochratoxins · Zearalenone · Aluminosilicic acid · Aluminum silicate · Carbon · Adsorption · Animal food · Binding site · Biological model · Metabolism · PH · Physiology · Stomach emptying · Adsorption · Aluminum Silicates · Animal Feed · Animals · Binding Sites · Carbon · Gastric Emptying · Gastrointestinal Tract · Gastrointestinal Transit · Hydrogen-Ion Concentration · Models, Biological · Swine · Animalia · Sus
[Abstract]

6 Identification and characterization of the furfural and 5-(hydroxymethyl)furfural degradation pathways of Cupriavidus basilensis HMF14
article 2010    
Author: Koopman, F. · Wierckx, N. · Winde, J.H.de · Ruijssenaars, H.J.
Keywords: Biology · Degradation · Hydolysate · Hydroxymethyl furfural · Inhibitors · Lignocellulosic · 5 (hydroxymethyl)furfural · aldehyde derivative · furan derivative · furfural · lignocellulose · protein hydrolysate · unclassified drug · article · bacterial gene · bacterial strain · bacterium identification · carbon source · catabolism · controlled study · Cupriavidus · Cupriavidus basilensis · detoxification · gene sequence · microbial degradation · nonhuman · nucleotide sequence · priority journal · Pseudomonas putida · Cupriavidus · DNA Transposable Elements · Furaldehyde · Genes, Bacterial · Metabolic Networks and Pathways · Mutagenesis · Oxidoreductases · Phenotype · Pseudomonas putida
[Abstract]

7 Glutathione conjugation of the cytostatic drug ifosfamide and the role of human glutathione S-transferases
article 1995    
Author: Dirven, H.A.A.M. · Megens, L. · Oudshoorn, M.J. · Dingemanse, M.A. · Ommen, B. van · Bladeren, P.J. van
Keywords: Nutrition · Glutathione · Glutathione transferase · Ifosfamide · Cancer chemotherapy · Drug conjugation · Drug detoxification · Drug resistance · Enzyme activity · Human · Human tissue · Leukemia · Lymphoma · Solid tumor · Antineoplastic Agents, Alkylating · Biotransformation · Chromatography, High Pressure Liquid · Drug Resistance, Neoplasm · Glutathione · Glutathione Transferase · Human · Ifosfamide · Isoenzymes · Magnetic Resonance Spectroscopy · Metabolic Detoxication, Drug · Spectrometry, Mass, Fast Atom Bombardment · Support, Non-U.S. Gov't
[Abstract]

8 Glutathione conjugation as a bioactivation reaction
article 2000    
Author: Bladeren, P.J. van
Keywords: Nutrition · Bioactivation · Glutathione conjugates · Glutathione S-transferases · Cysteine · Glutathione · Glutathione transferase · Lyase · Catalysis · Chemical binding · Chemical reaction · Chromosomal localization · Conjugation · Covalent bond · Detoxification · Enzyme activation · Enzyme activity · Enzyme induction · Enzyme inhibition · Enzyme mechanism · Gene location · Genetic polymorphism · Human · Nonhuman · Protein expression · Reaction analysis · Reduction · Animals · Biotransformation · Carbon-Sulfur Lyases · Enzyme Induction · Glutathione · Glutathione Transferase · Humans · Metabolic Detoxication, Drug · Oxidation-Reduction · Xenobiotics
[Abstract]

9 The role of biotransformation in dietary (anti)carcinogenesis
article 1999    
Author: Iersel, M.L.P.S. van · Verhagen, H. · Bladeren, P.J. van
Keywords: Nutrition · (Anti)carcinogenic · Biotransformation · Dietary compound · Modulation · Cytochrome p450 · Glutathione transferase · Biotransformation · Cancer risk · Carcinogenesis · Drug detoxification · Enzyme activity · Genetic polymorphism · Human · Nutrition · Priority journal · Review · Biotransformation · Carcinogens · Cytochrome P-450 Enzyme System · Diet · Gene Expression Regulation, Neoplastic · Glutathione Transferase · Humans · Kinetics · Neoplasms · Variation (Genetics) · Xenobiotics
[Abstract]

10 Recombinant Saccharomyces cerevisiae expressing P450 in artificial digestive systems : A model for biodetoxication in the human digestive environment
article 2003    
Author: Blanquet, S. · Meunier, J.P. · Minekus, M. · Marol-Bonnin, S. · Alric, M.
Keywords: Health Nutrition · Physiological Sciences · Digestive system · Disease control · Microbiology · Microorganisms · Biodrugs · Yeast · Cinnamate 4 monooxygenase · Cinnamic acid · cytochrome P450 · Oxygenase · Para coumaric acid · Unclassified drug · Biotechnology · Drug development · Microbiology · Article · Biotransformation · Computer simulation · Detoxification · Digestion · Digestive system · Duodenum · Enzyme activity · Gastrointestinal tract · Ileum · Incubation time · Intestine secretion · Jejunum · Quantitative analysis · Saccharomyces cerevisiae · Small intestine · Stomach secretion · Survival rate · Yeast · Genetic Engineering · Helianthus · Humans · Metabolic Detoxication, Drug · Mixed Function Oxygenases · Models, Biological · Saccharomyces cerevisiae · Trans-Cinnamate 4-Monooxygenase · Saccharomyces cerevisiae
[PDF] [Abstract]

