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Showing 1 to 13 of 13 found. | Sort by date

1 Degeneration, inflammation, regeneration, and pain/disability in dogs following destabilization or articular cartilage grooving of the stifle joint
article 2008    
Author: Frost-Christensen, L.N. · Mastbergen, S.C. · Vianen, M.E. · Hartog, A. · Groot, J. de · Voorhout, G. · Wees, A.M.C. van · Lafeber, F.P.J.G. · Hazewinkel, H.A.W.
Keywords: Health · ACLT · Gait · Groove-model · Meniscectomy · Osteoarthritis · Animal experiment · Animal model · Animal tissue · Anterior cruciate ligament injury · Article · Articular cartilage · Cartilage cell · Controlled study · Disease model · Dog · Gait · Joint degeneration · Knee osteoarthritis · Knee pain · Knee radiography · Nonhuman · Osteophyte · Physical disability · Priority journal · Synovitis · Tissue regeneration · Animals · Anterior Cruciate Ligament · Arthralgia · Cartilage, Articular · Chondrocytes · Dogs · Gait · Inflammation · Joint Instability · Models, Animal · Osteoarthritis · Osteophyte · Regeneration · Stifle
[Abstract]

2 The canine bilateral groove model of osteoarthritis
article 2008    
Author: Intema, F. · Groot, J. de · Elshof, B. · Vianen, M.E. · Yocum, S. · Zuurmond, A. · Mastbergen, S.C. · Lafeber, F.P.
Keywords: Biology · Bilateral model · Canine · Groove model · Osteoarthritis · Proteoglycan · Animal experiment · Animal model · Animal tissue · Article · Articular cartilage · Biochemistry · Clinical feature · Controlled study · Disease activity · Disease model · Dog · Experimental model · Female · Femur condyle · Histology · Knee · Nonhuman · Osteoarthritis · Priority journal · Proteoglycan synthesis · Tibia · Animal · Hindlimb · Knee osteoarthritis · Metabolism · Pathology · Synovium · Animals · Cartilage, Articular · Disease Models, Animal · Dogs · Hindlimb · Osteoarthritis, Knee · Proteoglycans · Stifle · Synovial Membrane · Food and Nutrition · Healthy Living
[Abstract]

3 Nonclinical testing of vaccines: Report from a workshop
article 2009    
Author: Laan, J.W. van der · Forster, R. · Ledwith, B. · Gruber, M. · Gould, S. · Segal, L. · Penninks, A.
Keywords: Health · Adjuvants · Developmental and reproductive toxicology · DNA vaccines · Nonclinical evaluation · Safety testing · Therapeutic vaccines · Vaccines · diphtheria pertussis tetanus vaccine · DNA vaccine · immunological adjuvant · immunomodulating agent · live vaccine · Meningococcus vaccine · pertussis vaccine · vaccine · Wart virus vaccine · conference paper · disease model · drug dose regimen · drug efficacy · drug research · drug safety · drug screening · drug tolerability · electroporation · human · immune response · immunogenicity · male fertility · nonhuman · pharmacodynamics · practice guideline · priority journal · reproductive toxicity · tattooing · toxicity testing · toxicology · vaccination · workshop
[Abstract]

4 A microsimulation model for the development and progression of chronic obstructive pulmonary disease
article 2015    
Author: Tan, E. · Boessen, R. · Fishwick, D. · Klein Entink, R. · Meijster, T. · Pronk, A. · Duuren-Stuurman, B. van · Warren, N.
Keywords: Health · Chronic obstructive pulmonary disease · Disease model · Microsimulation · Smoking · Adult · Chronic obstructive lung disease · Disease course · Disease simulation · Environmental exposure · Female · Follow up · Forced expiratory volume · Forced vital capacity · Health impact assessment · Health survey · Human · Longitudinal study · Lung function · Major clinical study · Male · Microsimulation model · Occupational exposure · Population dynamics · Prevalence · Risk factor · Smoking cessation · United Kingdom · Healthy for Life · Healthy Living · Life · RAPID - Risk Analysis for Products in Development · ELSS - Earth, Life and Social Sciences
[Abstract]

