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Showing 1 to 11 of 11 found. | Sort by date

1 Discovery of thrombin activatable fibrinolysis inhibitor (TAFI)
article 2006    
Author: Bertina, R.M. · Tilburg, N.H. van · Haverkate, F. · Bouma, B.N. · Borne, P.A.K. von dem · Meijers, J.C.M. · Campbell, W. · Eaton, D. · Hendriks, D.F. · Willemse, J.L.
Keywords: Biology · Biomedical Research · blood clotting factor 11 · thrombin · thrombin activatable fibrinolysis inhibitor · tissue plasminogen activator · protein C · article · bleeding tendency · blood clot lysis · blood clotting · blood clotting factor 11 deficiency · enzyme activity · fibrinolysis · human · laboratory · methodology · nonhuman · priority journal · thrombogenesis · thrombosis · drug antagonism · history · note · physiology · Carboxypeptidase U · Fibrinolysis · History, 20th Century · History, 21st Century · Humans · Protein C · Tissue Plasminogen Activator
[Abstract]

2 Doxycycline inhibits collagen synthesis by differentiated articular chondrocytes.
article 1998    
Author: TeKoppele, J.M. · Beekman, B. · Verzijl, N. · Koopman, J.L. · Groot, J. de · Bank, R.A.
Keywords: Biology · Biomedical Research · antiinfective agent · collagen · doxycycline · metalloproteinase · protein synthesis inhibitor · proteinase inhibitor · animal · article · articular cartilage · biosynthesis · cartilage cell · cattle · cell culture · cytology · dog · drug antagonism · metabolism · osteoarthritis · Animals · Anti-Bacterial Agents · Cartilage, Articular · Cattle · Cells, Cultured · Chondrocytes · Collagen · Dogs · Doxycycline · Metalloendopeptidases · Osteoarthritis · Protease Inhibitors · Protein Synthesis Inhibitors
[Abstract]

3 Metabolism of ATP-binding cassette drug transporter inhibitors: complicating factor for multidrug resistance.
article 2005    
Author: Cnubben, N.H. · Wortelboer, H.M. · Zanden, J.J. van · Rietjens, I.M. · Bladeren, P.J. van
Keywords: Health Pharmacology · Physiological Sciences · ABC transporter · cyclosporin derivative · dibenzo[a,d]cycloheptene derivative · glycoprotein P · quinoline derivative · valspodar · zosuquidar · drug antagonism · drug design · drug effect · genetics · human · metabolism · multidrug resistance · review · RNA interference · transport at the cellular level · ATP-Binding Cassette Transporters · Biological Transport · Cyclosporins · Dibenzocycloheptenes · Drug Design · Drug Resistance, Multiple · Humans · P-Glycoproteins · Quinolines · RNA Interference
[Abstract]

4 Chemically modified tetracyclines stimulate matrix metalloproteinase-s production by periodontal ligament cells
article 2006    
Author: Bildt, M.M. · Snoek-van Beurden, A.M.P. · Groot, J. de · El, B. van · Kuijpers-Jagtman, A.M. · Hoff, J.W. van den
Keywords: Biology · Biomedical Research · Chemically modified tetracyclines · Gelatin zymography · Matrix metalloproteinases · Periodontal ligament · DNA · Enzyme inhibitor · Gelatin · Gelatinase A · Gelatinase B · Recombinant protein · Tetracycline derivative · Analysis of variance · Iosynthesis · Cell culture · Chemistry · Drug antagonism · Drug effect · Human · Metabolism · Nonparametric test · Periodontal ligament · Polyacrylamide gel electrophoresis · Western blotting · Analysis of Variance · Blotting, Western · Cells, Cultured · DNA · Electrophoresis, Polyacrylamide Gel · Enzyme Inhibitors · Gelatin · Humans · Matrix Metalloproteinase 2 · Matrix Metalloproteinase 9 · Periodontal Ligament · Recombinant Proteins · Statistics, Nonparametric · Tetracyclines
[Abstract]

5 Binary PAH mixtures cause additive or antagonistic effects on gene expression but synergistic effects on DNA adduct formation
article 2007    
Author: Staal, Y.C.M. · Hebels, D.G.A.J. · Herwijnen, M.H.M. van · Gottschalk, R.W.H. · Schooten, F.J. van · Delft, J.H.M. van
Keywords: Toxicology and Applied Pharmacology · benzo[a]pyrene · benzo[b]fluoranthene · dibenz[a,h]anthracene · dibenzo[a,l]pyrene · fluoranthene · phenanthrene derivative · polycyclic aromatic hydrocarbon · apoptosis · article · carcinogenesis · carcinogenicity · cell cycle · cell strain HepG2 · controlled study · DNA adduct · exposure · gene expression · hepatoma cell · human · human cell · nucleotide sequence · priority journal · unindexed sequence · Air Pollutants · Apoptosis · Cell Cycle · Cell Line, Tumor · DNA Adducts · Drug Antagonism · Drug Synergism · Gene Expression Profiling · Gene Expression Regulation, Neoplastic · Humans · Polycyclic Hydrocarbons, Aromatic
[Abstract]