11 Hepatic epoxide concentrations during biotransformation of 1,2- and 1,4- dichlorobenzene: The use of in vitro and in vivo metabolism, kinetics and PB- PK modeling
article 1996    
Author: Hissink, E. · Ommen, B. van · Bogaards, J.J. · Bladeren, P.J. van
Keywords: Toxicology · 1,2 dichlorobenzene · 1,4 dichlorobenzene · alanine aminotransferase · ascorbic acid · cytochrome p450 isoenzyme · epoxide · glutathione · isoniazid · animal cell · animal experiment · animal model · biotransformation · conference paper · controlled study · detoxification · enzyme substrate · liver microsome · liver toxicity · male · mathematical model · nonhuman · priority journal · rat · toxicokinetics · Animals · Biotransformation · Carcinogens · Chlorobenzenes · Cytochrome P-450 Enzyme System · Epoxy Compounds · Humans · Liver · Male · Microsomes, Liver · Models, Biological · Rats · Rats, Wistar

12 Effects of high fat fish oil and high fat corn oil diets on initiation of AOM-induced colonic aberrant crypt foci in male F344 rats
article 2003    
Author: Dommels, Y.E.M. · Heemskerk, S. · Berg, H. van den · Alink, G.M. · Bladeren, P.J. van · Ommen, B. van
Keywords: Nutrition Biology · Physiological Sciences · Aberrant crypt foci · Corn oil · Fish oil · Lipid peroxidation · PGE2 · azoxymethane · corn oil · cytochrome P450 1A1 · cytochrome P450 2B1 · fish oil · liver enzyme · polyunsaturated fatty acid · prostaglandin E2 · animal experiment · animal model · animal tissue · article · ascending colon · blood level · cancer incidence · cancer prevention · colon carcinogenesis · controlled study · detoxification · early cancer · enzyme activity · fat intake · feeding · lipid peroxidation · male · metabolic activation · nonhuman · oxidative stress · rat · reduction · species comparison · Animals · Azoxymethane · Body Weight · Carcinogens · Cecum · Choristoma · Colonic Diseases · Corn Oil · Diet · Dinoprostone · Eating · Epithelial Cells · Feces · Fish Oils · Lipid Peroxidation · Liver · Male · Organ Size · Rats · Rats, Inbred F344 · Zea mays
[Abstract]

13 Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site
article 2003    
Author: Arand, M. · Hallberg, B.M. · Zou, J. · Bergfors, T. · Oesch, F. · Werf, M.J. van der · Bont, J.A.M. de · Jones, T.A. · Mowbray, S.L.
Keywords: Biology · Biotechnology · Crystal structure · Enantioselectivity · Epoxide hydrolase · Mechanism · Monoterpene degradation · bacterial enzyme · limonene 1,2 epoxide hydrolase · selenomethionine · unclassified drug · valpromide · alpha helix · article · beta sheet · catalysis · chemical reaction · crystal structure · detoxification · drug protein binding · enantioselectivity · enzyme active site · enzyme metabolism · enzyme structure · enzyme substrate complex · nonhuman · priority journal · reaction analysis · Rhodococcus erythropolis · site directed mutagenesis · Amino Acid Sequence · Bacterial Proteins · Catalytic Domain · Crystallography, X-Ray · Dimerization · Epoxide Hydrolases · Models, Molecular · Molecular Sequence Data · Mutagenesis, Site-Directed · Protein Subunits · Recombinant Proteins · Rhodococcus · Sequence Homology, Amino Acid · Actinobacteria (class) · Bacteria (microorganisms) · Rhodococcus · Rhodococcus erythropolis · uncultured actinomycete
[Abstract]

14 Disposition of 14C-α-cyclodextrin in germ-free and conventional rats
article 2004    
Author: Ommen, B. van · Bie, A.T.H.J. de · Bär, A.
Keywords: Biology · Physiological Sciences · alpha cyclodextrin · carbon 14 · alpha cyclodextrin derivative · alpha-cyclodextrin · carbon · cyclodextrin · animal experiment · animal tissue · article · blood analysis · carcass · controlled study · dietary fiber · female · fermentation · gastrointestinal tract · germfree animal · high performance liquid chromatography · intestine flora · isotope labeling · kidney tubule excretion · lung alveolus carbon dioxide tension · male · metabolic regulation · nonhuman · priority journal · radioisotope distribution · rat · rat strain · small intestine absorption · species comparison · stomach content · animal · blood · drug detoxification · intravenous drug administration · oral drug administration · tissue distribution · urine · Wistar rat · Mammalia · Microbiota · Rattus norvegicus · Administration, Oral · alpha-Cyclodextrins · Animals · Carbon Radioisotopes · Cyclodextrins · Female · Germ-Free Life · Injections, Intravenous · Male · Metabolic Detoxication, Drug · Rats · Rats, Wistar · Tissue Distribution
[Abstract]