5 1H-NMR spectroscopy combined with pattern recognition analysis reveals characteristic chemical patterns in urines of MS patients and non-human primates with MS-like disease
article 2003    
Author: Hart, B.A. 't · Vogels, J.T.W.E. · Spijksma, G. · Brok, H.P.M. · Polman, C. · Greef, J. van der
Keywords: Biology · Analytical research · Inflammatory demyelination · MS disease markers · NMR spectroscopy · Pattern recognition · Urine · myelin protein · organic compound · glycoprotein · tritium · animal model · article · autoimmune disease · chemical composition · clinical article · controlled study · disease course · encephalomyelitis · female · human · male · marmoset · molecular recognition · multiple sclerosis · multivariate analysis · nonhuman · primate · priority journal · proton nuclear magnetic resonance · urinalysis · validation process · allergic encephalomyelitis · animal · automated pattern recognition · chemistry · comparative study · disease model · immunization · immunology · methodology · nuclear magnetic resonance spectroscopy · species difference · time · urine · Animals · Callithrix · Disease Models, Animal · Encephalomyelitis, Autoimmune, Experimental · Female · Glycoproteins · Humans · Immunization · Magnetic Resonance Spectroscopy · Male · Multiple Sclerosis · Multivariate Analysis · Myelin Proteins · Pattern Recognition, Automated · Species Specificity · Time Factors · Tritium · Urine
[Abstract]

6 Reproducible long-term disc degeneration in a large animal model
article 2008    
Author: Hoogendoorn, R.J.W. · Helder, M.N. · Kroeze, R.J. · Bank, R.A. · Smit, T.H. · Wuisman, P.I.J.M.
Keywords: Biology · Biomedical Research · Animal model · Goat · Intervertebral disc degeneration · Long term · Reproducible · chondroitin ABC lyase · glycosaminoglycan · hydroxyproline · animal experiment · animal model · animal tissue · article · chemical analysis · disease severity · female · goat · histology · intervertebral disk · intervertebral disk degeneration · nonhuman · nuclear magnetic resonance imaging · priority journal · radiography · animal · chemically induced disorder · chronic disease · disease model · hospitalization · intraspinal drug administration · metabolism · osteophyte · pathology · reproducibility · spine disease · time · Animals · Chondroitin ABC Lyase · Chronic Disease · Disease Models, Animal · Female · Glycosaminoglycans · Goats · Hydroxyproline · Injections, Spinal · Intervertebral Disk · Magnetic Resonance Imaging · Osteophyte · Reproducibility of Results · Severity of Illness Index · Spinal Diseases · Time Factors
[Abstract]

7 Molecular changes in the degenerated goat intervertebral disc
article 2008    
Author: Hoogendoorn, R. · Doulabi, B.Z. · Huang, C.L. · Wuisman, P.I. · Bank, R.A. · Helder, M.N.
Keywords: Biomedical Research · Animal model · Biochemical composition · Disc degeneration · Gene expression · aggrecan · chondroitin ABC lyase · collagen · collagen type 1 · collagen type 2 · collagenase 3 · glycosaminoglycan · hydroxyproline · metalloproteinase · pyridinoline · thrombospondin · scleroprotein · animal experiment · animal model · article · cross linking · disease severity · female · gene expression · gene sequence · goat · intervertebral disk · intervertebral disk degeneration · nonhuman · priority journal · protein motif · animal · comparative study · disease model · gene expression profiling · genetics · lumbar vertebra · metabolism · methodology · pathology · physiology · spine disease · Animals · Collagen · Disease Models, Animal · Extracellular Matrix Proteins · Female · Gene Expression Profiling · Goats · Intervertebral Disk · Lumbar Vertebrae · Spinal Diseases
[Abstract]

8 The canine 'groove' model, compared with the ACLT model of osteoarthritis
article 2002    
Author: Marijnissen, A.C.A. · Roermund, P.M. van · TeKoppele, J.M. · Bijlsma, J.W.J. · Lafeber, F.P.J.G.
Keywords: Biology · Biomedical Research · Canine model · Cartilage · Osteoarthritis · Proteoglycans · collagen · collagenase 3 · interstitial collagenase · matrix protein · proteoglycan · stromelysin · animal experiment · animal model · animal tissue · anterior cruciate ligament · article · articular cartilage · biochemistry · cartilage cell · cartilage degeneration · collagen degradation · controlled study · disease model · disease severity · dog · enzyme activity · evaluation · female · femur condyle · histopathology · joint stability · knee · nonhuman · osteoarthritis · priority journal · protein depletion · synovial fluid · synovitis · tissue injury · weight bearing · Animals · Cartilage, Articular · Chondrocytes · Collagen · Collagenases · Dogs · Female · Matrix Metalloproteinase 1 · Matrix Metalloproteinase 13 · Matrix Metalloproteinase 3 · Models, Animal · Osteoarthritis · Proteoglycans · Synovial Fluid · Weight-Bearing
[Abstract]