6 Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system
article 1999    
Author: Iersel, M.L.P.S. van · Cnubben, N.H.P. · Smink, N. · Koeman, J.H. · Bladeren, P.J. van
Keywords: Nutrition · Cells · Glutathione S-transferases · Inhibition · Metabolism · Prostaglandin A2 · 1 chloro 2,4 dinitrobenzene · Glutathione · Glutathione transferase · Prostaglandin a2 · Glutathione transferase P1 · GSTP1 protein, human · Isoenzyme · Prostaglandin A · Prostaglandin A2 · Biotransformation · Cell function · Cell metabolism · Cell proliferation · Controlled study · Cytotoxicity · Enzyme activity · Enzyme modification · Human · Human cell · Melanoma cell · Priority journal · Cell culture · Drug antagonism · Melanoma · Metabolism · Biotransformation · Glutathione · Glutathione S-Transferase pi · Glutathione Transferase · Humans · Isoenzymes · Melanoma · Prostaglandins A · Tumor Cells, Cultured
[Abstract]

7 Stereoselectivity at the B2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of B2-agonists
article 2000    
Author: Izeboud, C.A. · Vermeulen, R.M. · Zwart, A. · Vos, H.P. · Miert, A.S.J.P.A.M. van · Witkamp, R.F.
Keywords: β-Adrenoceptor · Stereoselectivity · 3 isopropylamino 1 (7 methyl 4 indanyloxy) 2 butanol · 4 (3 tert butylamino 2 hydroxypropoxy) 2 benzimidazolone · Aprotinin · Benzylsulfonyl fluoride · Beta 2 adrenergic receptor · Beta 2 adrenergic receptor blocking agent · Beta 2 adrenergic receptor stimulating agent · Carmoterol · cyclic AMP · Interleukin 10 · Lipopolysaccharide · Tumor necrosis factor alpha · Xamoterol · Beta adrenergic receptor stimulating agent · Nonsteroid antiinflammatory agent · Antiinflammatory activity · Stereochemistry · Cell culture · Cell membrane · Drug antagonism · Metabolism · Radioassay · Signal transduction · Stereoisomerism · Adrenergic beta-Agonists · Anti-Inflammatory Agents, Non-Steroidal · Cell Membrane · Cells, Cultured · Cyclic AMP · Humans · Interleukin-10 · Lipopolysaccharides · Macrophages · Radioligand Assay · Receptors, Adrenergic, beta-2 · Signal Transduction · Stereoisomerism · Tumor Necrosis Factor-alpha
[Abstract]

8 Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro
article 2003    
Author: Walker, J.B. · Hughes, B. · James, I. · Haddock, P. · Kluft, C. · Bajzar, L.
Keywords: Biology · Biomedical Research · Chemical activation · Tissue · Competitive inhibitors · Biochemistry · 2 guanidinoethylmercaptosuccinic acid · Potato tuber carboxypeptidase inhibitor · Thrombin activatable fibrinolysis inhibitor · Tissue plasminogen activator · Unclassified drug · 3 (2 guanidinoethyl) 2 mercaptosuccinic acid · Carboxypeptidase · Carboxypeptidase inhibitor, plant · Succinic acid derivative · Vegetable protein · Blood clotting · Competitive inhibition · Concentration response · Enzyme kinetics · Enzyme stability · Half life time · In vitro study · Potato · Protein stability · Binding competition · Chemistry · Dose response · Drug antagonism · Metabolism · Theoretical model · Solanum tuberosum · Binding, Competitive · Carboxypeptidase U · Carboxypeptidases · Dose-Response Relationship, Drug · Enzyme Inhibitors · Fibrinolysis · Humans · Kinetics · Models, Theoretical · Plant Proteins · Protein Binding · Succinates · Temperature · Time Factors · Tissue Plasminogen Activator
[PDF] [Abstract]