15 The FEMA GRAS assessment of hydroxy- and alkoxy-substituted benzyl derivatives used as flavor ingredients
article 2005    
Author: Adams, T.B. · Cohen, S.M. · Doull, J. · Feron, V.J. · Goodman, J.I. · Marnett, L.J. · Munro, I.C. · Portoghese, P.S. · Smith, R.L. · Waddell, W.J. · Wagner, B.M.
Keywords: Nutrition Toxicology · Toxicology and Applied Pharmacology · Alkoxybenzylderivatives · FEMA GRAS · Flavoring ingredients · Hydroxybenzyl derivatives · 3 ethoxy 4 hydroxybenzaldehyde · acetal · alcohol · aldehyde · anisaldehyde · benzyl derivative · butyl paraben · ester · flavoring agent · methyl 2 methoxybenzoate · piperonal · salicylic acid isopentyl ester · salicylic acid methyl ester · unclassified drug · vanillin · acute toxicity · carcinogenicity · chemical structure · concentration (parameters) · data analysis · detoxification · dog · evaluation · excretion · exposure · feeding · flavor · food analysis · food composition · food intake · food safety · genotoxicity · health care organization · human · hydrolysis · in vitro study · in vivo study · information · metabolism · mutagenesis · nonhuman · rabbit · reproduction · review · risk assessment · science · structure analysis · Alcohols · Animals · Benzyl Compounds · Flavoring Agents · Food Industry · Humans · Toxicity Tests · United States · United States Food and Drug Administration · Animalia
[Abstract]

16 The FEMA GRAS assessment of benzyl derivatives used as flavor ingredients
article 2005    
Author: Adams, T.B. · Cohen, S.M. · Doull, J. · Feron, V.J. · Goodman, J.I. · Marnett, L.J. · Munro, I.C. · Portoghese, P.S. · Smith, R.L. · Waddell, W.J. · Wagner, B.M.
Keywords: Nutrition Toxicology · Toxicology and Applied Pharmacology · Benzyl derivatives · FEMA GRAS · Flavoring ingredients · 2,4 dimethylbenzaldehyde · benzaldehyde · benzaldehyde derivative · benzoic acid · benzoic acid derivative · benzyl acetate · benzyl alcohol derivative · benzyl benzoate · benzyl butyrate · benzyl derivative · ester derivative · flavoring agent · glyceryl tribenzoate · propylene glycol dibenzoate · unclassified drug · absorption · acute toxicity · carcinogenicity · chemical structure · chronic toxicity · concentration (parameters) · data analysis · detoxification · evaluation · excretion · experimental test · exposure · flavor · food analysis · food composition · food intake · food poisoning · food safety · genotoxicity · health care organization · human · hydrolysis · in vitro study · in vivo study · information · metabolism · mortality · mutagenesis · nonhuman · reproduction · review · risk assessment · science · structure analysis · teratology · toxicity · Animals · Benzaldehydes · Benzoic Acid · Benzyl Alcohol · Flavoring Agents · Food Industry · Humans · Toxicity Tests · United States · United States Food and Drug Administration · Animalia
[Abstract]

17 The FEMA GRAS assessment of phenethyl alcohol, aldehyde, acid, and related acetals and esters used as flavor ingredients
article 2005    
Author: Adams, T.B. · Cohen, S.M. · Doull, J. · Feron, V.J. · Goodman, J.I. · Marnett, L.J. · Munro, I.C. · Portoghese, P.S. · Smith, R.L. · Waddell, W.J. · Wagner, B.M.
Keywords: Nutrition Toxicology · Toxicology and Applied Pharmacology · FEMA GRAS · Flavoring ingredients · PEA · acetal derivative · acid · aldehyde · ester derivative · ethyl(4 tolyloxy)acetate · flavoring agent · isopropylphenylacetaldehyde · phenethyl alcohol · phenethyl phenylacetate · phenethyl senecioate · phenoxyacetic acid · phenoxyacetic acid derivative · phenoxyethyl alcohol · phenylacetic acid · sodium 2 (4 methoxyphenoxy)propanoate · unclassified drug · absorption · carcinogenicity · chemical analysis · chemical structure · data analysis · detoxification · evaluation · excretion · exposure · flavor · food analysis · food composition · food intake · food poisoning · food safety · genotoxicity · health care organization · human · hydrolysis · in vitro study · in vivo study · information · metabolism · mutagenesis · nonhuman · review · risk assessment · science · structure analysis · toxicity · Acetaldehyde · Acetals · Animals · Esters · Flavoring Agents · Food Industry · Humans · Phenylacetates · Phenylethyl Alcohol · Toxicity Tests · United States · United States Food and Drug Administration · Animalia
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 17 of 17 found. | Sort by date