9 Drug-eluting stents studies in mice: Do we need atherosclerosis to study restenosis?
article 2006    
Author: Pires, N.M.M. · Jukema, J.W. · Daemen, M.J.A.P. · Quax, P.H.A.
Keywords: Health · Biomedical Research · (Histo)Pathology · Animal models · Atherosclerosis · Drug-eluting stents · Restenosis · 7 hexanoyltaxol · Dactinomycin · Dexamethasone · Everolimus · Paclitaxel · Paclitaxel derivative · Qp 2 · Rapamycin · Tacrolimus · Thalidomide · Unclassified drug · Artery intima proliferation · Atherosclerosis · Blood pressure variability · Clinical trial · Coronary stent · Cost effectiveness analysis · Disease exacerbation · Disease model · Drug efficacy · Drug eluting stent · Drug release · Drug safety · Evaluation · Healing impairment · Hypersensitivity reaction · In-stent restenosis · Mouse strain · Nonhuman · Pain · Rash · Respiratory tract disease · Restenosis · Side effect · Thrombosis · Animals · Atherosclerosis · Coronary Restenosis · Disease Models, Animal · Drug Delivery Systems · Drug Evaluation, Preclinical · Humans · Mice · Paclitaxel · Sirolimus · Stents
[Abstract]

10 Niacin increases HDL by reducing hepatic expression and plasma levels of cholesteryl ester transfer protein in APOE*3Leiden.CETP mice
article 2008    
Author: Hoorn, J.W.A. van der · Haan, W. de · Berbée, J.P.P. · Havekes, L.M. · Jukema, J.W. · Rensen, P.C. · Princen, H.M.G.
Keywords: APOE*3Leiden.CETP transgenic mice · CETP · HDL-cholesterol · Hyperlipidemia · Niacin · cholesterol · cholesterol ester transfer protein · high density lipoprotein · high density lipoprotein cholesterol · low density lipoprotein cholesterol · nicotinic acid · triacylglycerol · antilipemic agent · CETP protein, human · messenger RNA · animal experiment · animal model · animal tissue · blood level · cholesterol blood level · controlled study · dose response · drug dose comparison · drug mechanism · female · gene activity · gene expression regulation · hypercholesterolemia · hypertriglyceridemia · kidney · lipid transport · lipoprotein blood level · liver · mouse · mouse strain · nonhuman · particle size · plasma clearance · priority journal · protein blood level · protein function · protein transport · transgenic mouse · triacylglycerol blood level · atherosclerosis · bile · blood · chemistry · disease model · drug effect · fat intake · feces · genetics · metabolism · time · upregulation · Animals · Antilipemic Agents · Apolipoprotein A-I · Apolipoprotein E3 · Atherosclerosis · Bile · Cholesterol Ester Transfer Proteins · Cholesterol, HDL · Dietary Fats · Disease Models, Animal · Dose-Response Relationship, Drug · Feces · Female · Humans · Liver · Mice · Mice, Transgenic · Niacin · RNA, Messenger · Time Factors · Triglycerides · Up-Regulation
[Abstract]

11 Mixed antibody and T cell responses to peanut and the peanut allergens Ara h 1, Ara h 2, Ara h 3 and Ara h 6 in an oral sensitization model
article 2004    
Author: Wijk, F. van · Hartgring, S. · Koppelman, S.J. · Pieters, R. · Knippels, L.M.J.
Keywords: Biology · Food technology · Cytokines · Oral mouse model · Peanut allergens · Peanut hyper-sensitivity · Sensitization · Th1/Th2 responses · antibody · cholera toxin · cytokine · food allergen · gamma interferon · immunoglobulin E · immunoglobulin G1 · immunoglobulin G2a · interleukin 10 · interleukin 4 · interleukin 5 · protein Ara h 1 · protein Ara h 2 · protein Ara h 3 · protein Ara h 6 · unclassified drug · anaphylaxis · animal cell · animal experiment · animal model · antibody detection · antibody response · article · controlled study · cytokine production · disease model · exposure · female · humoral immunity · immune response · mouse · nonhuman · peanut · peanut allergy · priority journal · sensitization · serum · spleen · T lymphocyte · Th1 cell · Th2 cell · Administration, Oral · Allergens · Animals · Arachis hypogaea · Cells, Cultured · Cytokines · Disease Models, Animal · Female · Glycoproteins · Immunoglobulin A · Immunoglobulin E · Immunoglobulin G · Immunoglobulins · Mice · Mice, Inbred C3H · Peanut Hypersensitivity · Plant Proteins · Spleen · T-Lymphocytes, Helper-Inducer · Th1 Cells · Th2 Cells
[Abstract]