9 DMBT1 functions as pattern-recognition molecule for poly-sulfated and poly-phosphorylated ligands
article 2009    
Author: End, C. · Bikker, F.J. · Renner, M. · Bergmann, G. · Lyer, S. · Blaich, S. · Hudler, M. · Helmke, B. · Gassler, N. · Autschbach, F. · Ligtenberg, A.J.M. · Benner, A. · Holmskov, U. · Schirmacher, P. · Nieuw Amerongen, A.V. · Rosenstiel, P. · Sina, C. · Franke, A. · Hafner, M. · Kioschis, P. · Schreiber, S. · Poustka, A. · Mollenhauer, J.
Keywords: Health · Inflammatory bowel disease · Innate immunity · Mucosal immunity · Pattern recognition · Scavenger receptor cysteine-rich · Carrageenan · Deleted in malignant brain tumors 1 · Dextran sulfate · Glycoprotein · Heparan sulfate · Lipopolysaccharide · Lipoteichoic acid · Unclassified drug · Cell surface receptor · DMBT1 protein, human · Ligand · Phosphate · Animal experiment · Animal model · Antiinflammatory activity · Antimicrobial activity · Binding competition · Cell aggregation · Colitis · Controlled study · Crohn disease · Cytotoxicity · Dose response · Enzyme linked immunosorbent assay · Escherichia coli · Experimental mouse · Host pathogen interaction · Human · Human cell · In vitro study · Innate immunity · Intestine epithelium cell · Mouse · Nonhuman · Protein binding · Protein determination · Protein expression · Protein function · Protein motif · Protein phosphorylation · Salmonella minnesota · Salmonella typhimurium · Streptococcus gordonii · Sulfation · Bacterium · Cell line · Drug antagonism · Epithelium cell · Genetics · Immunology · Intestine · Metabolism · Microbiology · Bacteria · Carrageenan · Cell Line · Dextran Sulfate · Epithelial Cells · Humans · Intestines · Ligands · Phosphates · Receptors, Cell Surface
[Abstract]

10 β1 integrins regulate chondrogenesis and rock signaling in adipose stem cells
article 2008    
Author: Lu, Z.F. · Doulabi, B.Z. · Huang, C.L. · Bank, R.A. · Helder, M.N.
Keywords: Health · Biomedical Research · β1 integrins · Adipose tissue · Cell shape · Chondrogenesis · Mesenchymal stem cells · Rock signaling · beta1 integrin · collagen type 10 · collagen type 2 · transcription factor Sox9 · transforming growth factor beta1 · DNA binding protein · high mobility group protein · immunoglobulin G · Rho kinase · sox-9 transcription factor · SOX6 protein, human · transcription factor · adipocyte · article · cell interaction · chondrogenesis · collagen 2 gene · collagen x gene · controlled study · down regulation · extracellular matrix · gene · gene expression · human · human cell · human tissue · priority journal · protein function · rock 1 gene · rock 2 gene · signal transduction · Sox9 gene · adipose tissue · cell shape · culture medium · cytology · drug antagonism · drug effect · gene expression regulation · genetics · physiology · stem cell · Adipose Tissue · Antigens, CD29 · Cell Shape · Chondrogenesis · Collagen Type II · Collagen Type X · Culture Media · DNA-Binding Proteins · Gene Expression · Gene Expression Regulation, Developmental · High Mobility Group Proteins · Humans · Immunoglobulin G · rho-Associated Kinases · Stem Cells · Transcription Factors · Transforming Growth Factor beta1 · Healthy for Life · Healthy Living
[Abstract]

11 Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
article 2006    
Author: Kitayama, K. · Nakai, D. · Kono, K. · Hoop, A.G. van der · Kurata, H. · Wit, E.C. de · Cohen, L.H. · Inaba, T. · Kohama, T.
Keywords: Biology · Apical sodium-dependent bile acid transporter · Cholesterol · Enterohepatic circulation · Hamster · Hypocholesterolemic agent · Monkey · Carbon 14 · Cholesterol · High density lipoprotein cholesterol · Ileum apical bile acid transporter inhibitor · Phospholipid · Piperidine derivative · R 146224 · Taurocholic acid · Triacylglycerol · Tritium · Unclassified drug · Bile acid · Carrier protein · Cotransporter · Organic anion transporter · Quinoline derivative · Sodium · Sodium bile acid cotransporter · Sodium-bile acid cotransporter · Absorption · Animal experiment · Animal tissue · Bile duct fistula · Bile flow · Cholesterol blood level · Cholesterol esterification · Concentration response · Controlled study · Diet · Dose response · Drug mechanism · Embryo · Feeding · Human cell · Hypercholesterolemia · Hypolipemia · Inhibition kinetics · Time · Triacylglycerol blood level · Urinary excretion · Biosynthesis · Blood · Cell line · Drug antagonism · Drug effect · Genetics · In vitro study · Macaca · Metabolism · Physiology · Sprague Dawley rat · Syrian hamster · Animals · Anticholesteremic Agents · Bile Acids and Salts · Cell Line · Cholesterol · Cricetinae · Humans · Ileum · Macaca fascicularis · Male · Membrane Transport Proteins · Mesocricetus · Organic Anion Transporters, Sodium-Dependent · Piperidines · Quinolines · Rats · Rats, Sprague-Dawley · Sodium · Symporters · Taurocholic Acid
[Abstract]

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Showing 1 to 11 of 11 found. | Sort by date