12 Intrauterine exposure to maternal atherosclerotic risk factors increases the susceptibility to atherosclerosis in adult life
article 2007    
Author: Alkemade, F.E. · Gittenberger-Groot, A.C. de · Schiel, A.E. · Munsteren, J.C. van · Hogers, B. · Vliet, L.S.J. van · Poelmann, R.E. · Havekes, L.M. · Dijk, K.W. van · Ruiter, M.C. de
Keywords: Health · Biomedical Research · Atherosclerosis · Carotid arteries · Hypercholesterolemia · Pregnancy · Risk factors · apolipoprotein E · cholesterol · triacylglycerol · atherosclerosis · cardiovascular risk · carotid artery · cell volume · comparative study · controlled study · disease predisposition · endothelium cell · epigenetics · female · heterozygosity · hypercholesterolemia · hyperlipoproteinemia type 3 · intima · maternal disease · mother · mouse · nonhuman · prenatal development · prenatal exposure · progeny · risk factor · statistical significance · wild type · animal · blood · C57BL mouse · carotid artery injury · cell size · disease course · disease model · fetus blood · genetic epigenesis · genetics · genome imprinting · hospitalization · human · magnetic resonance angiography · metabolism · mouse mutant · pathology · pregnancy · transgenic mouse · Animals · Apolipoproteins E · Atherosclerosis · Carotid Arteries · Carotid Artery Injuries · Cell Size · Cholesterol · Disease Models, Animal · Disease Progression · Endothelial Cells · Epigenesis, Genetic · Female · Fetal Blood · Genomic Imprinting · Humans · Hypercholesterolemia · Magnetic Resonance Angiography · Mice · Mice, Inbred C57BL · Mice, Knockout · Mice, Transgenic · Pregnancy · Prenatal Exposure Delayed Effects · Risk Factors · Severity of Illness Index · Triglycerides · Tunica Intima
[ABSTRACT] [Abstract]

13 Atherosclerosis and liver inflammation induced by increased dietary cholesterol intake: A combined transcriptomics and metabolomics analysis
article 2007    
Author: Kleemann, R. · Verschuren, L. · Erk, M.J. van · Nikolsky, Y. · Cnubben, N.H.P. · Verheij, E.R. · Smilde, A.K. · Hendriks, H.F.J. · Zadelaar, A.S.M. · Smith, G.J. · Kaznacheev, V. · Nikolskaya, T. · Melnikov, A. · Hurt-Camejo, E. · Greef, J. van der · Ommen, B. van · Kooistra, T.
Keywords: Analytical research · Biomedical research · alanine aminotransferase · aspartate aminotransferase · cholesterol · endothelial leukocyte adhesion molecule 1 · gamma interferon · high density lipoprotein · hydroxymethylglutaryl coenzyme A reductase · immunoglobulin enhancer binding protein · interleukin 1 · low density lipoprotein · peroxisome proliferator activated receptor alpha · platelet derived growth factor · protein p53 · retinoid X receptor · retinoid X receptor alpha · serum amyloid A · Smad3 protein · STAT1 protein · STAT3 protein · STAT5 protein · sterol regulatory element binding protein 1 · sterol regulatory element binding protein 2 · transcription factor FKHR · transcription factor Sp1 · transcription factor YY1 · triacylglycerol · tumor necrosis factor alpha · very low density lipoprotein · alanine aminotransferase blood level · animal experiment · animal model · animal tissue · article · aspartate aminotransferase blood level · atherosclerosis · cholesterol blood level · cholesterol diet · cholesterol intake · controlled study · diet supplementation · female · gene control · genetic transcription · hepatitis · hypercholesterolemia · lipid metabolism · metabolomics · mouse · nonhuman · pathophysiology · protein blood level · stress · transcription regulation · transcriptomics · triacylglycerol blood level · upregulation · animal · biological model · diet · disease model · gene expression regulation · inflammation · liver · metabolism · pathology · systems biology · Mus · Animals · Atherosclerosis · Cholesterol, Dietary · Diet · Disease Models, Animal · Female · Gene Expression Regulation · Inflammation · Lipid Metabolism · Liver · Metabolism · Mice · Models, Biological · Systems Biology · Transcription, Genetic
[Abstract]

Search results also available in MS Excel format.

Showing 1 to 13 of 13 found. | Sort by date